902 results match your criteria ocular alkali

Role of anterior segment optical coherence tomography angiography in assessing limbal vasculature in acute chemical injury of the eye.

Br J Ophthalmol 2021 Mar 30. Epub 2021 Mar 30.

Singapore Eye Research Institute, Singapore.

Purpose: To study the role of two anterior segment optical coherence tomography angiography (AS-OCTA) systems in eyes with acute chemical injury.

Methods: Prospective study in subjects with unilateral chemical injuries. Sequential slit-lamp assessment with spectral domain (SD) (AngioVue, Optovue, USA) and swept source (SS) (Plex Elite, Zeiss, Carl Zeiss Meditec, Dublin, California, USA) AS-OCTA was performed in both eyes within 24-48 hours of injury. Read More

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Comparison of therapeutic effects between topical 8-oxo-2'-deoxyguanosine and corticosteroid in ocular alkali burn model.

Sci Rep 2021 Mar 25;11(1):6909. Epub 2021 Mar 25.

Gachon Pain Center and Department of Physiology, Gachon University College of Medicine, Incheon, 21999, Korea.

We compared the therapeutic effects of topical 8-oxo-2'-deoxyguanosine (8-oxo-dG) and corticosteroid in a murine ocular alkali burn model. (n = 128) The corneal alkali burn model was established by applying 0.1 N sodium hydroxide (NaOH), followed by treatment with 8-oxo-dG, 0. Read More

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Corneal reconstruction in chemically damaged cornea using temperature responsive surface assisted mesenchymal stem cell transplantation in rabbits.

Graefes Arch Clin Exp Ophthalmol 2021 Mar 22. Epub 2021 Mar 22.

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, 160012, India.

Purpose: Transplantation of autologous stem cells over damaged cornea seems to be a promising approach for corneal reconstruction. Use of a biocompatible carrier is still a challenge in bedside translation of transplantation. We investigated corneal reconstruction and tissue remodelling by transplantation of mesenchymal stem cells (MSCs) using temperature responsive membranes in chemically damaged rabbit cornea model. Read More

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Effect of mesenchymal stromal cells encapsulated within polyethylene glycol-collagen hydrogels formed in situ on alkali-burned corneas in an ex vivo organ culture model.

Cytotherapy 2021 Mar 19. Epub 2021 Mar 19.

Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA; Department of Chemical and Biological Engineering, Gachon University, Seongnam-si, South Korea; VA Palo Alto HealthCare System, Palo Alto, California, USA. Electronic address:

Background Aims: Corneal inflammation after alkali burns often results in vision loss due to corneal opacification and neovascularization. Mesenchymal stem cells (MSCs) and their secreted factors (secretome) have been studied for their anti-inflammatory and anti-angiogenic properties with encouraging results. However, topical instillation of MSCs or their secretome is often accompanied by issues related to delivery or rapid washout. Read More

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PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage.

Exp Eye Res 2021 Mar 17;206:108539. Epub 2021 Mar 17.

Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan. Electronic address:

Oxidative stress-related ocular surface epithelial damage can be initiated by ambient oxygen, UV radiation, and chemical burns. The oxidative damage to cornea can lead to inflammation and even vision loss. Lingzhi (Ganoderma lucidum) is a Chinese herbal drug and has been shown to prevent chronic diseases in clinical practices and has been proven to possess anti-oxidative and anti-inflammatory properties. Read More

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Multifunctional nanocomposite eye drops of cyclodextrin complex@layered double hydroxides for relay drug delivery to the posterior segment of the eye.

Carbohydr Polym 2021 May 13;260:117800. Epub 2021 Feb 13.

Department of Pharmaceutical, School of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing, 210009, China. Electronic address:

Topical drug delivery system to the posterior segment of the eye is facing many challenges, such as rapid drug elimination, low permeability, and low concentration at the targeted sites. To overcome these challenges, Multifunctional nanocomposite eye drops of dexamethasone-carboxymethyl-β-cyclodextrin@layered double hydroxides-glycylsarcosine (DEX-CM-β-CD@LDH-GS) were developed for relay drug delivery. Herein, our studies demonstrated that DEX-CM-β-CD@LDH-GS could penetrate through human conjunctival epithelial cells with an intact structure and exhibited integrity in the sclera of rabbits' eyes with in vivo fluorescence resonance energy transfer imaging. Read More

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HDL nanoparticles have wound healing and anti-inflammatory properties and can topically deliver miRNAs.

Adv Ther (Weinh) 2020 Dec 30;3(12). Epub 2020 Sep 30.

Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

microRNAs regulate numerous biological processes, making them potential therapeutic agents. Problems with delivery and stability of these molecules have limited their usefulness as treatments. We demonstrate that synthetic high-density lipoprotein nanoparticles (HDL NPs) topically applied to the intact ocular surface are taken up by epithelial and stromal cells. Read More

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December 2020

Long term observation of ocular surface alkali burn in rabbit models: Quantitative analysis of corneal haze, vascularity and self-recovery.

Exp Eye Res 2021 Apr 2;205:108526. Epub 2021 Mar 2.

Stem Cell Laboratory, Prof. Brien Holden Eye Research Center, L V Prasad Eye Institute, Hyderabad, Telangana, India; Center for Ocular Regeneration (CORE), LV Prasad Eye Institute, Hyderabad, Telangana, India. Electronic address:

Limbal Stem Cell Deficiency (LSCD), caused due to corneal injury, primarily by chemical/alkali burns, leads to compromised vision. Recently, several animal models of corneal alkali burn injury have become available. The majority of the studies with these animal models start interventions soon after the injury. Read More

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Heparin-Modified Amniotic Membrane Combined With Growth Factors for Promoting Corneal Wound Healing After Alkali Burn.

Front Bioeng Biotechnol 2020 23;8:599800. Epub 2020 Nov 23.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Ocular chemical burns are potentially blinding ocular injuries and require urgent management. Amniotic membrane (AM) transplantation is an effective surgical treatment, one of the reasons is because AM is a rich source of growth factors that can promote epithelialization and wound healing. However, growth factors will be gradually lost and insufficient after preparation process and long-time storage, leading to unsatisfactory therapeutic effects. Read More

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November 2020

Subconjunctival Injection of Regulatory T Cells Potentiates Corneal Healing Via Orchestrating Inflammation and Tissue Repair After Acute Alkali Burn.

Invest Ophthalmol Vis Sci 2020 Dec;61(14):22

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Purpose: This study aimed to investigate the therapeutic effects and underlying mechanisms of locally delivered regulatory T cells (Tregs) on acute corneal wound healing after alkali burn.

Methods: After corneal alkali burn, the mice were injected subconjunctivally with regulatory T cells (Tregs) isolated from syngeneic mice. The wound healing process was monitored by clinical manifestation, flow cytometry, and enzyme-linked immunosorbent assay (ELISA). Read More

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December 2020

Amniotic membrane transplant in acute ocular surface burns in Western India: A tertiary eye care center study.

Indian J Ophthalmol 2021 01;69(1):58-64

Cornea Department, M and J Institute of Ophthalmology (Government Eye Hospital), B.J. Medical College, Ahmedabad, Gujarat, India.

Purpose: To evaluate the outcomes of early amniotic membrane transplant (AMT) in acute ocular surface burns using Dua's classification.

Methods: In this retrospective analysis conducted at a tertiary eye care center in Western India. We included 27 eyes of 24 patients from May 2014 to May 2019 who underwent AMT within 2 weeks post insult along with medical treatment for acute ocular surface burns using Dua's classification for grading on presentation. Read More

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January 2021

Alkali Burn Over a LASIK Flap.

Cornea 2020 Dec 3. Epub 2020 Dec 3.

Department of Ophthalmology, Mayo Clinic, Rochester, MN.

Purpose: To describe the management and outcome of an ocular surface alkali burn in the setting of previous laser in situ keratomileusis (LASIK).

Methods: This is a case report and review of relevant literature.

Results: A 25-year-old man with a history of LASIK presented 4 weeks after a sodium hydroxide splash to his left eye with visual acuity of 20/60 and a nonhealing epithelial defect adjacent to sectoral inferior limbal ischemia in the setting of trichiasis from upper eyelid cicatricial entropion. Read More

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December 2020

Subconjunctival injection of tumor necrosis factor-α pre-stimulated bone marrow-derived mesenchymal stem cells enhances anti-inflammation and anti-fibrosis in ocular alkali burns.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 25;259(4):929-940. Epub 2020 Nov 25.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China.

Purpose: To investigate the therapeutic effect of subconjunctival injection of tumor necrosis factor-α (TNF-α) pre-stimulated bone marrow-derived mesenchymal stem cells (BMMSCs) on ocular alkali burns in a rat model.

Methods: After applying a 6 mm filter paper soaking in 1 N NaOH on the cornea of rats, the suspension of TNF-α pre-stimulated BMMSCs, BMMSCs and PBS were given subconjunctivally and respectively. Corneal epithelial defect, corneal opacity, inflammation as well as PTGS2 and TSG-6 expression on day 7 and fibrosis on day 14 were compared. Read More

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Experimental Mouse Models of Ragweed- and Papain-Induced Allergic Conjunctivitis.

Methods Mol Biol 2021 ;2223:133-149

Laboratory of System Biology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Mouse models of allergic conjunctivitis mimic various aspects of human allergic conjunctivitis. They are useful as acute models of allergic conjunctivitis to study immunological aspects of this condition. In this chapter, we will describe ragweed-pollen-induced experimental allergic conjunctivitis (mostly driven by adaptive immunity), and papain-soaked contact lens-induced experimental allergic conjunctivitis (mostly driven by innate immunity). Read More

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Ocular Inserts of Voriconazole-Loaded Proniosomal Gels: Formulation, Evaluation and Microbiological Studies.

Int J Nanomedicine 2020 12;15:7825-7840. Epub 2020 Oct 12.

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Background: Voriconazole (VRC) is a triazole broad spectrum antifungal drug, used in the management of versatile fungal infections, particularly fungal keratitis. The obligatory use of niosomal delivery of VRC may reduce the frequency of dosing intervals resulting from its short biological half time and consequently improve patient compliance.

Methods: VRC loaded proniosomes (VRC-PNs) were set by the coacervation technique and completely characterized. Read More

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November 2020

Gelatin methacryloyl hydrogel eye pad loaded with amniotic extract prevents symblepharon in rabbit eyes.

Eur Rev Med Pharmacol Sci 2020 10;24(19):10134-10142

Eye Hospital, Nanjing Medical University, Nanjing, China.

Objective: The aim was to evaluate the ability of gelatin methacryloyl (GelMA) hydrogel eye pads loaded with amniotic extract to prevent symblepharon in rabbits.

Materials And Methods: Forty-eight rabbits were divided into 3 groups. After ocular alkali burn, Group A (n=16) was treated with amniotic extract-loaded hydrogel eye pads placed in the conjunctival sac, Group B (n=16) was treated with amniotic membrane transplantation, and Group C (n=16) received no treatment. Read More

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October 2020

Assault-related severe ocular chemical injury at a London ophthalmic referral hospital: a 3-year retrospective observational study.

BMJ Open 2020 10 19;10(10):e038109. Epub 2020 Oct 19.

National Institute of Health Research (NIHR) Biomedical Research Centre, University College London Institute of Ophthalmology, London, UK.

Objectives: To understand the incidence, causes, management and outcomes of intentional (assault) and unintentional severe ocular chemical injuries (SOCI) at an urban tertiary referral centre in the UK.

Design: Retrospective observational study.

Setting: A London tertiary referral ophthalmic centre, Moorfields Eye Hospital. Read More

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October 2020

Moxifloxacin based axially swept wide-field fluorescence microscopy for high-speed imaging of conjunctival goblet cells.

Biomed Opt Express 2020 Sep 6;11(9):4890-4900. Epub 2020 Aug 6.

Department of Mechanical Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-gu, Pohang, Gyeongbuk 37673, South Korea.

Goblet cells (GCs) in the conjunctiva are specialized epithelial cells producing mucins on the ocular surface. GCs play important roles in maintaining homeostasis of the ocular surface, and GC dysfunction is associated with various complications including dry eye diseases. Current GC examination methods, which are conjunctival impression cytology and confocal reflection microscopy, have limitations for routine examination. Read More

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September 2020

DCZ3301, an aryl-guanidino agent, inhibits ocular neovascularization via PI3K/AKT and ERK1/2 signaling pathways.

Exp Eye Res 2020 12 26;201:108267. Epub 2020 Sep 26.

Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, And Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, China. Electronic address:

Neovascularization is a critical process in the pathophysiology of neovascular eye diseases. Although anti-VEGF therapy has achieved remarkable curative effects, complications, limited efficacy and drug resistance remain the prominent problems. DCZ3301, an aryl-guanidino compound, was reported to have anti-tumor activity in the previous studies. Read More

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December 2020

Conjunctival limbal autografting (CLAU) combined with customised simple limbal epithelial transplantation (SLET) in a severe corneal chemical burn: Case report.

Am J Ophthalmol Case Rep 2020 Dec 28;20:100906. Epub 2020 Aug 28.

Department of Ophthalmology, Adolphe de Rothschild Foundation, Paris, France.

Purpose: The most common cause of severe limbal stem cell deficiency (LSCD) is chemical injury. We report a case of severe unilateral alkali injury complicated by total LSCD, treated with customized Simple limbal epithelial transplantation (SLET) combined with conjunctival-limbal autografting (CLAU).

Observation: A 23-year-old female sustained a severe unilateral alkali chemical injury, resulting in total LSCD, treated with customized SLET combined with CLAU. Read More

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December 2020

Management Strategies of Ocular Chemical Burns: Current Perspectives.

Clin Ophthalmol 2020 15;14:2687-2699. Epub 2020 Sep 15.

Ocular Trauma and Emergency Department, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Ocular chemical burns are absolute ophthalmic emergencies and require immediate management to minimize devastating sequelae. Management of alkali and acid burns is started at the scene of the accident by copious irrigation. Treatment is directed at improving epithelial integrity and stromal stability, reduction of undue inflammation, and prevention or timely management of complications. Read More

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September 2020

A rare presentation of ocular lime injury.

BMJ Case Rep 2020 Sep 7;13(9). Epub 2020 Sep 7.

Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India

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September 2020

Microporous Drug Delivery System for Sustained Anti-VEGF Delivery to the Eye.

Transl Vis Sci Technol 2020 07 2;9(8). Epub 2020 Jul 2.

Boston Keratoprosthesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear and Schepens Eye Research Institute, Boston, MA, USA.

Purpose: To describe a novel microporous drug delivery system (DDS) for sustained anti- vascular endothelial growth factor (VEGF) delivery to the eye and to evaluate its efficacy in a corneal injury model.

Methods: A macro-porous DDS (1.5 × 1. Read More

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Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers.

Mol Pharm 2020 10 3;17(10):3952-3965. Epub 2020 Sep 3.

Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

Drug repositioning is an important drug development strategy as it saves the time and efforts exerted in drug discovery. Since reepithelization of the cornea is a critical problem, we envisioned that the anticonvulsant phenytoin sodium can promote reepithelization of corneal ulcers as it was repurposed for skin wound healing. Herein, our aim is to develop novel crown ether-based nanovesicles "Crownsomes" of phenytoin sodium for ocular delivery with minimal drug-induced irritation and enhanced efficacy owing to "host-guest" properties of crown ethers. Read More

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October 2020

Plasma fibroblast skin tightening treatment resulting in bilateral chemical eye injury secondary to EMLA cream: a case report.

BMC Ophthalmol 2020 Aug 24;20(1):342. Epub 2020 Aug 24.

Department of Ophthalmology, Ninewells Hospital and Medical School Dundee, Dundee, DD1 9SY, UK.

Background: Plasma fibroblast skin tightening treatment is a relatively novel and growing minimally invasive aesthetic skin procedure. The treatment claims to rejuvenate skin by improving facial lines, wrinkles and skin pigmentation associated with photo-ageing. The skin is often anaesthetised prior to the procedure with topical creams such as EMLA (Eutectic mixture of local anaesthetics). Read More

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Diagnostic testing for ocular myasthenia gravis: Stronger together.

Neurology 2020 09 11;95(13):563-564. Epub 2020 Aug 11.

From Brigham and Women's Hospital (C.T.D.); Harvard Medical School (C.T.D., A.C.G.); and Massachusetts General Hospital (A.C.G.), Boston.

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September 2020

An Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of Alkali-Induced Oxidative Stress.

Oxid Med Cell Longev 2020 21;2020:7435260. Epub 2020 Jun 21.

Institute of Experimental Medicine of the Czech Academy of Sciences, Vídenska 1083, 14220 Prague 4, Czech Republic.

Corneal alkali burns are potentially blinding injuries. Alkali induces oxidative stress in corneas followed by excessive corneal inflammation, neovascularization, and untransparent scar formation. Molecular hydrogen (H), a potent reactive oxygen species (ROS) scavenger, suppresses oxidative stress and enables corneal healing when applied on the corneal surface. Read More

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Loss of SLC9A6/NHE6 impairs nociception in a mouse model of Christianson syndrome.

Pain 2020 11;161(11):2619-2628

Department of Physiology, Cell Information Systems Group, McGill University, Montreal, QC, Canada.

Children diagnosed with Christianson syndrome (CS), a rare X-linked neurodevelopmental disorder characterized by intellectual disability, epilepsy, ataxia, and mutism, also suffer from hyposensitivity to pain. This places them at risk of sustaining serious injuries that often go unattended. Christianson syndrome is caused by mutations in the alkali cation/proton exchanger SLC9A6/NHE6 that regulates recycling endosomal pH homeostasis and trafficking. Read More

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November 2020

A case of the blues: Inadvertent ocular injury from accidental instillation of blue ink.

Am J Ophthalmol Case Rep 2020 Sep 10;19:100773. Epub 2020 Jun 10.

Department of Ophthalmology, Weill Cornell Medical College, 1305 York Avenue, New York, NY, 10021, USA.

Purpose: Many consumer products and non-ophthalmic medications are packaged in plastic "eye dropper" bottles, posing a risk of accidental ocular chemical injury when these substances are mistaken for eye drops.

Observations: We present the case of an elderly glaucoma patient who mistook blue stamper ink for the glaucoma medication Combigan®, and suffered ocular injury as a result.

Conclusions And Importance: The packaging of non-ophthalmic products in plastic "eye dropper" bottles poses a significant risk of accidental ocular chemical injury. Read More

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September 2020

Suppression of pathological ocular neovascularization by a small molecule, SU1498.

Biomed Pharmacother 2020 Aug 23;128:110248. Epub 2020 May 23.

Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China; National Health Commission (NHC) Key Laboratory of Myopia, Fudan University, Shanghai, China. Electronic address:

Selective inhibition of vascular endothelial growth factor receptor (VEGFR), particularly VEGFR-2, is an efficient method for the treatment of ocular neovascularization. SU1498 is a specific inhibitor of VEGFR-2. In this study, we investigated the role of SU1498 in ocular neovascularization. Read More

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