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Long-Term Results of Single-Anastomosis Duodeno-ileal Bypass with Sleeve Gastrectomy (SADI-S).

Obes Surg 2022 Jan 15. Epub 2022 Jan 15.

Department of Surgery, Hospital Clínico San Carlos, C/Martín Lago S/N 28040, Madrid, Spain.

Background: Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is a simplification of the duodenal switch (DS) in which the alimentary limb is eliminated, and the common channel is lengthened from 200 to 300 cm. Short-term results have demonstrated that SADI-S is safe and reproducible and that weight loss and comorbidities resolution are comparable to biliopancreatic diversion or DS.

Objective: To analyze the long-term outcomes of SADI-S. Read More

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January 2022

Blinding Assessment: One Step Forward.

Dent Hypotheses 2021 Oct-Dec;12(4):169-173. Epub 2021 Dec 21.

Independent Research Scientist, Founder of Dental Hypotheses, Isfahan, Iran.

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December 2021

Single-Cell Sequencing Analysis and Weighted Co-Expression Network Analysis Based on Public Databases Identified That TNC Is a Novel Biomarker for Keloid.

Front Immunol 2021 22;12:783907. Epub 2021 Dec 22.

Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: The pathophysiology of keloid formation is not yet understood, so the identification of biomarkers for kelod can be one step towards designing new targeting therapies which will improve outcomes for patients with keloids or at risk of developing keloids.

Methods: In this study, we performed single-cell RNA sequencing analysis, weighted co-expression network analysis, and differential expression analysis of keloids based on public databases. And 3 RNA sequencing data from keloid patients in our center were used for validation. Read More

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December 2021

Surface modification of the cubic micro-cartilage by collagenase treatment and its efficacy in cartilage regeneration for ear tissue engineering.

Int J Pediatr Otorhinolaryngol 2022 Jan 3;153:111037. Epub 2022 Jan 3.

Department of Plastic and Reconstructive Surgery, Kindai University Faculty of Medicine, Osaka-sayama, Osaka, 5898511, Japan. Electronic address:

Background: In order to enhance cartilage regeneration, surface modification of the cubic micro-cartilage with the collagenase treatment was tested and its efficacy to tissue engineer ear cartilage was investigated.

Materials And Methods: Harvested cubic micro-cartilages were treated with collagenase with different digestion time (0, 15, 60, and 120 min). Histological, ultrastructural (SEM and TEM), and Western blot analyses were carried out. Read More

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January 2022

A one-step construction of adenovirus (OSCA) system using the Gibson DNA Assembly technology.

Mol Ther Oncolytics 2021 Dec 20;23:602-611. Epub 2021 Nov 20.

Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, The School of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.

Adenovirus (Ad) is a non-enveloped linear double-stranded DNA virus with >50 serotypes in humans. Ad vectors have been used as gene delivery vehicles to express transgenes, small interfering RNAs (siRNAs) for gene silencing, or CRISPR/Cas and designer nucleases for genome editing. Although several methods are used to generate Ad vectors, the Ad-making process remains technically challenging and time consuming. Read More

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December 2021

Innovative surgical solutions for laryngeal stenoses in newborns and infants

Orv Hetil 2021 12 26;162(52):2100-2106. Epub 2021 Dec 26.

1 Szegedi Tudományegyetem, Általános Orvostudományi Kar, Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika Szeged, Tisza Lajos krt. 111., 6725.

Összefoglaló. A veleszületett légúti szűkületek gyakran kombináltan jelentkeznek, és más szervrendszert is érintő kísérőbetegségekkel, illetve malformációkkal is társulhatnak. Figyelembe véve ezeket a tényezőket, illetve a csecsemőkori légút speciális anatómiáját és sérülékeny szöveteit, a felső légúti szűkületek sebészi kezelése újszülött- és csecsemőkorban igen nagy kihívást jelentő feladat, melynek célja a mihamarabbi definitív, stabil légút biztosítása a hangképzés és a nyelési funkció megőrzésével. Read More

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December 2021

Comparison of safety, efficacy, and long-term follow-up between "one-step" and "step-up" approaches for infected pancreatic necrosis.

World J Gastrointest Surg 2021 Nov;13(11):1372-1389

Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Background: Although the "Step-up" strategy is the primary surgical treatment for infected pancreatic necrosis, it is not suitable for all such patients. The "One-step" strategy represents a novel treatment, but the safety, efficacy, and long-term follow-up have not yet been compared between these two approaches.

Aim: To compare the safety, efficacy, and long-term follow-up of two surgical approaches to provide a reference for infected pancreatic necrosis treatment. Read More

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November 2021

The "Virtual Biopsy" of Cancerous Lesions in 3D: Non-Invasive Differentiation between Melanoma and Other Lesions Using Vibrational Optical Coherence Tomography.

Dermatopathology (Basel) 2021 Dec 13;8(4):539-551. Epub 2021 Dec 13.

Dermatology, Summit Health, Berkeley Heights, NJ 07922, USA.

Early detection of skin cancer is of critical importance to provide five year survival rates that approach 99%. By 2050, one out of five Americans by age 70 will develop some form of skin cancer. This will result in a projected rate of 50 million skin biopsies per year given the current rate of escalation. Read More

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December 2021

The effects of and on facial and other physical morphology in mice.

FASEB Bioadv 2021 Dec 3;3(12):1011-1019. Epub 2021 Sep 3.

CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences Beijing China.

DNA variants in or close to the human and genes have been repeatedly associated with facial morphology in independent genome-wide association studies, while their functional roles in determining facial morphology remain to be understood. We generated knockout ( ) and knockout ( ) mice by applying the one-step CRISPR/Cas9 method. A total of 75 adult mice were used for subsequent phenotype analysis, including 38 mice (10 homozygous , 18 heterozygous , 10 wild-type littermates) and 37 mice (12 homozygous , 15 heterozygous , 10 littermates). Read More

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December 2021

Trimetallic AuPtCo Nanopolyhedrons with Peroxidase- and Catalase-Like Catalytic Activity for Glow-Type Chemiluminescence Bioanalysis.

Anal Chem 2022 Jan 19;94(2):847-855. Epub 2021 Dec 19.

College of Chemistry and Chemical Engineering, Laboratory of Fiber Materials and Modern Textiles, the Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, P. R. China.

Chemiluminescence (CL) with stable and glowing light emission is vital for the accurate detection of biomarkers. Moreover, the catalyst plays an important role in CL systems. Herein, the trimetallic AuPtCo nanopolyhedrons with peroxidase- and catalase-like catalytic activities are readily synthesized via a one-step reduction method. Read More

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January 2022

Surgical Treatment of Cherubism with the Use of Three-Dimensional Virtual Planning and CAD-CAM Resection Guides: A Case Report and Systematic Literature Review.

J Craniofac Surg 2021 Dec 13. Epub 2021 Dec 13.

Helsinki University Hospital and University of Helsinki, Department of Oral and Maxillofacial Diseases, Helsinki Päijät-Häme Joint Authority for Health and Wellbeing, Department of Oral and Maxillofacial Surgery, Lahti Cleft Palate and Craniofacial Centre, Department of Plastic Surgery, Helsinki University Hospital HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital Orton Ltd, Helsinki, Finland.

Abstract: We report the use of a three-dimensional virtual surgical planning technique including both fusion and superimposition to obtain harmony and symmetry of the face in an 18-year-old woman suffering from cherubism. The treatment contained several three-dimensional techniques that allowed precise planning and a predictable surgical outcome. The reduction plasty was successful, and the postoperative healing was uneventful. Read More

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December 2021

Lower Extremity Splinting: A Head-to-Head Comparison of A Novel One-Step Spray-on Splint Versus Standard Splinting.

Mil Med 2021 Dec 4. Epub 2021 Dec 4.

Department of Orthopaedic Surgery, The Ohio State University, Columbus, OH 43202, USA.

Introduction: Splinting is an essential component of treating many lower extremity musculoskeletal injuries; however, little development has been made in splinting technology. The purpose of this study is to evaluate the efficacy of current immobilization equipment for lower extremity fractures by testing a novel one-step spray-on foam splint (Fast Cast) against structural aluminum malleable (SAM) lower extremity musculoskeletal injuries and 6-inch ACE (3M Corp., Minneapolis, MN, USA) bandage splints. Read More

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December 2021

Repair of a three-way congenital bronchoesophageal fistula in an adult patient: a case report.

BMC Gastroenterol 2021 Dec 3;21(1):452. Epub 2021 Dec 3.

Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277# Yanta West Road, Xi'an, 710061, Shaanxi, China.

Background: The incidence of congenital bronchoesophageal fistulas in adults is rare. Most fistulas discovered in adulthood are often small and can be repaired with a simple one-step method.

Case Presentation: A 46-year-old female patient complained of a 2-month history of chocking, coughing, and a 12 kg drop in weight. Read More

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December 2021

Re: "One Step Forward, Two Steps Backward".

Authors:
Jan H Lindeman

Eur J Vasc Endovasc Surg 2021 Nov 29. Epub 2021 Nov 29.

Department of Vascular Surgery, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands. Electronic address:

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November 2021

Improved anti-organic fouling and antibacterial properties of PVDF ultrafiltration membrane by one-step grafting imidazole-functionalized graphene oxide.

Mater Sci Eng C Mater Biol Appl 2021 Dec 2;131:112517. Epub 2021 Nov 2.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China.

At present, membrane fouling is a thorny issue that limits the development of polyvinylidene fluoride (PVDF) composite membrane, which seriously affects its separation performance and service lifespan. Herein, an imidazole-functionalized graphene oxide (Im-GO) with hydrophilicity and antibacterial performance was synthesized, and it was used as a modifier to improve the anti-organic fouling and antibacterial properties of PVDF membrane. The anti-organic fouling test showed that the maximum flux recovery ratios against bovine serum albumin and humic acid were 88. Read More

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December 2021

Targeted delivery by pH-responsive mPEG-S-PBLG micelles significantly enhances the anti-tumor efficacy of doxorubicin with reduced cardiotoxicity.

Drug Deliv 2021 Dec;28(1):2495-2509

Precision Medicine Research Center & Sichuan Provincial Key Laboratory of Precision Medicine and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Stimuli-responsive nanotherapeutics hold great promise in precision oncology. In this study, a facile strategy was used to develop a new class of pH-responsive micelles, which contain methoxy polyethylene glycol (mPEG) and poly(carbobenzoxy-l-glutamic acid, BLG) as amphiphilic copolymer, and β-thiopropionate as acid-labile linkage. The mPEG-S-PBLG copolymer was synthesized through one-step ring-opening polymerization (ROP) and thiol-ene click reaction, and was able to efficiently encapsulate doxorubicin (DOX) to form micelles. Read More

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December 2021

Minced Cartilage in Combination with Autologous Bone Grafting for One-Step Osteochondral Defect Reconstruction in an Athlete's Knee.

Case Rep Orthop 2021 18;2021:9501039. Epub 2021 Nov 18.

Department for Trauma and Reconstructive Surgery, BG Klinik, University of Tübingen, Tübingen, Germany.

A 17-year-old student athlete suffering from stress-related knee pain asked for help. MRI revealed an unstable osteochondral lesion. Because of time pressure due to the patient's academic exams and his schedule as a basketball player, an autologous chondrocyte transplantation (ACT) as the standard surgical treatment plan was not accepted by the patient. Read More

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November 2021

High-throughput ex vivo drug testing identifies potential drugs and drug combinations for NRAS-positive malignant melanoma.

Transl Oncol 2022 Jan 24;15(1):101290. Epub 2021 Nov 24.

Helsinki University Hospital, Comprehensive Cancer Center, Department of Oncology, Helsinki and University of Helsinki, Finland.

Therapy options for patients with metastatic melanoma (MM) have considerably improved over the past decade. However, many patients still need effective therapy after unsuccessful immunotherapy, especially patients with BRAF-negative tumors who lack the option of targeted treatment second line. Therefore, the elucidation of efficient and personalized therapy options for these patients is required. Read More

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January 2022

Surface coating prolongs the degradation and maintains the mechanical strength of surgical suture in vivo.

Colloids Surf B Biointerfaces 2022 Jan 16;209(Pt 1):112214. Epub 2021 Nov 16.

Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China; International Institutes of Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China. Electronic address:

Biodegradable and absorbable sutures have been widely used in surgical procedures. However, for the repair of ligament and tendon injures, the biodegradable suture cannot provide sufficient mechanical support to close the wound for a long period of time which is important to completely heal the tissue. Herein, we develop a simple method that makes a surface coating to prolong the degradation of the suture in vivo. Read More

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January 2022

Expanded Use of the One-Step Technique for Simultaneous Landing Zone Stenting and Placement of the Melody Transcatheter Pulmonary Valve.

J Invasive Cardiol 2021 Dec 18;33(12):E954-E959. Epub 2021 Nov 18.

Division of Pediatric Cardiology, Rady Children's Hospital, 3020 Children's Way, MC 5004, San Diego, CA 92123 USA.

Objectives: We report a multicenter experience with simultaneous right ventricular outflow tract (RVOT) stenting and transcatheter pulmonary valve implantation using the Melody valve (Medtronic).

Background: Prestenting the RVOT before Melody valve implantation is now the standard of care. Prestenting is usually performed as a separate step. Read More

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December 2021

Automated Calculation of Cochlear Implant Electrode Insertion Parameters in Clinical Cone-Beam CT.

Otol Neurotol 2022 Feb;43(2):199-205

Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio.

Hypothesis: Automated processing of postoperative clinical cone-beam CT (CBCT) of cochlear implant (CI) patients can be used to accurately determine electrode contacts and integrated with an atlas-based mapping of cochlear microstructures to calculate modiolar distance, angular insertion distance, and scalar location of electrode contacts.

Background: Hearing outcomes after CI surgery are dependent on electrode placement. CBCT is increasingly used for in-office temporal bone imaging and might be routinely used for pre- and post-surgical evaluation. Read More

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February 2022

EGF-functionalized lipid-polymer hybrid nanoparticles of 5-fluorouracil and sulforaphane with enhanced bioavailability and anticancer activity against colon carcinoma.

Biotechnol Appl Biochem 2021 Nov 14. Epub 2021 Nov 14.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

The present research work describes development of dual drug-loaded lipid-polymer hybrid nanoparticles (LPHNPs) of anticancer therapeutics for the management of colon cancer. The epidermal growth factor (EGF)-functionalized LPHNPs coloaded with 5-fluorouracil (FU) and sulforaphane (SFN) were prepared by one-step nanoprecipitation method. Box-Behnken design was applied for optimizing the material attributes and process parameters. Read More

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November 2021

Resection of meningiomas in a different location (sphenoid wing and tuberculum sellae) through a single craniotomy report of a case and review of the literature.

Cir Cir 2021 ;89(S1):66-69

Department of Functional Neurosurgery, Stereotactic and Radiosurgery, Hospital General de México.

Meningiomas are the most frequent extra-axial tumors of the nervous system. Multiple meningiomas are defined as the presence of two or more lesions that appear simultaneously or not, in different intracranial location, without association to neurofibromatosis. Each lesion must be evaluated individually for treatment, which consists in microsurgical resection in most cases. Read More

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November 2021

[Description of a technique that uses Lapidus arthrodesis plus osteochondral autotransplantation in the treatment of severe hallux rigidus].

Oper Orthop Traumatol 2021 Dec 10;33(6):495-502. Epub 2021 Nov 10.

Gelenkzentrum Rhein-Main, Frankfurter Str. 94, 65239, Hochheim am Main, Deutschland.

Objective: The objective of this technique is the treatment a severe hallux rigidus deformity by reorientation of an elevated first metatarsal using arthrodesis of the first tarsometatarsal joint and performing a one-step transplantation of an osteochondral graft, which is harvested from the first cuneiform, to the head of the first metatarsal bone.

Indications: Severe arthritis of the first metatarsophalangeal joint (MTP) stage 3 and 4 in the Vanore classification.

Contraindications: General contraindications for a foot surgery; ankylosis of MTP joint; severe arthritis of the sesamoid joint; osteonecrosis; short first metatarsal; previous infection in the metatarsophalangeal joint; large cysts at the head of the first metatarsal. Read More

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December 2021

Usefulness of histological superstudy of sentinel lymph nodes detected with radioisotopes in colon cancer.

Rev Esp Med Nucl Imagen Mol (Engl Ed) 2021 Nov-Dec;40(6):358-366. Epub 2021 Mar 30.

Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain.

Introduction: Adjuvant chemotherapy (CT) significally reduces the rate of relapse in +pN (stage III) colon cancer (CC) and in some pN0 (stage II) with risk factors such as pT4, vascular invasion V1, perineural invasion Pn1, and complicated tumors. However, unexpectedly, 20%-30% of pN0 present a relapse in the follow-up, which may suggest that the lymph node involvement was not discovered in the conventional histological study (CS), and its finding with a superstudy (SS) could increase the number of patients who would benefit from neoadjuvant CT. It is not possible to perform this SS in every lymph node (LN) from the specimen, but it is possible in a small group of LN which are representative of the N status (definition of sentinel node SN). Read More

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December 2021

Telemedicine facilitates surgical training in placenta accreta spectrum.

Int J Gynaecol Obstet 2021 Oct 29. Epub 2021 Oct 29.

Clinica de Espectro de Acretismo Placentario, Fundación Valle del Lili, Cali, Colombia.

Objective: The training of groups responsible for managing patients with placenta accreta spectrum (PAS) is complex because of the lack of hospitals with a high flow of patients and absence of formal educational programs. We report here the results of a virtual training program (VTP) that implemented one-step conservative surgery (OSCS).

Methods: A prospective observation study of OSCS VTP between three expert groups and PAS reference hospitals without experience in OSCS was performed. Read More

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October 2021

Facile synthesis of near-infrared bodipy by donor engineering for tumor targeted dual-modal imaging.

J Mater Chem B 2021 11 24;9(45):9308-9315. Epub 2021 Nov 24.

Molecular Imaging Innovations Institute (MI3), Department of Radiology, Weill Cornell Medical College, 413 East 69th Street, New York, NY 10065, USA.

Bodipy is one of the most popular dyes for bioimaging, however, a complicated synthetic protocol is needed to create and isolate ideal near-infrared (NIR) emissive Bodipy derivatives for optical bioimaging. It is noticed that the donor species impact the wavelength when the π-conjugation system of green light emissive Bodipy is elongated a one-step reaction. Herein, several Bodipy dyes bearing different common donors are synthesized. Read More

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November 2021

Prediction of lateral lymph node metastasis using OSNA method for mesorectal lymph nodes in low rectal cancer: A prospective study by the Kanagawa Yokohama Colorectal Cancer Study Group (KYCC1801).

J Surg Oncol 2021 Oct 27. Epub 2021 Oct 27.

Department of Surgery, Yokohama City University, Yokohama, Kanagawa, Japan.

Background And Objectives: Contrary to the Japanese guidelines recommendations regarding lateral lymph node dissection (LatLND) for rectal cancer, its omission is common in clinical practice without reliable omission criteria. Negative pathological mesorectal lymph node metastasis (MesLNM) is reportedly highly correlated with negative pathological lateral lymph node metastasis (p-LatLNM); however, this cannot be used as a criterion because pathological features are revealed postoperatively. Herein, we prospectively evaluated the negative predictive value (NPV) of MesLNM diagnosed via the one-step nucleic acid amplification (OSNA) method for p-LatLNM. Read More

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October 2021

[Experimental study on the effect of three-dimensional porous structures on the vascularization rate of artificial dermis].

Zhonghua Shao Shang Za Zhi 2021 Oct;37(10):959-969

Shenzhen Lando Biomaterials Co., Ltd., Shenzhen Engineering Research Center of Implantable Medical Polymer, Guangdong Engineering Research Center of Implantable Medical Polymer, Shenzhen 518107, China.

To explore the effects of orienting three-dimensional porous network (type A) and honeycomb briquette-shaped vertically penetrating three-dimensional porous network (type B) on the vascularization rate of artificial dermis. The experimental research method was used. The artificial dermis was composed of a double layer of silicone layer and scaffold layer. Read More

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October 2021

Usefulness of damage control approach in patients with limited acute mesenteric ischemia: a prospective study of 85 patients.

Updates Surg 2021 Oct 22. Epub 2021 Oct 22.

Department of Surgery, "A. Cardarelli" Hospital, Via A. Cardarelli 9, 80131, Naples, Italy.

To evaluate the efficacy of the damage control approach by two-step surgical procedure in not critical patients (without sepsis or septic shock) with peritonitis from limited acute mesenteric ischemia. From April 2013 to April 2020, 85 patients [49 (57.7%) women and 36 (42. Read More

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October 2021