698 results match your criteria opening sleep

From Precision Metapharmacology to Patient Empowerment: Delivery of Self-Care Practices for Epilepsy, Pain, Depression and Cancer Using Digital Health Technologies.

Front Pharmacol 2021 23;12:612602. Epub 2021 Apr 23.

Department of Pharmacotherapy, Skaggs Pharmacy Institute, University of Utah, Salt Lake City, UT, United States.

To improve long-term outcomes of therapies for chronic diseases, health promotion and lifestyle modifications are the most promising and sustainable strategies. In addition, advances in digital technologies provide new opportunities to address limitations of drug-based treatments, such as medication non-adherence, adverse effects, toxicity, drug resistance, drug shortages, affordability, and accessibility. Pharmaceutical drugs and biologics can be combined with digital health technologies, including mobile medical apps (digital therapeutics), which offer additional clinical benefits and cost-effectiveness. Read More

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The Dreamcatcher: Interactive Storytelling of Dreams.

IEEE Comput Graph Appl 2021 May-Jun;41(3):105-112

Sleep scientists have extensively validated the continuity hypothesis, according to which our dreams reflect what happens during our waking life. Yet, only a few attempts have been made to increase the general public's awareness about the benefits of dream analysis in better understanding and improving our daily life. We designed "The Dreamcatcher," an interactive visual tool that explores the link between dreams and waking life through a collection of dream reports. Read More

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Characteristics of visual sensitivity in familial cortical myoclonic tremor and epilepsy.

Epileptic Disord 2021 Apr 30. Epub 2021 Apr 30.

Epilepsy and Sleep Disorders Unit, Department of Neurology, Xijing hospital, Air Force Military Medical University, Xi'an, China.

The aim of the study was to describe the electroclinical features of visual sensitivity in patients with familial cortical myoclonic tremor and epilepsy. We searched the EEG database using the terms "familial cortical myoclonic tremor and epilepsy" and "visual sensitivity" over a seven-year period from March 2013 to April 2020 in the Xijing hospital, Xi'an, China. The inclusion criteria were demonstrable electroclinical visual sensitivity in the form of eye-opening sensitivity, eye-closure sensitivity, eyes-closed sensitivity and photosensitivity. Read More

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Altered swallowing biomechanics in people with moderate-severe obstructive sleep apnea.

J Clin Sleep Med 2021 Apr 27. Epub 2021 Apr 27.

Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University.

Study Objectives: Dysphagia is a common but under-recognized complication of obstructive sleep apnea (OSA). However, the mechanisms remain poorly described. Accordingly, the aim of this study was to assess swallowing symptoms and use high-resolution pharyngeal manometry (HRPM) to quantify swallowing biomechanics in patients with moderate-severe OSA. Read More

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Effect of Electrode Configuration and Impulse Strength on Airway Patency in Neurostimulation for Obstructive Sleep Apnea.

Laryngoscope 2021 Apr 17. Epub 2021 Apr 17.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Objectives/hypothesis: Hypoglossal nerve stimulation (HNS) has gained increasing interest for the treatment of patients with obstructive sleep apnea (OSA). Drug-induced sleep endoscopy (DISE) can both exclude improper airway collapse patterns and visualize airway changes under stimulation. Stimulation outcome effects depend on the impulse voltage and electric field resulting from the electrode configuration of the implanted device. Read More

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Sleep: Opening a portal to the dreaming brain.

Curr Biol 2021 Apr;31(7):R352-R353

Université de Montréal, Montreal, QC H3C 3J7, Canada.

The retrospective nature of dream reports represents a challenge to the study of dreams. Two-way, real-time communication between researchers and lucid dreamers immersed in REM sleep offers a new and exciting window into the study of dreams and dreaming. Read More

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Mandibular advancement device as treatment trial for catathrenia (nocturnal groaning).

J Clin Sleep Med 2021 Apr 12. Epub 2021 Apr 12.

Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China.

Study Objectives: Catathrenia is a rare disease, classified as isolated symptoms and normal variants under sleep-related breathing disorders in the International Classification of Sleep Disorders, third edition. Because of its rarity, the research on its pathogenesis and treatment is insufficient. This study aimed to evaluate whether the mandibular advancement device (MAD) could be considered an alternative treatment trial and if so, to explore factors predicting its effectiveness. Read More

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The Ontogenesis of Mammalian Sleep: Form and Function.

Marcos G Frank

Curr Sleep Med Rep 2020 Dec 13;6(4):267-279. Epub 2020 Nov 13.

Washington State University Spokane, Elson S. Floyd College of Medicine, Pharmaceutical and Biomedical Science Building 213, 412 E. Spokane Falls Blvd.

Purpose Of Review: To present an up-to-date review and synthesis of findings about perinatal sleep development and function. I discuss landmark events in sleep ontogenesis, evidence that sleep promotes brain development and plasticity, and experimental considerations in this topic.

Recent Findings: Mammalian sleep undergoes dramatic changes in expression and regulation during perinatal development. Read More

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December 2020

Changes in sleep duration, timing, and variability during the COVID-19 pandemic: Large-scale Fitbit data from 6 major US cities.

Sleep Health 2021 Mar 17. Epub 2021 Mar 17.

Sleep and Health Research Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson, Arizona, USA. Electronic address:

The COVID-19 pandemic has resulted in societal-level changes to sleep and other behavioral patterns. Objective data would allow for a greater understanding of sleep-related changes at the population level. About 163,524 active Fitbit users from 6 major US cities contributed data, representing areas particularly hard-hit by the pandemic (Chicago, Houston, Los Angeles, New York, San Francisco, and Miami). Read More

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Using EEG and MEG to characterize extreme delta brush in a patient with anti-NMDA receptor encephalitis.

BMC Neurol 2021 Mar 22;21(1):134. Epub 2021 Mar 22.

Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Guang Zhou Road 264, Jiangsu, 210029, Nanjing, China.

Background: Extreme delta brush (EDB) is considered a potential marker for anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. The brain regions involved in EDB are unclear.

Case Presentation: A 16-year-old woman with anti-NMDAR encephalitis who was experiencing psychosis was admitted. Read More

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Emulation of the BIS engine.

J Clin Monit Comput 2021 Mar 19. Epub 2021 Mar 19.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, CWN L1, Boston, MA, 02115, USA.

The operation of the BIS monitor remains undescribed, despite 20 years of clinical use and 3000 academic articles. The core algorithmic software (the BIS Engine) can be retrieved from the motherboard of the A-2000 monitor in binary form through forensic disassembly using debugging interfaces left in place by the original designers, opening the possibility of executing the BIS algorithms on contemporary computers through emulation. Three steps were required for emulation. Read More

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Total Temporomandibular Joint Prosthetic Reconstruction: The Importance of Lateral Pterygoid Muscle Reattachment to Lateral Excursive and Protrusive Mandibular Movement.

Edward Zebovitz

J Oral Maxillofac Surg 2021 Feb 18. Epub 2021 Feb 18.

Private Practice, Bowie, MD. Electronic address:

Severe temporomandibular joint (TMJ) disorders result in structural changes that can significantly and negatively impact the jaw and airway, resulting in pain, difficulty chewing, dietary restrictions, sleep apnea, and other functional changes. For more than 5 decades, alloplastic total TMJ replacement has been used to treat end-stage intra-articular TMJ disorders. Commonly accepted measures of postsurgical success include maximal incisal opening (MIO), pain relief, and dietary and functional improvement. Read More

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February 2021

Strain-Resolved Dynamics of the Lung Microbiome in Patients with Cystic Fibrosis.

mBio 2021 03 9;12(2). Epub 2021 Mar 9.

Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

In cystic fibrosis, dynamic and complex communities of microbial pathogens and commensals can colonize the lung. Cultured isolates from lung sputum reveal high inter- and intraindividual variability in pathogen strains, sequence variants, and phenotypes; disease progression likely depends on the precise combination of infecting lineages. Routine clinical protocols, however, provide a limited overview of the colonizer populations. Read More

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Photoperiod Manipulation Reveals a Light-Driven Component to Daily Patterns of Ventilation in Male C57Bl/6J Mice.

J Biol Rhythms 2021 Mar 8:748730421992581. Epub 2021 Mar 8.

Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin.

Obstructive sleep apnea is a common sleep disorder that increases risk for cardiovascular disease and mortality. The severity of sleep-disordered breathing in obstructive sleep apnea patients fluctuates with the seasons, opening the possibility that seasonal changes in light duration, or photoperiod, can influence mechanisms of breathing. Photoperiod can have profound effects on internal timekeeping and can reshape metabolic rhythms in mammals. Read More

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Georgian Med News 2021 Jan(310):36-39

Ivane Javakhishvili Tbilisi State University, Georgia.

Bruxism has become more and more debatable and pressing issue all over the world last years. the etiology of bruxism has been changing diverse definitions, over the years, however recently it is defined as a repetitive jaw-muscle activity characterized by clenching or grinding of the teeth and by bracing or thrusting of the mandible. This literature review discusses the possible risk factors of bruxism in children and adolescence, among which behavioral abnormalities and sleep disturbances predominates. Read More

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January 2021

RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Infection.

Am J Respir Cell Mol Biol 2021 May;64(5):579-591

Department of Medicine, Pulmonary and Critical Care, Weill Cornell Medicine, New York, New York.

Community-acquired pneumonia is the most common type of pneumonia and remains a leading cause of morbidity and mortality worldwide. Although many different pathogens can contribute to pneumonia, is one of the common bacterial pathogens that underlie community-acquired pneumonia. RIPK3 (receptor-interacting protein kinase 3) is widely recognized as a key modulator of inflammation and cell death. Read More

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Does Bilateral Gap Arthroplasty Increase the Severity of Obstructive Sleep Apnea in Patients With Temporomandibular Joint Ankylosis?

J Oral Maxillofac Surg 2021 Jan 22. Epub 2021 Jan 22.

Professor, Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Obstructive sleep apnea (OSA) is common in patients with bilateral temporomandibular joint ankylosis (TMJA). The purpose of this study was to compare the preoperative and postoperative apnea-hypopnea index (AHI) in patients with TMJA undergoing bilateral gap arthroplasty (BGA).

Methods: The investigators implemented a prospective cohort study on patients with bilateral TMJA treated with BGA. Read More

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January 2021

How demographic and clinical characteristics contribute to the recovery of post-stroke dysphagia?

Medicine (Baltimore) 2021 Jan;100(4):e24477

Department of Rehabilitation Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Abstract: According to the analysis to find out how demographic and clinical characteristics influent the dysphagia outcome after stroke, furthermore, giving some insights to clinical treatment.One hundred eighty post-stroke dysphagia (PSD) patients were enrolled in this retrospective study at the stroke rehabilitation department. The outcome measurements are beside water swallow test at discharge and length of stay at hospital. Read More

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January 2021

Psychogenic Seizure Imitating Narcolepsy.

Case Rep Neurol 2020 Sep-Dec;12(3):472-481. Epub 2020 Dec 11.

Department of Nervous Disease, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.

Psychogenic or functional neurological disorders (FND) often occur in the practice of a neurologist. Diagnosis of FND usually causes significant difficulties. Among FND, psychogenic non-epileptic seizures (PNES) comprise around 40% cases. Read More

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December 2020

Craniofacial morphology/phenotypes influence on mandibular range of movement in the design of a mandibular advancement device.

BMC Oral Health 2021 01 7;21(1):19. Epub 2021 Jan 7.

Faculty of Medicine and Dentistry, School of Dentistry, University of Alberta ECHA, 5-524, 11405-87 Avenue, Edmonton, AB, T6G 1C9, Canada.

Background: The mandibular opening path movements have different directions according to the craniofacial morphology of the patient but always downward and backward, therefore increasing the collapse of the upper airway. The aim of this work is to determine if there is a relationship between the craniofacial morphology and the mandibular movement to help understand the impact on the mandibular position.

Methods: 52 students with full permanent dentition aged 19 to 23 years (mean 21. Read More

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January 2021

Heliox administration in anesthetized rabbits with spontaneous inspiratory flow limitation.

J Appl Physiol (1985) 2021 May 7;130(5):1496-1509. Epub 2021 Jan 7.

Department of Information Engineering and Mathematics, Università di Siena, Siena, Italy.

We investigated the effects of heliox administration (80% helium in O) on tidal inspiratory flow limitation (tIFL) occurring in supine anesthetized spontaneously breathing rabbits, regarded as an animal model of obstructive apnea-hypopnea syndrome. 22 rabbits were instrumented to record oro-nasal mask flow, airway opening, tracheal and esophageal pressures, and diaphragm and genioglossus electromyographic activities while breathing either room air or heliox, and, in 12 rabbits, also during the application of continuous positive airway pressure (CPAP; 6 cmHO). For the group, heliox increased peak inspiratory flow, ventilation (18 ± 11%), peak inspiratory tracheal and dynamic transpulmonary pressures, but in no animal eliminated tIFL, as instead CPAP did in all. Read More

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Massive Traumatic Subcutaneous Emphysema.

Acta Medica (Hradec Kralove) 2020 ;63(4):194-197

Department of Internal Medicine, Centro Hospitalar Médio Ave, Vila Nova de Famalicão, Portugal.

74 year-old-man, former smoker, with chronic obstructive pulmonary disease GOLD grade 4, group D, with emphysema component, treated in a pulmonary rehabilitation program, on oxygen therapy and nocturnal bi-level positive airway pressure (BiPAP) ventilation. During the night he had a traumatic rib fracture (5-11th right ribs) but still he used BiPAP ventilation during the sleep. In the morning after he presented with a diffuse and massive emphysema in the face, thorax and abdominal regions. Read More

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January 2020

A field investigation of the thermal environment and adaptive thermal behavior in bedrooms in different climate regions in China.

Indoor Air 2020 Dec 17. Epub 2020 Dec 17.

The Bartlett School of Construction and Project Management, University College London (UCL), London, UK.

Sleep thermal environments substantially impact sleep quality. To study the sleep thermal environment and thermal comfort in China, this study carried out on-site monitoring of thermal environmental parameters in peoples' homes, including 166 households in five climate zones, for one year. A questionnaire survey on sleep thermal comfort and adaptive behavior was also conducted. Read More

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December 2020

Correlation between upper airway dimension and TMJ position in patients with sleep disordered breathing.

Cranio 2020 Dec 8:1-9. Epub 2020 Dec 8.

School of Dentistry and Oral Health, Griffith University , Gold Coast, Australia.

: The goal was to perform a 10-year retrospective study on the correlation between sleep disordered breathing (SDB) and upper airway dimensions, as well as the relation between SDB status and TMJ position. The study also examined links between airway dimensions and TMJ position. : Patients were categorized into Control (n = 28) or SDB (n = 45). Read More

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December 2020

High-Frequency Neuronal Bursting is Essential for Circadian and Sleep Behaviors in .

J Neurosci 2021 01 1;41(4):689-710. Epub 2020 Dec 1.

Fundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires C1405BWE, Argentina

Circadian rhythms have been extensively studied in ; however, still little is known about how the electrical properties of clock neurons are specified. We have performed a behavioral genetic screen through the downregulation of candidate ion channels in the lateral ventral neurons (LNvs) and show that the hyperpolarization-activated cation current I is important for the behaviors that the LNvs influence: temporal organization of locomotor activity, analyzed in males, and sleep, analyzed in females. Using whole-cell patch clamp electrophysiology we demonstrate that small LNvs (sLNvs) are bursting neurons, and that I is necessary to achieve the high-frequency bursting firing pattern characteristic of both types of LNvs in females. Read More

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January 2021

Development and Validation of a Disease-Specific Oromandibular Dystonia Rating Scale (OMDRS).

Kazuya Yoshida

Front Neurol 2020 3;11:583177. Epub 2020 Nov 3.

Department of Oral and Maxillofacial Surgery, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan.

Oromandibular dystonia manifests with sustained or task-specific contractions of the masticatory, tongue, and/or other muscles in the stomatognathic system. Since its symptoms can vary, it has been difficult to objectively measure disease severity and post-treatment changes. To develop and validate a comprehensive measurement tool for oromandibular dystonia. Read More

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November 2020

Quality of life, chronic pain, insomnia, and jaw malfunction in patients after alloplastic temporomandibular joint replacement: a questionnaire-based pilot study.

Int J Oral Maxillofac Surg 2020 Nov 5. Epub 2020 Nov 5.

Clinic of Masticatory Disorders, Centre of Dental Medicine, University of Zurich, Zurich, Switzerland.

Studies of patients undergoing alloplastic total temporomandibular joint replacement seldom report on quality of life (QoL) and sleep. The aim of this pilot study was to assess these factors in such a patient cohort using validated psychometric questionnaires. Data were collected via online surveys comprising the following six questionnaires: Short Form-12 Health Survey (SF-12), Patient Health Questionnaire-15, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30, Insomnia Severity Index, Graded Chronic Pain Scale, and Jaw Disability List. Read More

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November 2020

Efficacy of botulinum toxin in the management of temporomandibular myofascial pain and sleep bruxism.

J Korean Assoc Oral Maxillofac Surg 2020 Oct;46(5):335-340

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey.

Objectives: : This study sought to evaluate the efficacy of injecting botulinum toxin into the masseter and temporal muscles in patients with temporomandibular myofascial pain and sleep bruxism.

Materials And Methods: The study was conducted based on a clinical record review of 44 patients (36 females and eight males; mean age, 35.70±12. Read More

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October 2020

Evaluation of sleep bruxism and temporomandibular disorders in patients undergoing hemodialysis.

Niger J Clin Pract 2020 Oct;23(10):1375-1380

Department of Nephrology, Specialist in Nephrology, Baskent University Adana, Dr. Turgut Noyan Research and Practice Hospital, Adana, Turkey.

Background: Chronic renal failure can cause anxiety, stress, and decrease the life quality. Therefore, this may lead to sleep bruxism, temporomandibular disorders (TMDs), and related health problems.

Aim: This study evaluated the incidence of sleep bruxism and TMDs in patients undergoing hemodialysis and compared it with that of healthy individuals. Read More

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October 2020