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A prospective cohort study of ambient air pollution exposure and risk of uterine leiomyomata.

Hum Reprod 2021 May 13. Epub 2021 May 13.

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Study Question: To what extent are ambient concentrations of particulate matter <2.5 microns (PM2.5), nitrogen dioxide (NO2) and ozone (O3) associated with risk of self-reported physician-diagnosed uterine leiomyomata (UL)?

Summary Answer: In this large prospective cohort study of Black women, ambient concentrations of O3, but not PM2. Read More

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Audiovisual Simultaneity Judgements in Synaesthesia.

Multisens Res 2021 May 12:1-12. Epub 2021 May 12.

Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

Synaesthesia is a multimodal phenomenon in which the activation of one sensory modality leads to an involuntary additional experience in another sensory modality. To date, normal multisensory processing has hardly been investigated in synaesthetes. In the present study we examine processes of audiovisual separation in synaesthesia by using a simultaneity judgement task. Read More

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The clinical effects of sleep restriction therapy for insomnia: A meta-analysis of randomised controlled trials.

Sleep Med Rev 2021 Apr 21;58:101493. Epub 2021 Apr 21.

Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, UK. Electronic address:

Sleep restriction therapy (SRT) is an established treatment for insomnia that has been used in clinical practise for over 30 y. It is commonly delivered as part of multicomponent cognitive-behavioural therapy (CBT-I) but has also been linked to beneficial effects as a standalone intervention. In order to quantify the efficacy of SRT we performed a comprehensive meta-analysis of randomised controlled trials (RCTs) comparing SRT to minimally active or non-active control groups. Read More

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Inflammatory Biomarkers Correlate with Time Evolution in Cerebral Venous Thrombosis.

J Stroke Cerebrovasc Dis 2021 May 10;30(7):105844. Epub 2021 May 10.

Department of Neurology, Centro Hospitalar Universitário de São João, EPE, Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto.

Objectives: We aimed to analyse the relationship between specific inflammatory biomarkers' levels and the temporal pattern of cerebral venous thrombosis (CVT) symptoms.

Materials And Methods: We performed a retrospective study of adult CVT patients admitted between Jan 01 2006 and Dec 31 2019. We excluded patients with infection at admission, autoimmune, inflammatory or haematological disorders. Read More

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Unknown Onset Stroke: Differences Between Patients with Wake-Up Stroke and Daytime-Unwitnessed Stroke.

J Stroke Cerebrovasc Dis 2021 May 10;30(7):105842. Epub 2021 May 10.

Department of Neurology, Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address:

Objectives: Patients with unknown onset stroke (UOS) can be categorized as wake-up stroke (WUS) and daytime-unwitnessed stroke (DUS). We sought to determine whether decisions for initial imaging modalities, frequency of mismatch findings, resulting treatment decisions and outcome differ between WUS and DUS patients.

Materials And Methods: In a retrospective analysis, all patients with UOS admitted to our Stroke Unit from January to December 2018 were evaluated and classified as either WUS or DUS. Read More

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Ecological stress, amygdala reactivity, and internalizing symptoms in preadolescence: Is parenting a buffer?

Cortex 2021 Apr 15;140:128-144. Epub 2021 Apr 15.

Department of Psychology, University of Michigan, USA; Survey Research Center, Institute for Social Research, University of Michigan, USA.

Ecological stress during adolescent development may increase the sensitivity to negative emotional processes that can contribute to the onset and progression of internalizing behaviors during preadolescence. Although a small number of studies have considered the link among the relations between ecological stress, amygdala reactivity, and internalizing symptoms in childhood and adolescence, these studies have largely been small, cross-sectional, and often do not consider unique roles of parenting or sex. In the current study, we evaluated the interrelations between ecological stress, amygdala reactivity, subsequent internalizing symptoms, and the moderating roles of parenting and sex among 9- and 10-year-old preadolescents from the Adolescent Brain Cognitive Development (ABCD) Study ®. Read More

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Quantitative assessment of lung involvement on chest CT at admission: Impact on hypoxia and outcome in COVID-19 patients.

Clin Imaging 2021 Apr 29;77:194-201. Epub 2021 Apr 29.

Experimental Imaging Center, Radiology Unit, IRCCS San Raffaele Hospital, Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

Background: The aim of this study was to quantify COVID-19 pneumonia features using CT performed at time of admission to emergency department in order to predict patients' hypoxia during the hospitalization and outcome.

Methods: Consecutive chest CT performed in the emergency department between March 1st and April 7th 2020 for COVID-19 pneumonia were analyzed. The three features of pneumonia (GGO, semi-consolidation and consolidation) and the percentage of well-aerated lung were quantified using a HU threshold based software. Read More

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Predicting outcome of patients with psychogenic nonepileptic seizures after diagnosis in an epilepsy monitoring unit.

Epilepsy Behav 2021 May 10;120:108004. Epub 2021 May 10.

Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada; Psychology, Western University, London, Ontario, Canada.

Objective: To identify predictors of Psychogenic NonEpileptic Seizure (PNES) improvement and anti-seizure medication (ASM) discontinuation in patients with PNES only.

Methods: This is a retrospective study of a consecutively enrolled cohort of 271 patients diagnosed with PNES by video-EEG (vEEG) telemetry in our Epilepsy Monitoring Unit (EMU) between May 2000 and February 2010. Patients with any possibility of past or present comorbid epilepsy based on clinical, EEG, and neuroimaging, or less than one year of follow-up after discharge were excluded. Read More

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Blood pressure control measured as "time in range" during initial 24 h for inpatients with spontaneous nontraumatic intracerebral haemorrhage.

J Neurol Sci 2021 May 5;426:117480. Epub 2021 May 5.

PO Box 4545, Rashid Hospital, Umm Hurair, Dubai, United Arab Emirates.

Background And Purpose: Blood pressure (BP) control is an integral part in the management of spontaneous nontraumatic intracerebral haemorrhage. The aim of this study is to propose a novel concept of blood pressure control measured as 'Time in Range'(TiR) and assess its relationship to neurological deterioration.

Method: Retrospective study of 120 patients with Intracerebral haemorrhage who were admitted within 6 h of the symptom onset. Read More

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Dopamine neuron-specific LRRK2 G2019S effects on gene expression revealed by translatome profiling.

Neurobiol Dis 2021 May 10:105390. Epub 2021 May 10.

Jungers Center for Neurosciences, Department of Neurology, Oregon Health and Science University, Portland, OR, USA. Electronic address:

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of late-onset autosomal dominant Parkinson's disease. The pathogenic G2019S mutation enhances LRRK2 kinase activity and induces neurodegeneration in C. elegans, Drosophila and rodent models through unclear mechanisms. Read More

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Outbreak investigation of symptomatic SARS-COV-2 VOC 202012/01-lineage B.1.1.7 infection in healthcare workers, Italy.

Clin Microbiol Infect 2021 May 10. Epub 2021 May 10.

Department of Biomedical Sciences and Human Oncology-Hygiene Section, University of Bari, Bari, Italy. Electronic address:

Objectives: In December 2020, Italy began a national immunization campaign using the BNT162b2 mRNA COVID-19 vaccine, prioritizing healthcare workers (HCWs). Immune serum from vaccinated subjects seems to (largely) retain titres of neutralizing antibodies, even against SARS-CoV-2 VOC 202012/01-lineage B.1. Read More

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Risk of acute lung injury after esophagectomy.

Semin Thorac Cardiovasc Surg 2021 May 10. Epub 2021 May 10.

Division of Thoracic Surgery, Department of Surgery, Affiliated Hospital of Qingdao University, Qingdao, China; Surgery, Health management center, Affiliated Hospital of Qingdao University, Qingdao, China.

To develop a new approach for identifying acute lung injury (ALI) in surgical ward setting and to assess incidence rate, clinical outcomes, and risk factors for ALI cases after esophagectomy. We also compare the degree of lung injury between operative and non-operative sides. Consecutive esophageal cancer patients (n=1022) who underwent esophagectomy from Dec 2012 to Nov 2018 in our hospital were studied. Read More

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Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 10:110348. Epub 2021 May 10.

Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, SP, Brazil. Electronic address:

Schizophrenia is a severe mental disorder with complex etiopathogenesis. Based on its neurodevelopmental features, an animal model induced by "two-hit" based on perinatal immune activation followed by peripubertal unpredictable stress was proposed. Sex influences the immune response, and concerning schizophrenia, it impacts the age of onset and symptoms severity. Read More

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Development of an immunochromatographic kit to detect severe acute respiratory syndrome coronavirus 2.

J Virol Methods 2021 May 10:114183. Epub 2021 May 10.

Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address:

Background: The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the worldwide coronavirus disease-19 (COVID-19) pandemic, starting in late 2019. The standard diagnostic methods to detect SARS-CoV-2 are PCR-based genetic assays. Antigen-antibody-based immunochromatographic assays are alternative methods of detecting this virus. Read More

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Electrophysiological evidence for the coexistence of expectancy fulfillment and semantic integration during the processing of binding and compound nouns.

Fei Li Xu Xu

Int J Psychophysiol 2021 May 10. Epub 2021 May 10.

School of Foreign Languages, Shanghai Jiao Tong University, China. Electronic address:

This study employed electrophysiological measures to investigate the processes of expectancy fulfillment and semantic integration during the processing of binding and compound nouns in Chinese. Sequential expectancy and cloze probability between the two constituents of a two-character noun were manipulated in two experiments, resulting in four types of target characters (i.e. Read More

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Applying prospective genomic surveillance to support investigation of hospital-onset COVID-19.

Lancet Infect Dis 2021 May 10. Epub 2021 May 10.

Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK; Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK.

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Adverse childhood experience in patients with psoriasis.

Trends Psychiatry Psychother 2021 May 12. Epub 2021 May 12.

Mackenzie Evangelical School of Medicine Paraná, Curitiba, Brazil.

Introduction: Adverse childhood experiences (ACEs) have been linked to the occurrence of autoimmune diseases in adults, including psoriasis.

Aim: To study the prevalence of ACEs in psoriasis patients comparing it with general population.

Methods: Three hundred and eighteen individuals were included (104 psoriasis patients and 214 controls). Read More

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Natural gene therapy by reverse mosaicism leads to improved hematology in Fanconi anemia patients.

Am J Hematol 2021 May 13. Epub 2021 May 13.

Genomic Instability and DNA repair Syndromes group and Joint Research Unit on Genomic Medicine UAB-Sant Pau Biomedical Research Institute (IIB Sant Pau), Institut de Recerca Hospital de la Santa Creu i Sant Pau-IIB Sant Pau, Barcelona, Spain.

Fanconi anemia (FA) is characterized by chromosome fragility, bone marrow failure (BMF) and predisposition to cancer. As reverse genetic mosaicism has been described as "natural gene therapy" in patients with FA, we sought to evaluate the clinical course of a cohort of FA mosaic patients followed at referral centers in Spain over a 30-year period. This cohort includes patients with a majority of T-cells without chromosomal aberrations in the DEB-chromosomal breakage test. Read More

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Cancer progression as a sequence of atavistic reversions.

Bioessays 2021 May 13:e2000305. Epub 2021 May 13.

Beyond Center for Fundamental Concepts in Science, Arizona State University, Tempe, Arizona, USA.

It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi-unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular-to-unicellular reversion predicted by the atavism model has come from phylostratigraphy. Read More

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Swept-Source OCT Angiographic Characteristics of Treatment-Naïve Nonexudative Macular Neovascularization in AMD Prior to Exudation.

Invest Ophthalmol Vis Sci 2021 May;62(6):14

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.

Purpose: To investigate the characteristics of treatment-naïve nonexudative macular neovascularization (MNV) in age-related macular degeneration before the onset of exudation using swept-source optical coherence tomography angiography.

Methods: MNV area, choriocapillaris (CC) flow deficits (FDs), vessel area density (VAD), vessel skeleton density (VSD), retinal pigment epithelial detachment (PED) volume, mean choroidal thickness (MCT), and choroid vascularity index (CVI) measurements were assessed at two visits prior to exudation. We compared measurements made at the second visit and the rate of change between visits in eyes with and without exudation. Read More

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Late-Onset Encephalopathy Associated With SARS-CoV-2 Infection.

J Neurol Res 2020 Dec 9;10(6):237-239. Epub 2020 Dec 9.

Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Several typical and atypical neurological manifestations of viral pandemics have been reported. Neurological manifestations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have recently been reported. In this case report, we present a patient with encephalopathy as a late neurologic manifestation of SARS-CoV-2 infection. Read More

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December 2020

Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.

PLoS One 2021 13;16(5):e0251598. Epub 2021 May 13.

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.

Background: Many studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development.

Objective: Our objective was to examine whether changes in endocrine levels can indicate the onset of pubertal development prior to changes in self-rated Tanner stage. Read More

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Evaluation of the test accuracy of a SARS-CoV-2 rapid antigen test in symptomatic community dwelling individuals in the Netherlands.

PLoS One 2021 13;16(5):e0250886. Epub 2021 May 13.

Microvida Laboratory for Medical Microbiology, Amphia Hospital, Breda, The Netherlands.

Background: SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction (qRT-PCR) is well suited for the diagnosis of clinically ill patients requiring treatment. Application for community testing of symptomatic individuals for disease control purposes however raises challenges. SARS-CoV-2 rapid antigen tests might offer an alternative, but quality evidence on their performance is limited. Read More

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Diagnostic Performance of an Antigen Test with RT-PCR for the Detection of SARS-CoV-2 in a Hospital Setting - Los Angeles County, California, June-August 2020.

MMWR Morb Mortal Wkly Rep 2021 May 14;70(19):702-706. Epub 2021 May 14.

Prompt and accurate detection of SARS-CoV-2, the virus that causes COVID-19, has been important during public health responses for containing the spread of COVID-19, including in hospital settings (1-3). In vitro diagnostic nucleic acid amplification tests (NAAT), such as real-time reverse transcription-polymerase chain reaction (RT-PCR) can be expensive, have relatively long turnaround times, and require experienced laboratory personnel.* Antigen detection tests can be rapidly and more easily performed and are less expensive. Read More

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A case report of sudden-onset auditory neuropathy spectrum disorder associated with Brown-Vialetto-Van Laere syndrome (riboflavin transporter deficiency).

Int J Audiol 2021 May 13:1-7. Epub 2021 May 13.

Department of Neurology, Division of Child Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objective: The purpose of this paper is to describe a child with auditory neuropathy spectrum disorder (ANSD) associated with Brown-Vialetto-Van Laere (BVVL) syndrome, which is a rare, inherited, neurodegenerative disorder that is caused by defects in riboflavin transporter genes.

Design: We report the audiological and clinical profile of a child who presented with a complaint of sudden loss of speech understanding associated with an atypical form of ANSD. He was later diagnosed with BVVL. Read More

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Sleep Difficulties among Mexican Adolescents: Subjective and Objective Assessments of Sleep.

Behav Sleep Med 2021 May 13:1-15. Epub 2021 May 13.

Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan.

: Self-reported sleep difficulties, such as insomnia symptoms, have been reported among adolescents. Yet, studies of their prevalence and correlates are scarce among Latin Americans. This study sought (1) to describe associations between sociodemographic and lifestyle factors with self-reported sleep difficulties and (2) to examine associations between self-reported sleep difficulties and actigraphy-based sleep. Read More

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Evaluating the Impact of Summer Drought on Vegetation Growth Using Space-Based Solar-Induced Chlorophyll Fluorescence Across Extensive Spatial Measures.

Big Data 2021 May 13. Epub 2021 May 13.

Key Laboratory of Advanced Process Control for Light Industry, Ministry of Education, Jiangnan University, Wuxi, China.

Drought is the primary and dominant natural cause of stress on vegetation, and thus, it needs our full attention. Current understanding of drought across extensive spatial measures, around the world, is considerably limited. As case studies to evaluate the feasibility of utilizing space-based solar-induced chlorophyll fluorescence (SIF) across extensive spatial measures, here, we have used data from 2007 to 2017 in Heilongjiang and Jiangsu provinces of China. Read More

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The Effects of Early Oropharyngeal Administration of Microdosed Colostrum on Feeding Status in Ventilated Extremely Low-Birth-Weight Infants.

Breastfeed Med 2021 May 13. Epub 2021 May 13.

Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

For extremely low-birth-weight infants (ELBWIs), mechanical ventilation and total parenteral nutrition are generally required in the early stages and lose the protective effect of early gastrointestinal nutrition of colostrum. We conducted a prospective randomized controlled trial to explore the effectiveness of early colostrum oropharyngeal administration on the feeding status of ELBWIs on mechanical ventilation. We randomly divided mechanically ventilated ELBWIs into an intervention group and a control group. Read More

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