1,925 results match your criteria oht incidencedesign

Urinary androgens excretion pattern and prostate cancer in Mexican men.

Endocr Relat Cancer 2021 Sep 1. Epub 2021 Sep 1.

M Figueroa, Departamento de Farmacia, Universidad Nacional Autonoma de Mexico, Coyoacan, Mexico.

Epidemiological studies related to androgens and prostate cancer have focused on serum determination of testosterone, androstenedione, and dehydroepiandrosterone, with inconsistent results. Herein, we hypothesized that differences in androgen biosynthetic and metabolic pathways, rather than differences in specific androgen concentrations, are associated with prostatic carcinogenesis. Therefore, spot urine samples from 111 incident prostate cancer cases with Gleason score at diagnosis and 227 healthy population controls, were analyzed. Read More

View Article and Full-Text PDF
September 2021

Association of Donor Hypertension and Outcomes in Orthotopic Heart Transplantation.

Clin Transplant 2021 Sep 13:e14484. Epub 2021 Sep 13.

Cardiovascular Outcomes Research Laboratories, David Geffen School of Medicine University of California, Los Angeles, CA, USA.

The present study examined the impact of donor hypertension on recipient survival and offer acceptance practices in the United States. This was a retrospective study of all patients undergoing OHT from 1995 to 2019 using the United Network for Organ Sharing and Potential Transplant Recipient file databases. Hypertensive donors were stratified by Short (0-5 years) and Prolonged (>5 years) hypertension. Read More

View Article and Full-Text PDF
September 2021

Intraocular pressure fluctuation following intravitreal dexamethasone implant and incidence of secondary ocular hypertension: a Zambian perspective.

Pan Afr Med J 2021 6;39:108. Epub 2021 Jun 6.

Dr. Agarwal's Eye Hospital, Alwarpet, Chennai, India.

Introduction: to evaluate the effect of dexamethasone biodegradable implant (DEX-I), on intraocular pressure (IOP), to determine the incidence of secondary ocular hypertension (OHT) and to analyze the IOP changes as per the treatment indication in Zambian cohort.

Methods: retrospective consecutive case series of patients receiving one DEX-I between January 2016 and September 2018 with a minimum follow-up of four months in a tertiary care centre in Zambia. The IOP was recorded before the injection and at 1 week, 1, 2, 3 and 4 month after the injection. Read More

View Article and Full-Text PDF

Elucidation of Agonist and Antagonist Dynamic Binding Patterns in ER-α by Integration of Molecular Docking, Molecular Dynamics Simulations and Quantum Mechanical Calculations.

Int J Mol Sci 2021 Aug 29;22(17). Epub 2021 Aug 29.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

Estrogen receptor alpha (ERα) is a ligand-dependent transcriptional factor in the nuclear receptor superfamily. Many structures of ERα bound with agonists and antagonists have been determined. However, the dynamic binding patterns of agonists and antagonists in the binding site of ERα remains unclear. Read More

View Article and Full-Text PDF

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma.

Invest Ophthalmol Vis Sci 2021 Sep;62(12)

Eugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States.

Purpose: Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide with elevated intraocular pressure (IOP) as the most important risk factor. POAG IOP elevation is due to pathological changes in the trabecular meshwork (TM). Elevated TGFβ2 contributes to these changes and increases IOP. Read More

View Article and Full-Text PDF
September 2021

Twelve-month efficacy and safety of omidenepag isopropyl, a selective EP2 agonist, in open-angle glaucoma and ocular hypertension: the RENGE study.

Jpn J Ophthalmol 2021 Sep 8. Epub 2021 Sep 8.

Santen Inc., 6401 Hollis Street, Suite 125, Emeryville, CA, 94608, USA.

Purpose: To assess the long-term safety and efficacy of omidenepag isopropyl (OMDI) 0.002% (a first-in-class, selective, non-prostaglandin, prostanoid EP2 receptor agonist), alone or administered concomitantly with timolol 0.5%, in patients with open-angle glaucoma (OAG, including normal-tension and exfoliation glaucoma) or ocular hypertension (OHT). Read More

View Article and Full-Text PDF
September 2021

Percutaneous Tricuspid Valve Repair: A Promising Treatment for Heart Transplant Patients With Severe Tricuspid Regurgitation.

JACC Case Rep 2021 Aug 19;3(10):1269-1274. Epub 2021 Aug 19.

Heart Clinic Zurich, Zurich, Switzerland.

Two heart transplant patients aged 80 and 83 years with recurrent heart failure due to severe tricuspid regurgitation are reported. In view of their high perioperative risk, both patients underwent percutaneous transcatheter edge-to-edge tricuspid valve repair, and both experienced excellent technical success, with favorable 2-year clinical outcome. (). Read More

View Article and Full-Text PDF

Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells.

Biol Pharm Bull 2021 ;44(9):1247-1253

Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University.

The rate of glycolysis in cancer cells is higher than that of normal cells owing to high energy demands, which results in the production of excess lactate. Monocarboxylate transporters (MCTs), especially MCT1 and MCT4, play a critical role in maintaining an appropriate pH environment through lactate transport, and their high expression is associated with poor prognosis in breast cancer. Thus, we hypothesized that inhibition of MCTs is a promising therapeutic target for adjuvant breast cancer treatment. Read More

View Article and Full-Text PDF
January 2021

Association of Oral Health Teams implantation with collective actions and extractions in Paraná State, Brazil.

Cien Saude Colet 2021 30;26(suppl 2):3705-3714. Epub 2021 Aug 30.

Departamento de Odontologia, Universidade Estadual de Maringá. Av. Mandacaru 1550, Parque das Laranjeiras. 87083-240 Maringá PR Brasil.

This article aims to monitor the indicators of outpatient production of Dentistry and to evaluate the association of collective action and extraction indicators with the number of Oral Health Teams (OHT) between 2006 and 2015 in Paraná. In this longitudinal ecological study, consolidated secondary data were analyzed (collective actions of supervised brushing-SB, topical application of fluoride-TAF, fluoride mouthwash-FM, oral examination for epidemiological purposes-OE and extractions of permanent teeth-EX) from the Ambulatory Information System (SIA-SUS) and OHT numbers from the National Registry System of Health Establishments. Descriptive analyzes and Pearson's correlation were performed, with significance level of p<0. Read More

View Article and Full-Text PDF
September 2021

Influence of Chronic Ocular Hypertension on Emmetropia: Refractive, Structural and Functional Study in Two Rat Models.

J Clin Med 2021 Aug 20;10(16). Epub 2021 Aug 20.

Department of Ophthalmology, Miguel Servet University Hospital, 50009 Zaragoza, Spain.

Chronic ocular hypertension (OHT) influences on refraction in youth and causes glaucoma in adulthood. However, the origin of the responsible mechanism is unclear. This study analyzes the effect of mild-moderate chronic OHT on refraction and neuroretina (structure and function) in young-adult Long-Evans rats using optical coherence tomography and electroretinography over 24 weeks. Read More

View Article and Full-Text PDF

TRIM47 activates NF-κB signaling via PKC-ε/PKD3 stabilization and contributes to endocrine therapy resistance in breast cancer.

Proc Natl Acad Sci U S A 2021 Aug;118(35)

Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan;

Increasing attention has been paid to roles of tripartite motif-containing (TRIM) family proteins in cancer biology, often functioning as E3 ubiquitin ligases. In the present study, we focus on a contribution of TRIM47 to breast cancer biology, particularly to endocrine therapy resistance, which is a major clinical problem in breast cancer treatment. We performed immunohistochemical analysis of TRIM47 protein expression in 116 clinical samples of breast cancer patients with postoperative endocrine therapy using tamoxifen. Read More

View Article and Full-Text PDF

Charge Behavior of Terminal Hydroxyl on Rutile TiO(110).

Langmuir 2021 Sep 26;37(35):10588-10593. Epub 2021 Aug 26.

Department of Applied Physics, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Titanium dioxide (TiO) is of considerable interest as a photocatalyst and a catalyst support. Surface hydroxyl groups (OH) are the most common adsorbates on the TiO surface and are believed to play crucial roles in their applications. Although the characteristics of bridging hydroxyl (OH) have been well understood, the adsorption structure and charged states of terminal hydroxyl (OH) have not yet been experimentally elucidated at an atomic scale. Read More

View Article and Full-Text PDF
September 2021

Lifestyle Counseling for Medication Adherence in Glaucoma.

Clin Ophthalmol 2021 17;15:3521-3529. Epub 2021 Aug 17.

Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Medication adherence in glaucoma patients remains sub-par despite proven benefits of regular administration. The objective was to analyze medication adherence before and after lifestyle counseling in patients with ocular hypertension (OHT) or primary open-angle glaucoma (POAG) (mild, moderate, severe).

Methods: Prospective cohort study from May to July 2018 at a single academic center. Read More

View Article and Full-Text PDF

Sex differences in cocaine-associated memory: The interplay between CB, mGluR5, and estradiol.

Psychoneuroendocrinology 2021 Jul 31;133:105366. Epub 2021 Jul 31.

Department of Psychology, National Cheng Kung University, Tainan 70101, Taiwan. Electronic address:

We know surprisingly little about the sex differences in the neurobiology of cocaine addiction, except females are more susceptible to the rewarding effects of cocaine than their male counterparts. Only a handful of recent studies have examined the neurobiology of cocaine-induced conditioned place preference (CPP) memory among female rodents. We contribute to this emerging line of research by documenting sex differences in cocaine-associated memory and illustrating the underlying signaling pathways in five experiments. Read More

View Article and Full-Text PDF

Using machine learning to improve survival prediction after heart transplantation.

J Card Surg 2021 Aug 19. Epub 2021 Aug 19.

Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Background: This study investigates the use of modern machine learning (ML) techniques to improve prediction of survival after orthotopic heart transplantation (OHT).

Methods: Retrospective study of adult patients undergoing primary, isolated OHT between 2000 and 2019 as identified in the United Network for Organ Sharing (UNOS) registry. The primary outcome was 1-year post-transplant survival. Read More

View Article and Full-Text PDF

Mid-term results of patterned laser trabeculoplasty for uncontrolled ocular hypertension and primary open angle glaucoma.

Int J Ophthalmol 2021 18;14(8):1199-1204. Epub 2021 Aug 18.

Fundación Oftalmológica de Santander, Bucaramanga, Santander 681004, Colombia.

Aim: To describe the safety and efficacy of patterned laser trabeculoplasty (PLT) as an adjunctive treatment in primary open angle glaucoma (POAG) and ocular hypertension (OHT) after 18-month follow-up in Hispanic population.

Methods: A single-center, retrospective study was conducted. All patients with OHT or POAG undergoing PLT from June 2016 to August 2016 were included in the study. Read More

View Article and Full-Text PDF

A critical assessment of the estrogenic potency of benzyl salicylate.

Toxicol Rep 2021 4;8:1002-1007. Epub 2021 May 4.

Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, CH-8310 Kemptthal, Switzerland.

Benzyl salicylate (BS) is a natural ingredient of essential oils and a widely used fragrance chemical. A number of screening studies have evaluated the estrogenic potential of BS with ambiguous results. Lack of dose-response information for the positive control 17β-estradiol (E2) in most studies makes an assessment of the relative potency and efficacy challenging. Read More

View Article and Full-Text PDF

Geographic disparities in heart transplantation persist under the new allocation policy.

Clin Transplant 2021 Aug 16:e14459. Epub 2021 Aug 16.

Division of Cardiac Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Background: This study evaluated the impact of the 2018 heart allocation policy change on geographic disparities in United States orthotopic heart transplantation (OHT).

Methods: The United Network for Organ Sharing registry was queried to measure geographic disparity in OHT rates between pre-policy and post-policy change eras. We performed multilevel Poisson regression to measure region-level OHT rates. Read More

View Article and Full-Text PDF

Comparative effectiveness of interventions for improving adherence to ocular hypotensive therapy in patients with glaucoma or ocular hypertension: protocol for network meta-analysis.

BMJ Open 2021 08 13;11(8):e054340. Epub 2021 Aug 13.

Department of Ophthalmology, Seoul National University Hospital, Seoul, South Korea

Introduction: Poor medication adherence is an important issue in healthcare. Various types of interventions for improved adherence to ocular hypotensive therapy have been proposed, though evidence on the effectiveness of any isolated intervention remains limited. The current protocol is an ongoing network meta-analysis (NMA) design that enables comparative investigation of any and all interventions for which there are available randomised controlled trials (RCTs). Read More

View Article and Full-Text PDF

A Description of Infection Control Structure in Primary Dental Health Care, Brazil.

Biomed Res Int 2021 30;2021:5369133. Epub 2021 Jul 30.

Department of Community and Preventive Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Objective: This study is aimed at describing a score to assess infection control structures in Oral Health Teams (OHT) in Primary Health Care (PHC) in Brazil.

Methods: Secondary data from a national external evaluation of PHC conducted in 2017 and 2018 were analyzed. The construction of the score used 14 variables, divided into the following: structural characteristics of the PHC, infection control equipment under conditions of use, and biosafety supplies in sufficient quantity. Read More

View Article and Full-Text PDF

Impact of center donor acceptance patterns on utilization of extended-criteria donors and outcomes.

J Card Surg 2021 Aug 8. Epub 2021 Aug 8.

Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Background: This study investigated the impact of transplanting center donor acceptance patterns on usage of extended-criteria donors (ECDs) and posttransplant outcomes following orthotopic heart transplantation (OHT).

Methods: The Scientific Registry of Transplant Recipients was queried to identify heart donor offers and adult, isolated OHT recipients in the United States from January 1, 2013 to October 17, 2018. Centers were stratified into three equal-size terciles based on donor heart acceptance rates (<13. Read More

View Article and Full-Text PDF

Selective Laser Trabeculoplasty in the Treatment of Ocular Hypertension and Open-Angle Glaucoma: Clinical Review.

J Clin Med 2021 Jul 27;10(15). Epub 2021 Jul 27.

Clinic of Ophthalmology, University Teaching Hospital, ul. Borowska 213, 50-556 Wroclaw, Poland.

Selective laser trabeculoplasty (SLT) is a glaucoma treatment that reduces intraocular pressure (IOP). Its mechanism is based on the biological effects of the selective application of laser energy to pigmented trabecular meshwork (TM) cells, resulting in increased outflow facility. Herein, we review current publications on SLT and summarize its efficacy and safety for different indications in open-angle glaucoma (OAG) and ocular hypertension (OHT) treatment. Read More

View Article and Full-Text PDF

Macular integrity assessment microperimeter, humphrey field analyzer and OCT in glaucoma practice: a correlation study.

Can J Ophthalmol 2021 Aug 3. Epub 2021 Aug 3.

Department of Ophthalmology, Istanbul Hospital, Baskent University, Istanbul, Turkey. Electronic address:

Objective: To compare and correlate retinal sensitivities measured with macular integrity assessment microperimetry (MAIA-MP) and Humphrey field analyzer (HFA) 10-2 tests with structural parameters obtained from optical coherence tomography (OCT) in primary open-angle glaucoma (POAG) and ocular hypertension.

Methods: This study included 63 participants (22 with POAG, 20 with ocular hypertension, and 21 control individuals). All participants underwent HFA 10-2 and MAIA-MP (macular retinal sensitivity tests) and measurements for optic nerve head (ONH), peripapillary retinal nerve fibre layer thickness (PRNFLT), and ganglion cell inner plexiform layer thickness (GCIPLT) using OCT. Read More

View Article and Full-Text PDF

Macular Thickness and Microvasculature Loss in Glaucoma Suspect Eyes.

Ophthalmol Glaucoma 2021 Jul 30. Epub 2021 Jul 30.

Hamilton Glaucoma Center and Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California. Electronic address:

Purpose: To characterize the change of ganglion cell complex (GCC) thickness and macular vessel density in glaucoma suspect eyes with ocular hypertension (OHT) or glaucomatous optic neuropathy (GON).

Design: Prospective, longitudinal study.

Participants: Eight-three eyes (24 healthy, 30 OHT, and 29 GON) of 65 patients who underwent at least 3 visits were included from the Diagnostic Innovations in Glaucoma Study. Read More

View Article and Full-Text PDF

Incidence and Risk Factors of Ocular Hypertension and Glaucoma in Patients With Acanthamoeba Keratitis.

Eye Contact Lens 2021 Jul 30. Epub 2021 Jul 30.

King Khaled Eye Specialist Hospital (A.M.A.O., S.A., S.A.-S.), Riyadh, Saudi Arabia; Ophthalmology Unit (A.M.A.O., S.A.-O.), Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia; and Department of Ophthalmology (S.H.A.), College of Medicine, Majmaah University, Majmaah, Saudi Arabia.

Objectives: To determine the incidence of ocular hypertension (OHT) and glaucoma in patients with acanthamoeba keratitis (AK) and to outline the risk factors for the development of glaucoma.

Methods: A retrospective review of patients diagnosed with AK at our institute during the period from 2000 to 2018. The main outcome measures were the incidence of OHT and glaucoma, and risk factors for the development of glaucoma. Read More

View Article and Full-Text PDF

Incidence of ocular hypertension after anti-VEGF injections: examining the effect of drug filtration and silicone-free syringes.

Can J Ophthalmol 2021 Jul 28. Epub 2021 Jul 28.

From the Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, B.C.. Electronic address:

Objective: To examine the difference in incidence of ocular hypertension (OHT) following the introduction of filtered anti-vascular endothelial growth factor (anti-VEGF) medication in silicone-free syringes.

Design: Retrospective cohort study.

Methods: A retrospective review of consecutive treatment-naive patients receiving intravitreal anti-VEGF injections in a group practice was performed. Read More

View Article and Full-Text PDF

Frequency of Congruence and Incongruence Between the Clinical and Morphological Diagnoses in Patients Having Orthotopic Heart Transplantations at the Baylor University Medical Center at Dallas From 1993 to 2020.

Am J Cardiol 2021 10 26;156:114-122. Epub 2021 Jul 26.

Baylor Scott & White Heart and Vascular Institute, Baylor University Medical Center, Baylor Scott & White Health, Dallas, Texas.

We studied the explanted hearts of 519 patients having Orthotopic Heart Transplant (OHT) at Baylor University Medical Center from 2013 to 2020 and compared the morphologic diagnoses to the clinical diagnoses before OHT. We then combined these findings with the findings from 314 patients who had been studied in the laboratory from 1993 to 2012. Thus, the total number of patients included in the overall study were 833. Read More

View Article and Full-Text PDF
October 2021

Symptomatic Presentation of Acute Myocardial Infarction in Heart Transplantation Patients.

JACC Case Rep 2021 Mar 3;3(3):400-406. Epub 2021 Feb 3.

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Patients with acute myocardial infarction with a history of an orthotopic heart transplantation rarely present with classic anginal symptoms, secondary to cardiac denervation. We present 2 cases, the first of a patient with a ST-segment elevation myocardial infarction and the second who presented with a non-ST-segment elevation myocardial infarction. Both patients presented with typical symptoms and were treated with percutaneous coronary intervention. Read More

View Article and Full-Text PDF

Use of TandemHeart as Bridge to Recovery for Antibody-Mediated Rejection in a Heart Transplant Patient.

JACC Case Rep 2020 Dec 16;2(15):2358-2362. Epub 2020 Dec 16.

Section of Cardiomyopathy and Heart Transplantation, Division of Cardiology, John Ochsner Heart and Vascular Institute, Ochsner Clinic Foundation, The University of Queensland School of Medicine, New Orleans, Louisiana, USA.

Antibody-mediated rejection is a major cause of graft failure, mortality, and morbidity among cardiac transplant recipients. We present the first reported case of TandemHeart (LivaNova, Pittsburgh, Pennsylvania) used in the management of antibody-mediated rejection associated with cardiogenic shock. (). Read More

View Article and Full-Text PDF
December 2020

Left Bundle Branch Block-Induced Cardiomyopathy in a Transplanted Heart Treated With His Bundle Pacing.

JACC Case Rep 2020 Oct 12;2(12):1932-1936. Epub 2020 Aug 12.

Division of Cardiology, CHI Franciscan, Tacoma, Washington.

A 70-year-old male with prior orthotopic heart transplant developed left bundle branch block followed by new-onset left ventricular systolic dysfunction. He underwent His bundle pacing for cardiac resynchronization therapy with complete normalization of his ejection fraction. This is the first reported case of left bundle branch block-induced cardiomyopathy in a transplanted heart. Read More

View Article and Full-Text PDF
October 2020