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Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates.

Sci Rep 2021 Jul 22;11(1):15043. Epub 2021 Jul 22.

Department of Biomedical Engineering, Columbia University, New York City, NY, 10032, USA.

An emerging approach with potential in improving the treatment of neurodegenerative diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood-brain barrier (BBB) in a non-invasive and localized manner. A large body of pre-clinical work has paved the way for the gradual clinical implementation of FUS-induced BBB opening. Even though the safety profile of FUS treatments in rodents has been extensively studied, the histological and behavioral effects of clinically relevant BBB opening in large animals are relatively understudied. Read More

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Feasibility of Repeated Assessment of Cognitive Function in Older Adults Using a Wireless, Mobile, Dry-EEG Headset and Tablet-Based Games.

Front Psychiatry 2021 25;12:574482. Epub 2021 Jun 25.

Cumulus Neuroscience Ltd, Belfast, United Kingdom.

Access to affordable, objective and scalable biomarkers of brain function is needed to transform the healthcare burden of neuropsychiatric and neurodegenerative disease. Electroencephalography (EEG) recordings, both resting and in combination with targeted cognitive tasks, have demonstrated utility in tracking disease state and therapy response in a range of conditions from schizophrenia to Alzheimer's disease. But conventional methods of recording this data involve burdensome clinic visits, and behavioural tasks that are not effective in frequent repeated use. Read More

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Reliability and validity of a novel instrument for the quantification of hand forces during a jar opening task.

J Hand Ther 2021 Apr 16. Epub 2021 Apr 16.

University of Minnesota, Program in Occupational Therapy, Minneapolis, MN, USA.

Study Design: Clinical Measurement INTRODUCTION: Jar opening is a task that relies heavily on the ability to generate adequate hand forces and is often reported in the literature as being difficult for women with hand arthritis. Many have studied relationships between diminished grip/pinch strength and occupational performance but few have investigated how much hand force is necessary to successfully engage in manual tasks. Those who studied this have relied on approaches and tools which lack ecology. Read More

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Description of a novel curriculum on equity, diversity and inclusion for pediatric residents.

J Natl Med Assoc 2021 Jun 22. Epub 2021 Jun 22.

Department of Pediatrics, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA 98105, United States.

Background: Accreditation standards in medical education require curricular elements dedicated to understanding diversity and addressing inequities in health care. The development and implementation of culturally effective care curricula are crucial to improving health care outcomes, yet these curricular elements are currently limited in residency training.

Methods: A needs assessment of 125 pediatric residents was conducted that revealed minimal prior culturally effective care instruction. Read More

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Potential for Behavioural Pressure Modulation at the Upper Oesophageal Sphincter in Healthy Swallowing.

Dysphagia 2021 Jun 16. Epub 2021 Jun 16.

Department of Psychology, Speech and Hearing, University of Canterbury, Private Bag 4800, Christchurch, 8140, New Zealand.

Supratentorial structures are known to be involved in the neural control of swallowing, thus the potential for volitional manipulation of pharyngeal swallowing is of rehabilitative interest. The extent of volitional control of the upper oesophageal sphincter (UOS) during swallowing remains unclear. Prior research has shown that the UOS opening duration can be volitionally prolonged during execution of the Mendelsohn manoeuvre, which does not change the UOS opening time in isolation but the swallowing response in its entirety. Read More

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Aversive Conditioning of Spatial Position Sharpens Neural Population-Level Tuning in Visual Cortex and Selectively Alters Alpha-Band Activity.

J Neurosci 2021 Jun 25;41(26):5723-5733. Epub 2021 May 25.

Center for the Study of Emotion and Attention, University of Florida, Gainesville, Florida 32610.

Processing capabilities for many low-level visual features are experientially malleable, aiding sighted organisms in adapting to dynamic environments. Explicit instructions to attend a specific visual field location influence retinotopic visuocortical activity, amplifying responses to stimuli appearing at cued spatial positions. It remains undetermined both how such prioritization affects surrounding nonprioritized locations, and if a given retinotopic spatial position can attain enhanced cortical representation through experience rather than instruction. Read More

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Effect of photobiomodulation therapy on painful temporomandibular disorders.

Sci Rep 2021 Apr 27;11(1):9049. Epub 2021 Apr 27.

Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.

To evaluate the effect of photobiomodulation therapy (PBMT) on painful temporomandibular disorders (TMD) patients in a randomized, double-blinded, placebo-controlled manner. Participants were divided into a masseter myalgia group (n = 88) and a temporomandibular joint (TMJ) arthralgia group (n = 87) according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Both groups randomly received PBMT or placebo treatment once a day for 7 consecutive days, one session. Read More

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Menopause experience in First Nations women and initiatives for menopause symptom awareness; a community-based participatory research approach.

BMC Womens Health 2021 04 26;21(1):179. Epub 2021 Apr 26.

Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, University of Alberta, 626-1 Community Service Centre, Royal Alexandra Hospital, 10240 Kingsway Ave, Edmonton, T5H-3V9, Canada.

Background: Little research has been conducted about menopause in First Nations women. In response to the wishes of Cree women living in Maskwacis, Alberta, to start a dialogue on menopause, we undertook community-based participatory research (CBPR) to explore menopause experience and raise awareness of menopause symptoms in the community.

Methods: The research adhered to the principles of Ownership, Control, Access and Possession (OCAP™) and was guided by the interest of the participating women. Read More

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Efficient photodynamic inactivation of Leishmania parasites mediated by lipophilic water-soluble Zn(II) porphyrin ZnTnHex-2-PyP.

Biochim Biophys Acta Gen Subj 2021 Jul 1;1865(7):129897. Epub 2021 Apr 1.

Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil. Electronic address:

Background: Photodynamic inactivation (PDI) is emerging as a promising alternative for cutaneous leishmaniasis (CL). The chemotherapy currently used presents adverse effects and cases of drug resistance have been reported. ZnTnHex-2-PyP is a porphyrin with a high potential as a photosensitizer (PS) for PDI, due to its photophysical properties, structural stability, and cationic/amphiphilic character that can enhance interaction with cells. Read More

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Combination of Robotic Pyeloplasty and Percutaneous Renal Surgery for Simultaneous Treatment of Ureteropelvic Junction Obstruction and Calyx Stones.

Urol Int 2021 10;105(7-8):637-641. Epub 2021 Mar 10.

Department of Urology, Nuremberg General Hospital, Paracelsus Medical University, Nuremberg, Germany.

Introduction: Ureteropelvic junction obstruction (UPJO) and the simultaneous presence of kidney calyx stones represent a challenge for renal surgery. We present a novel technique for the simultaneous treatment of UPJO by robotic pyeloplasty in combination with the percutaneous endoscopic treatment of kidney calyx stones by flexible nephroscopy.

Patients And Methods: Between January 2018 and February 2020, 4 patients were diagnosed with UPJO and simultaneous pelvic or calyceal stones. Read More

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Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticular hyaluronic acid injection. A randomized clinical trial.

J Craniomaxillofac Surg 2021 Feb 22. Epub 2021 Feb 22.

Department of Oral and Maxillofacial Surgery,Faculty of Dentistry, Atatürk University, Erzurum, 25240, Turkey. Electronic address:

The purpose of this study was to compare clinical outcomes obtained with the use of glucosamine, chondroitin sulfate, and methylsulfonylmethane (GCM) supplementation after arthrocentesis plus intraarticular hyaluronic acid (HA) injection. A randomized clinical trial was implemented with adult participants with TMJ-OA who were referred to the author's clinic between February 2014 and May 2015. The sample was entirely composed of patients with TMJ-OA who were treated randomly with a one-session arthrocentesis plus intraarticular HA injection only (control group), or an initial one-session arthrocentesis plus intraarticular HA injection followed by 3 months of GCM supplementation (study group). Read More

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February 2021

Improving vision for surgeons during laparoscopy: the Enhanced Laparoscopic Vision System (ELViS).

Surg Endosc 2021 05 1;35(5):2403-2415. Epub 2021 Mar 1.

TIMC-IMAG Laboratory, Grenoble Alps University, National Centre for Scientific Research, Grenoble National Polytechnical Institute, Grenoble Alps University Hospital, Grenoble, France.

Background: For many abdominal surgical interventions, laparotomy has gradually been replaced by laparoscopy, with numerous benefits for the patient in terms of post-operative recovery. However, during laparoscopy, the endoscope only provides a single viewpoint to the surgeon, leaving numerous blind spots and opening the way to peri-operative adverse events. Alternative camera systems have been proposed, but many lack the requisite resolution/robustness for use during surgery or cannot provide real-time images. Read More

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Simulated training model in a low cost for laparoscopic inguinal hernioplasty.

Acta Cir Bras 2021 15;36(1):e360108. Epub 2021 Feb 15.

MD. Centro Universitário Christus - Professional Master`s Degree in Minimally Invasive Technology and Simulation in the Health field- Fortaleza (Ceará), Brazil.

Purpose: Develop a 3D model for the simulation of laparoscopic inguinal hernioplasty transabdominal preperitoneal (TAPP).

Methods: This is an experimental study, 18 participants were selected, divided into three groups, experimental (GE) surgeons in training, control (GC) experienced surgeons and Shaw (GS) nonexperienced surgeons. The simulation in the 3D model was carried out in 6 sessions fulfilling the 5 stages. Read More

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February 2021

Anomalous atrium associated with persistent left superior vena cava.

Anat Sci Int 2021 Jan 24. Epub 2021 Jan 24.

Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8577, Japan.

Persistent left superior vena cava (PLSVC) is the most common venous anomaly with an incidence of 0.3-0.5% in the general population. Read More

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January 2021

Short-Term Morphological Changes in Asymptomatic Perimandibular Muscles after Dry Needling Assessed with Rehabilitative Ultrasound Imaging: A Proof-of-Concept Study.

J Clin Med 2021 Jan 8;10(2). Epub 2021 Jan 8.

Laboratory of Clinical Integrative Physiology, University of Brescia, 25123 Brescia, Italy.

Facial anatomical structures are not easily accessible to manual palpation. The aim of our study is to objectively assess temporomandibular joint and perimandibular muscles dimensions by means of sonographic measurements before and after dry needling (DN) in asymptomatic subjects. Seventeen subjects participated in this before-after study with a within-subject control. Read More

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January 2021

Opening Up: Clients' Inner Struggles in the Initial Phase of Therapy.

Front Psychol 2020 15;11:591146. Epub 2020 Dec 15.

District General Hospital of Førde, Førde, Norway.

Objective: To explore how clients in clinical settings experience the process of opening up and sharing their inner experiences in the initial phase of therapy.

Methods: Two psychotherapy sessions of clients ( = 11) were videotaped and followed by interviews. Interpersonal process recall was used to obtain in-depth descriptions of clients' immediate experiences in session. Read More

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December 2020

Bouveret syndrome masquerading as a gastric mass-unmasked with endoscopic luminal laser lithotripsy: A case report.

World J Clin Cases 2020 Nov;8(22):5701-5706

Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, PA 17822, United States.

Background: Bouveret syndrome, also known as gallstone ileus, is a rare form of gastric outlet obstruction accounting for 1%-3% of cases. This condition is most often reported in females. The diagnosis can be challenging and is often missed due to atypical presentations, which occasionally mimic gastric outlet obstruction symptoms such as nausea, vomiting, loss of appetite and hematemesis. Read More

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November 2020

Efficacy of prolotherapy and arthrocentesis in management of temporomandibular joint hypermobility.

Cranio 2020 Dec 16:1-9. Epub 2020 Dec 16.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ordu University, Ordu, Turkey.

: The aim of this study was to compare the efficacy of dextrose prolotherapy in conjunction with arthrocentesis and dextrose prolotherapy alone in the management of symptomatic TMJ hypermobility.: Twenty-four patients suffering from TMJ symptomatic hypermobility received 10% dextrose injections for three sessions at four-week intervals. Twelve patients (P group) received prolotherapy alone; the other 12 (PA group) also underwent a single arthrocentesis session. Read More

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December 2020

Endoscopic radial incision and cutting technique for treatment-naive stricture of colorectal anastomosis: Two case reports.

World J Gastrointest Surg 2020 Nov;12(11):460-467

Department of Surgery, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju-si 28644, Chungcheongbuk-do, South Korea.

Background: Anastomotic stenosis (AS) after colorectal surgery was treated with balloon dilation, endoscopic procedure or surgery. The endoscopic procedures including dilation, electrocautery incision, or radial incision and cutting (RIC) were preferred because of lower complication rates than surgery and are less invasive. Endoscopic RIC has a greater success rate than dilation methods. Read More

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November 2020

Report of Alliance of International Science Organizations on Disaster Risk Reduction (ANSO-DRR) Conference 2020.

Int J Environ Res Public Health 2020 11 26;17(23). Epub 2020 Nov 26.

Graduate School of Media and Governance, Keio University, Tokyo 252-0882, Japan.

This article summarizes the proceedings of the four-session meeting (webinar) conducted by the Alliance of International Science Organizations on Disaster Risk Reduction (ANSO-DRR) on 18 May 2020. ANSO-DRR is an international, nonprofit and nongovernmental scientific alliance bringing together academies of science, research organizations and universities which share a strong interest in disaster risk reduction in the regions along the land-based and maritime routes of the Belt and Road Initiative. ANSO-DRR convenes an annual meeting to review its work progress and discuss its scientific programs. Read More

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November 2020

Max Wilson and the Principles and Practice of Screening for Disease.

Kate Hall

Int J Neonatal Screen 2020 03 29;6(1):15. Epub 2020 Feb 29.

UK Newborn Screening Laboratories Network, UK;

The name Wilson will be forever associated with co-author Jungner and ten principles of population screening published in 1968 by the World Health Organisation (WHO) as Public Health Papers No 34. These principles have since been used, modified or extended throughout much of Europe and beyond. Very little was known about Dr. Read More

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PET Imaging of Tumor Perfusion: A Potential Cancer Biomarker?

Semin Nucl Med 2020 11 7;50(6):549-561. Epub 2020 Aug 7.

Department of Radiology, Mayo Clinic, Rochester, MNDepartment of Neurology, Mayo Clinic, Rochester, MN.

Perfusion, as measured by imaging, is considered a standard of care biomarker for the evaluation of many tumors. Measurements of tumor perfusion may be used in a number of ways, including improving the visual detection of lesions, differentiating malignant from benign findings, assessing aggressiveness of tumors, identifying ischemia and by extension hypoxia within tumors, and assessing treatment response. While most clinical perfusion imaging is currently performed with CT or MR, a number of methods for PET imaging of tumor perfusion have been described. Read More

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November 2020

Intracellular pH Regulates Cancer and Stem Cell Behaviors: A Protein Dynamics Perspective.

Front Oncol 2020 26;10:1401. Epub 2020 Aug 26.

Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, United States.

The International Society of Cancer Metabolism (ISCaM) meeting on Cancer Metabolic Rewiring, held in Braga Portugal in October 2019, provided an outstanding forum for investigators to present current findings and views, and discuss ideas and future directions on fundamental biology as well as clinical translations. The first session on was preceded by the opening keynote presentation from our group entitled . In this review we introduce a brief background on intracellular pH (pHi) dynamics, including how it is regulated as well as functional consequences, summarize key findings included in our presentation, and conclude with perspectives on how understanding the role of pHi dynamics in stem cells can be relevant for understanding how pHi dynamics enables cancer progression. Read More

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INYBI: A New Tool for Self-Myofascial Release of the Suboccipital Muscles in Patients With Chronic Non-Specific Neck Pain: A Randomized Controlled Trial.

Spine (Phila Pa 1976) 2020 Nov;45(21):E1367-E1375

Department of Physiotherapy, Faculty of Nursing, Physiotherapy and Podiatry, University of Sevilla, Sevilla, Spain.

Study Design: A randomized, single-blinded (the outcome assessor was unaware of participants' allocation group) controlled clinical trial.

Objective: To investigate the effects of myofascial release therapy (MRT) over the suboccipital muscles, compared with self-MRT using a novel device, the INYBI tool, on pain-related outcomes, active cervical mobility, and vertical mouth opening, in adults with chronic non-specific neck pain (NSNP).

Summary Of Background Data: MRT is used to manage chronic musculoskeletal pain conditions, with purported positive effects. Read More

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November 2020

SARS-CoV-2 Transmission and Infection Among Attendees of an Overnight Camp - Georgia, June 2020.

MMWR Morb Mortal Wkly Rep 2020 Aug 7;69(31):1023-1025. Epub 2020 Aug 7.

Limited data are available about transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), among youths. During June 17-20, an overnight camp in Georgia (camp A) held orientation for 138 trainees and 120 staff members; staff members remained for the first camp session, scheduled during June 21-27, and were joined by 363 campers and three senior staff members on June 21. Camp A adhered to the measures in Georgia's Executive Order* that allowed overnight camps to operate beginning on May 31, including requiring all trainees, staff members, and campers to provide documentation of a negative viral SARS-CoV-2 test ≤12 days before arriving. Read More

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Predictors of Self-Determined Module Choice in a Web-Based Computer-Tailored Diet and Physical Activity Intervention: Secondary Analysis of Data From a Randomized Controlled Trial.

J Med Internet Res 2020 07 23;22(7):e15024. Epub 2020 Jul 23.

Department of Health Psychology, Faculty of Psychology, Open University of the Netherlands, Heerlen, Netherlands.

Background: Tailoring an online intervention to participant preferences (eg, by giving participants a choice which modules to follow) may increase engagement in the intervention, motivation for behavioral change, and possibly intervention effects. So far, little is known about what characteristics predict these module choices. Filling this knowledge gap is useful for optimizing program engagement. Read More

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The effects of switching from 10 to 5-dose vials of MR vaccine on vaccination coverage and wastage: A mixed-method study in Zambia.

Vaccine 2020 08 21;38(37):5905-5913. Epub 2020 Jul 21.

John Snow, Inc, United States.

Introduction: Vaccines procured for low-income countries are often packaged in multi-dose vials to reduce program costs. To avoid wastage, health workers may refrain from opening a vial if few children attend an immunization session, possibly leading to lower coverage. Lowering the number of doses in a vial may increase coverage and reduce wastage. Read More

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3-Dimensional magnetic resonance imaging of the freely moving human eye.

Prog Neurobiol 2020 11 9;194:101885. Epub 2020 Jul 9.

The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des aveugles, Lausanne, Switzerland; Center for Biomedical Imaging (CIBM), Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University Nashville, TN, USA. Electronic address:

Eye motion is a major confound for magnetic resonance imaging (MRI) in neuroscience or ophthalmology. Currently, solutions toward eye stabilisation include participants fixating or administration of paralytics/anaesthetics. We developed a novel MRI protocol for acquiring 3-dimensional images while the eye freely moves. Read More

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November 2020

A Comparison of OCT Parameters in Identifying Glaucoma Damage in Eyes Suspected of Having Glaucoma.

Ophthalmol Glaucoma 2020 Mar-Apr;3(2):90-96. Epub 2019 Nov 27.

Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina, USA.

Purpose: To compare retinal nerve fiber layer thickness (RNFLT) and Bruch's membrane opening minimum rim width (BMO-MRW) measured by spectral domain optical coherence tomography (SDOCT) for diagnosing glaucoma in those suspected of having the disease.

Design: Observational cohort study.

Participants: 113 eyes from 81 patients suspected of having glaucoma based on optic nerve appearance. Read More

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November 2019

Effects of ketamine in electroconvulsive therapy for major depressive disorder: meta-analysis of randomised controlled trials.

Gen Psychiatr 2020 16;33(3):e100117. Epub 2020 Jun 16.

Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: The use of ketamine in electroconvulsive therapy (ECT) has been examined in the treatment of major depressive disorder (MDD); however, there has been no systematic review and meta-analysis of related randomised controlled trials (RCTs).

Aim: To examine the efficacy and safety of ketamine augmentation of ECT in MDD treatment.

Methods: Two reviewers searched Chinese (China National Knowledge Infrastructure and Wanfang) and English (PubMed, PsycINFO, Embase and Cochrane Library) databases from their inception to 23 July 2019. Read More

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