8,577 results match your criteria oncological outcomes

The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.

Immunity 2021 Apr 19. Epub 2021 Apr 19.

Department of Obstetrics & Gynaecology, University of Cambridge, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge CB2 0SW, UK; University of Cambridge Centre for Trophoblast Research, Cambridge, UK. Electronic address:

The conserved CD94/NKG2A inhibitory receptor is expressed by nearly all human and ∼50% of mouse uterine natural killer (uNK) cells. Binding human HLA-E and mouse Qa-1, NKG2A drives NK cell education, a process of unknown physiological importance influenced by HLA-B alleles. Here, we show that NKG2A genetic ablation in dams mated with wild-type males caused suboptimal maternal vascular responses in pregnancy, accompanied by perturbed placental gene expression, reduced fetal weight, greater rates of smaller fetuses with asymmetric growth, and abnormal brain development. Read More

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Functional impairments and rehabilitation outcomes of patients with immunotherapy-induced Acute Inflammatory Demyelinating Polyradiculoneuropathy, Myasthenia Gravis and Myositis.

Am J Phys Med Rehabil 2021 Apr 8. Epub 2021 Apr 8.

The University of Texas MD Anderson Cancer Center, Department of Palliative, Rehabilitation and Integrative Medicine, Houston, Texas.

Abstract: Immunotherapy has led to a higher survival rate among different oncological disease groups but also associated with adverse related events in multiple organ systems. Immunotherapy related musculoskeletal weakness often results in a loss of cancer survivors' physical function, ultimately impacting their independence and quality of life. This is a retrospective study of 24 cancer patients who were treated with immunotherapy either alone or in conjunction with other oncological treatments. Read More

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Clinical and reproductive outcomes of uterine smooth muscle tumor of uncertain malignant potential: a single-center retrospective study.

J Int Med Res 2021 Apr;49(4):3000605211008065

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Objective: To evaluate the clinical outcomes, histopathological features, and obstetric and oncological outcomes of uterine smooth muscle tumor of uncertain malignant potential (STUMP).

Methods: We conducted a single-center, database review of patients with STUMP between January 2001 and December 2015. We investigated the clinical, operative, histopathologic, recurrence, and fertility outcomes of the included cases. Read More

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Oral Tongue Cancer in a Patient with Fanconi Anemia: A Case Report and Literature Review.

Cancer Manag Res 2021 12;13:3145-3154. Epub 2021 Apr 12.

Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.

Purpose: Fanconi anemia (FA) is a rare genetic disorder characterized by congenital anomalies, progressive bone marrow failure and high susceptibility to solid tumors, especially head and neck squamous cell carcinoma (HNSCC). Management of FA patients with head and neck cancer is a challenge due to increased risk of surgery, poor tolerance of chemotherapy, and severe myelotoxicity of radiotherapy.

Patients And Methods: We present a case of a 33-year-old man with carcinoma of oral tongue (T1N2M0), who experienced prolonged and profound bone marrow failure as a consequence of concurrent cisplatin/radiation. Read More

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Sarcopenia with inflammation as a predictor of survival in patients with head and neck cancer.

Auris Nasus Larynx 2021 Apr 18. Epub 2021 Apr 18.

Department of Otolaryngology, Head and Neck Surgery, Shizuoka City Shizuoka Hospital, 10-93 Oute-cho, Aoi-ku, Shizuoka, Shizuoka 420-8630, Japan.

Objective: Although both sarcopenia and systemic inflammation affect the outcomes of head and neck cancer (HNC) patients, the association between sarcopenia and systemic inflammation and the combined prognostic effect of these factors in HNC patients remain unknown. This study aimed to evaluate the effect of sarcopenia with systemic inflammation on survival and disease control in HNC patients.

Methods: We retrospectively reviewed medical records of HNC patients treated between 2009 and 2016. Read More

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Medium-term oncological and functional outcomes of hemi-gland brachytherapy using iodine-125 seeds for intermediate-risk unilateral prostate cancer.

Brachytherapy 2021 Apr 18. Epub 2021 Apr 18.

Department of Urology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.

Purpose: To examine medium-term outcomes of hemi-gland low-dose-rate brachytherapy as a primary treatment for intermediate-risk prostate cancer.

Methods: We recruited intermediate-risk unilateral prostate cancer patients for a prospective trial of hemi-gland brachytherapy. Twenty-four patients underwent hemi-gland iodine-125 seed implantation with a prescribed dose of 160 Gy. Read More

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Safety and efficacy of side-to-end anastomosis versus colonic J-pouch anastomosis in sphincter-preserving resections: an updated meta-analysis of randomized controlled trials.

World J Surg Oncol 2021 Apr 21;19(1):130. Epub 2021 Apr 21.

Department of Gastrointestinal Surgery, Peking University People's Hospital, Beijing, 100044, People's Republic of China.

Background: The application of side-to-end anastomosis (SEA) in sphincter-preserving resection (SPR) is controversial. We performed a meta-analysis to compare the safety and efficacy of SEA with colonic J-pouch (CJP) anastomosis, which had been proven effective in improving postoperative bowel function.

Methods: The protocol was registered in PROSPERO under number CRD42020206764. Read More

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Oncological outcomes of laparoscopic versus open nephroureterectomy for the treatment of upper tract urothelial carcinoma: an updated meta-analysis.

World J Surg Oncol 2021 Apr 21;19(1):129. Epub 2021 Apr 21.

Department of Urology and Urological Oncology, Wroclaw Medical University, Borowska 213 Street, 50-556, Wroclaw, Poland.

Background: During the past two decades, laparoscopic radical nephroureterectomy (LRNU) has been proposed as an alternative technique to open radical nephroureterectomy (ORNU) and has become increasingly accepted for the treatment of patients with upper tract urothelial carcinoma (UTUC). Nevertheless, the oncologic efficacy of LRNU remains controversial, especially for the treatment of locally advanced (T3/T4 and/or N+) UTUC. In this meta-analysis, we aimed to cumulatively compare the oncological outcomes of LRNU versus ORNU. Read More

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Surgical volume reduction and the announcement of triage during the 1st wave of the COVID-19 pandemic in Japan: a cohort study using an interrupted time series analysis.

Surg Today 2021 Apr 21. Epub 2021 Apr 21.

Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University, Kyoto City, Kyoto, Japan.

Purpose: The coronavirus disease (COVID-19) pandemic has caused unprecedented challenges for surgical staffs to minimize exposure to COVID-19 or save medical resources without harmful patient outcomes, in accordance with the statement of each surgical society. No research has empirically validated declines in surgical volume in Japan, based on the usage of surgical triage. We aimed to identify whether the announcement of surgical priorities by each Japanese surgical society may have affected the surgical volume decline during the 1st wave of this pandemic. Read More

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Triggers and oncologic outcome of salvage radical prostatectomy, salvage radiotherapy and active surveillance after focal therapy of prostate cancer.

World J Urol 2021 Apr 21. Epub 2021 Apr 21.

Clinic of Urology, Urooncology, Robotic-Assisted and Focal Therapy, Medical Faculty and University Clinics of Magdeburg, Magdeburg, Germany.

Purpose: Due to the tissue preserving approach of focal therapy (FT), local cancer relapse can occur. Uncertainty exists regarding triggers and outcome of salvage strategies.

Methods: Patients with biopsy-proven prostate cancer (PCa) after FT for localized PCa from 2011 to 2020 at eight tertiary referral hospitals in Germany that underwent salvage radical prostatectomy (S-RP), salvage radiotherapy (S-RT) or active surveillance (AS) were reported. Read More

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An injectable double-crosslinking iodinated composite hydrogel as a potential radioprotective spacer with durable imaging function.

J Mater Chem B 2021 Apr 6;9(15):3346-3356. Epub 2021 Apr 6.

College of Materials Science & Engineering, Zhejiang University of Technology, China.

Prostate cancer is one of the leading causes of cancer incidence among males worldwide. Radiotherapy can achieve similar oncological outcomes to those of radical prostatectomy. One concern is, however, radiation damage to the rectum because of the extreme proximity between the two organs. Read More

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Functional and oncological outcomes of salvage transoral robotic surgery: a comparative study.

Eur Arch Otorhinolaryngol 2021 Apr 20. Epub 2021 Apr 20.

Department of ENT Head and Neck Surgery, Institut Claudius Regaud, IUCT-Oncopole, 1 Av. Irène Joliot-Curie, 31059, Toulouse, France.

Purpose: Transoral robotic surgery (TORS) as a first-line therapy has been well-documented but evidence is missing regarding salvage therapy. The aim of this study is to compare the oncological and functional outcomes of TORS as a primary and salvage therapy.

Methods: This retrospective monocentric study included 74 patients operated by a single surgeon and sorted out into two groups: primary treatment (PT) or Salvage treatment (ST) in case of previous history of radiation therapy. Read More

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Clinicians' knowledge and attitudes towards patient reported outcomes in colorectal cancer care - insights from qualitative interviews.

BMC Health Serv Res 2021 Apr 20;21(1):366. Epub 2021 Apr 20.

German Cancer Society, Kuno-Fischer-Straße 8, 14057, Berlin, Germany.

Introduction: Patient-reported outcomes (PROs) can be used in cancer care to monitor patients' disease-related symptoms and functional status. However, successful implementation of such instruments is only possible if clinical staff are convinced of the clinical benefits. It is therefore crucial to investigate the attitudes of clinical staff to PROs in routine cancer care. Read More

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Characteristics and patient-reported outcomes associated with dropout in severely affected oncological patients: an exploratory study.

BMC Med Res Methodol 2021 Apr 20;21(1):77. Epub 2021 Apr 20.

Berlin Institute of Health at Charité -Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Background: Patient-reported outcome measures (PROMs) are commonly-used surrogates for clinical outcomes in cancer research. When researching severe diseases such as cancer, it is difficult to avoid the problem of incomplete questionnaires from drop-outs or missing data from patients who pass away during the observation period. The aim of this exploratory study was to explore patient characteristics and the patient-reported outcomes associated with the time-to-dropout. Read More

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[Significance of the intact of the fascia propria in protection of pelvic plexus during total mesorectal excision].

P Chi X J Wang

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Apr;24(4):297-300

Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, China.

Total mesorectal excision (TME) is the gold standard of surgical treatment for mid and low rectal cancer. It aims to improve the oncological outcomes as well as preserve anal sphincter, sexual and urinary function. Compared with sympathetic nerve injury alone, pelvic plexus and neurovascular bundle (NVB) injury has significant effect on postoperative sexual dysfunction, especially erectile function. Read More

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A matter of size? Health-related quality of life after radical prostatectomy for patients with giant prostates.

Prostate 2021 Jun;81(8):443-451

Department of Urology, University Hospital Großhadern, Ludwig-Maximilians-University Munich, Munich, Germany.

Background: Evidence regarding the impact of giant prostate volume (PV) on outcome after radical prostatectomy (RP) is controversial with a lack of evidence on the impact of PV on health-related quality of life (HRQOL). We aimed to assess the impact of giant PV on HRQOL and functional outcomes for men with prostate cancer (PC) undergoing RP.

Methods: Giant PV was defined based on the 95th percentile of PV measured by specimen weight of 3929 patients that underwent RP between 2013 and 2018 in a large tertiary care center. Read More

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Impact of Percutaneous Transhepatic Biliary Drainage on Clinical Outcomes of Patients with Malignant Obstructive Jaundice Undergoing Laparoscopic Pancreaticoduodenectomy.

Curr Med Sci 2021 Apr 20;41(2):375-380. Epub 2021 Apr 20.

Department of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Preoperative biliary drainage may increase the morbidity and mortality of pancreaticoduodenectomy. Studies on percutaneous transhepatic biliary drainage (PTBD) before laparoscopic pancreaticoduodenectomy (LPD), however, are scarce. The aim of this study was to examine the impact of PTBD on clinical outcomes of patients with malignant obstructive jaundice undergoing LPD. Read More

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Oral tongue squamous cell carcinomas in young patients according to their smoking status: a GETTEC study.

Eur Arch Otorhinolaryngol 2021 Apr 20. Epub 2021 Apr 20.

INSERM UA8, Radiation: Défense, Santé , Environnement, Lyon, France.

Background: Incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing, especially in young adults, despite decreasing tobacco and alcohol consumption.

Methods: This multicentric retrospective study of 185 young adults with OTSCC (median follow-up 43 months), investigated risk factors, tumour characteristics and oncological outcomes according to the smoking status.

Results: Overall, 38% of patients were smokers (S). Read More

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Laparoscopic gastrectomy for stage II and III advanced gastric cancer: long‑term follow‑up data from a Western multicenter retrospective study.

Surg Endosc 2021 Apr 20. Epub 2021 Apr 20.

Department of General Surgery and Specialty, School of Medicine University, Federico II of Naples, Naples, Italy.

Introduction: There has been an increasing interest for the laparoscopic treatment of early gastric cancer, especially among Eastern surgeons. However, the oncological effectiveness of Laparoscopic Gastrectomy (LG) for Advanced Gastric Cancer (AGC) remains a subject of debate, especially in Western countries where limited reports have been published. The aim of this paper is to retrospectively analyze short- and long-term results of LG for AGC in a real-life Western practice. Read More

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Long-term neurodevelopmental outcome after prenatal exposure to maternal hematological malignancies with or without cytotoxic treatment.

Child Neuropsychol 2021 Apr 20:1-12. Epub 2021 Apr 20.

Center for Gynecologic Oncology Amsterdam, the Netherlands Cancer Institute, Amsterdam, The Netherlands.

Data on the long-term neurodevelopmental outcomes of children exposed to hematological maternal cancer with or without treatment during pregnancy are lacking. A total of 57 children, of whom 33 males and 24 females, prenatally exposed to hematological malignancies and its treatment, were invited for neuropsychological and physical examinations at 18 months, 36 months, 6, 9, 12, 15 and 18 years of age. Oncological, obstetrical, neonatal and follow-up data of these children were collected. Read More

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Age and cancer treatment factors influence patient-reported outcomes following therapeutic mammoplasty and contralateral symmetrisation for the treatment of breast cancer.

J Plast Reconstr Aesthet Surg 2021 Mar 28. Epub 2021 Mar 28.

Department of Breast Surgery, Level 6, Ninewells Hospital and Medical School, Dundee, DD1 9SY United Kingdom.

Background: Oncoplastic surgery for breast cancer has increased in popularity over the last few years, with oncological safety confirmed in several studies. There are, however, limited published data on patient-reported outcomes from this surgical approach. This study assessed patient-reported outcomes of satisfaction following therapeutic mammoplasty and contralateral symmetrisation (TMCS) as part of breast cancer treatment in relation to other patient and treatment factors. Read More

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Comparison of Bronchial Sleeve Lobectomy with Pulmonary Arterioplasty versus Pneumonectomy.

Ann Thorac Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University. Electronic address:

Background: To evaluate the efficacy of bronchial sleeve lobectomy with pulmonary arterioplasty by comparing to pneumonectomy in centrally located non-small cell lung cancer (NSCLC) with bronchovascular invasion.

Methods: The entire cohort consisted of 212 patients receiving pneumonectomy and 156 patients undergoing bronchial sleeve lobectomy with pulmonary arterioplasty. Propensity score matching was adopted to create a fully balanced cohort, after which, baseline characteristics, perioperative performance and oncological results were compared between two groups. Read More

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Real-world experience of olaparib as maintenance therapy in BRCA-mutated recurrent ovarian cancer.

Arch Gynecol Obstet 2021 Apr 19. Epub 2021 Apr 19.

Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Purpose: The primary objective of our study was to investigate the effectiveness and safety of olaparib maintenance therapy in patients with BRCA-mutated recurrent ovarian cancer in daily practice. The secondary objective of this study was to identify prognostic factors associated with prolonged progression-free survival (PFS) in such patients.

Methods: We conducted a retrospective analysis of 40 patients who received olaparib maintenance treatment. Read More

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Percutaneous Carbon-PEEK instrumentation for spine tumors: a prospective observational study.

J Neurosurg Sci 2021 Apr 16. Epub 2021 Apr 16.

N.E.S.M.O.S. Department, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.

Background: Minimally invasive spine surgery (MISS) has been progressively accepted as a useful approach for spine tumors. Recently released carbon-PEEK implants have been already reported as effective in open surgeries for spine tumors. This study aimed to evaluate the feasibility, surgical, clinical and radiological outcomes of a new percutaneous carbon-PEEK instrumentations for spine tumors. Read More

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Outcomes of diverting loop ileostomy reversal in the elderly: a case-control study.

ANZ J Surg 2021 Apr 18. Epub 2021 Apr 18.

Department of General and Oncological Surgery - Surgery C, The Chaim Sheba Medical Center, Ramat Gan, Israel.

Background: Although diverting loop ileostomy (DLI) reversal is considered to be a relatively simple procedure, it is not immune from major morbidity. We aimed to compare outcomes of DLI reversal between elderly and non-elderly patients.

Methods: Retrospective review of all patients who underwent DLI reversal at a single tertiary medical centre between 2010 and 2020. Read More

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Laparoscopic transhiatal esophagectomy in esophageal cancer patients with high-risk post-operative complications.

Dis Esophagus 2021 Apr 19. Epub 2021 Apr 19.

Department of Gastroenterology, Digestive Surgery Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Surgical treatment of esophageal cancer is challenging, due to considerable morbidity, especially in high surgical risk patients. While transhiatal esophagectomy leads to good oncological outcomes and reduced postoperative complications, less invasive techniques might further improve outcomes. Our goal was to compare results of laparoscopic transhiatal esophagectomy (LTE) with open transhiatal esophagectomy (OTE) in esophageal cancer patients at high surgical risk. Read More

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Angiotensin System Inhibitors May Improve Outcomes of Patients With Castration-Resistant Prostate Cancer During Abiraterone Acetate Treatment-A Cardio-Oncology Study.

Front Oncol 2021 1;11:664741. Epub 2021 Apr 1.

Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre, Otwock, Poland.

Background: Abiraterone acetate (ABI) therapy improves overall survival in metastatic prostate cancer (PC) patients; however, this effect may be diminished by concurrent comorbidities. We aimed to evaluate the influence of pre-existing chronic diseases and concomitant medications on the course of ABI treatment among post-chemotherapy patients with metastatic castration-resistant prostate cancer patients (mCRPC).

Methods: From the Polish National Health Fund database, we identified 93 post-chemotherapy, mCRPC patients, who were qualified for ABI treatment in our oncology center between 2014 and 2018. Read More

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Reconstruction with customized, 3D-printed prosthesis after resection of periacetabular Ewing's sarcoma in children using "triradiate cartilage-based" surgical strategy:a technical note.

J Orthop Translat 2021 May 26;28:108-117. Epub 2021 Mar 26.

Department of Orthopedic Surgery, Xi-jing Hospital, Air Force Medical University, Xi'an, 710032, China.

Background: Surgery for Ewing sarcoma involving acetabulum in children is challenging. Considering the intrinsic structure of immature pelvis, trans-acetabular osteotomy through triradiate cartilage might be applied. The study was to describe the surgical technique and function outcomes of trans-acetabular osteotomy through triradiate cartilage and reconstruction with customized, 3D-printed prosthesis. Read More

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Oncogenic mechanism-based pharmaceutical validation of therapeutics targeting MET receptor tyrosine kinase.

Ther Adv Med Oncol 2021 3;13:17588359211006957. Epub 2021 Apr 3.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated hospital, Zhejiang University School of Medicine, Hangzhou, China.

Aberrant expression and/or activation of the MET receptor tyrosine kinase is characterized by genomic recombination, gene amplification, activating mutation, alternative exon-splicing, increased transcription, and their different combinations. These dysregulations serve as oncogenic determinants contributing to cancerous initiation, progression, malignancy, and stemness. Moreover, integration of the MET pathway into the cellular signaling network as an addiction mechanism for survival has made this receptor an attractive pharmaceutical target for oncological intervention. Read More

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Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy.

Eur Urol Focus 2021 Apr 15. Epub 2021 Apr 15.

Department of Urology, Luzerner Kantonsspital, Lucerne, Switzerland.

Background: Correct identification of variant histologies (VHs) of bladder cancer (BCa) at transurethral resection of the bladder (TURB) could drive the subsequent treatment.

Objective: To evaluate the concordance in detecting VHs between TURB and radical cystectomy (RC) specimens in BCa patients.

Design, Setting, And Participants: We retrospectively analyzed 1881 BCa patients who underwent TURB and subsequent RC at seven tertiary care centers between 1980 and 2018. Read More

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