669,046 results match your criteria open


Advanced score system and automated search strategies for parameter estimation in mechanistic chromatography modeling.

J Chromatogr A 2021 Nov 20;1661:462693. Epub 2021 Nov 20.

Institute of Geo- and Biosciences 1 (IBG-1), Forschungszentrum Jülich, Wilhelm-Johnen-Str. 1, 52428 Jülich, Germany. Electronic address:

Least squares estimation of unknown parameters from measurement data is a well-established standard method in chromatography modeling but can suffer from critical disadvantages. The description of real-world systems is generally prone to unaccounted mechanisms, such as dispersion in external holdup volumes, and systematic measurement errors, such as caused by pump delays. In this scenario, matching the shape between simulated and measured chromatograms has been found to be more important than the exact peak positions. Read More

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November 2021

Double-headed amphiphile-based sponge droplets: synthesis, characterization and potential for the extraction of compounds over a wide polarity range.

Talanta 2021 Nov 27;239:123108. Epub 2021 Nov 27.

Department of Analytical Chemistry. Institute of Fine Chemistry and Nanochemistry. Universidad de Córdoba, Campus de Rabanales, Edificio Marie Curie (anexo), E-14071, Córdoba, Spain.

Supramolecular solvents (SUPRASs) are gaining momentum in the multi-residue analysis of liquid samples thanks to the delimited hydrophilic and hydrophobic microenvironments in their nanostructures. In this work, SUPRASs with increased hydrophilicity were synthesized with the aim of enhancing the extractability of polar compounds. For this purpose, a double-headed amphiphile, 1,2-decanediol, was self-assembled in hydro-organic media in the presence and absence of sodium chloride. Read More

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November 2021

Relationships of social support and attitudes towards death: A mediator role of depression in older patients on haemodialysis.

Nurs Open 2021 Dec 4. Epub 2021 Dec 4.

Department of nursing, Taipei Veterans General Hospital, Taipei, Taiwan.

Aim: To explore the mediating role of depression in older people receiving haemodialysis on social support and the attitude of participants towards death.

Design: A cross-sectional questionnaire survey.

Methods: Data were collected from older people undergoing dialysis (N = 209) at two regional hospitals in the north of Taiwan. Read More

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December 2021

Fish eDNA metabarcoding from aquatic biofilm samples: methodological aspects.

Mol Ecol Resour 2021 Dec 4. Epub 2021 Dec 4.

Université Savoie Mont-Blanc, INRA, UMR CARRTEL, FR-74200, Thonon-les-Bains, France.

Fish eDNA metabarcoding is usually performed from filtered water samples. The volume of filtered water depends on the study scope and can rapidly become time consuming according to the number of samples that have to be processed. To avoid time allocated to filtration, passive DNA samplers have been used to recover fish eDNA from marine environments faster. Read More

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December 2021

Delineating the Type 2 Diabetes Population in the Netherlands Using an All-Payer Claims Database: Specialist Care, Medication Utilization and Expenditures 2016-2018.

Pharmacoecon Open 2021 Dec 4. Epub 2021 Dec 4.

Department of Health Services Research, CAPHRI Care and Public Health Research Institute, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.

Objectives: The aim of this study was to describe the healthcare utilization and expenditures related to medical specialist care and medication of the entire type 2 diabetes population in the Netherlands in detail.

Methods: For this retrospective, observational study, we used an all-payer claims database. Comprehensive data on specialist care and medication utilization and expenditures of the type 2 diabetes population (n = 900,522 in 2018) were obtained and analyzed descriptively. Read More

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December 2021

Comparison of Long-Term Effects After Modified CO Laser-Assisted Deep Sclerectomy and Conventional Trabeculectomy in Chinese Primary Open-Angle Glaucoma.

Ophthalmol Ther 2021 Dec 4. Epub 2021 Dec 4.

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Dongdan Shuaifuyuan 1#, Beijing, 100730, China.

Introduction: To compare the long-term effect after modified CO laser-assisted sclerectomy surgery (MCLASS) and conventional trabeculectomy (TRAB) in medically uncontrolled Chinese primary open-angle glaucoma (POAG) patients. This was a retrospective comparative study.

Methods: A total of 87 patients were reviewed, including 45 in the MCLASS group and 42 in the TRAB group. Read More

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December 2021

Exercise-Based Cardiac Rehabilitation: Secondary Data Analyses of Mortality and Working Capacity in Germany, 2010-2017.

Sports Med Open 2021 Dec 4;7(1):88. Epub 2021 Dec 4.

Department of Applied Health Sciences, University of Applied Sciences for Health, Bochum, Germany.

Background: Exercise-based cardiac rehabilitation is safe and implemented in international cardiac rehabilitation guidelines. Evidence for long-term health effects is scarce and rare for health care service research.

Objective: The aim of this study is to evaluate the effectiveness of exercise-based phase III cardiac rehabilitation programs in improving mortality and working capacity outcomes. Read More

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December 2021

Adrenal function during long-term ACTH therapy for patients with developmental and epileptic encephalopathy.

Epilepsia Open 2021 Dec 4. Epub 2021 Dec 4.

Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan.

Some patients with developmental and epileptic encephalopathy (DEE) respond to adrenocorticotropic hormone (ACTH) therapy but relapse soon after. While long-term ACTH therapy (LT-ACTH) has been attempted for these patients, no previous studies have carefully assessed adrenal function during LT-ACTH. We evaluated the effectiveness of LT-ACTH, as well as adverse effects (AE), including their adrenal function in three DEE patients. Read More

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December 2021

Deep brain stimulation of the centromedian thalamic nucleus for the treatment of FIRES.

Epilepsia Open 2021 Dec 4. Epub 2021 Dec 4.

Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Febrile infection-related epilepsy syndrome (FIRES) is a rare, life-threatening complication of febrile illness in previously healthy individuals followed by super-refractory status epilepticus. Deep brain stimulation (DBS) has been demonstrated to be a promising therapy for the treatment of intractable epilepsy. Here we present a pediatric patient with FIRES whose seizures were mitigated by acute DBS of the bilateral centromedian thalamic nucleus (CMTN). Read More

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December 2021

Biodegradable nanoparticles for the treatment of epilepsy: from current advances to future challenges.

Epilepsia Open 2021 Dec 4. Epub 2021 Dec 4.

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.

Epilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Read More

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December 2021

Lithium Storage Mechanism and Application of Micron-Sized Lattice-Reversible Binary Intermetallic Compounds as High-Performance Flexible Lithium-Ion Battery Anodes.

Small 2021 Dec 4:e2105172. Epub 2021 Dec 4.

Department of Physics and Tsinghua-Foxconn Nanotechnology Research Center, Tsinghua University, Beijing, 100084, China.

A strategy of lattice-reversible binary intermetallic compounds of metallic elements is proposed for applications in flexible lithium-ion battery (LIB) anode with high capacity and cycling stability. First, the use of metallic elements can ensure excellent electronic conductivity and high capacity of the active anode substance. Second, binary intermetallic compounds possess a larger initial lattice volume than metallic monomers, so that the problem of volume expansion can be alleviated. Read More

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December 2021

Simultaneous Interfacial Modification and Crystallization Control by Biguanide Hydrochloride for Stable Perovskite Solar Cell with PCE of 24.4.

Adv Mater 2021 Dec 4:e2106118. Epub 2021 Dec 4.

MOE Key Laboratory of Low-grade Energy Utilization Technologies and Systems, School of Energy & Power Engineering, Chongqing University, Chongqing, 400044, China.

Interfacial modification that serves multiple roles is vital for the fabrication of efficient and stable perovskite solar cells. Here, a multi-functional interfacial material, biguanide hydrochloride (BGCl), is introduced between SnO and perovskite to enhance electron extraction as well as crystal growth of perovskite. The BGCl can chemically link to the SnO through Lewis coordination/electrostatic coupling and help to anchor the PbI . Read More

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December 2021

Anticoagulant treatment regimens in patients with Covid-19: a meta-analysis.

Clin Pharmacol Ther 2021 Dec 4. Epub 2021 Dec 4.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Coronavirus disease 2019 (Covid-19) is associated with a hypercoagulable state. It has been hypothesized that higher-dose anticoagulation, including therapeutic-dose and intermediate-dose anticoagulation, is superior to prophylactic-dose anticoagulation in the treatment of Covid-19. This meta-analysis evaluated the efficacy and safety of higher-dose anticoagulation compared with prophylactic-dose anticoagulation in patients with Covid-19. Read More

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December 2021

Effects of AST-120 on muscle health and quality of life in chronic kidney disease patients: results of RECOVERY study.

J Cachexia Sarcopenia Muscle 2021 Dec 3. Epub 2021 Dec 3.

Department of Internal Medicine, CHA Gumi Medical Center, CHA University, Gumi, Republic of Korea.

Background: The prevalence of sarcopenia is increased with declining renal function. Elevated serum indoxyl sulfate levels are associated with poor skeletal muscle conditions. We aimed to determine the effects of AST-120, the oral adsorbent of indoxyl sulfate, on sarcopenia and sarcopenia-associated factors in chronic kidney disease patients. Read More

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December 2021

The Small Open Reading Frame-encoded Peptides: Advances in Methodologies and Functional Studies.

Chembiochem 2021 Dec 4. Epub 2021 Dec 4.

The Hong Kong Polytechnic University, Department of Applied Biology and Chemical Technology, 11 Yuk Choi Rd, Hung Hom, 999077, Hong Kong, HONG KONG.

Small open reading frames are an important class of genes with less than 100 codons. They were historically annotated as noncoding or even junk sequences. In recent years, accumulating evidence suggested that sORFs could encode a considerable number of polypeptides, many of which played important roles in both physiology and disease pathology. Read More

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December 2021

A Dual Photoelectrode Photoassisted Fe-Air Battery: The Photo-Electrocatalysis Mechanism Accounting for the Improved Oxygen Evolution Reaction and Oxygen Reduction Reaction of Air Electrodes.

Small 2021 Dec 4:e2103933. Epub 2021 Dec 4.

Liaoning Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, Shenyang, 110036, China.

Effective utilization of solar energy in battery systems is a promising solution to achieve sustainable and green development. In this work, a photoassisted Fe-air battery (PFAB) with two photoelectrodes of ZnO-TiO heterostructure and polyterthiophene (pTTh)-coated CuO (pTTh-CuO) grown on fluorine-doped tin oxide (FTO) is proposed. The band structure of semiconductors and the charge-transfer mechanism of heterostructure are studied. Read More

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December 2021

Practices and Perceptions Living Donor Liver Transplant, Non-Directed Donation, and Liver Paired Exchange: A National Survey.

Liver Transpl 2021 Dec 3. Epub 2021 Dec 3.

Cornell University, United States.

Living donor liver transplant (LDLT) remains under-utilized in the United States. Barriers to LDLT and acceptance of non-directed living liver donation (ND-LLD) and liver paired exchange (LPE) are unclear. The medical and surgical directors of 99 unique transplant programs (56 LDLT programs and 43 non-LDLT programs) were surveyed to gain insight into perceptions and practices of LDLT and types of donors utilized. Read More

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December 2021

Recurrent PTBP1-MAML2 Fusions in Composite Hemangioendothelioma with Neuroendocrine Differentiation: A Report of 2 cases Involving Neck Lymph Nodes.

Genes Chromosomes Cancer 2021 Dec 4. Epub 2021 Dec 4.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Composite hemangioendothelioma (CHE) displaying neuroendocrine differentiation is a rare histologic variant that is often mistaken for angiosarcoma, having a predilection for visceral locations and being associated with an aggressive clinical course. Their pathogenesis is still evolving, with only 2 cases to date from separate studies reporting a recurrent PTBP1-MAML2 fusion. Herein, we report two new cases of neuroendocrine CHE harboring PTBP1-MAML2 fusions occurring in two elderly patients (70-year-old male and 71-year-old female), both involving neck lymph nodes. Read More

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December 2021

Statistical testing in transcriptomic-neuroimaging studies: A how-to and evaluation of methods assessing spatial and gene specificity.

Hum Brain Mapp 2021 Dec 4. Epub 2021 Dec 4.

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Multiscale integration of gene transcriptomic and neuroimaging data is becoming a widely used approach for exploring the molecular underpinnings of large-scale brain organization in health and disease. Proper statistical evaluation of determined associations between imaging-based phenotypic and transcriptomic data is key in these explorations, in particular to establish whether observed associations exceed "chance level" of random, nonspecific effects. Recent approaches have shown the importance of statistical models that can correct for spatial autocorrelation effects in the data to avoid inflation of reported statistics. Read More

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December 2021

Ru360 and Mitoxantrone inhibit MCU channel to relieve liver steatosis induced by high-fat diet.

Br J Pharmacol 2021 Dec 3. Epub 2021 Dec 3.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Animal Science and Technology, Guangxi University, Nanning, P.R. China.

Background And Purpose: Nonalcoholic fatty liver disease (NAFLD) affects over 25% of the general population and lacks an effective treatment. Recent evidence implicates disrupted mitochondrial calcium homeostasis in the pathogenesis of hepatic steatosis.

Experimental Approach: In this study, mitochondrial calcium uniporter (MCU) was inhibited through classical genetic approaches, viral vectors or small molecule inhibitors in vivo to study its role in hepatic steatosis induced by HFD. Read More

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December 2021

What makes a good prediction? Feature importance and beginning to open the black box of machine learning in genetics.

Hum Genet 2021 Dec 4. Epub 2021 Dec 4.

Statistical Genetics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive Suite 1200, Baltimore, MD, 21224, USA.

Genetic data have become increasingly complex within the past decade, leading researchers to pursue increasingly complex questions, such as those involving epistatic interactions and protein prediction. Traditional methods are ill-suited to answer these questions, but machine learning (ML) techniques offer an alternative solution. ML algorithms are commonly used in genetics to predict or classify subjects, but some methods evaluate which features (variables) are responsible for creating a good prediction; this is called feature importance. Read More

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December 2021

Deployment of Clinical Prediction Models: A Practical Guide to Nomograms and Online Calculators.

Acta Neurochir Suppl 2022 ;134:101-108

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

The use of predictive models within neurosurgery is increasing and many models described in published journal articles are made available to readers in formats such as nomograms and online calculators. The present chapter details a step-by-step methodology with accompanying R code that may be used to implement models both in the form of traditional nomograms and as open-access, online calculators through RStudio's Shinyapps. The chapter assumes a basic understanding of predictive modeling in R and utilizes open-access files created by the Machine Intelligence in Clinical Neuroscience (MICN) Lab (Department of Neurosurgery and the Clinical Neuroscience Center of the University Hospital Zurich). Read More

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January 2022

Dimensionality Reduction: Foundations and Applications in Clinical Neuroscience.

Acta Neurochir Suppl 2022 ;134:59-63

Department of Neurosurgery, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

Advancements in population neuroscience are spurred by the availability of large scale, open datasets, such as the Human Connectome Project or recently introduced UK Biobank. With the increasing data availability, analyses of brain imaging data employ more and more sophisticated machine learning algorithms. However, all machine learning algorithms must balance generalization and complexity. Read More

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January 2022

Machine Intelligence in Clinical Neuroscience: Taming the Unchained Prometheus.

Acta Neurochir Suppl 2022 ;134:1-4

Machine Intelligence in Clinical Neuroscience (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

The democratization of machine learning (ML) through availability of open-source learning libraries, the availability of datasets in the "big data" era, increasing computing power even on mobile devices, and online training resources have both led to an explosion in applications and publications of ML in the clinical neurosciences, but has also enabled a dangerous amount of flawed analyses and cardinal methodological errors committed by benevolent authors. While powerful ML methods are nowadays available to almost anyone and can be applied after just few minutes of familiarizing oneself with these methods, that does not imply that one has mastered these techniques. This textbook for clinicians aims to demystify ML by illustrating its methodological foundations, as well as some specific applications throughout clinical neuroscience, and its limitations. Read More

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January 2022

Micro-Meta App: an interactive tool for collecting microscopy metadata based on community specifications.

Nat Methods 2021 Dec 3. Epub 2021 Dec 3.

Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.

For quality, interpretation, reproducibility and sharing value, microscopy images should be accompanied by detailed descriptions of the conditions that were used to produce them. Micro-Meta App is an intuitive, highly interoperable, open-source software tool that was developed in the context of the 4D Nucleome (4DN) consortium and is designed to facilitate the extraction and collection of relevant microscopy metadata as specified by the recent 4DN-BINA-OME tiered-system of Microscopy Metadata specifications. In addition to substantially lowering the burden of quality assurance, the visual nature of Micro-Meta App makes it particularly suited for training purposes. Read More

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December 2021

Sketching open and closed chromatin.

Authors:
Lei Tang

Nat Methods 2021 Dec 3. Epub 2021 Dec 3.

Nature Methods, .

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December 2021

Management of cardiovascular disease using an mHealth tool: a randomized clinical trial.

NPJ Digit Med 2021 Dec 3;4(1):165. Epub 2021 Dec 3.

Division of Cardiology, Department of Internal Medicine, Seoul National University and Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of death and morbidity worldwide. This randomized controlled, single-center, open-label trial tested the impact of a mobile health (mHealth) service tool optimized for ASCVD patient care. Patients with clinical ASCVD were enrolled and randomly assigned to the intervention or control group. Read More

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December 2021

Genome-wide characterization of bZIP gene family identifies potential members involved in flavonoids biosynthesis in Ginkgo biloba L.

Sci Rep 2021 Dec 3;11(1):23420. Epub 2021 Dec 3.

College of Horticulture and Gardening, Yangtze University, Jingzhou, 434025, Hubei, China.

Ginkgo biloba L. is an ancient relict plant with rich pharmacological activity and nutritional value, and its main physiologically active components are flavonoids and terpene lactones. The bZIP gene family is one of the largest gene families in plants and regulates many processes including pathogen defense, secondary metabolism, stress response, seed maturation, and flower development. Read More

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December 2021

Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation.

Sci Rep 2021 Dec 3;11(1):23373. Epub 2021 Dec 3.

Department of Chemistry, University of Gulph, 50 Stone Road E, Guelph, ON, N1G 2W1, Canada.

SARS-CoV-2, the virus that causes COVID-19, is still a widespread threat to society. The spike protein of this virus facilitates viral entry into the host cell. Here, the denaturation of the S1 subunit of this spike protein by 2. Read More

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December 2021

Modulation of magnetoencephalography alpha band activity by radiofrequency electromagnetic field depicted in sensor and source space.

Sci Rep 2021 Dec 3;11(1):23403. Epub 2021 Dec 3.

Department of Experimental Toxicology and Modeling (TEAM), Institut National de l'Environnement Industriel et des Risques (INERIS), Parc Technologique Alata, BP 2, 60550, Verneuil-en-Halatte, France.

Several studies reported changes in spontaneous electroencephalogram alpha band activity related to radiofrequency electromagnetic fields, but findings showed both an increase and a decrease of its spectral power or no effect. Here, we studied the alpha band modulation after 900 MHz mobile phone radiofrequency exposure and localized cortical regions involved in these changes, via a magnetoencephalography (MEG) protocol with healthy volunteers in a double-blind, randomized, counterbalanced crossover design. MEG was recorded during eyes open and eyes closed resting-state before and after radiofrequency exposure. Read More

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December 2021