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Patient Experiences of Postinfectious Olfactory Dysfunction.

ORL J Otorhinolaryngol Relat Spec 2021 May 10:1-5. Epub 2021 May 10.

Fifth Sense, Phoenix Business Centre, Unit 8, Barrow-in-Furness, United Kingdom.

Introduction: To highlight the importance of the need for new treatment modalities, this study aimed to characterise the experience of patients with postinfectious olfactory dysfunction (PIOD) in terms of the treatment they received.

Methods: An online survey was hosted by the Norwich Clinical Trials Unit on the secure REDCap server. Members of the charity Fifth Sense (the UK charity that represents and supports people affected by smell and taste disorders) were invited to participate. Read More

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Effect of microplastics on aquatic biota: A hormetic perspective.

Environ Pollut 2021 Apr 30;285:117206. Epub 2021 Apr 30.

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS); Shandong Key Laboratory of Coastal Environmental Processes, YICCAS, Yantai, 264003, PR China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, PR China; Center for Ocean Mega-Science, Chinese Academy of Sciences (CAS), Qingdao, 266071, PR China. Electronic address:

As emerging pollutants, microplastics (MPs) have been found globally in various freshwater and marine matrices. This study recompiled 270 endpoints of 3765 individuals from 43 publications, reporting the onset of enhanced biological performance and reduced oxidative stress biomarkers induced by MPs in aquatic organisms at environmentally relevant concentrations (≤1 mg/L, median = 0.1 mg/L). Read More

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Healthcare utilization and cost outcomes for a multicenter first seizure and new onset epilepsy clinic.

Epilepsy Behav 2021 May 7;120:107972. Epub 2021 May 7.

Western University of Health Sciences College of Osteopathic Medicine of the Pacific, Northwest, 200 Mullins Dr, Lebanon, OR 97355, United States; Providence Brain and Spine Institute, 9135 SW Barnes Rd., Suite 363, Portland, OR 97225, United States.

Rationale: A First Seizure/New Onset Epilepsy (FS/NOE) protocol was implemented to ensure proper evaluation by an epileptologist and improve overall care for patients. We compared healthcare utilization and cost incurred by patients pre and post protocol implementation.

Methods: Clinical data were retrospectively collected from the EMR and cost data from the financial database. Read More

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Insights into Allergic Risk Factors from Birth Cohort Studies.

Ann Allergy Asthma Immunol 2021 May 7. Epub 2021 May 7.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada; Department of Medicine, Queen's University, Kingston, ON, Canada; Allergy Research Unit, Kingston Health Sciences Center - KGH Site, Kingston, ON, Canada. Electronic address:

Objective: To present an update of birth cohort study designs and their contributions to allergic risk.

Data Sources: The PubMed database was used to search for relevant articles.

Study: Selections Peer-reviewed prospective and retrospective studies involving the assessment of allergy using human birth cohorts between 2014-2021 were examined. Read More

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Self-sampling versus health care professional-guided swab collection for SARS-CoV-2 testing.

Infection 2021 May 10. Epub 2021 May 10.

Department of Internal Medicine II, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Purpose: To evaluate the diagnostic reliability and practicability of self-collected oropharyngeal swab samples for the detection of SARS-CoV-2 infection as self-sampling could enable broader testing availability and reduce both personal protective equipment and potential exposure.

Methods: Hospitalized SARS-CoV-2-infected patients were asked to collect two oropharyngeal swabs (SC-OPS1/2), and an additional oropharyngeal swab was collected by a health care professional (HCP-OPS). SARS-CoV-2 PCR testing for samples from 58 participants was performed, with a 48-h delay in half of the self-collected samples (SC-OPS2). Read More

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TREM2 Variants as A Possible Cause of Frontotemporal Dementia with Distinct Neuroimaging Features.

Eur J Neurol 2021 May 9. Epub 2021 May 9.

Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: Nasu-Hakola disease (NHD) is a rare, autosomal recessive disorder characterized by skeletal and neurological symptoms. Behavioral symptoms with cognitive impairment may mimic the behavioral variant of frontotemporal dementia (bvFTD) and other early-onset dementias. We analyzed our patients and reviewed the literature to delineate neurological and neuroimaging findings suggestive of NHD. Read More

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Dataset for Longitudinal Evaluation of the Abbott ARCHITECT SARS-CoV-2 IgM and IgG Assays in a Pediatric Population Divided by Age.

Data Brief 2021 Apr 30:107110. Epub 2021 Apr 30.

Department of Pathology and Laboratory Medicine, Children's Healthcare of Atlanta, Atlanta, GA.

Background: SARS-CoV-2 infection in children does not seem to follow the same pattern as in adults. Limited information is published on the level of antibody production and the duration of antibody response in children with COVID-19. Moreover, it is unknown if all children have a similar immune response to the infection, or if there are age dependent differences. Read More

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Misdiagnosed dystrophic epidermolysis bullosa pruriginosa: A case report.

World J Clin Cases 2021 May;9(13):3090-3094

Department of Dermatology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100000, China.

Background: Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare subtype of DEB, characterized by recurrent pruritus of the extremities, pruritus papules, nodules, and mossy-like plaques. To date, fewer than 100 cases have been reported. We report a misdiagnosed 30-year-old man with sporadic late-onset DEB-Pr who responded well to tacrolimus treatment, thereby serving as a guide to correct diagnosis and treatment. Read More

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Transient global amnesia after radiofrequency catheter ablation of supraventricular tachycardia: a case report.

Cardiovasc Diagn Ther 2021 Apr;11(2):472-477

Department of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China.

Transient global amnesia (TGA) is a neurological disorder characterized by sudden onset of anterograde amnesia with or without retrograde amnesia, lasting less than 24 hours, without other clinical neurological dysfunction. TGA with short duration and benign prognosis is usually neglected in clinical practice. Transient total amnesia after radiofrequency ablation is rare and its etiology is unknown. Read More

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A Case of Postural Orthostatic Tachycardia Syndrome Secondary to the Messenger RNA COVID-19 Vaccine.

Cureus 2021 May 4;13(5):e14837. Epub 2021 May 4.

Internal Medicine/Gastroenterology, Decatur-Morgan Hospital, Decatur, USA.

Postural orthostatic tachycardia syndrome (POTS) is an impaction of the autonomic nervous system initiating orthostatic tachycardia. There are numerous triggers for POTS including viruses, vaccines, and an autoimmune basis. This case report is clinically relevant to better understand the pathophysiology behind the messenger RNA (mRNA) coronavirus disease 2019 (COVID-19) vaccine and the mechanism that triggers autonomic nervous system dysfunction. Read More

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Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo.

Dermatol Res Pract 2021 21;2021:5524566. Epub 2021 Apr 21.

Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Background: Vitiligo is a chronic condition characterized by skin depigmentation. Although not life-threatening, it significantly impacts quality of life. The pathophysiology of vitiligo remains poorly understood, and treatment options are limited. Read More

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Exploring Variances of White Matter Integrity and the Glymphatic System in Simple Febrile Seizures and Epilepsy.

Front Neurol 2021 21;12:595647. Epub 2021 Apr 21.

Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Simple febrile seizures (SFS) and epilepsy are common seizures in childhood. However, the mechanism underlying SFS is uncertain, and the presence of obvious variances in white matter (WM) integrity and glymphatic function between SFS and epilepsy remain unclear. Therefore, this study aimed to investigate the differences in WM integrity and glymphatic function between SFS and epilepsy. Read More

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Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline.

Front Aging Neurosci 2021 21;13:626974. Epub 2021 Apr 21.

Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.

The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases. We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6. Read More

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Predictors of mortality in patients with severe COVID-19 pneumonia - a retrospective study.

Adv Respir Med 2021 ;89(2):135-144

Department of Respiratory Medicine, JSS Medical College, JSS University, Mysore, Karnataka, India.

Introduction: The novel coronavirus pandemic has caused significant mortality throughout the world. This study was done as there is scarce data on mortality predictors in severe COVID-19 pneumonia patients admitted to ICU in the Indian population.

Material And Methods: A retrospective study was conducted on COVID-19 pneumonia patients admitted to tertiary care center during June-October 2020. Read More

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January 2021

Evaluation of cardiovascular events in patients with hepatocellular carcinoma treated with sorafenib in the clinical practice. The CARDIO-SOR study.

Liver Int 2021 May 9. Epub 2021 May 9.

Liver Unit, Division of Gastroenterology and Hepatology, Hospital Universitario Central de Asturias, Oviedo, Spain.

Background And Aims: The effectiveness of systemic treatment in advanced hepatocellular carcinoma (HCC) depends on the selection of patients, management of cirrhosis complications and expertise to treat adverse events. The aims of the study are to assess the frequency and management of cardiovascular events in HCC patients treated with sorafenib (SOR) and to create a scale to predict the onset of major adverse cardiovascular events (MACE).

Method: observational retrospective study with consecutive HCC patients treated with SOR between 2007 and 2019 in a western centre. Read More

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Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism.

Eur Child Adolesc Psychiatry 2021 May 9. Epub 2021 May 9.

Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

With this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and show for the first time strong effects in a male patient with AN. A 15.9 year old adolescent with severe AN of eight-month duration was treated off-label with metreleptin. Read More

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Care-home outbreaks of COVID-19 in Scotland March to May 2020: national linked data cohort analysis.

Age Ageing 2021 May 8. Epub 2021 May 8.

Usher Institute, University of Edinburgh, Doorway 3 Old Medical School, Teviot Place, Edinburgh EH8 9AG.

Background: understanding care-home outbreaks of COVID-19 is a key public health priority in the ongoing pandemic to help protect vulnerable residents.

Objective: to describe all outbreaks of COVID-19 infection in Scottish care-homes for older people between 01/03/2020 to 31/03/2020, with follow-up to 30/06/2020.

Design And Setting: national linked data cohort analysis of Scottish care-homes for older people. Read More

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Hepatitis C virus eradication decreases the risks of liver cirrhosis and cirrhosis-related complications (T-COACH).

J Gastroenterol Hepatol 2021 May 7. Epub 2021 May 7.

Division of Gastroenterology and Hepatology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Background And Aims: It is currently unknown how hepatitis C virus (HCV) eradication with pegylated interferon and ribavirin (PR) therapy affects the incidence of new-onset liver cirrhosis (LC) in patients without cirrhosis and the incidence of decompensated liver disease (DLD) or hepatocellular carcinoma (HCC) in patients with cirrhosis.

Methods: Taiwanese chronic hepatitis C cohort (T-COACH) is a nationwide HCV registry cohort from 23 hospitals in Taiwan recruited between 2003 and 2015. This study enrolled 10,693 patients with chronic hepatitis C (CHC), linked to the Taiwan National Health Insurance Research Database, receiving PR therapy for at least 4 weeks for new-onset LC and liver-related complications (DLD or HCC). Read More

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Determinants of LV dP/dt and QRS duration with different fusion strategies in cardiac resynchronisation therapy.

Open Heart 2021 May;8(1)

Department of Cardiology, Oslo University Hospital, Oslo, Norway.

Background: We designed this study to assess the acute effects of different fusion strategies and left ventricular (LV) pre-excitation/post-excitation on LV dP/dt and QRS duration (QRSd).

Methods: We measured LV dP/dt and QRSd in 19 patients having cardiac resynchronisation therapy (CRT). Two groups of biventricular pacing were compared: pacing the left ventricle (LV) with FUSION with intrinsic right ventricle (RV) activation (FUSION), and pacing the LV and RV with NO FUSION with intrinsic RV activation. Read More

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Single dose perioperative intrathecal ketamine as an adjuvant to intrathecal bupivacaine: A systematic review and meta-analysis of adult human randomized controlled trials.

J Clin Anesth 2021 May 5;73:110331. Epub 2021 May 5.

Zucker School of Medicine at Hofstra/Northwell, Department of Anesthesiology, Northwell Health, New Hyde Park, NY, United States of America.

Study Objective: To identify whether adding intrathecal ketamine to intrathecal bupivacaine prolongs the time to first analgesic request in adult humans.

Design: A meta-analysis of randomized controlled trials in humans.

Setting: The majority of data was obtained in an operating room and postoperative recovery area. Read More

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A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells.

PLoS One 2021 7;16(5):e0251172. Epub 2021 May 7.

Complexity Science Group, Department of Physics and Astronomy, University of Calgary, Calgary, Alberta, Canada.

Within the classical eye-blink conditioning, Purkinje cells within the cerebellum are known to suppress their tonic firing rates for a well defined time period in response to the conditional stimulus after training. The temporal profile of the drop in tonic firing rate, i.e. Read More

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Long-term shedding of viable SARS-CoV-2 in kidney transplant recipients with COVID-19.

Am J Transplant 2021 May 7. Epub 2021 May 7.

Department of Virology, Strasbourg University Hospital, Strasbourg, France.

The exact duration of viable SARS-CoV-2 shedding in kidney transplant recipients (KTRs) remains unclear. Here, we retrospectively investigated this issue using cell cultures of SARS-CoV-2 RT-PCR-positive nasopharyngeal samples (n = 40) obtained from 16 KTRs with symptomatic COVID-19 up to 39 days from symptom onset. A length of viable SARS-CoV-2 shedding >3 weeks from the onset of symptoms was identified in four KTRs (25%). Read More

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Effect of early intervention for anxiety on sleep outcomes in adolescents: a randomized trial.

Eur Child Adolesc Psychiatry 2021 May 7. Epub 2021 May 7.

Regional Centre for Child and Youth Mental Health and Child Welfare, Norwegian Research Center, NORCE, Bergen, Norway.

The potential effect of early intervention for anxiety on sleep outcomes was examined in a sample of adolescents with anxiety (N = 313, mean 14.0 years, SD = 0.84, 84% girls, 95. Read More

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Altered ripple density inside seizure onset zone in patients with focal cortical dysplasia-associated epilepsy.

Brain Behav 2021 May 7:e02169. Epub 2021 May 7.

Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Purpose: To evaluate the clinical and stereoelectroencephalography (SEEG) features and postsurgical outcome in a uniform series of patients who underwent epilepsy surgery and had pathologically confirmation of focal cortical dysplasia (FCD).

Methods: We studied consecutive patients with drug-refractory epilepsy who underwent SEEG recording. The high-frequency oscillations (HFOs) features of SEEG, clinical characteristics, and surgical outcome were evaluated. Read More

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Very Late-onset Neuromyelitis Optica Spectrum Disorders.

Eur J Neurol 2021 May 7. Epub 2021 May 7.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Background: Neuromyelitis optica spectrum disorder (NMOSD) often presents in the elderly with an insidious onset of symptoms and aggressive progression. There have been anecdotal cases of very late-onset (VLO)-NMOSD, but case series reports are rare. The aim of this retrospective study was to clarify the clinical features of VLO-NMOSD. Read More

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Efficacy and Safety of Tripterygium Glycoside in the Treatment of Diabetic Nephropathy: A Systematic Review and Meta-Analysis Based on the Duration of Medication.

Front Endocrinol (Lausanne) 2021 20;12:656621. Epub 2021 Apr 20.

School of Life and Science, Beijing University of Chinese Medicine, Beijing, China.

Aim: The aim of this study was to assess the clinical efficacy and safety of Tripterygium-derived glycosides (TG) after 3-month and 6-month of treatments of diabetic nephropathy (DN) and to resolve the conflict between medicine guidance and clinical practice for TG application.

Methods: We conducted a systematic review and meta-analysis of randomized controlled trials involving TG application in treating DN. We extensively searched PubMed, Cochrane Library, CNKI, VIP, Wan-Fang, CBM, Chinese Clinical Trial Registry, and WHO International Clinical Trial Registration Platform till November 2020, along with grey literature for diabetes and all other relevant publications to gather eligible studies. Read More

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Unattended Emotional Prosody Affects Visual Processing of Facial Expressions in Mandarin-Speaking Chinese: A Comparison With English-Speaking Canadians.

J Cross Cult Psychol 2021 Apr 15;52(3):275-294. Epub 2021 Feb 15.

McGill University, Montréal, QC, Canada.

Emotional cues from different modalities have to be integrated during communication, a process that can be shaped by an individual's cultural background. We explored this issue in 25 Chinese participants by examining how listening to emotional prosody in Mandarin influenced participants' gazes at emotional faces in a modified visual search task. We also conducted a cross-cultural comparison between data of this study and that of our previous work in English-speaking Canadians using analogous methodology. Read More

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Assessing implementation fidelity in the First Episode Rapid Early Intervention for Eating Disorders service model.

BJPsych Open 2021 May 7;7(3):e98. Epub 2021 May 7.

Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; and Eating Disorder Outpatient Service, South London and Maudsley NHS Foundation Trust, UK.

Background: The First Episode Rapid Early Intervention for Eating Disorders (FREED) service model is associated with significant reductions in wait times and improved clinical outcomes for emerging adults with recent-onset eating disorders. An understanding of how FREED is implemented is a necessary precondition to enable an attribution of these findings to key components of the model, namely the wait-time targets and care package.

Aims: This study evaluated fidelity to the FREED service model during the multicentre FREED-Up study. Read More

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Patterns of whole-body muscle activations following vertical perturbations during standing and walking.

J Neuroeng Rehabil 2021 May 6;18(1):75. Epub 2021 May 6.

Center of Advanced Technologies in Rehabilitation, Sheba Medical Center, Ramat Gan, Israel.

Background: Falls commonly occur due to losses of balance associated with vertical body movements (e.g. reacting to uneven ground, street curbs). Read More

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Classification of first-episode psychosis using cortical thickness: A large multicenter MRI study.

Eur Neuropsychopharmacol 2021 May 3;47:34-47. Epub 2021 May 3.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.

Machine learning classifications of first-episode psychosis (FEP) using neuroimaging have predominantly analyzed brain volumes. Some studies examined cortical thickness, but most of them have used parcellation approaches with data from single sites, which limits claims of generalizability. To address these limitations, we conducted a large-scale, multi-site analysis of cortical thickness comparing parcellations and vertex-wise approaches. Read More

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