Mol Oncol 2021 May 6. Epub 2021 May 6.
Université de Strasbourg, Inserm, IRFAC / UMR-S1113, FHU ARRIMAGE, ITI InnoVec, FMTS, 67200, Strasbourg, France.
The intestine-specific CDX2 homeobox gene, while being a tumor suppressor in the gut, is ectopically expressed in a large proportion of acute leukemia, and is associated with poor prognosis. Here, we report that turning on human CDX2 expression in the hematopoietic lineage of mice induces acute monoblastic leukemia, characterized by the decrease in erythroid and lymphoid cells at the benefit of immature monocytic and granulocytic cells. One of the highly stimulated genes in leukemic bone marrow cells was Bambi, an inhibitor of TGFβ signaling. Read More