24,079 results match your criteria oleic acid


Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs Artemether-Lumefantrine.

Biomed Mater 2021 Sep 20. Epub 2021 Sep 20.

Faculdade de Ciências Farmacêuticas, UNICAMP, Rua Candido Portinari, 200, Campinas, 13083871, BRAZIL.

Artemether (ART) and lumefantrine (LUM) are the gold standard antimalarial drugs used for the treatment of malaria in children and pregnant women. Typically, ART and LUM are delivered orally in the form of a combined tablet, however, the appropriateness of this route of administration for these drugs is questionable due to the poor absorption and therefore bioavailability observed unless administered alongside lipid-rich foods.Transdermal drug delivery in the form of a patch-type system has been identified as a viable alternative to the conventional tablet-based therapy. Read More

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September 2021

Deciphering functional biomolecule potential of marine diatoms through complex network approach.

Bioresour Technol 2021 Sep 13;342:125927. Epub 2021 Sep 13.

Amity Institute of Biotechnology, Amity University, Uttar Pradesh, India. Electronic address:

Marine diatoms are unique reservoirs of bioactive compounds having enormous applications in therapeutics. But high-throughput screening methods are needed to elucidate the interaction between numerous biomolecules and their targets, facilitating rapid screening for novel drug molecules. So, in the present study chemical constituents were extracted from five marine diatoms using un-targeted metabolite profiling and in-silico virtual screening bioinformatics was employed to predict their bioactivity and molecular targets. Read More

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September 2021

Potassium fertilization improves growth, yield and seed quality of sunflower (Helianthus annuus L.) under drought stress at different growth stages.

PLoS One 2021 20;16(9):e0256075. Epub 2021 Sep 20.

Department of Biology, College of Sciences, Taif University, Taif, Saudi Arabia.

Water scarcity is a major concern for sunflower production in the semi-arid and arid regions of the world. Potassium (K) application has been found effective to alleviate the influence of drought stress; however, the impact of drought stress on seed quality of sunflower has not been reported frequently. Therefore, a field experiment was performed to determine the optimum K requirement for mitigating the adverse effects of water stress and improving growth and seed quality of spring-planted sunflower. Read More

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September 2021

Delineating a potent antiviral activity of extract loaded nano-formulation against SARS-CoV-2: studies.

J Drug Deliv Sci Technol 2021 Sep 15:102845. Epub 2021 Sep 15.

Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.

The outbreak of coronavirus disease-2019, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a worldwide emerging crisis. Polyphenols are a class of herbal metabolites with a broad-spectrum antiviral activity. However, most polyphenols encounter limited efficacy due to their poor solubility and degradation in neutral and basic environments. Read More

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September 2021

Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions.

Front Immunol 2021 3;12:707267. Epub 2021 Sep 3.

Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Periapical abscesses, radicular cysts, and periapical granulomas are the most frequently identified pathological lesions in the alveolar bone. While little is known about the initiation and progression of these conditions, the metabolic environment and the related immunological behaviors were examined for the first time to model the development of each pathological condition. Metabolites were extracted from each lesion and profiled using gas chromatography-mass spectrometry in comparison with healthy pulp tissue. Read More

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September 2021

Effects of Lipid Deposition on Viscoelastic Response in Human Hepatic Cell Line HepG2.

Front Physiol 2021 1;12:684121. Epub 2021 Sep 1.

Key Laboratory of Mechanics on Disaster and Environment in Western China, Ministry of Education, College of Civil Engineering and Mechanics, Lanzhou University, Lanzhou, China.

Hepatic steatosis is associated with various liver diseases. The main pathological feature of steatosis is the excessive lipid accumulation. Ultrasound has been extensively used for the diagnosis of hepatic steatosis. Read More

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September 2021

Integrated Proteomics and Metabolomics Link Acne to the Action Mechanisms of Cryptotanshinone Intervention.

Front Pharmacol 2021 1;12:700696. Epub 2021 Sep 1.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.

The label-free methods of proteomic combined with metabolomics were applied to explore the mechanisms of Cryptotanshinone (CPT) intervention in rats with acne. The model group consisted of rats given oleic acid (MC), then treated with CPT, while control groups did not receive treatment. The skin samples were significantly different between control, model and CPT-treated groups in hierarchical clustering dendrogram. Read More

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September 2021

Abomasal infusion of oleic acid increases fatty acid digestibility and plasma insulin of lactating dairy cows.

J Dairy Sci 2021 Sep 15. Epub 2021 Sep 15.

Department of Animal Science, Michigan State University, East Lansing 48824. Electronic address:

Our objective was to determine whether abomasal infusions of increasing doses of oleic acid (cis-9 C18:1; OA) improved fatty acid (FA) digestibility and milk production of lactating dairy cows. Eight rumen-cannulated multiparous Holstein cows (138 d in milk ± 52) were randomly assigned to treatment sequence in a replicated 4 × 4 Latin square design with 18-d periods consisting of 7 d of washout and 11 d of infusion. Production and digestibility data were collected during the last 4 d of each infusion period. Read More

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September 2021

Changes in volatile flavor of yak meat during oxidation based on multi-omics.

Food Chem 2021 Sep 8;371:131103. Epub 2021 Sep 8.

School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang 550000, China. Electronic address:

Hydroxyl radical system combined with GC-IMS and metabolomics were used to assess the effect of oxidation on the formation of volatile flavor emitted from yak meat. The formation of volatile compounds, including heptanal, octanal, nonanal, 2,3-glutaraldehyde, 3-hydroxy-2-butanone, etc. were promoted by oxidation. Read More

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September 2021

Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma.

J Ethnopharmacol 2021 Sep 14;282:114643. Epub 2021 Sep 14.

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address:

Ethnopharmacological Relevance: With the features of multiple-components and targets as well as multifunction, traditional Chinese medicine (TCM) has been widely used in the prevention and treatment of various diseases for a long time. During the application of TCM, the researches about bioavailability enhancement of the bioactive constituents in formula are flourishing. Bushen-Yizhi formula (BSYZ), a TCM prescription with osthole (OST) as one of the main bioactive ingredients, have been widely used to treat kidney deficiency, mental retardation and Alzheimer's disease. Read More

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September 2021

Accumulation of neutral lipids and carotenoids of Rhodorula diobovata and Rhodosporidium babajevae cultivated under nitrogen-limited conditions with glycerol as a sole carbon source.

FEMS Microbiol Lett 2021 Sep 17. Epub 2021 Sep 17.

Department of Biostsyems Engineering, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2.

Two red oleaginous yeasts, Rhodotorula diobovata and Rhodosporidium babjevae, were investigated for their potential to grow on nitrogen-limited media with sufficient glycerol as carbon source and produce biomass, triacylglycerides (TAGs), and carotenoids. The two yeasts produced equal quantities of biomass by 120 hours post-inoculation (hrs pi), but R. diobovata consumed more glycerol than R. Read More

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September 2021

ω3PUFAs improve hepatic steatosis in postnatal overfed rats and HepG2 cells by inhibiting acetyl-CoA carboxylase.

Food Sci Nutr 2021 Sep 22;9(9):5153-5165. Epub 2021 Jul 22.

Department of Child Health Care Children's Hospital of Nanjing Medical University Nanjing China.

Postnatal overfeeding can lead to persistent increases in hepatic lipid synthesis and the risk of nonalcoholic fatty liver disease (NAFLD) in adulthood. The ω3 polyunsaturated fatty acids (ω3PUFAs) exhibit beneficial effects on NAFLD. Here, we employed a rat model and an in vitro HepG2 cell model to investigate whether fish oil (FO) affects hepatic lipid synthesis due to postnatal overfeeding. Read More

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September 2021

Phytochemistry and pharmacology of Wild.: a nootropic drug.

Authors:
Mohd Aleem

J Complement Integr Med 2021 Sep 15. Epub 2021 Sep 15.

Department of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bengaluru, Karnataka, India.

Objectives: Wild is an evergreen climbing shrub. The plant is of great significance in the traditional Indian System of Medicine, such as Ayurveda, Unani, and Siddha. The seeds and their oil are extensively used to treat neurological disorders such as cognitive dysfunction, paralysis, epilepsy, insomnia, and other ailments like rheumatism, arthritis, sciatica, and leprosy. Read More

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September 2021

Influence of Dietary Nutrient Intake on Episodic Memory Across the Adult Life Span.

Front Aging Neurosci 2021 30;13:724595. Epub 2021 Aug 30.

Applied Mathematics and Systems Research Institute, National Autonomous University of Mexico, Mexico City, Mexico.

The aim of the study was to identify nutrients that have the ability to impact brain functioning and, as a consequence, influence episodic memory. In particular, we examined recollection, the ability to recall details of previous experiences, which is the episodic memory process most affected as age advances. A sample of 1,550 healthy participants between 21 and 80 years old participated in the study. Read More

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Influence of rosuvastatin treatment on cerebral inflammation and nitro-oxidative stress in experimental lung injury in pigs.

BMC Anesthesiol 2021 Sep 13;21(1):224. Epub 2021 Sep 13.

Department of Anesthesiology, University Medical Centre, Mainz, Germany.

Background: Many patients with acute respiratory distress syndrome (ARDS) suffer from cognitive impairment after hospital discharge. Different mechanisms have been implicated as potential causes for this impairment, inter alia cerebral inflammation. A class of drugs with antioxidant and anti-inflammatory properties are β-HMG-CoA-reductase inhibitors ("statins"). Read More

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September 2021

Lipophilic salts and lipid-based formulations for bridging the food effect gap of venetoclax.

J Pharm Sci 2021 Sep 10. Epub 2021 Sep 10.

School of Pharmacy, University College Cork, College Road, Cork, T12 YN60, Ireland. Electronic address:

Lipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF vehicles. This study investigated the solubility and drug loading increases in LBFs using lipophilic counterions to form lipophilic salts of venetoclax. Read More

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September 2021

Charge Carrier Diffusion Dynamics in Multisized Quaternary Alkylammonium-Capped CsPbBr Perovskite Nanocrystal Solids.

ACS Appl Mater Interfaces 2021 Sep 13. Epub 2021 Sep 13.

Department of Chemistry, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.

CsPbBr quantum dots (QDs) are promising candidates for optoelectronic devices. The substitution of oleic acid (OA) and oleylamine (OLA) capping agents with a quaternary alkylammonium such as di-dodecyl dimethyl ammonium bromide (DDAB) has shown an increase in external quantum efficiency (EQE) from 0.19% (OA/OLA) to 13. Read More

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September 2021

Effects of ethanol, activated carbon, and activated kaolin on perilla seed oil: Volatile organic compounds, physicochemical characteristics, and fatty acid composition.

J Food Sci 2021 Sep 12. Epub 2021 Sep 12.

School of Chemical Engineering and Technology, North University of China, Taiyuan, P. R. China.

Perilla seed oil (PSO) has a special aromatic odor, which is unpleasant to the personal preferences of some consumers. To this end, this article evaluated the differences in volatile organic compounds (VOCs), physicochemical characteristics, and fatty acid composition of PSO treated with ethanol (PSO-EA), activated carbon (PSO-AC), and activated kaolin (PSO-AK). The results showed that in the PSO, PSO-EA, PSO-AC, and PSO-AK samples, the content of linolenic acid, oleic acid, and linoleic acid hardly changed. Read More

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September 2021

Dietary and Pharmacologic Manipulations of Host Lipids and Their Interaction With the Gut Microbiome in Non-human Primates.

Front Med (Lausanne) 2021 26;8:646710. Epub 2021 Aug 26.

Departments of Medicine, Microbiology and Human Genetics, University of California, Los Angeles, Los Angeles, CA, United States.

The gut microbiome influences nutrient processing as well as host physiology. Plasma lipid levels have been associated with the microbiome, although the underlying mechanisms are largely unknown, and the effects of dietary lipids on the gut microbiome in humans are not well-studied. We used a compilation of four studies utilizing non-human primates ( and ) with treatments that manipulated plasma lipid levels using dietary and pharmacological techniques, and characterized the microbiome using 16S rDNA. Read More

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Cinnamic Acid Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Hepatic Lipogenesis and Promoting Fatty Acid Oxidation.

Evid Based Complement Alternat Med 2021 2;2021:9561613. Epub 2021 Sep 2.

Key Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese Medicine, Beijing 100029, China.

Background: Cinnamic acid (CA) has been shown to have many beneficial effects including regulating lipid metabolism and reducing obesity. However, its effect on nonalcoholic fatty liver disease (NAFDL) has not been investigated in detail. Thus, we performed this study in order to explore CA's effect on hepatic lipid metabolism and the underlying mechanisms. Read More

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September 2021

Olive Oil: Nutritional Applications, Beneficial Health Aspects and its Prospective Application in Poultry Production.

Front Pharmacol 2021 25;12:723040. Epub 2021 Aug 25.

Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, China.

Plant polyphenols have promoting health features, including anti-mutagenic, anti-inflammatory, anti-thrombotic, anti-atherogenic, and anti-allergic effects. These polyphenols improve the immune system by affecting the white blood cell proliferation, as well as by the synthesis of cytokines and other factors, which contribute to immunological resistance. Olive trees are one of the most famous trees in the world. Read More

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Association between diet quality index, food and nutrient intake, and metabolic parameters in adolescents from Recife, northeastern Brazil.

Br J Nutr 2021 Sep 13:1-28. Epub 2021 Sep 13.

Postgraduate Program in Child and Adolescent Health, Federal University of Pernambuco, Recife, Pernambuco, Brazil.

Nutritional studies shifted the focus of attention to the analysis of food quality, addressing general diet considering the foods, food groups, and nutrients included. This study evaluates the association between diet quality index, food and nutrient intake, and metabolic parameters of adolescents from Recife, northeastern Brazil. It is a cross-sectional study involving adolescents aged 12 to 19 years. Read More

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September 2021

Naturally Extracted Hydrophobic Solvent and Self-Assembly in Interfacial Polymerization.

ACS Appl Mater Interfaces 2021 Sep 12. Epub 2021 Sep 12.

Biological and Environmental Science Engineering Division (BESE), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, 23955-6900 Thuwal, Saudi Arabia.

Pharmaceutical, chemical, and food industries are actively implementing membrane nanofiltration modules in their processes to separate valuable products and recover solvents. Interfacial polymerization (IP) is the most widely used method to produce thin-film composite membranes for nanofiltration and reverse osmosis processes. Although membrane processes are considered green and environmentally friendly, membrane fabrication has still to be further developed in such direction. Read More

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September 2021

Analysis of lipidomics profile of Carya cathayensis nuts and lipid dynamic changes during embryonic development.

Food Chem 2021 Aug 31;370:130975. Epub 2021 Aug 31.

State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Lin'an, Zhejiang 311300, China. Electronic address:

Hickory (Carya cathayensis) nuts contain higher amount of lipids, and possess high nutritional value and substantial health benefits. However, their lipid composition and dynamic changes during embryogenesis have not been thoroughly investigated. Therefore, lipidomics profile and lipid dynamic changes during embryonic development were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Read More

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The assessment of plasma fatty acid profiles in newly diagnosed treatment-naive paediatric Crohn's disease.

Physiol Res 2021 Sep 10. Epub 2021 Sep 10.

Charles University in Prague, Faculty of Medicine in Pilsen, Faculty Hospital, Department of Pediatrics, Division of Pediatric Gastroenterology, Pilsen, Czech Republic.

Fatty acid (FA) profiles as potentially relevant components of Crohn's disease (CD) have been insufficiently analysed. We sought to explore the plasma profiles of n-3 and n-6 polyunsaturated fatty acids (PUFAs) in newly diagnosed untreated active CD. We included 26 consecutive CD pediatric patients (<19 years) and 14 healthy controls (HCs). Read More

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September 2021

Hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary Bifidobacterium bifidum and mannan-oligosaccharides.

Sci Rep 2021 Sep 9;11(1):17895. Epub 2021 Sep 9.

Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj (Allahabad), 211007, India.

This study investigated the role of dietary prebiotic mannan-oligosaccharides (MOS), and probiotic Bifidobacterium bifidum (BFD) in lipid metabolism, deposition, and consequent health indices in broiler chicken. The supplementation of 0.2% MOS along with either 10 or 10 CFU BFD/g feed resulted in downregulation of Acetyl-CoA carboxylase, fatty acid synthase, sterolregulatory element binding protein-1, and apolipoprotein B100; and up-regulation of peroxisome proliferator activated receptor-α AMP-activated protein kinase α-1, and stearoyl CoA (∆9) desaturase-1 hepatic expression in broiler chicken. Read More

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September 2021

Evaluation of the Potential of Modified Calcium Carbonate as a Carrier for Unsaturated Fatty Acids in Oxygen Scavenging Applications.

Materials (Basel) 2021 Sep 1;14(17). Epub 2021 Sep 1.

Institute of Food and Beverage Innovation, Department of Life Sciences and Facility Management, Zurich University of Applied Sciences, Campus Reidbach, 8820 Wädenswil, Switzerland.

Modified calcium carbonates (MCC) are inorganic mineral-based particles with a large surface area, which is enlarged by their porous internal structure consisting of hydroxyapatite and calcium carbonate crystal structures. Such materials have high potential for use as carriers for active substances such as oxygen scavenging agents. Oxygen scavengers are applied to packaging to preserve the quality of oxygen-sensitive products. Read More

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September 2021

The Chemical Composition of Oils and Cakes of (Ochnaceae) and Other Underutilized Traditional Oil Trees from Western Zambia.

Molecules 2021 Aug 27;26(17). Epub 2021 Aug 27.

Department of Food Science, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamycká 129, 16500 Praha-Suchdol, Czech Republic.

Currently, the negative effects of unified and intensive agriculture are of growing concern. To mitigate them, the possibilities of using local but nowadays underused crop for food production should be more thoroughly investigated and promoted. The soybean is the major crop cultivated for vegetable oil production in Zambia, while the oil production from local oil-bearing plants is neglected. Read More

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Infrared spectra of the β and γ phases of oleic acid under high pressure.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Aug 19;265:120290. Epub 2021 Aug 19.

Research Institute for Material and Chemical Measurement, National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), AIST Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.

Infrared spectra for the β and γ phases of oleic acid were obtained at room temperature (~25 °C) under pressures of up to 5 and 10 GPa, respectively. Density functional theory (DFT) calculations were performed to examine the changes in the infrared spectra and crystal lattices of the β and γ phases that occur under pressure. Mode assignments for peaks that were observed to have a low-wavenumber shift with pressure were made based on the DFT-calculated infrared spectra. Read More

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Nitro-oleic acid-mediated blood-brain barrier protection reduces ischemic brain injury.

Exp Neurol 2021 Sep 7;346:113861. Epub 2021 Sep 7.

Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15261, USA; Pittsburgh Institute of Brain Disorders & Recovery, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

Nitro-oleic acid (OA-NO), a nitroalkene formed in nitric oxide-dependent oxidative reactions, has been found in human plasma and is thought to regulate pathophysiological functions. Recently, accumulating evidence suggests that OA-NO may function as an anti-inflammatory mediator, and ameliorate the progression of diabetes and cardiovascular diseases. However, the role of OA-NO in ischemic brain injury remains unexplored. Read More

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September 2021