12,825 results match your criteria online database


A Matched Comparison of the Long-Term Outcomes of Cemented and Cementless Total Knee Replacements: An Analysis from the National Joint Registry of England, Wales, Northern Ireland and the Isle of Man.

J Bone Joint Surg Am 2021 Sep 20. Epub 2021 Sep 20.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, University of Oxford, Oxford, United Kingdom.

Background: Total knee replacements (TKRs) can be implanted with or without the use of cement. It is currently uncertain how cemented and cementless TKRs compare overall and in different age groups of the population in the long term.

Methods: The National Joint Registry collects information on knee replacements inserted in England, Wales, Northern Ireland, and the Isle of Man and was linked for multiple confounders to the National Health Service Hospital Episode Statistics database. Read More

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September 2021

Varied RLN Course is Associated with Increased Risk of Nerve Dysfunction during Thyroidectomy:Results of the Surgical Anatomy of the RLN in Thyroid Surgery (SAR) Study, an International Multicenter Prospective Anatomic and Electrophysiologic Study of 1000 Monitored Nerves at Risk from the International Neural Monitoring Study Group (INMSG).

Thyroid 2021 Sep 19. Epub 2021 Sep 19.

MEEI, 1866, Otolaryngology, Boston, Massachusetts, United States;

Background: The recurrent laryngeal nerve (RLN) can be injured during thyroid surgery, which can negatively affect a patient's quality of life. The impact of intraoperative anatomic variations of the RLN on nerve injury remains unclear. Objectives of this study were to (1) better understand the detailed surgical anatomic variability of the RLN with a world-wide perspective; (2) establish potential correlates between intraoperative RLN anatomy and electrophysiologic responses; and (3) use the information to minimize complications and assure accurate and safe intraoperative neural monitoring (IONM). Read More

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September 2021

An Evaluation of the Online Quality of Content of United States Accredited Pain Medicine Fellowship Training Programs.

Anesth Pain Med 2021 Jun 27;11(3):e115981. Epub 2021 Jun 27.

Department of Anesthesiology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States.

Background: Pain medicine fellowship applicants often seek information about programs from the Internet, which is becoming even more relevant with the transition to virtual interviews as a consequence of the global pandemic. Previous literature has revealed the significance of training program websites as part of the application process in other specialties.

Objectives: The objective of this cross-sectional study was to evaluate the content, design, organization, and user friendliness by using a composite score to determine the quality of the pain medicine fellowship websites (PMFW). Read More

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Evidence-based complementary and alternative medicine bioinformatics approach through network pharmacology and molecular docking to determine the molecular mechanisms of Erjing pill in Alzheimer's disease.

Exp Ther Med 2021 Nov 2;22(5):1252. Epub 2021 Sep 2.

Department of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, P.R. China.

Erjing pill, a Traditional Chinese Medicine (TCM) formulation composed of and , has an important role in the treatment of Alzheimer's disease (AD). However, the underlying mechanisms of the action of Erjing pill in AD have remained elusive. In the present study, the key ingredients of Erjing pill were investigated and the active components and their mechanisms of action on AD were analyzed based on networks pharmacology. Read More

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November 2021

Knockdown of DLGAP5 suppresses cell proliferation, induces G/M phase arrest and apoptosis in ovarian cancer.

Exp Ther Med 2021 Nov 2;22(5):1245. Epub 2021 Sep 2.

Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441000, P.R. China.

Discs large-associated protein 5 (DLGAP5) is a microtubule-associated protein and is reported to exert oncogenic role in tumorigenesis, including lung cancer and hepatocellular carcinoma. However, the prognostic value and biological function of DLGAP5 in ovarian cancer (OC) still remain unclear. The present study investigated the expression pattern of DLGAP5 by searching the Oncomine microarray database. Read More

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November 2021

Parental Sensitivity and Responsiveness as Mediators Between Postpartum Mental Health and Bonding in Mothers and Fathers.

Front Psychiatry 2021 1;12:723418. Epub 2021 Sep 1.

Department of Psychology, Catholic University of Croatia, Zagreb, Croatia.

There is a lack of studies that examine the complex relationship between parental mental health, parental sensitivity and responsiveness, and parent-infant bonding. This study aimed to test whether parental sensitivity and responsiveness were mediators between postpartum mental health (depression, anxiety, and stress) and parent-infant bonding in mothers and fathers. Mothers ( = 427) and fathers ( = 170) of infants aged up to 1-year-old participated in an online study. Read More

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September 2021

GBS-SNP and SSR based genetic mapping and QTL analysis for drought tolerance in upland cotton.

Physiol Mol Biol Plants 2021 Aug 20;27(8):1731-1745. Epub 2021 Aug 20.

Plant Molecular Genetics Laboratory, CSIR-National Botanical Research Institute, Rana Pratap Marg, Lucknow, (U.P.) 226001 India.

A recombinant inbred line mapping population of intra-species upland cotton was generated from a cross between the drought-tolerant female parent (AS2) and the susceptible male parent (MCU13). A linkage map was constructed deploying 1,116 GBS-based SNPs and public domain-based 782 SSRs spanning a total genetic distance of 28,083.03 cM with an average chromosomal span length of 1,080. Read More

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Patient and public preferences for being recontacted with updated genomic results: a mixed methods study.

Hum Genet 2021 Sep 18. Epub 2021 Sep 18.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Variants of uncertain significance (VUS) are frequently reclassified but recontacting patients with updated results poses significant resource challenges. We aimed to characterize public and patient preferences for being recontacted with updated results. A discrete choice experiment (DCE) was administered to representative samples of the Canadian public and cancer patients. Read More

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September 2021

Exosome-mediated circ_0001846 participates in IL-1β-induced chondrocyte cell damage by miR-149-5p-dependent regulation of WNT5B.

Clin Immunol 2021 Sep 15:108856. Epub 2021 Sep 15.

Trauma Center, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China. Electronic address:

Aims: Osteoarthritis (OA) is the leading cause of physical disability in middle-aged and elderly people globally. Previous studies have revealed that circular RNA (circRNA) is involved in the pathogenesis of OA. In this study, we studied the role of circ_0001846 in interleukin-1β (IL-1β)-induced OA progression. Read More

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September 2021

How Does Geographic Region Affect the Total and Individual Costs for Medical Students Applying to the Competitive Surgical Residencies?

J Surg Educ 2021 Sep 14. Epub 2021 Sep 14.

University of California, Irvine, Department of Urology, Orange, CA.

Objective: Studies have individually assessed the expenses for medical students desiring a surgical residency in neurosurgery, orthopaedic surgery, otolaryngology, plastic surgery, and urology. A detailed comparison of expenses by geographic region have not been reported. The aim was to geographically compare the expenses of United States medical students applying to the 5 most competitive surgical residencies. Read More

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September 2021

Network pharmacology study on the mechanism of Qiangzhifang in the treatment of panic disorder.

Ann Transl Med 2021 Aug;9(16):1350

Department of Psychosomatic Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Background: Panic disorder (PD) is a kind of mental illness characterized by the symptom of recurring panic attacks. Qiangzhifang (QZF) is a novel decoction developed by Professor Zhaojun Yan based on a unique system of syndrome differentiation and clinical experience. It has achieved remarkable results after long-term clinical practice, but its mechanism of action is still unclear. Read More

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The predictive value of RNA binding proteins in colon adenocarcinoma.

J Gastrointest Oncol 2021 Aug;12(4):1543-1557

Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China.

Background: RNA binding proteins (RBPs) play an important role in regulating post-transcriptional gene expression and have been reported to be closely associated with the occurrence and development of tumors. However, the effect of RBPs in colon cancer remains unclear.

Methods: We downloaded clinical information and transcriptome data of colon adenocarcinoma (COAD) from The Cancer Genome Atlas database (TCGA) database. Read More

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Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.

Front Immunol 2021 31;12:721030. Epub 2021 Aug 31.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: Poly (ADP-ribose) polymerases-1 (PARP1) alterations are associated with PARP1 inhibitor resistance, regulating the function of Treg cells and PDL1 expression in tumor cells, and high PARP1 expression is significantly associated with aggressive behavior and chemotherapeutic resistance in several tumors. However, a comprehensive analysis of the predictive values of PARP1 alteration for immune checkpoint inhibitor (ICI) effectiveness in tumors remains unclear, and the associations between its expression and immunotherapy signatures also needs to be explored further.

Methods: We performed some analyses with the cBioPortal online database (https://www. Read More

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Potential mechanism of Ziyin Tongluo Formula in the treatment of postmenopausal osteoporosis: based on network pharmacology and ovariectomized rat model.

Chin Med 2021 Sep 16;16(1):88. Epub 2021 Sep 16.

Guangdong Province Hospital of Traditional Chinese Medicine ZHUHAI BRANCH, 519015, Zhuhai, China.

Background: Amending from ancient classic, Ziyin Tongluo Formula (ZYTLF) has been prescribed to treat postmenopausal osteoporosis (PMOP) for decades with good curative effect. However, the possible mechanisms of it are still unknown.

Methods: Ovariectomized rat model was established to validate the therapeutic effect of ZYTLF on PMOP by Micro-CT bone analysis and pathological observation. Read More

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September 2021

circMine: a comprehensive database to integrate, analyze and visualize human disease-related circRNA transcriptome.

Nucleic Acids Res 2021 Sep 16. Epub 2021 Sep 16.

Department of Pediatrics, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong 518053, China.

Many circRNA transcriptome data were deposited in public resources, but these data show great heterogeneity. Researchers without bioinformatics skills have difficulty in investigating these invaluable data or their own data. Here, we specifically designed circMine (http://hpcc. Read More

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September 2021

Pediatric spectacle prescription: Understanding practice patterns among ophthalmologists and optometrists in Saudi Arabia.

Saudi J Ophthalmol 2020 Oct-Dec;34(4):278-283. Epub 2021 Jul 29.

Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Purpose: This study aims to understand the approach to prescribing spectacles for children and the interpretation of refractive errors among ophthalmologists/optometrists in Saudi Arabia.

Methods: A cross-sectional survey was conducted between September and November 2018 using a database of online registrants for ophthalmologists and optometrists practicing in Saudi Arabia. The survey included 10 multiple-choice questions designed to elicit information about how ophthalmologists and optometrists deal with commonly encountered case scenarios covering different practical aspects of pediatric refraction. Read More

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Effects of consumers and health providers working in partnership on health services planning, delivery and evaluation.

Cochrane Database Syst Rev 2021 Sep 15;9:CD013373. Epub 2021 Sep 15.

Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University, Bundoora, Australia.

Background: Health services have traditionally been developed to focus on specific diseases or medical specialties. Involving consumers as partners in planning, delivering and evaluating health services may lead to services that are person-centred and so better able to meet the needs of and provide care for individuals. Globally, governments recommend consumer involvement in healthcare decision-making at the systems level, as a strategy for promoting person-centred health services. Read More

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September 2021

Bioinformatics analysis identified shared differentially expressed genes as potential biomarkers for Hashimoto's thyroiditis-related papillary thyroid cancer.

Int J Med Sci 2021 13;18(15):3478-3487. Epub 2021 Aug 13.

Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Although the etiology of Hashimoto's thyroiditis (HT), a common autoimmune endocrine disease, is unknown, studies suggest a potential association with genetic factors and environmental conditions inducing excessive iodine intake. Additionally, HT patients have a high risk of papillary thyroid cancer (PTC), which is probably related to the chronic inflammation and autoimmune pathologic process occurring in HT, as it is thought to be associated with neoplastic transformation. Bioinformatics approaches can identify differentially expressed genes (DEGs) and analyze DEG functions in diseases. Read More

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The LOVD3 platform: efficient genome-wide sharing of genetic variants.

Eur J Hum Genet 2021 Sep 15. Epub 2021 Sep 15.

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.

Gene variant databases are the backbone of DNA-based diagnostics. These databases, also called Locus-Specific DataBases (LSDBs), store information on variants in the human genome and the observed phenotypic consequences. The largest collection of public databases uses the free, open-source LOVD software platform. Read More

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September 2021

Direct (new) oral anticoagulants (DOACs): Drawbacks, bleeding and reversal.

Cardiovasc Hematol Agents Med Chem 2021 Sep 13. Epub 2021 Sep 13.

Emergency Physician, M.D., University of Health Sciences, Dept. of Emergency Medicine, Haseki Education and Research Hospital, Fatih, Istanbul. Turkey.

Background And Objective: Direct (new) Oral Anticoagulants (DOACs) have emerged as a contemporary and promising option in the treatment of thromboses and VTE, while protecting the coagulation cascade against untoward bleeding events. They are used in the management and prophylaxis of Venous Thromboembolism (VTE) and other thrombotic diseases. The most prominent complication of these agents is bleeding. Read More

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September 2021

Estrogen-regulated AGR3 activates the estrogen receptor signaling pathway to promote tamoxifen resistance in breast cancer.

Breast Cancer Res Treat 2021 Sep 14. Epub 2021 Sep 14.

Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwuweiqi Road, Huaiyin District, Jinan, 250000, China.

Purpose: Anterior gradient 3 (AGR3) is associated with breast cancer progression, but its relationship with estrogen and tamoxifen resistance in breast cancer is still unclear. This study was designed to investigate the correlation of ARG3 and estrogen as well as the roles of ARG3 in tamoxifen resistance in breast cancer.

Methods: Online database including GEPIA, UALCAN, and TCGA and rVista predictive tool were applied to analyze the expression patterns of AGR3 and its relationship with estrogen receptor 1. Read More

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September 2021

Evaluation of the Drug-Drug Interaction Potential of Treosulfan using a Physiologically-Based Pharmacokinetic Modelling Approach.

Br J Clin Pharmacol 2021 Sep 13. Epub 2021 Sep 13.

medac Gesellschaft für klinische Spezialpräparate mbH, Wedel, Germany.

Aims: The aim of this work is the development of a mechanistic Physiologically Based Pharmacokinetic (PBPK) model using in vitro to in vivo extrapolation (IVIVE) to conduct a DDI (drug-drug interaction) assessment of treosulfan against two cytochrome p450 isoenzymes and P-gp substrates.

Methods: A PBPK model for treosulfan was developed de-novo based on literature and unpublished clinical data. The PBPK DDI analysis was conducted using the FDA DDI index drugs (probe substrates) midazolam, omeprazole, and digoxin for CYP3A4, CYP2C19, and P-gp, respectively. Read More

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September 2021

Meta-analysis of structural MRI studies in anorexia nervosa and the role of recovery: a systematic review protocol.

Syst Rev 2021 Sep 13;10(1):247. Epub 2021 Sep 13.

Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA.

Background: Anorexia nervosa (AN) is associated with structural brain abnormalities. Studies have reported less cerebral tissue and more cerebrospinal fluid (CSF) in individuals with AN relative to healthy controls, although findings are variable and inconsistent due to variations in sample size, age, and disease state (e.g. Read More

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September 2021

DPYSL2 as potential diagnostic and prognostic biomarker linked to immune infiltration in lung adenocarcinoma.

World J Surg Oncol 2021 Sep 13;19(1):274. Epub 2021 Sep 13.

Department of Radiation Oncology, The First Affiliated Hospital of University of South China, Hengyang, 421001, China.

Background: Dihydropyrimidinase like 2 (DPYSL2) has been linked to tumor metastasis. However, the function of DPSY2L in lung adenocarcinoma (LUAD) is yet to be explored.

Methods: Herein, we assessed DPYSL2 expression in various tumor types via online databases such as Oncomine and Tumor Immune Estimation Resource (TIMER). Read More

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September 2021

Exploration of prognostic biomarkers and therapeutic targets in the microenvironment of bladder cancer based on CXC chemokines.

Math Biosci Eng 2021 Jul;18(5):6262-6287

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

Background: Bladder cancer (BLCA) has a high rate of morbidity and mortality, and is considered as one of the most malignant tumors of the urinary system. Tumor cells interact with surrounding interstitial cells, playing a key role in carcinogenesis and progression, which is partly mediated by chemokines. CXC chemokines exert anti-tumor biological roles in the tumor microenvironment and affect patient prognosis. Read More

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Postoperative complications observed with robotic versus laparoscopic surgery for the treatment of rectal cancer: An updated meta-analysis of recently published studies.

Medicine (Baltimore) 2021 Sep;100(36):e27158

Department of Gastrointestinal Surgery, Zibo Central Hospital, Zibo, Shandong, PR China.

Background: This is an updated meta-analysis comparing the postoperative complications observed with robotic versus laparoscopic surgery (LS) for the treatment of rectal cancer.

Methods: Cochrane central, MEDLNE (Medical Literature Analysis and Retrieval System Online), EMBASE (Excerpta Medica dataBASE), Google Scholar, Web of Science and http://www.ClinicalTrials. Read More

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September 2021

Expanding Role of Technology in Rehabilitation After Lower-Extremity Joint Replacement: A Systematic Review.

JBJS Rev 2021 09 13;9(9). Epub 2021 Sep 13.

Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: The effectiveness of telehealth programs in the administration of rehabilitation and the monitoring of postoperative progress after joint replacement is not well studied. The purpose of the present study was to systematically review the currently available evidence on the use of smart-device technology and telehealth programs to guide and monitor postoperative rehabilitation following total joint arthroplasty and to assess their impact on outcomes following surgery.

Methods: A literature search of the MEDLINE database was performed using keywords "mobile," "app," "telehealth," "virtual," "arthroplasty," "outcomes," "joint replacement," "web based," "telemedicine," "TKA," "THA," "activity tracker," "fitness tracker," "monitor," "rehab," "online," and "stepcounter" in all possible combinations. Read More

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September 2021

Role of blame and rape-related shame in distress among rape victims.

Psychol Trauma 2021 Sep 13. Epub 2021 Sep 13.

Department of Psychology.

Objective: Posttraumatic stress disorder (PTSD) and depression are highly prevalent among rape victims. Both blame (self-blame and victim-blaming responses to rape disclosure) and shame are frequently elevated among rape victims and contribute to PTSD and depression. However, it is unclear which type of shame is relevant. Read More

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September 2021

Identifying central symptoms of eating disorders among ethnic and racial minority women.

J Abnorm Psychol 2021 Sep 13. Epub 2021 Sep 13.

Department of Psychology, Arizona State University.

Experiencing eating disorder symptoms is associated with maladaptive outcomes and impairment in functioning. A paucity of research exists examining eating disorder symptoms among ethnic/racial minority women. Using a network analysis, we evaluated core symptoms of eating disorder psychopathology and the degree of association between eating disorder symptoms in a sample of ethnic/racial minority women. Read More

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September 2021

PredMS: a random Forest model for predicting metabolic stability of drug candidates in human liver microsomes.

Bioinformatics 2021 Sep 13. Epub 2021 Sep 13.

Data Convergence Drug Research Center, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.

Motivation: Poor metabolic stability leads to drug development failure. Therefore, it is essential to evaluate the metabolic stability of small compounds for successful drug discovery and development. However, evaluating metabolic stability in vitro and in vivo is expensive, time-consuming, and laborious. Read More

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September 2021