15,171 results match your criteria ophthalmological signs


The prevalence of dry eye in a very old population.

Acta Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: To assess the prevalence of dry eye disease (DED) and Meibomian gland dysfunction (MGD) in a very old population.

Methods: The Ural Very Old Study (UVOS), a population-based cohort study performed in rural and urban Bashkortostan/Russia, included 1526 (81.1%) out of 1882 eligible individuals aged 85+ years. Read More

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Vitrectomy With Silicone Oil Tamponade and Without Internal Limiting Membrane Peeling for the Treatment of Myopic Foveoschisis With High Risk of Macular Hole Development.

Front Med (Lausanne) 2021 28;8:648540. Epub 2021 May 28.

Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Department of Ophthalmology, Peking University People's Hospital, Beijing, China.

To explore the efficiency and safety of the surgical procedure of pars plana vitrectomy (PPV) with silicone oil (SO) tamponade and without internal limiting membrane (ILM) peeling for myopic foveoschisis (MF) eyes with high risk of macular hole formation. Three eyes (three patients) with MF and foveal detachment were enrolled into the study. Comprehensive preoperative ophthalmological assessments, including best corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT) were performed on the eyes. Read More

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Monocular Diplopia in Idiopathic Intracranial Hypertension: A Case Report and Literature Review.

Eur J Case Rep Intern Med 2021 4;8(5):002509. Epub 2021 May 4.

Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.

Background: Diplopia is the double vision of a single object, and can be binocular or monocular. Binocular diplopia is caused by the misalignment of the visual axes, with images falling on the fovea of the fixating eye and on the extra-foveal retina of the non-fixating eye, as a consequence of both neurological (i.e. Read More

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Challenges in Patients with Trisomy 21: A Review of Current Knowledge and Recommendations.

J Ophthalmol 2021 26;2021:8870680. Epub 2021 May 26.

Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Purpose: To summarize and review the common ophthalmic anomalies in children with trisomy 21 (Down syndrome) in order to propose an update to current clinical recommendations.

Methods: A retrospective chart review, systemic literature review, and international survey of the frequency of ocular abnormalities, screening schedules, and challenging aspects examining children with trisomy 21. The chart review included patients treated at the Department of Ophthalmology at the University Hospital of Zurich over a two-year period. Read More

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Frequency and risk factors for hydroxychloroquine retinopathy among patients with systemic lupus erythematosus.

Egypt J Intern Med 2021 8;33(1):18. Epub 2021 Jun 8.

Department of Medicine Division of Rheumatology, Ain Shams University, Cairo, Egypt.

Background: Hydroxychloroquine (HCQ) is an antimalarial drug, recently used in COVID-19 treatment. Also it is considered over many years the cornerstone in treating systemic lupus erythematosus (SLE) in adults and children. The incidence of retinal affection and retinal toxicity from hydroxychloroquine is rare, but even after the HCQ is stopped, loss of vision may not be reversible and may continue to progress. Read More

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Isolated abducens nerve palsy in a patient with asymptomatic SARS-CoV-2 infection.

J Clin Neurosci 2021 Jul 19;89:65-67. Epub 2021 Apr 19.

Department of Neurology, North Bristol NHS Trust, Bristol BS10 5NB, UK; Population Health Sciences, University of Bristol, Bristol BS8 2PL, UK. Electronic address:

The neuro-ophthalmological complications of SARS-CoV-2 infection are emerging but the spectrum of presentations and pathophysiological mechanism underpinning the association remains to be fully determined. We describe the case of a 44-year-old female who presented with a 12-hour history of diplopia preceded by a mild headache and found to have an isolated right abducens nerve palsy. Initial vital signs were normal but she developed a fever and nasopharyngeal swab confirmed SARS-CoV-2 infection by RT-PCR. Read More

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Noninfectious Intermediate, Posterior, or Panuveitis: Results from the Retrospective, Observational, International EyeCOPE Study.

Ophthalmol Ther 2021 Jun 12. Epub 2021 Jun 12.

Department of Ophthalmology, Faculty of Medicine, Gazi University, 13th Floor, Besevler, Cankaya, 06500, Ankara, Turkey.

Introduction: The EyeCOPE study characterized noninfectious intermediate posterior, or panuveitis (NIIPPU) before biologic agents were widely available.

Methods: This retrospective, observational study included adults with NIIPPU attending a routine ophthalmological visit. Data were collected from the study visit and medical records. Read More

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Expanding the clinical phenotype and genetic spectrum of PURA-related neurodevelopmental disorders.

Brain Dev 2021 Jun 8. Epub 2021 Jun 8.

Division of Pediatric Neurology, Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Rare Disease Center, Seoul National University Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: PURA-related neurodevelopmental disorders (PURA-NDDs) include 5q31.3 deletion syndrome and PURA syndrome. PURA-NDDs are characterized by neonatal hypotonia, moderate to severe global developmental delay/intellectual disability (GDD/ID), facial dysmorphism, epileptic seizures, nonepileptic movement disorders, and ophthalmological problems. Read More

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Persistent visual dysfunction following PRES due to COVID-19: Case series and literature review.

Eur J Neurol 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Colorado University School of Medicine, 1675 North Aurora Ct. F731, Aurora, CO, 80045, USA.

Background: The full spectrum of neurological sequelae in COVID-19 is beginning to emerge. SARS-CoV-2 has the potential to cause both direct and indirect brain vascular endothelial damage through infection and inflammation that may result in long-term neurological signs and symptoms. We sought to illuminate persistent neuro-ophthalmological deficits that may be seen following posterior reversible encephalopathy syndrome (PRES) due to COVID-19. Read More

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Combination Model of Thyrotrophin Receptor Antibody and Volumetric Orbital Apex Crowding Index as an Indicator of Dysthyroid Optic Neuropathy.

Dis Markers 2021 18;2021:9964232. Epub 2021 May 18.

Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Dysthyroid optic neuropathy (DON) is one of the most serious vision-threatening complications of thyroid eye disease (TED); however, accurate and established diagnostic tools for DON are yet lacking. The present study was aimed at identifying new diagnostic factors for the accurate diagnosis of DON.

Methods: This retrospective cross-sectional study included 25 TED patients (50 eyes) with enlarged extraocular muscles, no previous anti-inflammatory therapy, and the absence of other vision-affecting diseases between May 2017 and August 2019. Read More

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A woman in her forties with unilateral blurred vision and pain upon eye movement.

Tidsskr Nor Laegeforen 2021 06 3;141(9). Epub 2021 Jun 3.

Background: Toxoplasmosis is a relatively common cause of infectious papillitis and neuroretinitis, which may affect both immunocompetent and immunodeficient patients.

Case Presentation: A previously healthy woman in her mid-forties presented with subacute onset of unilateral blurred vision and retrobulbar pain exacerbated by eye movements. Ophthalmological assessment revealed decimal best-corrected visual acuity of 0. Read More

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Comparative study of AQP4-NMOSD, MOGAD and seronegative NMOSD: a single-center Belgian cohort.

Acta Neurol Belg 2021 Jun 7. Epub 2021 Jun 7.

Clinical Neuroimmunology Unit, Department of Neurology, CHU Liège, University Hospital of Liège, Liège, Belgium.

To emphasize physio-pathological, clinical and prognosis differences between conditions causing serious and sometimes very similar clinical manifestations: anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies related diseases, and seronegative NMOSD (neuromyelitis optica spectrum disorders).  Based on Wingerchuk et al. (Neurology 85:177-189, 2015) criteria for NMOSD and on those more recently proposed by Jarius et al. Read More

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More Than Meets the Eye: Infective Endocarditis Presenting as Endogenous Endophthalmitis.

Cureus 2021 Apr 28;13(4):e14745. Epub 2021 Apr 28.

Internal Medicine, Florida State University College of Medicine Internal Medicine Residency Program, Sarasota, USA.

Endogenous endophthalmitis (EE) is a potentially blinding ophthalmological emergency with poor visual prognosis requiring a high index of clinical suspicion to obtain a prompt diagnosis. The main factors associated with poor visual outcomes include the virulence of the causative organism and timing of intervention. Infective endocarditis can present with nonspecific ocular complaints and remains an important risk factor for developing EE. Read More

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Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging-Part I: MR imaging with pathologic correlation and technical considerations.

Insights Imaging 2021 Jun 3;12(1):66. Epub 2021 Jun 3.

Department of Medical Surgical Sciences and Advanced Technologies "G.F. Ingrassia" - Radiology I Unit, University Hospital Policlinico "G. Rodolico-San Marco", Via Santa Sofia 78, 95123, Catania, Italy.

Uveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris. Its prognosis is related to histopathologic and genetic features, tumor size and location, extraocular extension. The diagnosis is fundamentally based on clinical evaluation (ophthalmoscopy, biomicroscopy) and ultrasonography. Read More

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Clinical and surgical factors affecting the prognosis and survival rates in patients with mucormycosis.

Eur Arch Otorhinolaryngol 2021 Jun 1. Epub 2021 Jun 1.

Department of Otorhinolaryngology, University of Mersin School of Medicine, Çiftlikköy Kampüsü, Çiftlikköy/Yenişehir, Mersin, Turkey.

Purpose: To investigate the factors affecting disease specific mortality (DSM) in patients with mucormycosis.

Methods: This retrospective study included 24 patients diagnosed with mucormycosis and who had undergone surgical and medical treatment between 2010 and 2020. There were 14 male and 10 female patients whose mean age was 53. Read More

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Bilateral Vertebral Artery Vasculitis-A Rare Manifestation of Giant Cell Arteritis and a Difficult Diagnosis Made Possible by 2-[F]FDG PET/CT.

Diagnostics (Basel) 2021 May 14;11(5). Epub 2021 May 14.

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, 2600 Glostrup, Denmark.

Giant cell arteritis (GCA) is the most common form of large vessel vasculitis. GCA is a medical and ophthalmological emergency, and rapid diagnosis and treatment with high-dose corticosteroids is critical in order to reduce the risk of stroke and sudden irreversible loss of vision. GCA can be difficult to diagnose due to insidious and unspecific symptoms-especially if typical superficial extracranial arteries are not affected. Read More

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Multidisciplinary approach to lacrimal system diseases.

Acta Otorhinolaryngol Ital 2021 Apr;41(Suppl. 1):S102-S107

Otorhinolaryngology Unit, Head and Neck Department, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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Neuroophthalmic Manifestations of Intracranial Tumours in Children.

Case Rep Ophthalmol Med 2021 15;2021:7793382. Epub 2021 May 15.

Department of Neurosurgery, Dr. D.Y. Patil Medical College and Hospital, Pimpri, Pune, Maharashtra, India.

Background: All children between 0 and 16 years presenting with brain tumours confirmed by Magnetic Resonance Imaging (MRI) and treated surgically in our institute were included in this study.

Objective: The aim of this study is to evaluate the neuroophthalmic and clinical characteristics of intracranial space occupying lesions in children.

Methods: Neuroophthalmic manifestations along with location of the tumour by contrast-enhanced MRI, type of surgical intervention, and postoperative histopathological diagnosis were evaluated. Read More

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Surgical approach in a case of unilateral retinal pigment epithelium dysgenesis and literature review.

Am J Ophthalmol Case Rep 2021 Sep 11;23:101116. Epub 2021 May 11.

Department of Ophthalmology, University of Thessaly, Larissa, Greece.

Purpose: To present a case of unilateral retinal pigment epithelium dysgenesis (URPED) complicated with tractional retinal detachment and macular hole formation, and highlight the successful anatomical and functional restoration following surgical repair. To conduct an updated review of the literature.

Observations: A 16-year-old asymptomatic female presented with a unilateral atypical peripapillary lesion of the retinal pigment epithelium (RPE) in the left eye. Read More

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September 2021

Ocular findings among patients surviving COVID-19.

Sci Rep 2021 05 26;11(1):11085. Epub 2021 May 26.

Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

To describe the medium-term ophthalmological findings in patients recovering from COVID-19. Patients recovered from the acute phase of COVID-19 underwent a complete ophthalmological evaluation, including presenting and best-corrected visual acuity (BCVA), refractometry, biomicroscopy, tonometry, break-up time and Schirmer tests, indirect ophthalmoscopy, color fundus picture, and retinal architecture evaluation using optical coherence tomography. Socio-demographic data and personal medical history were also collected. Read More

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Primary vitreoretinal lymphoma: A diagnostic and management challenge.

Blood 2021 May 25. Epub 2021 May 25.

Université de Paris, UMR 144 CNRS, France.

Primary vitreoretinal lymphoma (PVRL) is a rare form of primary central nervous system lymphoma (PCNSL) arising in the intraocular compartment without brain involvement. Despite its apparent indolent clinical course, PVRL can cause permanent vision loss and CNS relapse, the major cause of death in PVRL patients. The pathophysiology of PVRL is unknown. Read More

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Spectrum of Syphilitic Chorioretinitis and Its Evolution Based on Multimodal Imaging.

Ocul Immunol Inflamm 2021 May 25:1-12. Epub 2021 May 25.

Department of Ophthalmology, Fundación Jiménez Díaz University Hospital, Madrid, Spain.

: To describe the different phenotypes of syphilitic chorioretinitis (SCR) and its clinical features in multimodal imaging (MI). Complete ophthalmological examination and MI including spectral domain optic coherence tomography (SD-OCT), fundus autofluorescence (FAF) and fluorescein angiography (FA) were performed at diagnosis and during follow-up in patients diagnosed with SCR. 17 eyes of 10 patients were included. Read More

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Orbital varix: A rare case of unilateral exophthalmos, case report.

Ann Med Surg (Lond) 2021 Jun 29;66:102346. Epub 2021 Apr 29.

Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, B.P 5696, Casablanca, Morocco.

The etiologies of unilateral exophthalmos are multiple, rarely represented by an intra- or extra-conical vascular mass. Orbito-palpebral varixes are rare (2% of orbital masses) and represent a main cause of unilateral intermittent exophthalmos, often of an inflammatory nature. We report a Case of right orbito-palpebral varix in a 65-year-old adult, with no particular history, evolving for 2 years. Read More

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Ocular Involvement in COVID-19: Conjunctivitis and More.

Klin Monbl Augenheilkd 2021 May 21;238(5):555-560. Epub 2021 May 21.

Zentrum für Augenheilkunde, Universität zu Köln, Medizinische Fakultät und Uniklinik Köln, Köln, Deutschland.

Since the beginning of 2020, SARS-CoV-2, the pathogen of COVID-19, has led to a global pandemic that also affects ophthalmology. Ophthalmologists can be confronted at any time with potentially COVID-19 associated ocular symptoms or manifestations in patients and also become infected through close patient contact. Even without systemic infection, the ocular surface can come into direct contact with aerosols or liquids containing SARS-CoV-2 particles. Read More

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Rise of the phoenix: Mucormycosis in COVID-19 times.

Indian J Ophthalmol 2021 Jun;69(6):1563-1568

Department of Oculoplastics and Ocular Oncology, M and J Western Regional Institute of Ophthalmology, B. J. Medical College, Ahmedabad, Gujarat, India.

Purpose: Rhino-orbital mucormycosis in times of ongoing COVID-19 pandemic.

Aims: The aim of the study was to document cases of rhino-orbital mucormycosis seen at our Regional Institute of Ophthalmology during COVID-19 (coronavirus disease 2019) times.

Methods: The study is a retrospective, institutional cohort, interventional study. Read More

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The effect of corneal crosslinking on the rigidity of the cornea estimated using a modified algorithm for the Schiøtz tonometer.

Indian J Ophthalmol 2021 06;69(6):1531-1536

Kyiv City Clinical Ophthalmological Hospital "Eye Microsurgical Center", Kyiv, Ukraine.

Purpose: The aim of this study was to test a method for estimating corneal rigidity before and after cross-linking (CXL) using a Schiøtz tonometer.

Methods: The study was performed in the Kyiv City Clinical Ophthalmological Hospital "Eye Microsurgical Center", Ukraine. This was a prospective, consecutive, randomized, masked, case-by-case, clinical study. Read More

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Effect of congenital ptosis correction on corneal topography- A prospective study.

Indian J Ophthalmol 2021 06;69(6):1527-1530

Department of Orbit and Oculoplasty, Department of Cornea, Aravind Eye Hospital, Pondicherry, India.

Purpose: The aim of this study was to evaluate the changes in corneal topography, cycloplegic refraction, and best-corrected visual acuity (BCVA) after ptosis correction surgery in patients with congenital ptosis.

Methods: Our study represents a prospective observational study conducted on 27 eyes of 21 patients with congenital ptosis. All patients underwent complete ophthalmological evaluation, cycloplegic refraction, and baseline Orbscan prior to ptosis surgery. Read More

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Corneal endothelial cells and central corneal thickness in patients with neurofibromatosis type 1.

Indian J Ophthalmol 2021 06;69(6):1522-1526

First Department of Ophthalmology, National and Kapodistrian University of Athens, General Hospital "G. Gennimatas", Athens, Greece.

Purpose: The aim of this study was to evaluate the morphological properties of corneal endothelial cells and central corneal thickness (CCT) in patients with neurofibromatosis type 1 (NF1) and to compare them with age-matched healthy controls.

Methods: Nineteen NF1 patients and 38 healthy individuals were recruited. All participants underwent complete ophthalmological examination as well as noncontact specular microscopy to measure endothelial cell density (ECD), average cell area (AVG), coefficient of variation of cell area (CV), the percentage of hexagonal cells, and CCT. Read More

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Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammation markers in patients with papilledema due to idiopathic intracranial hypertension.

Indian J Ophthalmol 2021 06;69(6):1499-1505

Department of Radiology, Dıskapi Training and Research Hospital, Health Sciences University, Ankara, Turkey.

Purpose: The aim of this study was to investigate the role of inflammation in the pathogenesis of idiopathic intracranial hypertension (IIH) using the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as inflammation markers.

Methods: The files of 33 IIH patients and 33 controls were screened for this retrospective study. For each patient, the NLR and PLR values were calculated using a single fasting blood sample. Read More

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Eye-Movement-Based Assessment of the Perceptual Consequences of Glaucomatous and Neuro-Ophthalmological Visual Field Defects.

Transl Vis Sci Technol 2021 Feb;10(2)

Laboratory of Experimental Ophthalmology, University Medical Center Groningen, University of Groningen, The Netherlands.

Purpose: Assessing the presence of visual field defects (VFD) through procedures such as perimetry is an essential aspect of the management and diagnosis of ocular disorders. However, even the latest perimetric methods have shortcomings-a high cognitive demand and requiring prolonged stable fixation and feedback through a button response. Consequently, an approach using eye movements (EM)-as a natural response-has been proposed as an alternate way to evaluate the presence of VFD. Read More

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February 2021