131,287 results match your criteria oestradiol


DrugWAS: Drug-wide association studies for COVID-19 drug repurposing.

Clin Pharmacol Ther 2021 Jul 27. Epub 2021 Jul 27.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, USA.

This study aimed to systematically investigate if any of the available drugs in Electronic Health Record (EHR) can be repurposed as potential treatment for COVID-19. Based on a retrospective cohort analysis of EHR data, drug-wide association studies (DrugWAS) were performed on 9,748 COVID-19 patients at Vanderbilt University Medical Center (VUMC). For each drug study, multivariable logistic regression with overlap weighting using propensity score was applied to estimate the effect of drug exposure on COVID-19 disease outcomes. Read More

View Article and Full-Text PDF

[Inhibidores de la aromatasa para estatura baja en niños y adolescentes de sexo masculino].

Bol Med Hosp Infant Mex 2021 Jul 27. Epub 2021 Jul 27.

Ediciones Médicas, Hospital Infantil de México Federico Gómez, Ciudad de México, México.

Los inhibidores de la aromatasa son fármacos disponibles por vía oral que inhiben la conversión de la testosterona en estradiol. Los estrógenos desempeñan un papel esencial en la maduración del cartílago de crecimiento y del cierre epifisario, evento que marca el final del proceso de crecimiento esquelético. Por este motivo, los inhibidores de la aromatasa se han probado como una intervención para mejorar la talla en niños y adolescentes de sexo masculino mediante el retraso en la maduración esquelética al disminuir la concentración de estradiol en la placa de crecimiento. Read More

View Article and Full-Text PDF

Expression and role of resistin on steroid secretion in the porcine corpus luteum.

Reproduction 2021 Jul 1. Epub 2021 Jul 1.

A Rak, Department of Physiology and Toxicology of Reproduction, Jagiellonian University, Krakow, Poland.

Resistin plays an important role in adipogenesis, obesity, insulin resistance and reproduction. Previous studies showed resistin action on ovarian follicular cells; however, whether resistin regulates steroid secretion in luteal cells is still unknown. Our aim was first to determine the expression of resistin and its potential receptors (tyrosine kinase-like orphan receptor 1 [ROR1] and Toll-like receptor 4 [TLR4]) in the porcine corpus luteum (CL), regulation of its expression, effect on kinases phosphorylation and luteal steroidogenesis. Read More

View Article and Full-Text PDF

Hormone therapy formulation, dose, route of delivery, and risk of hypertension: findings from the Women's Health Initiative Observational Study (WHI-OS).

Menopause 2021 Jul 26. Epub 2021 Jul 26.

Department of Obstetrics and Gynecology, Biostatistics and Epidemiology, Family and Preventive Medicine University of Oklahoma Health Sciences Center, Oklahoma City, OK Statistical Research Associate, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Medicine, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA Department of Family Medicine, University of California San Diego School of Medicine, La Jolla, CA The North American Menopause Society Emeritus, Cleveland, OH Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA.

Objective: Using data from the Women's Health Initiative Observational Study (WHI-OS), to determine the role of estrogen formulation, dose, route of delivery, and its combination with different progestogens on the risk for hypertension in the WHI-OS.

Methods: After excluding women with diagnosed hypertension, receiving antihypertensive medication, presenting with elevated blood pressure ( ≥ 140/90), and those not taking menopausal hormone therapy at baseline, 19,986 women remained eligible for the analyses. Using hierarchal modeling, proportional hazard rate calculation, and linear and logistic regression analyses, we evaluated incident treated hypertension and mean systolic and diastolic blood pressure changes at 3 years. Read More

View Article and Full-Text PDF

Comparative venous thromboembolic safety of oral and transdermal postmenopausal hormone therapies among women Veterans.

Menopause 2021 Jul 26. Epub 2021 Jul 26.

Division of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA Department of Epidemiology, University of Washington, Seattle, WA Department of Medicine, University of Washington, Seattle, WA Kaiser Permanente Washington Health Research Institute, Seattle, WA Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

Objective: Hormone therapy (HT) is used by menopausal women to treat vasomotor symptoms. Venous thromboembolism (VTE) is an important risk of HT use, and more knowledge on the comparative safety of different estrogenic compounds is useful for women who use HT for these symptoms. The objective was to compare the risk of VTE among users of oral conjugated equine estrogen (CEE), oral estradiol (E2), and transdermal E2, in a cohort of women veterans. Read More

View Article and Full-Text PDF

The Association between Sex Hormones, Pubertal Milestones and Benzophenone-3 Exposure, Measured by Urinary Biomarker or Questionnaire.

Int J Environ Health Res 2021 Jul 27:1-13. Epub 2021 Jul 27.

Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, Ohio, USA.

Experimental studies have suggested benzophenone-3 (BP-3), a sunscreen ingredient, may have endocrine-disrupting properties. A cohort of girls were recruited at ages 6-7 years and returned semi-annually for pubertal maturation staging, provided blood for serum hormone analyses [estradiol, estrone, testosterone, dehydroepiandrosterone-sulfate (DHEA-S)], and urine to measure BP-3 concentrations. We found a significant negative linear association between amount of reported sunscreen use and testosterone levels at the onset of puberty (N = 157, adjusted β = -0. Read More

View Article and Full-Text PDF

Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons.

Proc Natl Acad Sci U S A 2021 Aug;118(31)

Ushimado Marine Institute, Graduate School of Natural Science and Technology, Okayama University, Setouchi 701-4303, Japan.

There are sex differences in somatosensory sensitivity. Circulating estrogens appear to have a pronociceptive effect that explains why females are reported to be more sensitive to pain than males. Although itch symptoms develop during pregnancy in many women, the underlying mechanism of female-specific pruritus is unknown. Read More

View Article and Full-Text PDF

Evaluation of serum G protein-coupled estrogen receptor 1 (GPER-1) levels in patients with androgenetic alopecia.

Arch Dermatol Res 2021 Jul 23. Epub 2021 Jul 23.

Department of Dermatology, Kahramanmaraş Sutcu Imam University School of Medicine, Kahramanmaraş, 46100, Turkey.

The effect of oestrogens in androgenetic alopecia (AGA) pathophysiology has not been clearly understood. However, they are considered to have a place in the AGA pathogenesis as the androgens do. The effects of estrogen occur via the estrogen receptors alpha and beta, and the recently discovered G protein-coupled estrogen receptor 1 (GPER-1). Read More

View Article and Full-Text PDF

The acute effect of the menstrual cycle and oral contraceptive cycle on measures of body composition.

Eur J Appl Physiol 2021 Jul 22. Epub 2021 Jul 22.

Exercise and Sport Science, The University of Newcastle, Ourimbah, Australia.

Purpose: This study aimed to investigate the effect of fluctuating female hormones during the menstrual cycle (MC) and oral contraceptive (OC) cycle on different measures of body composition.

Methods: Twenty-two women with a natural MC and thirty women currently taking combined monophasic OC were assessed over three phases of the menstrual or oral contraceptive cycle. Body weight, skinfolds, bioelectric impedance analysis (BIA), ultrasound, dual-energy X-ray absorptiometry (DXA), and peripheral quantitative computed tomography (pQCT) measurements were performed to assess body composition. Read More

View Article and Full-Text PDF

A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells.

Reprod Toxicol 2021 Jul 23. Epub 2021 Jul 23.

Laboratory of Physiology and Toxicology of Reproduction, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland. Electronic address:

Disruption of granulosa cells (GCs), the main functional cells in the ovary, is associated with impaired female fertility. Epidemiological studies demonstrated that women have detectable levels of organic pollutants (e.g. Read More

View Article and Full-Text PDF

Exogenous oxytocin administration improves the testicular blood flow in rams.

Andrologia 2021 Jul 26:e14193. Epub 2021 Jul 26.

Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

The current research aimed to examine the effects of single-dose oxytocin administration on testicular blood flow measurements peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index (RI) and pulsatility index (PI) and plasma steroid (testosterone and oestradiol-17β) concentrations in rams. In the treated group, eight mature Ossimi rams during the breeding season were injected intravenously (iv) with 20 IU oxytocin, while the other eight male rams were administered normal saline (2 ml) iv as a control group. Venous blood samples and testicular blood flow in the left and right testes were examined immediately before (0) and 5, 30, 60 and 120 min after injections. Read More

View Article and Full-Text PDF

Factors associated with vitrification-warming survival in 6167 euploid blastocysts.

J Assist Reprod Genet 2021 Jul 26. Epub 2021 Jul 26.

Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, Klingenstein Pavilion, 1176 Fifth Ave., 9th Floor, New York, NY, 10029, USA.

Purpose: To understand the clinical factors associated with embryo survival after vitrification in a cohort of human blastocysts screened by preimplantation genetic testing for aneuploidy (PGT-A).

Methods: Patient demographic, embryo, and cycle characteristics associated with failed euploid blastocyst survival were compared in a cohort of women (n = 6167) who underwent IVF-PGT-A.

Results: Compared to those that survived warming, vitrified euploid embryos that failed to survive after warming came from IVF cycles with significantly higher estradiol levels at time of surge (2754. Read More

View Article and Full-Text PDF

17-a-estradiol has sex-specific effects on neuroinflammation that are partly reversed by gonadectomy.

J Gerontol A Biol Sci Med Sci 2021 Jul 26. Epub 2021 Jul 26.

Department of Biological Sciences, IBio (Integrative Biosciences Center), Wayne State University, Detroit, Michigan, MI.

17-α-estradiol (17aE2) treatment from 4-months of age extends lifespan in male mice and can reduce neuroinflammatory responses in the hypothalamus of 12-month-old males. Although 17aE2 improves longevity in males, female mice are unaffected, suggesting a sexually dimorphic pattern of lifespan regulation. We tested whether the sex-specific effects of 17aE2 on neuroinflammatory responses are affected by gonadal removal and whether hypothalamic changes extend to other brain regions in old age. Read More

View Article and Full-Text PDF

Hypogonadism in male and female: which is the best treatment?

Minerva Pediatr (Torino) 2021 Jul 26. Epub 2021 Jul 26.

Pediatric Endocrinology Unit, Department of Public Health and Pediatric Sciences, Regina Margherita Children Hospital, University of Turin, Turin, Italy -

Background: Subjects with hypo-or hypergonadotropic hypogonadism need hormone replacement therapy (HRT) to initiate puberty and maintain it with a normal hormonal status. While general recommendations for the management of HRT in adults have been published, no systematic suggestions focused on adolescents and young adults. The focus of this review is the HRT in males and females with hypogonadism, from puberty to late reproductive age, covering the different management options, encompassing sex steroid or gonadotropin therapy, with discussion of benefits, limitations and specific considerations of the different treatments. Read More

View Article and Full-Text PDF

Efficacy and safety of Zi Gui Nv Zhen capsules used in TCM for fertility preservation in patients with diminished ovarian reserve.

Gynecol Endocrinol 2021 Jul 26:1-5. Epub 2021 Jul 26.

Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Objective: To evaluate for the first time whether Zi Gui Nv Zhen capsules (ZGNZC), until now used in traditional Chinese medicine (TCM) for menopausal complaints, can increase the fertility of Chinese women with diminished ovarian reserve (DOR).

Methods: Prospective, randomized, open-labeled 3-monthly study; 109 DOR patients (aged 20-40 years) receiving either ZGNZC (experimental group,  = 75) or not (control group,  = 34). Main outcomes: markers for ovarian function, thickness/type of the endometrium during ovulation, and pregnancy rate. Read More

View Article and Full-Text PDF

A quinoxaline-based compound ameliorates bone loss in ovariectomized mice.

Exp Biol Med (Maywood) 2021 Jul 25:15353702211032133. Epub 2021 Jul 25.

Department of Basic Medicine, Xi'an Medical University, Xi'an 710021, PR China.

DMB (6,7-dichloro-2-methylsulfonyl-3-Ntert-butylaminoquinoxaline) is a quinoxaline-based compound that has been investigated as a glucagon-like peptide-1 receptor (GLP-1R) agonist. To clarify anti-osteoporosis effect of DMB, an osteoporotic mice model was established by ovariectomy (OVX) operation. The OVX mice were given intraperitoneally DMB, exendin-4 (EX-4), or 17β-estradiol (E) for two months. Read More

View Article and Full-Text PDF

The Enhanced Inhibitory Effect of Estrogen on PD-L1 Expression Following Nrf2 Deficiency in the AOM/DSS Model of Colitis-Associated Cancer.

Front Oncol 2021 8;11:679324. Epub 2021 Jul 8.

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.

Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a dual role in carcinogenesis. We previously reported that Nrf2 deficiency enhances the anti-tumorigenic effect of 17β-estradiol (E2) in an azoxymethane (AOM)/dextran sodium sulfate (DSS) model of colitis-associated cancer (CAC). Herein, we aimed to determine a possible explanation for our recent work and investigated the immune microenvironment represented by programmed death-ligand 1 (PD-L1) expression. Read More

View Article and Full-Text PDF

Effect of oral and transdermal oestrogen therapy on bone mineral density in functional hypothalamic amenorrhoea: a systematic review and meta-analysis.

BMJ Open Sport Exerc Med 2021 7;7(3):e001112. Epub 2021 Jul 7.

Head and Neck Research Group, Division for Research and Innovation, Akershus University Hospital, Lorenskog, Norway.

Background: Female athletes might develop reduced bone mineral density (BMD) and amenorrhoea due to low energy intake.

Objective: To systematically review the literature of randomised controlled trials (RCTs) assessing the effect of oestrogen oral contraceptives (OCP), conjugated oestrogens (CE) and transdermal estradiol (TE) on BMD in premenopausal women with functional hypothalamic amenorrhoea (FHA) due to weight loss, vigorous exercise and/or stress.

Methods: A comprehensive literature search in PubMed, MEDLINE, Cochrane Library, Ovid and CINAHL from inception to 1 October 2020. Read More

View Article and Full-Text PDF

Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children.

Comput Struct Biotechnol J 2021 1;19:3908-3921. Epub 2021 Jul 1.

Clinical Data Center, Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China.

Identification of exact causative genes is important for drug repositioning based on drug-gene-disease relationships. However, the complex polygenic etiology of the autism spectrum disorder (ASD) is a challenge in the identification of etiological genes. The network-based core gene identification method can effectively use the interactions between genes and accurately identify the pathogenic genes of ASD. Read More

View Article and Full-Text PDF

An overview of sex hormones in relation to SARS-CoV-2 infection.

Future Virol 2021 Jul 20. Epub 2021 Jul 20.

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 1985717413, Iran.

Sex differences in COVID-19 outcomes might be explained from a sex hormones (SexHs) perspective. PubMed, Scopus, Web of Science, EMBASE and Google Scholar were searched up to March 2021. Based on the literature review, the crosstalk between SexHs (estrogens, progesterone and testosterone), their receptors (estrogen α and β, androgen, and progesterone) and the immune system shaped the sex-related differences in immune responses against COVID-19. Read More

View Article and Full-Text PDF

Impact of Thyroid Autoimmunity on Fertilization/Intracytoplasmic Sperm Injection Outcomes and Fetal Weight.

Front Endocrinol (Lausanne) 2021 8;12:698579. Epub 2021 Jul 8.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Several studies have reported the association between thyroid autoimmunity (TAI) and fertilization (IVF)/intracytoplasmic sperm injection (ICSI) outcomes. However, the findings remain controversial. We performed a large-scale retrospective cohort study to verify the effect of the presence of thyroid antibodies on IVF/ICSI outcomes and fetal growth and to evaluate the association between the types and titers of thyroid antibodies and adverse IVF/ICSI outcomes. Read More

View Article and Full-Text PDF

Leptin Modulates the mRNA Expression of Follicle Development Markers in Post-hatch Chicks in an Age-Dependent Manner.

Front Physiol 2021 7;12:657527. Epub 2021 Jul 7.

College of Agriculture, Ibaraki University, Ami, Japan.

Leptin is involved in regulating reproductive function in chickens, and the development of the leptin system is initiated during the early embryonic stage; however, whether leptin has a specific role in regulating the ovarian development in early post-hatch days is still not fully understood. This study investigated the expression of ovarian functional markers in growing juvenile chickens, along with the effects of leptin on gene expression in the hypothalamus-pituitary-gonadal (HPG) axis on specific ovarian-remodeling days. Leptin receptor (LEPR), follicle-stimulating hormone receptor (FSHR), and the mRNA expression of aromatase (CYP19A1) tended to increase with age in the ovaries of growing chicks. Read More

View Article and Full-Text PDF

The Straw That Broke the Camel's Back: Natural Variations in 17β-Estradiol and COMT-Val158Met Genotype Interact in the Modulation of Model-Free and Model-Based Control.

Front Behav Neurosci 2021 8;15:658769. Epub 2021 Jul 8.

Department of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI, United States.

The sex hormone estradiol has recently gained attention in human decision-making research. Animal studies have already shown that estradiol promotes dopaminergic transmission and thus supports reward-seeking behavior and aspects of addiction. In humans, natural variations of estradiol across the menstrual cycle modulate the ability to learn from direct performance feedback ("model-free" learning). Read More

View Article and Full-Text PDF

Associations of HDL metrics with coronary artery calcium score and density among women traversing menopause.

J Lipid Res 2021 Jul 22:100098. Epub 2021 Jul 22.

Departments of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

The cardioprotective association of high-density lipoprotein cholesterol (HDL-C) may vary by menopause stage or estradiol level. We tested whether associations of comprehensive HDL metrics [HDL subclasses, phospholipid and triglyceride content and HDL cholesterol efflux capacity (HDL-CEC)] with coronary artery calcium (CAC) score and density vary by menopause stage or estradiol level in women transitioning through menopause. Participants [N=294; mean age(SD): 51. Read More

View Article and Full-Text PDF

Oscillations of estradiol and gonadotropins are a missing link to solving the mystery of mono-ovulation in humans.

Fertil Steril 2021 Jul 21. Epub 2021 Jul 21.

Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta University, Augusta, Georgia.

View Article and Full-Text PDF

Improvement in early antral follicle development and gene expression modulation prior to follicle aspiration in bovine cumulus-oocyte complexes by equine chorionic gonadotropin.

Theriogenology 2021 Jul 15;172:281-288. Epub 2021 Jul 15.

Department of Cell and Developmental Biology, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil. Electronic address:

We aimed to evaluate the morphological ovarian response to equine chorionic gonadotropin (eCG) prior to ovum pick-up (OPU) and its effects on the molecular phenotype of immature cumulus-oocyte complexes (COCs) from Nelore cow (Bos indicus) donors. To this end, 20 Nelore cows were distributed randomly into the synchronized-OPU (Sync-OPU) and synchronized plus stimulated-OPU (Sync + eCG-OPU) groups using a cross-over experimental design, as each cow was used in both treatments. On a random day of the estrus cycle (Day 0), all cows received an intravaginal implant with 1. Read More

View Article and Full-Text PDF

Pre-validation of choriogenin H transgenic medaka eleutheroembryos as a quantitative estrogenic activity test method.

Anal Biochem 2021 Jul 21:114311. Epub 2021 Jul 21.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, O & N II Herestraat 49-Box 824, 3000, Leuven, Belgium. Electronic address:

The choriogenin H - EGFP transgenic medaka (Oryzias melastigma) has been used to test estrogenic substances and quantify estrogenic activity into 17β-estradiol (E2) equivalency (EEQ). The method uses 8 eleutheroembryos in 2 ml solution per well and 3 wells per treatment in 24-well plates at 26 ± 1 °C for 24 ± 2 h, with subsequent measurements of induced GFP signal intensity. EEQ measurements are calculated using a E2 probit regression model with a coefficient of determination (R) > 0. Read More

View Article and Full-Text PDF

Metabolomics and physiological analysis of the effect of calcium supplements on reducing bone loss in ovariectomized rats by increasing estradiol levels.

Nutr Metab (Lond) 2021 Jul 23;18(1):76. Epub 2021 Jul 23.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing, 100050, China.

Background: Data from the 2010-2012 Chinese National Nutrition and Health Survey showed that the vast majority of postmenopausal women in China had dual deficiencies in calcium and estrogen.

Objective: This study aimed to clarify whether calcium supplementation alleviated bone loss caused by calcium restriction combined with estrogen deficiency in rats.

Methods: Forty-eight female rats aged 9 weeks were assigned to 4 groups and fed a low-calcium diet: sham-operated (SHAM-LC), ovariectomized (OVX-LC), and ovariectomized rats treated with 750 mg/kg (OVX-LC-M) or 2800 mg/kg CaCO (OVX-LC-H). Read More

View Article and Full-Text PDF

Fabrication of Drug-Eluting Polycaprolactone/poly(lactic--glycolic Acid) Prolapse Mats Using Solution-Extrusion 3D Printing and Coaxial Electrospinning Techniques.

Polymers (Basel) 2021 Jul 13;13(14). Epub 2021 Jul 13.

Department of Mechanical Engineering, Chang Gung University, Taoyuan 33302, Taiwan.

We developed biodegradable drug-eluting prolapse mats using solution-extrusion 3D printing and coaxial electrospinning techniques. The mats were composed of polycaprolactone (PCL) mesh and lidocaine-, estradiol-, metronidazole-, and connective tissue growth factor (CTGF)-incorporated poly(lactic--glycolic acid) (PLGA) nanofibers that mimic the structure of the natural extracellular matrix of most connective tissues. The mechanical properties of degradable prolapse membrane were assessed and compared to commercial non-degradable polypropylene knitted meshes clinically used for pelvic organ prolapse (POP) repair. Read More

View Article and Full-Text PDF