297,703 results match your criteria onset symptoms

Pituitary metastasis unveiling a lung adenocarcinoma.

Endocrinol Diabetes Metab Case Rep 2021 Feb 26;2021. Epub 2021 Feb 26.

Endocrinology Department, Centro Hospitalar e Universitário do Porto, EPE, Porto, Portugal.

Summary: Pituitary metastasis (PM) can be the initial presentation of an otherwise unknown malignancy. As PM has no clinical or radiological pathognomonic features, diagnosis is challenging. The authors describe the case of a symptomatic PM that revealed a primary lung adenocarcinoma. Read More

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February 2021

Chronical rhino-orbital mucormycosis in an immunocompetent host: A case report.

Int J Surg Case Rep 2021 Apr 10;82:105882. Epub 2021 Apr 10.

Faculté de Médecine et Pharmacie, Hassan II University of Casablanca, B.P 5696, Casablanca, Morocco; Service de Stomatologie et chirurgie Maxillo-faciale, Hôpital 20 Août, CHU Ibn Rochd, B.P 2698, Casablanca, Morocco.

Mucormycosis is an opportunistic fungal infection caused by molds within the order Mucorales. The rhino-orbital-cerebral localization is the most frequent. It is a destructive, necrotizing and potentially fatal disease. Read More

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Decreased quality of life and spirometric alterations even after mild-moderate COVID-19.

Respir Med 2021 Apr 14;181:106391. Epub 2021 Apr 14.

Department of Internal Medicine, Hospital General de Zona No.27 Del Instituto Mexicano Del Seguro Social, Mexico City, Mexico. Electronic address:

Background: The follow-up of recovered COVID-19 patients is still limited. We aimed to evaluate the changes in quality-of-life (QOL) and spirometric alterations in the convalescent phase of 115 patients with at least 30 days post-COVID-19.

Methods: We included patients with confirmed COVID-19 infection, available past medical records and at least 30 days after the onset of symptoms. Read More

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Molecular diagnosis of childhood immune dysregulation, polyendocrinopathy and enteropathy, and implications for clinical management.

J Allergy Clin Immunol 2021 Apr 14. Epub 2021 Apr 14.

Department of Medicine (Medical Genetics) and Department of Genome Sciences, University of Washington, Seattle WA. Electronic address:

Background: Most patients with childhood-onset immune dysregulation, polyendocrinopathy and enteropathy have no genetic diagnosis for their illness. These patients may undergo empirical immunosuppressive treatment with highly variable outcomes.

Objective: To determine the genetic basis of disease in patients referred with "IPEX-like" disease, but with no mutation in FOXP3; then to assess consequences of genetic diagnoses for clinical management. Read More

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Crystalline gene mutations in Turkish children with congenital cataracts.

Int Ophthalmol 2021 Apr 16. Epub 2021 Apr 16.

Department of Ophthalmology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Purpose: To detect crystallin gene mutations in Turkish children with congenital cataracts.

Methods: The present study included 56 children (38 males and 18 females) who were diagnosed with congenital cataract in our ophthalmology clinic. The patients' blood samples were collected and sent to the medical genetics laboratory. Read More

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Young-onset trigeminal neuralgia: a clinical study and literature review.

Feng Yu Jia Yin

Acta Neurochir (Wien) 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurosurgery, Tenth People's Hospital of Tongji University, No. 301 Middle Yanchang Road, Shanghai, 200072, China.

Objective: Trigeminal neuralgia (TN) primarily occurs in elderly adults and is thought to be induced by neurovascular compression. However, a few children and young adults may present with the clinical features of TN. In this study, we aim to retrospectively assess the data of young patients with TN from a single center. Read More

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Clinical presentations and long term prognosis of childhood onset polyarteritis nodosa in single centre of Korea.

Sci Rep 2021 Apr 16;11(1):8393. Epub 2021 Apr 16.

Department of Paediatrics, Seoul National University Children's Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Childhood-onset polyarteritis nodosa (PAN) is a rare and systemic necrotising vasculitis in children affecting small- to medium-sized arteries. To date, there have been only a few reports because of its rarity. Thus, we aimed to investigate the clinical manifestations, laboratory findings, treatment, and long-term outcomes in patients with childhood-onset PAN and to evaluate the usefulness of the paediatric vasculitis activity score (PVAS). Read More

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Amoxicillin oral provocation challenge in a primary care clinic: a descriptive analysis.

CMAJ Open 2021 Apr-Jun;9(2):E394-E399. Epub 2021 Apr 16.

Department of Family Medicine (Gateman), McMaster University, Kitchener, Ont.; Department of Family Medicine (Gateman), Western University, Kitchener, Ont.; North Perth Family Health Team (Rumble), Listowel, Ont.; Departments of Pediatrics and Child Health, and Food and Human Nutritional Sciences (Protudjer), University of Manitoba; George & Fay Yee Centre for Healthcare Innovation (Protudjer); The Children's Hospital Research Institute of Manitoba (Protudjer), Winnipeg, Man.; Department of Medicine (Kim), Western University; Department of Medicine (Kim), McMaster University, Kitchener, Ont.

Background: Penicillin is the most frequently reported drug allergen; however, most of these allergies are not true allergies and do not justify the prescription of alternative, less effective and more expensive antibiotic drugs. We aimed to show that patients at low risk of amoxicillin allergy can safely and efficiently undergo oral provocation challenge (OPC) by their primary care physician.

Methods: In this descriptive analysis, we conducted a retrospective chart review of all primary care patients who had undergone OPC from November 2017 to October 2019 in the Amoxicillin Allergy Clinic at the North Perth Family Health Team, Listowel, Ontario. Read More

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Can targeting women with behavioural science 'nudges' help black men to find out more about their high risk of contracting prostate cancer?

Patient Educ Couns 2021 Apr 9. Epub 2021 Apr 9.

University of Warwick, United Kingdom. Electronic address:

Objective: Prostate cancer is now deadlier than breast cancer in the UK, with more than 12,000 men dying from it in the country in 2018. Black men are nearly three times more likely to suffer prostate cancer, with one in four contracting the disease in their lifetime. Despite being a high risk group very few black men aged 45 and over visit their GP to discuss the pros and cons of screening. Read More

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SARS-CoV-2-associated first episode of acute mania with psychotic features.

J Clin Neurosci 2021 May 1;87:29-31. Epub 2021 Mar 1.

Department of Psychiatry, Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey. Electronic address:

Despite neuropsychiatric outcomes of SARS-CoV-2 infection are now under close scrutiny, psychoneuroimmunological characteristics of COVID-19 and precise pathophysiology of neuropsychiatric manifestations of the infection are still obscure. Moreover, there still exists a shortfall in demonstrating specific clinical manifestations of the brain involvement of the virus. Here, we presented a 33-year-old female patient with COVID-19, reporting acute-onset paranoid delusions symptoms, insomnia and irritability. Read More

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Management of syringomyelia associated with tuberculous meningitis: A case report and systematic review of the literature.

J Clin Neurosci 2021 May 5;87:20-25. Epub 2021 Mar 5.

Division of Neurosciences Critical Care, Department of Neurology, Neurosurgery, Anesthesiology and Critical Care Medicine and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:

Determinants of tuberculosis (TB) syringomyelia, its management options and outcomes are still under investigation. The aim of this study is to present a case of TB syringomyelia with markedly improved symptoms status-post surgery and to understand the clinical characteristics and outcomes of 33 TB syringomyelia cases reported in the literature. Specifically, we examined the differences between patients who were managed medically and those who underwent surgical intervention. Read More

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COVID-19-related cognitive dysfunction may be associated with transient disruption in the DLPFC glutamatergic pathway.

J Clin Neurosci 2021 May 14;87:153-155. Epub 2021 Mar 14.

Department of Psychiatry, Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey. Electronic address:

Cognitive impairment has recently attracted researchers as one of the possible neuropsychiatric manifestations of COVID-19, although how the infection perpetuates impairment of cognitive functions is still obscure. We presented a 29-year-old male patient with COVID-19 who developed new-onset transient attention deficit and memory problems following a SARS-CoV-2 infection. Structural neuroimaging was normal. Read More

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mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus.

J Neurodev Disord 2021 Apr 17;13(1):14. Epub 2021 Apr 17.

Department of Child and Adolescent Psychiatry, University Hospital and Medical Faculty Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.

Background: Tuberous sclerosis complex (TSC), a multi-system genetic disorder often associated with autism spectrum disorder (ASD), is caused by mutations of TSC1 or TSC2, which lead to constitutive overactivation of mammalian target of rapamycin (mTOR). In several Tsc1+/- and Tsc2+/- animal models, cognitive and social behavior deficits were reversed by mTOR inhibitors. However, phase II studies have not shown amelioration of ASD and cognitive deficits in individuals with TSC during mTOR inhibitor therapy. Read More

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Clinical features and outcomes of neonatal dengue at the Children's Hospital 1, Ho Chi Minh, Vietnam.

J Clin Virol 2021 Feb 9;138:104758. Epub 2021 Feb 9.

School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan; Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam. Electronic address:

Objectives Neonatal dengue has been reported in the literature with contradictory findings of clinical characteristics and diagnosis; thereby, misdiagnosis of neonatal dengue has been frequently reported. We aim to delve into the epidemiology, clinical features, and outcomes of neonatal dengue, thus avoid misdiagnosis and obtain early intervention. Study design A retrospective study was conducted at Children's Hospital 1, Ho Chi Minh, Vietnam with laboratory-confirmed dengue in neonates by positive viral antigen nonstructural protein one rapid test (NS1) and positive IgM antibody for dengue by MAC-ELISA. Read More

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February 2021

Surgical management of diaphragmatic and thoracic endometriosis': a French multicentric descriptive study.

J Gynecol Obstet Hum Reprod 2021 Apr 13:102147. Epub 2021 Apr 13.

Department of gynecology, Croix Rousse University Hospital, Hospices civils de Lyon (HCL), 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France. Electronic address:

Introduction: Surgical management of Diaphragmatic and thoracic endometriosis (DTE) is still controversial, a thoracic or an abdominal approach can be proposed.

Methods: We conducted a multicentric retrospective study in 8 thoracic, gynecology or digestive surgery units in 5 French university hospitals. The main objective was to review the current management of DTE. Read More

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Diagnostic accuracy of LAMP versus PCR over the course of SARS-CoV-2 infection.

Int J Infect Dis 2021 Apr 13. Epub 2021 Apr 13.

Department of Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Objective: Reverse transcription loop-mediated isothermal amplification (RT-LAMP) has been validated for diagnosis of several viral infections. However, its diagnostic accuracy in detecting SARS-CoV-2 in real-life clinical settings remains unclear. The aim of this study was to determine the diagnostic sensitivity and specificity of RT-LAMP compared to reverse transcription-quantitative polymerase chain reaction (RT-qPCR) over the disease course of COVID-19. Read More

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Cognitive and behavioural impairment in amyotrophic lateral sclerosis: a landmark of the disease? A mini review of longitudinal studies.

Neurosci Lett 2021 Apr 13:135898. Epub 2021 Apr 13.

3rd Neurology Unit and Motor Neuron Diseases Centre, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy; Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Via Festa del Perdono 7, 20122, Milan, Italy.

Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative disease marked by progressive loss of motor abilities. Approximately half of patents with ALS experience cognitive (ALSci) or behavioural impairment (ALSbi) during the course of the disease, with a small percentage developing overt frontotemporal dementia (FTD). ALSci and/or ALSbi can occur simultaneously with motor neuron degeneration or develop in advanced stages of the disease, but it can even precede motor involvement in some cases, namely in ALS patients meeting criteria for FTD. Read More

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Mini-Review Free Sialic Acid Storage Disorder: Progress and Promise.

Neurosci Lett 2021 Apr 13:135896. Epub 2021 Apr 13.

Department of Molecular and Cell Biology, University of California, Berkeley, 94729, CA, United States.

Lysosomal free sialic acid storage disorder (FSASD) is an extremely rare, autosomal recessive, neurodegenerative, multisystemic disorder caused by defects in the lysosomal sialic acid membrane exporter SLC17A5 (sialin). SLC17A5 defects cause free sialic acid and some other acidic hexoses to accumulate in lysosomes, resulting in enlarged lysosomes in some cell types and 10-100-fold increased urinary excretion of free sialic acid. Clinical features of FSASD include coarse facial features, organomegaly, and progressive neurodegenerative symptoms with cognitive impairment, cerebellar ataxia and muscular hypotonia. Read More

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The Utility of Chest CT imaging in suspected or diagnosed COVID-19 Patients - a review of literature.

Chest 2021 Apr 13. Epub 2021 Apr 13.

Lenox Hill Hospital, Pulmonary Medicine. Electronic address:

The COVID-19 pandemic has had devastating medical and economic consequences globally. The severity of COVID-19 is related, in a large measure, to the extent of pulmonary involvement. The role of chest CT in the management of patients with COVID-19 has evolved since the onset of the pandemic. Read More

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Hypoglycemic attacks and growth failure are the most common manifestations of citrin deficiency after one year of age.

J Inherit Metab Dis 2021 Apr 16. Epub 2021 Apr 16.

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.

Citrin deficiency develops in different symptomatic periods from the neonatal period to adulthood. Some infantile patients are diagnosed by newborn mass screening or symptoms of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), some patients in childhood may develop hepatopathy or dyslipidemia as failure to thrive and dyslipidemia caused by citrin deficiency (FTTDCD), and some adults are diagnosed after developing adult-onset type 2 citrullinemia (CTLN2) with hyperammonemia or encephalopathy. A diagnosis is needed before the development of severe phenotypic CTLN2 but is often difficult to obtain because newborn mass screening cannot detect all patients with citrin deficiency, and undiagnosed patients often appear healthy in childhood. Read More

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Organizing pneumonia following Covid19 pneumonia.

Wien Klin Wochenschr 2021 Apr 16. Epub 2021 Apr 16.

Karl-Landsteiner-Institute for Lung Research and Pulmonary Oncology, Montleartstraße 37, 1160, Vienna, Austria.

The potential mid-term and long-term consequences after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are as yet unknown. This is the first report of bronchoscopically verified organizing pneumonia as a complication of coronavirus disease 2019 (Covid19). It caused persisting dyspnea, impaired pulmonary function, and radiological abnormalities over 5 weeks after onset of symptoms. Read More

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Clinical characteristics and antibody response to SARS-CoV-2 spike 1 protein using VITROS Anti-SARS-CoV-2 antibody tests in COVID-19 patients in Japan.

J Med Microbiol 2021 Apr;70(4)

Department of Clinical Laboratory, Saitama Medical University Hospital, Saitama, Japan.

Serological tests for COVID-19 are important in providing results for surveillance and supporting diagnosis. Investigating the serological response in COVID-19 patients with different disease severity is important for assessing the clinical utility of serological assays. However, few studies have investigated the clinical utility of antibody assays for COVID-19 or differences in antibody response in association with disease severity. Read More

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Treatment-related leukemia after taxane and platinum therapy in gynecological cancer patients (Gynecologic Oncology Trial and Investigation Consortium 011).

J Obstet Gynaecol Res 2021 Apr 15. Epub 2021 Apr 15.

Department of Obstetrics and Gynecology, SHIN-YURIGAOKA General Hospital, Kawasaki, Japan.

Aim: To clarify incidence and clinical features of treatment-related leukemia (TRL) due to taxane/platinum therapy in gynecological cancer patients.

Methods: We conducted a retrospective study of gynecological cancer patients who were diagnosed at facilities participating in the Gynecologic Oncology Trial and Investigation Consortium and started only taxane/platinum therapy as chemotherapy between 2002 and 2006.

Results: The site of the primary lesion was the ovary in 124, endometrium in 37, and uterine cervix in 4. Read More

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Antidepressants for people with epilepsy and depression.

Cochrane Database Syst Rev 2021 Apr 16;4:CD010682. Epub 2021 Apr 16.

Department of Health Data Science, University of Liverpool, Liverpool, UK.

Background: Depressive disorders are the most common psychiatric comorbidity in people with epilepsy, affecting around one-third, with a significant negative impact on quality of life. There is concern that people may not be receiving appropriate treatment for their depression because of uncertainty regarding which antidepressant or class works best, and the perceived risk of exacerbating seizures. This review aimed to address these issues, and inform clinical practice and future research. Read More

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Disease Progression and Obstetric Outcomes of Women with Multiple Sclerosis at a Reference Center in Northeastern Brazil.

Rev Bras Ginecol Obstet 2021 Mar 15;43(3):165-171. Epub 2021 Apr 15.

Department of Obstetrics and Gynecology, Centro de Ciências Médicas, Universidade Federal da Paraíba, João Pessoa, PB, Brazil.

Objective:  To describe the obstetric outcomes of patients with multiple sclerosis (MS) and the impact of pregnancy and the postpartum period on the progression of the disease.

Methods:  A case series study performed between December 2019 and February 2020, reporting pregnancies occurred between 1996 and 2019. The subjects included were women with MS undergoing follow-up at an MS referral center in Northeastern Brazil, and who had at least one pregnancy after the onset of MS symptoms, or who had their first relapse in the first year after delivery. Read More

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COVID-19-related refractory status epilepticus with the presence of SARS-CoV-2 (RNA) in the CSF: a case report.

Neurol Sci 2021 Apr 15. Epub 2021 Apr 15.

Department of Infectious Disease, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Amongst the neurologic complications of COVID-19 disease, very few reports have shown the presence of the virus in the cerebrospinal fluid (CSF). Seizure and rarely status epilepticus can be associated with COVID-19 disease. Here we present a 73-year-old male with prior history of stroke who has never experienced seizure before. Read More

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Longitudinal structural brain changes in Friedreich ataxia depend on disease severity: the IMAGE-FRDA study.

J Neurol 2021 Apr 15. Epub 2021 Apr 15.

School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Clayton Campus, Clayton, VIC, 3800, Australia.

Background: Friedreich ataxia is an inherited neurodegenerative disease, with cerebral and cerebellar pathology evident. Despite an increased understanding of its neuropathology, disease progression in this disease remains poorly understood. This study aimed to characterise longitudinal change in brain structure using a multi-modal approach across cerebral and cerebellar grey and white matter. Read More

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Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease.

J Neuropathol Exp Neurol 2021 Apr 16. Epub 2021 Apr 16.

From the Department of Pathology and Laboratory Medicine (JMW, KFB, TER); Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases (JMW, KFB, SS, TER), University of Texas Health Science Center, San Antonio, Texas, USA; Department of Pathology, State University of New York, Upstate Medical University, Syracuse, New York (YF, TER); Department of Pathology, University of Michigan, Ann Arbor, Michigan (YF), USA; Department of Pathology (KF, MAI, JFC); Department of Neuroscience (KF, MAI, JFC); Ronald M. Loeb Center for Alzheimer's Disease (KF, MAI, JFC), Icahn School of Medicine at Mount Sinai, New York, New York, USA; School of Medicine, University of Michigan, Ann Arbor, Michigan (MAI); Department of Neuroscience, Mayo Clinic, Jacksonville, Florida (KFB), USA; Department of Neurology, University of Texas Health Science Center, San Antonio, Texas (SS); The Framingham Heart Study, Framingham, Massachusetts (SS); and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas (CLW), USA.

Primary age-related tauopathy (PART) is a neurodegenerative entity defined as neurofibrillary degeneration generally restricted to the medial temporal region (Braak stage I-IV) with complete or near absence of diffuse and neuritic plaques. Symptoms range in severity but are generally milder and later in onset than in Alzheimer disease (AD). Recently, an early predilection for neurofibrillary degeneration in the hippocampal CA2 subregion has been demonstrated in PART, whereas AD neuropathologic change (ADNC) typically displays relative sparing of CA2 until later stages. Read More

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Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis.

ACS Pharmacol Transl Sci 2021 Apr 26;4(2):765-779. Epub 2021 Mar 26.

Institute of Biochemistry and Molecular Medicine, Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, 3012 Bern, Switzerland.

The modulation of the endocannabinoid system (ECS) has shown positive results in animal models of multiple sclerosis (MS) and immune and inflammatory disorders. However, chronic administration of CB1 receptor agonists and degrading enzyme inhibitors can lead to CB1 receptor desensitization and sedation. WOBE437 is the prototype of a new class of ECS modulators named selective endocannabinoid reuptake inhibitors (SERIs), which mildly and selectively increase central endocannabinoid levels with a self-limiting mode of action. Read More

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Resting-State fMRI in Studies of Acupuncture.

Evid Based Complement Alternat Med 2021 23;2021:6616060. Epub 2021 Mar 23.

First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.

Research exploring the mechanism of acupuncture has been a hot topic in medicine. Resting-state functional magnetic resonance imaging (rs-fMRI) research is a noninvasive and extensive method, which is aimed at the research of the mechanism of acupuncture. Researchers use fMRI technologies to inspect the acupuncture process. Read More

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