52,102 results match your criteria ongoing therapies

Longer term outcomes with single-agent belantamab mafodotin in patients with relapsed or refractory multiple myeloma: 13-month follow-up from the pivotal DREAMM-2 study.

Cancer 2021 Jul 27. Epub 2021 Jul 27.

Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: On the basis of the DREAMM-2 study (ClinicalTrials.gov identifier NCT03525678), single-agent belantamab mafodotin (belamaf) was approved for patients with relapsed or refractory multiple myeloma (RRMM) who received ≥4 prior therapies, including anti-CD38 therapy. The authors investigated longer term efficacy and safety outcomes in DREAMM-2 after 13 months of follow-up among patients who received belamaf 2. Read More

View Article and Full-Text PDF

Blood First Assay Screening Trial (BFAST) in Treatment-Naïve Advanced or Metastatic Non-Small Cell Lung Cancer: Initial Results of the Phase 2 ALK-Positive Cohort.

J Thorac Oncol 2021 Jul 23. Epub 2021 Jul 23.

Department of Internal Medicine, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, USA. Electronic address:

Introduction: The Blood First Assay Screening Trial (BFAST) is an ongoing open-label, multi-cohort study, prospectively evaluating the relationship between blood-based next-generation sequencing (NGS) detection of actionable genetic alterations and activity of targeted therapies/immunotherapy in treatment-naïve advanced/metastatic NSCLC. We present data from the ALK-positive cohort.

Methods: Patients aged ≥18 years with stage IIIB/IV NSCLC and ALK rearrangements detected by blood-based NGS using hybrid capture technology (FoundationACT™) received alectinib 600 mg twice-daily. Read More

View Article and Full-Text PDF

Multifunctional Dressing for Wound Diagnosis and Rehabilitation.

Adv Healthc Mater 2021 Jul 26:e2101292. Epub 2021 Jul 26.

Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.

A wound dressing is a sterile pad or compress that is used in direct contact with a wound to help it heal and prevent further issues or complications. Though wound healing is an intricate dynamic process that involves multiple biomolecular species, conventional wound dressings have a limited ability to provide timely information of abnormal conditions, missing the best time for early treatment. The current perspective presents and discusses the design and development of smart wound dressings that are integrated with multifunctional materials, wearable sensors and drug delivery systems as well as their application ranging from wound monitoring to timely application of therapeutics. Read More

View Article and Full-Text PDF

Drug repurposing strategies of relevance for Parkinson's disease.

Pharmacol Res Perspect 2021 Aug;9(4):e00841

King's College London, Institute of Psychiatry, Psychology & Neuroscience, Wolfson Centre for Age-Related Diseases, London, UK.

Parkinson's disease is a highly disabling, progressive neurodegenerative disease that manifests as a mix of motor and non-motor signs. Although we are equipped with some symptomatic treatments, especially for the motor signs of the disease, there are still no established disease-modifying drugs so the disease progresses unchecked. Standard drug discovery programs for disease-modifying therapies have provided key insights into the pathogenesis of Parkinson's disease but, of the many positive candidates identified in pre-clinical studies, none has yet translated into a successful clinically efficacious drug. Read More

View Article and Full-Text PDF

[Association of number and quality of embryos transferred with early pregnancy loss in infertile women at an advanced age undergoing frozen-thawed embryo transfer].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1050-1055

Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To investigate the association of the number and quality of embryos transferred in frozen-thawed embryo transfer (FET) cycle with the occurrence of early pregnancy loss in infertile women at an advanced age.

Methods: We collected the data of a total of 2622 infertile women aged 36 years or older receiving FET between January, 2015 and December, 2018. The occurrence of early pregnancy loss was analyzed in these women, and the relation of age, the number and quality of embryos transferred with early pregnancy loss was explored in the overall cohort and in different age (36-37, 38-39, 40, 41, 42, 43, 44 and 45-48 years) groups. Read More

View Article and Full-Text PDF

Clinical Trials in Metastatic Uveal Melanoma: Immunotherapy.

Marlana Orloff

Ocul Oncol Pathol 2021 Jun 31;7(3):168-176. Epub 2021 Mar 31.

Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Background: Uveal melanoma (UM) is a rare subtype of melanoma that generally has a poor prognosis once it has metastasized. Clinical trials evaluating immune checkpoint inhibitors (ICIs) in UM have demonstrated response rates lower than those seen in cutaneous melanoma. Despite lower efficacy demonstrated in initial ICI studies, there are a number of ongoing clinical trials investigating novel immunotherapy approaches in UM. Read More

View Article and Full-Text PDF

Managing gastrointestinal complications in patients with systemic sclerosis.

Curr Treat Options Gastroenterol 2020 Dec 13;18:531-544. Epub 2020 Nov 13.

University of Michigan, Division of Rheumatology, Ann Arbor, MI, USA.

Objective: We sought to critically evaluate the literature published over the past 3 years on the management of gastrointestinal complications in systemic sclerosis (SSc). We emphasize interesting and important new findings to bring the reader up-to-date. We also discuss controversial discoveries and hypotheses currently of interest. Read More

View Article and Full-Text PDF
December 2020

Cell cycle on the crossroad of tumorigenesis and cancer therapy.

Trends Cell Biol 2021 Jul 22. Epub 2021 Jul 22.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

Aberrancy in cell cycle progression is one of the fundamental mechanisms underlying tumorigenesis, making regulators of the cell cycle machinery rational anticancer therapeutic targets. A growing body of evidence indicates that the cell cycle regulatory pathway integrates into other hallmarks of cancer, including metabolism remodeling and immune escape. Thus, therapies against cell cycle machinery components can not only repress the division of cancer cells, but also reverse cancer metabolism and restore cancer immune surveillance. Read More

View Article and Full-Text PDF

Alternative strategies for optimizing treatment of chronic lymphocytic leukemia with complex clonal architecture.

Leuk Res 2021 Jul 6;110:106663. Epub 2021 Jul 6.

Back Bay Biosciences, Boston, MA, USA.

In silico simulation of pre-clinical and clinical data may accelerate pre-clinical and clinical trial advances, leading to benefits for therapeutic outcomes, toxicity and cost savings. Combining this with clonal architecture data may permit truly personalized therapy. Chronic lymphocytic leukemia (CLL) exhibits clonal diversity, evolution and selection, spontaneously and under treatment pressure. Read More

View Article and Full-Text PDF

Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase.

Antiviral Res 2021 Jul 22:105142. Epub 2021 Jul 22.

Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland. Electronic address:

SARS-CoV-2, the cause of the currently ongoing COVID-19 pandemic, encodes its own mRNA capping machinery. Insights into this capping system may provide new ideas for therapeutic interventions and drug discovery. In this work, we employ a previously developed Py-FLINT screening approach to study the inhibitory effects of compounds against the cap guanine N7-methyltransferase enzyme, which is involved in SARS-CoV-2 mRNA capping. Read More

View Article and Full-Text PDF

Extended criteria grafts and emerging therapeutics strategy in liver transplantation. The unstable balance between damage and repair.

Transplant Rev (Orlando) 2021 Jul 16;35(4):100639. Epub 2021 Jul 16.

Institute of Clinical Physiology, CNR San Cataldo Research Area, via Moruzzi 1, 56124 Pisa, Italy. Electronic address:

Due to increasing demand for donor organs, "extended criteria" donors are increasingly considered for liver transplantation, including elderly donors and donors after cardiac death. The grafts of this subgroup of donors share a major risk to develop significant features of ischemia reperfusion injury, that may eventually lead to graft failure. Ex-situ machine perfusion technology has gained much interest in liver transplantation, because represents both a useful tool for improving graft quality before transplantation and a platform for the delivery of therapeutics directly to the organ. Read More

View Article and Full-Text PDF

Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial.

Lancet Respir Med 2021 Jul 21. Epub 2021 Jul 21.

Sanofi, Chilly-Mazarin, France.

Background: Genetic data implicate IL-33 in asthma susceptibility. Itepekimab, a monoclonal antibody targeting IL-33, demonstrated clinical activity in asthma, with potential in chronic obstructive pulmonary disease (COPD). In this study we first aimed to test the hypothesis that genetic variants in the IL-33 pathway were also associated with COPD. Read More

View Article and Full-Text PDF

Neutrophils in the era of immune checkpoint blockade.

J Immunother Cancer 2021 Jul;9(7)

IRCM, Inserm, Univ Montpellier, ICM, Montpellier, France, INSERM U1194, Montpellier, France

The immune checkpoint blockade-based immunotherapies are revolutionizing cancer management. Tumor-associated neutrophils (TANs) were recently highlighted to have a pivotal role in modulating the tumor microenvironment and the antitumor immune response. However, these cells were largely ignored during the development of therapies based on programmed cell death receptor or ligand-1 and cytotoxic T lymphocyte antigen-4 immune checkpoint inhibitors (ICIs). Read More

View Article and Full-Text PDF

Immunomodulatory Nanomedicine for the Treatment of Atherosclerosis.

J Clin Med 2021 Jul 20;10(14). Epub 2021 Jul 20.

Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, 52074 Aachen, Germany.

Atherosclerosis is the main underlying cause of cardiovascular diseases (CVDs), which remain the number one contributor to mortality worldwide. Although current therapies can slow down disease progression, no treatment is available that can fully cure or reverse atherosclerosis. Nanomedicine, which is the application of nanotechnology in medicine, is an emerging field in the treatment of many pathologies, including CVDs. Read More

View Article and Full-Text PDF

Current Concepts of Stem Cell Therapy for Chronic Spinal Cord Injury.

Int J Mol Sci 2021 Jul 11;22(14). Epub 2021 Jul 11.

Department of Orthopedics Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan.

Chronic spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit and social and financial burdens. It is currently being managed symptomatically with no real therapeutic strategies available. In recent years, a number of innovative regenerative strategies have emerged and have been continuously investigated in clinical trials. Read More

View Article and Full-Text PDF

The Pivotal Player: Components of NF-κB Pathway as Promising Biomarkers in Colorectal Cancer.

Int J Mol Sci 2021 Jul 11;22(14). Epub 2021 Jul 11.

Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA.

Over the last several decades, colorectal cancer (CRC) has been one of the most prevalent cancers. While significant progress has been made in both diagnostic screening and therapeutic approaches, a large knowledge gap still remains regarding the early identification and treatment of CRC. Specifically, identification of CRC biomarkers that can help with the creation of targeted therapies as well as increasing the ability for clinicians to predict the biological response of a patient to therapeutics, is of particular importance. Read More

View Article and Full-Text PDF

Structural Evaluation of the Spike Glycoprotein Variants on SARS-CoV-2 Transmission and Immune Evasion.

Int J Mol Sci 2021 Jul 10;22(14). Epub 2021 Jul 10.

Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Malaysia.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents significant social, economic and political challenges worldwide. SARS-CoV-2 has caused over 3.5 million deaths since late 2019. Read More

View Article and Full-Text PDF

Current Aspects and Future Considerations of EGFR Inhibition in Locally Advanced and Recurrent Metastatic Squamous Cell Carcinoma of the Head and Neck.

Cancers (Basel) 2021 Jul 15;13(14). Epub 2021 Jul 15.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.

Recurrent metastatic (RM) and locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN) are devasting disease states with limited therapeutic options and poor overall survival. Targeting the epidermal growth factor receptor (EGFR) is one area that has helped improve outcomes in this disease. Anti-EGFR based therapies have been shown to improve overall survival and mitigate the significant toxicities incurred from standard radiation, chemotherapy, and/or surgical options. Read More

View Article and Full-Text PDF

Immunotherapy in malignant pleural mesothelioma: a review of literature data.

Transl Lung Cancer Res 2021 Jun;10(6):2988-3000

Department of Medical Oncology, Centro Integral Oncológico Clara Campal (HM-CIOCC), Hospital HM Delfos, HM Hospitales, Barcelona, Spain.

Malignant pleural mesothelioma (MPM) is a rare, aggressive cancer of the pleural surface, associated with asbestos exposure, whose incidence is still growing in some areas of the world. MPM is still considered a rare and an orphan disease with an unchanged median overall survival (OS) ranging from 8 to 14 months and no treatment advances in the last 15 years both in local and advanced disease. In the recent years, chronic inflammation of the mesothelium together with local tumor suppression plays a major role in the malignant transformation. Read More

View Article and Full-Text PDF

Immunotherapy in small cell lung cancer: one step at a time: a narrative review.

Transl Lung Cancer Res 2021 Jun;10(6):2970-2987

Department of Respiratory Medicine, Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology, Maastricht, The Netherlands.

Chemotherapy with or without radiotherapy has been the standard of care for many years for patients with small cell lung cancer (SCLC). Despite exceptionally high responses (up to 80%) with chemotherapy, the majority of patients relapse rapidly within weeks to months after treatment completion. Therefore, new and better treatment options are necessary. Read More

View Article and Full-Text PDF

Strategies for managing asherman's syndrome and endometrial atrophy: Since the classical experimental models to the new bioengineering approach.

Mol Reprod Dev 2021 Jul 22. Epub 2021 Jul 22.

Fundación Instituto Valenciano de Infertilidad (FIVI), La Fe Health Research Institute, Valencia, Spain.

Endometrial function is essential for embryo implantation and pregnancy, but managing endometrial thickness that is too thin to support pregnancy or an endometrium of compromised functionality due to intrauterine adhesions is an ongoing challenge in reproductive medicine. Here, we review current and emerging therapeutic and experimental options for endometrial regeneration with a focus on animal models used to study solutions for Asherman's syndrome and endometrial atrophy, which both involve a damaged endometrium. A review of existing literature was performed that confirmed the lack of consensus on endometrial therapeutic options, though promising new alternatives have emerged in recent years (platelet-rich plasma, exosomes derived from stem cells, bioengineering-based techniques, endometrial organoids, among others). Read More

View Article and Full-Text PDF

Targeting the Host Response: Can We Manipulate Extracellular Matrix Metalloproteinase Activity to Improve Influenza Virus Infection Outcomes?

Front Mol Biosci 2021 5;8:703456. Epub 2021 Jul 5.

Faculty of Health, School of Medicine, Deakin University, Geelong, VIC, Australia.

Each year, hundreds of thousands of individuals succumb to influenza virus infection and its associated complications. Several preventative and therapeutic options may be applied in order to preserve life. These traditional approaches include administration of seasonal influenza vaccines, pharmacological interventions in the form of antiviral drug therapy and supportive clinical approaches including mechanical ventilation and extracorporeal membrane oxygenation. Read More

View Article and Full-Text PDF

Acute coronary syndrome as the first presentation of antiphospholipid antibody syndrome.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Division of Cardiology, University of Florida Department of Medicine, Gainesville, Florida, USA.

We describe a case of a 42-year-old man who presented with anginal chest pain. He had objective evidence of ongoing cardiac injury. After initial treatment for coronary arterial disease, cardiac catheterisation revealed diffuse coronary arterial thrombosis with embolisation. Read More

View Article and Full-Text PDF

Construct validity of the OCTOPuS stratification algorithm for allocating patients with knee osteoarthritis into subgroups.

BMC Musculoskelet Disord 2021 Jul 21;22(1):633. Epub 2021 Jul 21.

Department of Rehabilitation Medicine, Amsterdam UMC, Location VUmc, Amsterdam, Netherlands.

Background: We recently developed a model of stratified exercise therapy, consisting of (i) a stratification algorithm allocating patients with knee osteoarthritis (OA) into one of the three subgroups ('high muscle strength subgroup' representing a post-traumatic phenotype, 'low muscle strength subgroup' representing an age-induced phenotype, and 'obesity subgroup' representing a metabolic phenotype) and (ii) subgroup-specific exercise therapy. In the present study, we aimed to test the construct validity of this algorithm.

Methods: Data from five studies (four exercise therapy trial cohorts and one cross-sectional cohort) were used to test the construct validity of our algorithm by 63 a priori formulated hypotheses regarding three research questions: (i) are the proportions of patients in each subgroup similar across cohorts? (15 hypotheses); (ii) are the characteristics of each of the subgroups in line with their proposed underlying phenotypes? (30 hypotheses); (iii) are the effects of usual exercise therapy in the 3 subgroups in line with the proposed effect sizes? (18 hypotheses). Read More

View Article and Full-Text PDF

Is Mucormycosis an inevitable complication of Covid-19 in India?

Braz J Infect Dis 2021 Jul 5;25(3):101597. Epub 2021 Jul 5.

Department of Pharmacology, Siddha Central Research Institute, Central Council for Research in Siddha, Anna Govt. Hospital Campus, Arumbakkam, Chennai-600 106, Tamil Nadu, India.

Mucormycosis or black fungus infection is a less common disease but highly fatal infection, infecting the immunocompromised individuals. The site of predilection of the fungus is found to be lungs and brain in addition to its sequestration in sinusoidal spaces. Presently with the ongoing COVID 19 pandemic, the prevalence of this infection is found to be high in the Indian population. Read More

View Article and Full-Text PDF

Describing Sources of Uncertainty in Cancer Drug Formulary Priority Setting across Canada.

Curr Oncol 2021 Jul 17;28(4):2708-2719. Epub 2021 Jul 17.

School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

Over the years, there have been significant advances in oncology. However, the rate that therapeutics come to market has increased, while the strength of evidence has decreased. Currently, there is limited understanding about how these uncertainties are managed in provincial funding decisions for cancer therapeutics. Read More

View Article and Full-Text PDF

Comparing GOZILA and COLOMATE: Ongoing Umbrella/Basket Trials Examining Genetic Testing in Gastrointestinal Malignancies.

Oncology (Williston Park) 2021 Jul 17;35(7):382-389. Epub 2021 Jul 17.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Circulating tumor DNA (ctDNA)-based next-generation sequencing (NGS) assays have advantages over classic tissue-based analyses because of their low invasiveness and availability of repeated sampling. Because of the low incidence of target gene alterations such as HER2 or BRAF V600E in gastrointestinal cancers, very large screening platforms are needed to develop genome-based clinical trials. For those reasons, ctDNA-based screening studies are being actively conducted; among them are the GOZILA (Guardant Originates in Zipangu Liquid biopsy Arrival) study in Japan and the COLOMATE (COlorectal Cancer Liquid BiOpsy Screening Protocol for Molecularly Assigned ThErapy) study in the United States. Read More

View Article and Full-Text PDF

Plasma lyso-sphingomyelin levels are positively associated with clinical severity in acid sphingomyelinase deficiency.

Mol Genet Metab Rep 2021 Sep 7;28:100780. Epub 2021 Jul 7.

Albert Einstein College of Medicine and the Children's Hospital at Montefiore, Bronx, New York, USA.

Introduction: A reliable biomarker is urgently needed in the diagnosis and management of acid sphingomyelinase deficiency (ASMD, also known as Niemann Pick A, A/B, and B). Lyso-sphingomyelin (LSM) has previously been proposed as a biomarker for this disease. However, existing studies have not investigated the relationship between LSM levels and clinical subtype or severity. Read More

View Article and Full-Text PDF
September 2021

Exploring the Mystery of Angiotensin-Converting Enzyme II (ACE2) in the Battle against SARS-CoV-2.

J Renin Angiotensin Aldosterone Syst 2021 4;2021:9939929. Epub 2021 Jun 4.

CCRF, All India Institute of Medical Sciences, New Delhi 110029, India.

COVID-19 is the newly born pandemic caused by the SARS-CoV-2 virus, which is the recently emerged betacoronavirus that crosses the species barrier. It predominantly infects pneumocytes of the respiratory tract, but due to the presence of angiotensin-converting enzyme II (ACE2) on other cells like surface enterocytes of the upper esophagus and colon, these are also considered as the primary sites of infection. ACE2 receptor served as a cellular entry point for SARS-CoV-2. Read More

View Article and Full-Text PDF