66,215 results match your criteria odds mortality

Development and outcomes of hyperkalemia in hospitalized patients: potential implications for care.

Am Heart J 2021 Jul 19. Epub 2021 Jul 19.

Chronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota; Department of Internal Medicine, Hennepin Healthcare, and University of Minnesota, Minneapolis, Minnesota. Electronic address:

Introduction: While severe hyperkalemia is commonly encountered, its manifestation in hospitalized patients and related outcomes are unclear. We aimed to examine development of hyperkalemia in hospitalized patients and associated outcomes.

Methods: Data from a county hospital electronic health record were used to assess all inpatient admissions, 2012-2016, for non-dialysis-dependent patients with ≥1 K value for development of hyperkalemia. Read More

View Article and Full-Text PDF

Longitudinal analysis of client appointment adherence under Universal Test and Treat strategy: A stepped-wedge trial.

HIV Med 2021 Jul 22. Epub 2021 Jul 22.

Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Objectives: Universal Test and Treat (UTT) strategies are being adopted across sub-Saharan Africa based on clinical benefits to morbidity and mortality and to attain targets of the Joint United Nations Programme on HIV/AIDS (UNAIDS). Universal Test and Treat is expected to change the client population at clinics, due to more asymptomatic HIV clients initiating antiretroviral therapy (ART). We assessed the impact of UTT on client appointment adherence at 14 government-managed health facilities in Eswatini's public sector health system. Read More

View Article and Full-Text PDF

Variation in outcomes across surgeons meeting the Leapfrog volume standard for complex oncologic surgery.

Cancer 2021 Jul 22. Epub 2021 Jul 22.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: A large body of evidence supports regionalization of complex oncologic surgery to high-volume surgeons at high-volume hospitals. However, whether there is heterogeneity of outcomes among high-volume surgeons at high-volume hospitals remains unknown.

Methods: Patients who underwent esophagectomy, lung resection, pancreatectomy, or proctectomy for primary cancer were identified within the Medicare 100% Standard Analytic File (2013-2017). Read More

View Article and Full-Text PDF

The clinical and prognostic value of late Gadolinium enhancement imaging in heart failure with mid-range and preserved ejection fraction.

Heart Vessels 2021 Jul 22. Epub 2021 Jul 22.

Department of Cardiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands.

Heart failure (HF) with mid-range or preserved ejection fraction (HFmrEF; HFpEF) is a heterogeneous disorder that could benefit from strategies to identify subpopulations at increased risk. We tested the hypothesis that HFmrEF and HFpEF patients with myocardial scars detected with late gadolinium enhancement (LGE) are at increased risk for all-cause mortality. Symptomatic HF patients with left ventricular ejection fraction (LVEF) > 40%, who underwent cardiac magnetic resonance (CMR) imaging were included. Read More

View Article and Full-Text PDF

Remnant cholesterol and cardiovascular mortality in patients with type 2 diabetes and incident diabetic nephropathy.

J Clin Endocrinol Metab 2021 Jul 22. Epub 2021 Jul 22.

Department of Nephrology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Purpose: This study examined the association between remnant cholesterol (remnant-C) and cardiovascular mortality in patients with type 2 diabetes (T2D), chronic kidney disease (CKD) stages 3-5 and newly diagnosed diabetic nephropathy (DN).

Methods: This study determined the baseline lipid profile and searched for deaths with cardiovascular disease (CVD) within 2 years of baseline among 2282 adults enrolled between 01/01/2015 and 31/12/2016 who had T2D, CKD stages 3-5 and newly diagnosed DN. Adjusted Logistic regression models were used to assess the associations between lipid, especially remnant-C concentration (either as continuous or categorical variables), and risk of cardiovascular mortality. Read More

View Article and Full-Text PDF

The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211026385

Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.

Diabetes, regarded as a global health concerned disease, was focused by the World Health Organization (WHO). Patients with diabetes may have a hypercoagulable and hypo-fibrinolysis state. There is lots of research about cardiovascular effects on diabetes patients, but less about the coagulation system. Read More

View Article and Full-Text PDF

Disparities in Palliative Care Utilization Among Hospitalized People With Huntington Disease: A National Cross-Sectional Study.

Am J Hosp Palliat Care 2021 Jul 22:10499091211034419. Epub 2021 Jul 22.

Eastern Colorado VA Geriatric Research Education and Clinical Center, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.

Background: People with Huntington's disease (HD) often become institutionalized and more frequently die away from the home setting. The reasons behind differences in end-of-life care are poorly understood. Less than 5% of people with HD report utilization of palliative care (PC) or hospice services, regardless of the lack of curative therapies for this neurodegenerative disease. Read More

View Article and Full-Text PDF

Hospital variation in sphincter-preservation rates in rectal cancer treatment: results of a population-based study in the Netherlands.

BJS Open 2021 Jul;5(4)

Department of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.

Background: This study aimed to examine the sphincter-preservation rate variations in rectal cancer surgery. The influence of hospital volume on sphincter-preservation rates and short-term outcomes (anastomotic leakage (AL), positive circumferential resection margin (CRM), 30- and 90-day mortality rates) were also analysed.

Methods: Non-metastasized rectal cancer patients treated between 2009 and 2016 were selected from the Netherlands Cancer Registry. Read More

View Article and Full-Text PDF

Prognostic Value of Nucleated RBCs for Patients With Suspected Sepsis in the Emergency Department: A Single-Center Prospective Cohort Study.

Crit Care Explor 2021 Jul 16;3(7):e0490. Epub 2021 Jul 16.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Objectives: Increase of nucleated RBCs in peripheral blood has been shown to be predictive of mortality in ICU patients. The aim of this study was to explore the prognostic value of nucleated RBCs in the first blood sample taken at admission to the emergency department from patients with suspected sepsis.

Design: Single-center prospective cohort study. Read More

View Article and Full-Text PDF

Clinical Outcome of COVID-19 Patients Presenting With Gastrointestinal Symptoms.

Cureus 2021 Jun 17;13(6):e15710. Epub 2021 Jun 17.

Gastroenterology and Hepatology, Isra University Hospital, Hyderabad, PAK.

Background Patients with coronavirus disease 2019 (COVID-19) usually have fever and respiratory tract complaints; however, many report gastrointestinal (GI) symptoms. The frequency of GI symptoms ranges from 16% to 61%. Although COVID-19 morbidity and mortality are related to pulmonary disease, poor outcomes have been linked to GI symptoms. Read More

View Article and Full-Text PDF

Acute Kidney Injury and Associated Factors in Intensive Care Units at a Tertiary Hospital in Northern Tanzania.

Can J Kidney Health Dis 2021 8;8:20543581211027971. Epub 2021 Jul 8.

Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Background: Acute kidney injury (AKI) is a recognized complication in critically ill patients. The epidemiology of AKI varies worldwide, depending on the diagnostic criteria used and the setting. The International Society of Nephrology has called for a reduction in preventable deaths from AKI to zero by the year 2025. Read More

View Article and Full-Text PDF

Incidence and Outcomes of Acute Kidney Injury in Patients Admitted to Hospital With COVID-19: A Retrospective Cohort Study.

Can J Kidney Health Dis 2021 11;8:20543581211027759. Epub 2021 Jul 11.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.

Background: The incidence of acute kidney injury (AKI) in patients with COVID-19 and its association with mortality and disease severity is understudied in the Canadian population.

Objective: To determine the incidence of AKI in a cohort of patients with COVID-19 admitted to medicine and intensive care unit (ICU) wards, its association with in-hospital mortality, and disease severity. Our aim was to stratify these outcomes by out-of-hospital AKI and in-hospital AKI. Read More

View Article and Full-Text PDF

Serum levels of small HDL particles are negatively correlated with death or lung transplantation in an observational study of idiopathic pulmonary fibrosis.

Eur Respir J 2021 Jul 21. Epub 2021 Jul 21.

Laboratory of Asthma and Lung Inflammation, Pulmonary Branch, NHLBI, NIH, Bethesda, MD, USA.

Background: Serum lipoproteins, such as high density lipoproteins (HDL), may influence disease severity in idiopathic pulmonary fibrosis (IPF). Here, we investigated associations between serum lipids and lipoproteins and clinical endpoints in IPF.

Methods: Clinical data and serum lipids were analyzed from a discovery cohort (59 IPF subjects, 56 healthy volunteers) and validated using an independent, multicenter cohort (207 IPF subjects) from the Pulmonary Fibrosis Foundation registry. Read More

View Article and Full-Text PDF

"Low initial pre-hospital end-tidal carbon dioxide predicts inferior clinical outcomes in trauma patients".

Injury 2021 Jul 9. Epub 2021 Jul 9.

Department of General Surgery & Trauma, WakeMed Health & Hospitals, Raleigh, NC, USA. Electronic address:

Introduction: Current guidelines continue to lead to under- and over-triage of injured patients in the pre-hospital setting. End-tidal carbon dioxide (ETCO2) has been correlated with mortality and hemorrhagic shock in trauma patients. This study examines the correlation between ETCO2 and in-hospital outcomes among non-intubated patients in the pre-hospital setting. Read More

View Article and Full-Text PDF

Differential in infant, childhood and under-five death clustering among the empowered and non-empowered action group regions in India.

BMC Public Health 2021 Jul 21;21(1):1436. Epub 2021 Jul 21.

International Institute for Population Sciences, Mumbai, 400088, India.

Background: With 8,82,000 deaths in the under-five period, India observed varied intra-state and inter-regional differences across infant and child mortality in 2018. However, scarce literature is present to capture this unusual concentration of mortality in certain families by examining the association of the mortality risks among the siblings of those families along with various unobserved characteristics of the mother. Looking towards the regional and age differential in mortality, this paper attempts to provide evidence for the differential in mortality clustering among infants (aged 0-11 months), children (12-59 months) and under-five (0-59 months) period among mothers from the Empowered Action Group (EAG) and non-EAG regions of India. Read More

View Article and Full-Text PDF

Association between ARDS Etiology and Risk of Noninvasive Ventilation Failure.

Ann Am Thorac Soc 2021 Jul 21. Epub 2021 Jul 21.

The First Affiliated Hospital of Chongqing Medical University, 117972, Department of Respiratory and Critical Care Medicine, Chongqing, Sichuan, China;

Rationale: The etiology of acute respiratory distress syndrome (ARDS) may play an important role in the failure of noninvasive ventilation (NIV).

Objectives: To explore the association between ARDS etiology and risk of noninvasive ventilation failure.

Methods: A multicenter prospective observational study was performed in 17 ICUs in China from September 2017 to December 2019. Read More

View Article and Full-Text PDF

Association of Parenteral Anticoagulation Therapy with Outcomes in Non-ST-Segment Elevation Acute Coronary Syndrome Patients Without Invasive Therapy.

Clin Pharmacol Ther 2021 Jul 19. Epub 2021 Jul 19.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Our previous study showed that parenteral anticoagulation therapy (PACT) in the context of aggressive antiplatelet therapy failed to improve clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) for non-ST-segment elevation acute coronary syndrome (NSTE-ACS). However, the roles of PACT in patients managed medically remains unknown. This observational cohort study enrolled NSTE-ACS patients receiving medical therapy from November 2014 to June 2017 in the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome project. Read More

View Article and Full-Text PDF

Transition care continuity promotes long-term retention in adult care among young adults with sickle cell disease.

Pediatr Blood Cancer 2021 Jul 19:e29209. Epub 2021 Jul 19.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Background/objectives: Care continuity prevents increased health care utilization and mortality during transition from pediatric to adult care. Our program employs a co-located care delivery model, in which pediatric provider involvement continues during young adulthood. We tested the hypothesis that individuals who participated in the co-located model have greater retention in adult care compared to those who only received pediatric transition services. Read More

View Article and Full-Text PDF

Adaptation of a respiratory service to provide CPAP for patients with COVID-19 pneumonia, outside of a critical care setting, in a district general hospital.

Future Healthc J 2021 Jul;8(2):e302-e306

Croydon University Hospital, London, UK.

Introduction: One-hundred and forty patients at Croydon University Hospital received continuous positive airway pressure (CPAP) on a specialist respiratory ward, as a bridge to invasive mechanical ventilation (IMV) or as a ceiling of care for COVID-19. This retrospective study aimed to outline service expansion, patient characteristics and explore risk factors in outcomes.

Results: Mean age of patients on CPAP was 64 years (standard deviation 12). Read More

View Article and Full-Text PDF

The Prevalence, Antibiotic Resistance Pattern, and Associated Factors of Bacterial Vaginosis Among Women of the Reproductive Age Group from Felege Hiwot Referral Hospital, Ethiopia.

Infect Drug Resist 2021 13;14:2685-2696. Epub 2021 Jul 13.

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.

Background: Bacterial vaginosis is an infection of the vagina, which results due to change in the normal balance of vaginal bacteria. The aim of this study was to assess the magnitude and determinants of bacterial vaginosis among women of reproductive age group from Felege Hiwot Referral Hospital.

Materials And Methods: A cross-sectional study was conducted among women during the reproductive period at Felege Hiwot Referral Hospital from September 1, 2019 to October 2020. Read More

View Article and Full-Text PDF

Sedation strategy and ICU delirium: a multicentre, population-based propensity score-matched cohort study.

BMJ Open 2021 Jul 20;11(7):e045087. Epub 2021 Jul 20.

Department of Critical Care Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.

Objectives: We examined the relationship between dominant sedation strategy, risk of delirium and patient-centred outcomes in adults admitted to intensive care units (ICUs).

Design: Retrospective propensity-matched cohort study.

Setting: Mechanically ventilated adults (≥ 18 years) admitted to four Canadian hospital medical/surgical ICUs from 2014 to 2016 in Calgary, Alberta, Canada. Read More

View Article and Full-Text PDF

National Early Warning Score 2 and laboratory predictors correlate with clinical deterioration in hospitalized patients with COVID-19.

Biomark Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Infectious Diseases & Clinical Microbiology, Haseki Training & Research Hospital, Istanbul, Turkey.

We aimed to determine the prognostic values of the National Early Warning Score 2 (NEWS2) and laboratory parameters during the first week of COVID-19. All adult patients who were hospitalized for confirmed COVID-19 between 11 March and 11 May 2020 were retrospectively included. Overall, 611 patients were included. Read More

View Article and Full-Text PDF

Association between latency period and perinatal outcomes after preterm premature rupture of membranes at 32-37 weeks of gestation: a perinatal registry-based cohort study.

J Perinat Med 2021 Jul 20. Epub 2021 Jul 20.

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Objectives: To investigate association between latency after preterm premature rupture of membranes (PPROM) and perinatal outcomes at moderately and late preterm gestation.

Methods: National perinatal registry-based cohort study using data for the period 2013-2018. Singleton pregnancies with non-malformed fetuses in cephalic presentation complicated by PPROM at 32-36 weeks were included. Read More

View Article and Full-Text PDF

Respiratory Events After Intensive Care Unit Discharge in Trauma Patients: Epidemiology, Outcomes, and Risk factors.

J Trauma Acute Care Surg 2021 Jul 20. Epub 2021 Jul 20.

Surgical Outcomes Research Center, Department of Surgery, University of Washington, Seattle, WA Department of Surgery, Harborview Medical Center, Seattle, WA Department of Surgery, University of California San Francisco, San Francisco, CA.

Background: Respiratory complications are associated with significant morbidity and mortality in trauma patients. The care transition from the intensive care unit (ICU) to the acute care ward is a vulnerable time for injured patients. There is a lack of knowledge about the epidemiology of respiratory events and their outcomes during this transition. Read More

View Article and Full-Text PDF

Characteristics and Outcomes of Children With Necrotizing Pneumonia.

Pediatr Crit Care Med 2021 Jul 20. Epub 2021 Jul 20.

Division of Critical Care Medicine, Nicklaus Children's Hospital, Miami, FL. Pediatrics Department, Herbert Wertheim College of Medicine, Florida International University, Miami, FL.

Objectives: In this study, we describe the characteristics and outcomes of pediatric necrotizing pneumonia in the United States.

Design And Setting: A retrospective analysis of the Healthcare Cost and Utilization Project 2016 Kids Inpatient Database was performed. The Kids Inpatient Database is a large deidentified hospital discharge database of pediatric patients in the United States. Read More

View Article and Full-Text PDF

GCS-Pupil Score Has a Stronger Association with Mortality and Poor Functional Outcome than GCS Alone in Pediatric Severe Traumatic Brain Injury.

Pediatr Neurosurg 2021 Jul 20:1-8. Epub 2021 Jul 20.

Section of Critical Care, Children's Hospital of Wisconsin, Milwaukee, Wisconsin, USA.

Background: The Glasgow Coma Scale (GCS), used to classify the severity of traumatic brain injury (TBI), is associated with mortality and functional outcomes. However, GCS can be affected by sedation and neuromuscular blockade. GCS-Pupil (GCS-P) score, calculated as GCS minus Pupil Reactivity Score (PRS), was shown to better predict outcomes in a retrospective cohort of adult TBI patients. Read More

View Article and Full-Text PDF

Effect of Canakinumab vs Placebo on Survival Without Invasive Mechanical Ventilation in Patients Hospitalized With Severe COVID-19: A Randomized Clinical Trial.

JAMA 2021 07;326(3):230-239

Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.

Importance: Effective treatments for patients with severe COVID-19 are needed.

Objective: To evaluate the efficacy of canakinumab, an anti-interleukin-1β antibody, in patients hospitalized with severe COVID-19.

Design, Setting, And Participants: This randomized, double-blind, placebo-controlled phase 3 trial was conducted at 39 hospitals in Europe and the United States. Read More

View Article and Full-Text PDF

Remdesivir Versus Standard-of-Care for Severe Coronavirus Disease 2019 Infection: An Analysis of 28-Day Mortality.

Open Forum Infect Dis 2021 Jul 26;8(7):ofab278. Epub 2021 May 26.

Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom.

Background: Remdesivir is approved by the US Food and Drug Administration for the treatment of patients hospitalized with coronavirus disease 2019 (COVID-19) and has been shown to shorten time to recovery and improve clinical outcomes in randomized trials.

Methods: This was the final day 28 comparative analysis of data from a phase 3, randomized, open-label study comparing 2 remdesivir regimens (5 vs 10 days, combined for this analysis [remdesivir cohort]) and a real-world retrospective longitudinal cohort study of patients receiving standard-of-care treatment (nonremdesivir cohort). Eligible patients, aged ≥18 years, had confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), oxygen saturation ≤94% on room air or required supplemental oxygen, with pulmonary infiltrates. Read More

View Article and Full-Text PDF

Combination fixed-dose β agonist and steroid inhaler as required for adults or children with mild asthma: a Cochrane systematic review.

BMJ Evid Based Med 2021 Jul 19. Epub 2021 Jul 19.

Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, University of Oxford, Oxford, UK

Background: In people with mild asthma poor adherence to regular therapy is common and increases the risk of exacerbations, morbidity and mortality. The use of fixed-dose combination inhalers containing an inhaled corticosteroid (ICS) and a fast-acting β-agonist (FABA) is established in moderate asthma, but they may also have potential utility in mild asthma.

Objectives: To evaluate the efficacy and safety of single combined FABA/ICS inhaler only used as needed in people with mild asthma. Read More

View Article and Full-Text PDF

Association of obesity with venous thromboembolism and myocardial injury in COVID-19.

Obes Res Clin Pract 2021 Jul 16. Epub 2021 Jul 16.

Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, 06510, USA. Electronic address:

Introduction: Although both obesity and coronavirus disease 2019 (COVID-19) independently induce inflammation and thrombosis, the association between obesity class and risk of thrombosis in patients with COVID-19 remains unclear.

Methods: This retrospective cohort study included consecutive patients hospitalized with COVID-19 at a single institution. Patients were categorized based on obesity class. Read More

View Article and Full-Text PDF