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Clearance of buprenorphine during pregnancy and neonatal outcomes.

Arch Womens Ment Health 2021 Apr 16. Epub 2021 Apr 16.

Department of Psychiatry, University of Wisconsin, Madison, WI, USA.

Buprenorphine is emerging as the preferred pharmacologic treatment for opioid use disorder during pregnancy. We examined the relative plasma clearance of buprenorphine (BUP) across pregnancy. Pregnant women with opioid use disorder participating in a prospective, observational study from 2013 to 2016 on stress in pregnancy who were receiving BUP for opioid use disorder were included. Read More

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Corrected QT Interval Prolongation in Pediatric and Young Adult Patients on Methadone for Cancer-Related Pain.

J Pain Symptom Manage 2019 10 11;58(4):678-684. Epub 2019 Jun 11.

Department of Palliative, Rehabilitation and Integrative Medicine, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA.

Context: Methadone has been reported to prolong the corrected QT (QTc) interval and increase the risk of torsades de pointes.

Objectives: Our study examined the frequency of QTc prolongation among pediatric and young adult patients starting methadone for cancer pain.

Methods: All patients followed a standardized protocol. Read More

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October 2019

Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye.

Exp Eye Res 2014 Aug 14;125:1-8. Epub 2014 May 14.

School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan West Road, Wenzhou, Zhejiang 325027, China. Electronic address:

Tear film hyperosmolarity along with exposure to oxidant stress are factors that can induce chronic ocular surface inflammation and pain. However, there is limited information on how increases in reactive oxygen species (ROS) generated by oxidant exposure can induce inflammation. There is emerging evidence in other tissues that innate immune responses to a variety of environmental stresses stem from ROS-induced cytosolic NLRP3 inflammasome activation. Read More

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Acute and chronic pain in calves after different methods of rubber-ring castration.

Vet J 2012 Dec 28;194(3):380-5. Epub 2012 May 28.

Clinic for Ruminants, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 109a, PO Box 8466, 3001 Berne, Switzerland.

The goal of the present study was to evaluate the effect of different methods of rubber-ring castration on acute and chronic pain in calves. Sixty-three 4-6 week-old calves were randomly and sequentially allocated to one of five groups: Group RR (traditional rubber ring castration); group BRR (combination of one rubber ring with Burdizzo); group Rcut (one rubber ring applied with the scrotal tissue and rubber ring removed on day 9); group 3RR (three rubber rings placed one above the other around the scrotal neck); and group CO (controls; sham-castrated). All calves received 0. Read More

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December 2012

Hepatic encephalopathy in two goat kids with common paternity.

J Vet Diagn Invest 2008 Nov;20(6):807-11

Colorado State University, Fort Collins, CO 80523-1619, USA.

Two juvenile, intact, female mixed-breed goats from a common sire were presented for periodic neurologic deficits, seizures, and a generalized loss of body condition that occurred over a 4-6-week period. On physical examination, both goats were thin, obtunded, blind, and ataxic. Laboratory diagnostics revealed increased serum bile acids (95 micromol/l; reference interval: 0-50 micromol/l) in one of the goats. Read More

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November 2008

Phase II study of hepatic arterial infusion of a fine-powder formulation of cisplatin for advanced hepatocellular carcinoma.

Hepatol Res 2008 May;38(5):474-83

Department of Medicine and Clinical Oncology, Chiba University, Chiba, Japan.

Aim: Intra-arterial cisplatin appears to have high therapeutic efficacy, but this has not been studied in detail. Accordingly, we developed a fine-powder cisplatin formulation and tested it in advanced hepatocellular carcinoma (HCC) patients in an open-label, uncontrolled study in which 27 institutions participated.

Methods: The patients in this study had inoperable advanced HCC without extrahepatic metastases. Read More

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[Lymphosarcoma of abdominal lymph nodes in children].

Georgian Med News 2006 Jan(130):41-4

We investigated 79 patients (76.0%) with lymphosarcoma of abdominal lymph nodes among all 104 with general abdominal lymphosarcoma. Ultrasound tomography was used in 98. Read More

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January 2006

Bacteriological outcome after valve surgery for active infective endocarditis: implications for duration of treatment after surgery.

Clin Infect Dis 2005 Jul 7;41(2):187-94. Epub 2005 Jun 7.

Department of Microbiology, Green Lane Hospital, Auckland, New Zealand.

Background: There has been no systematic evaluation of outcome after surgery for infective endocarditis with respect to duration of antibiotic treatment.

Methods: We performed a retrospective chart review of episodes of valve surgery for active infective endocarditis at Green Lane Hospital (Auckland, New Zealand) for 1963-1999. We recorded the duration of antibiotic treatment before and after valve surgery; the extent of infection at operation; Gram stain, culture, and histopathological testing results for valve samples; and the bacteriological outcome after surgery. Read More

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Prolonged dystrophin expression and functional correction of mdx mouse muscle following gene transfer with a helper-dependent (gutted) adenovirus-encoding murine dystrophin.

Hum Mol Genet 2003 Jun;12(11):1287-99

Neuromuscular Research Group, Montreal Neurological Institute, McGill University, Montréal, Québec, Canada H3A 2B4.

Dystrophin gene transfer using helper-dependent adenoviruses (HDAd), which are deleted of all viral genes, is a promising option to treat muscles in Duchenne muscular dystrophy. We investigated the benefits of this approach by injecting the tibialis anterior (TA) muscle of neonatal and juvenile (4-6-week-old) dystrophin-deficient (mdx) mice with a fully deleted HDAd (HDCBDysM). This vector encoded two full-length murine dystrophin cDNAs regulated by the powerful cytomegalovirus enhancer/beta-actin promoter. Read More

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Long-term control of T2-T3 rectal adenocarcinoma with radiotherapy alone.

Int J Radiat Oncol Biol Phys 2002 Sep;54(1):142-9

Service de Radiothérapie-Oncologie, Centre Hospitlier Lyon Sud, Lyon, France.

Purpose: To analyze the long-term result of patients presenting with T2-T3 rectal adenocarcinoma treated with curative intent by radiotherapy (RT) alone, using a combination of contact RT, external beam RT, and brachytherapy with an iridium implant. Patients were considered unsuitable for surgery because of the presence of severe comorbidity or because they did not consent to surgery and the possibility of a permanent stoma.

Methods And Materials: Between 1986 and 1998, 63 patients (56 staged with endorectal ultrasonography) were entered into a pilot study. Read More

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September 2002

Immunogenicity and reactogenicity of acellular diphtheria/tetanus/pertussis vaccines given as a pre-school booster: effect of simultaneous administration of MMR.

Vaccine 2001 Jul;19(28-29):3904-11

Immunisation Division, PHLS Communicable Disease Surveillance Centre, 61 Colindale Avenue, London NW9 5EQ, UK.

Four acellular diphtheria/tetanus/pertussis (aDTP) vaccines were compared with two diphtheria/tetanus (DT) vaccines given as a pre-school booster to 1033 children aged 4 to < 6 years who had completed primary immunisation with DTP vaccine according to the UK 2, 3 and 4 month schedule; 71 children had received aDTP vaccine and the remaining 962 a whole cell DTP vaccine for primary immunisation. The effect of simultaneous administration of a second dose of MMR vaccine was evaluated in 374 (37%). Overall, there was little difference in the frequency of post-vaccination symptoms in DT and aDTP vaccinees, although local reactions occurred more quickly in the aDTP group. Read More

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Use of sentinel lambs to survey the effect of an education programme on control of transmission of Echinococcus granulosus in South Powys, Wales.

Bull World Health Organ 1998 ;76(5):469-73

Department of Clinical Veterinary Medicine, University of Cambridge, England.

In this article the effects of an education programme (area II) on transmission of Echinococcus granulosus from dogs to sheep in Wales and of substitution of the education programme by a 6-weekly anthelmintic control programme (area I) are compared with the situation in an area where no control interventions had occurred (area III). The education programme failed to prevent transmission of E. granulosus to sentinel lambs examined at 15 months of age, 6%, 4%, and 10% of which were infected in areas I, II, and III, respectively. Read More

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January 1999

Lumbar transplants of immortalized serotonergic neurons alleviate chronic neuropathic pain.

Pain 1997 Aug;72(1-2):59-69

The Miami Project To Cure Paralysis, University of Miami School of Medicine, FL 33136, USA.

The RN46A cell line was derived from embryonic day 13 rat medullary raphe cells by infection with a retrovirus encoding the temperature-sensitive mutant of SV40 large T antigen. This cell line is neuronally restricted and constitutively differentiates following a shift to non-permissive temperature. Brain-derived neurotrophic factor (BDNF) induced the serotonergic phenotype and increased the survival of RN46A cells in vitro. Read More

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Long-term intrathecal infusion of morphine in the home care of patients with advanced cancer.

Acta Anaesthesiol Scand 1997 Jan;41(1 Pt 1):12-7

Montpellier Cancer Institute Val d'Aurelle, France.

Background: Fear of infections and other complications has made many clinicians avoid intrathecal application of morphine in chronic cancer pain. However, recent comparative studies show that, in long-term treatment, intrathecal morphine administration may give a more satisfactory pain relief with lower doses of morphine and fewer side-effects than epidural administration. In Montpellier Cancer Institute, first cancer pain patients received long-term intrathecal morphine as early as in 1979, and since then more than 400 patients have been treated. Read More

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January 1997

A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia.

Arthritis Rheum 1996 Nov;39(11):1852-9

Newton-Wellesley Hospital, Massachusette, USA.

Objective: To study the effect of fluoxetine (FL) and amitriptyline (AM), alone and in combination, in patients with fibromyalgia (FM).

Methods: Nineteen patients with FM completed a randomized, double-blind crossover study, which consisted of 4 6-week trials of FL (20 mg), AM (25 mg), a combination of FL and AM, or placebo. Patients were evaluated on the first and last day of each trial period. Read More

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November 1996

[Successive ischemic events to a first acute myocardial infarct treated with fibrinolysis. An analysis of GISSI-2 patients considered reperfused by a clinical criterion. Participants in the GISSI-2 study. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico].

G Ital Cardiol 1995 Apr;25(4):463-72

Divisione di Cardiologia, Ospedale Fornaroli, Magenta, Milano.

Background: The fast normalisation of the ST, after thrombolysis, is early sign related to coronary artery reperfusion and to prognosis of acute myocardial infarction (AMI). The aim of this analysis is the evaluation, in the large patients cohort of the GISSI-2 trial, of the relationship between the ST segment evolution after fibrinolytic therapy of AMI and recurrent ischaemic events [angina-reinfarction-ischaemia to exercise testing (ET)] at 30 and 180 days from randomisation.

Methods: Patients with first confirmed IMA and ECG before randomisation and 4 hours later, are chosen from GISSI-2 trial. Read More

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A multicenter study of lomefloxacin and trimethoprim/sulfamethoxazole in the treatment of uncomplicated acute pyelonephritis.

Am J Med 1992 Apr;92(4A):87S-90S

Service des Maladies Infectieuses, Centre Hospitalier de Tourcoing, France.

A total of 63 adult patients with uncomplicated acute pyelonephritis were enrolled in a multicenter, randomized comparison of lomefloxacin (400 mg orally once daily for 14 days) and trimethoprim/sulfamethoxazole (TMP/SMX, 160/800 mg orally twice daily for 14 days). Study participants were predominantly female (70% in the lomefloxacin group and 80% in the TMP/SMX group). Escherichia coli was isolated from pretreatment urine cultures in 87. Read More

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Isolation of short-wavelength-sensitive cone photoreceptors in 4-6-week-old human infants.

Vision Res 1987 ;27(3):469-78

Department of Psychology, University of Colorado, Boulder 80309.

Spectral sensitivity was measured for nine infants, 4-6 weeks of age, and three adults under conditions of chromatic adaptation chosen to reveal the presence of short-wavelength-sensitive cones. Monochromatic test stimuli (400-550 nm) were presented at 2 Hz superimposed on a broadband, yellow background. Following 4 min of adaptation to the background, test stimuli were presented while recording the steady-state, visually-evoked cortical potential (VECP). Read More

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November 1987

Association between regularly occurring complex partial seizures and thyroid function parameters.

Epilepsia 1986 Jul-Aug;27(4):419-22

A 28-year-old man with regularly occurring clusters of complex partial seizures was studied over a total of 224 days. His seizure periods lasted 2-4 days and occurred at intervals of 5-6 weeks. Several parameters were studied. Read More

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Myocardial infarction in the guinea pig: cellular electrophysiology.

Life Sci 1985 Jun;36(25):2391-401

The cellular electrophysiology of left ventricular preparations from guinea pig hearts was studied 1 hour, 24 hours, and 4-6 weeks after myocardial infarction produced by 6-8 single ties of the distal left coronary artery system or after sham operation. Microelectrode recordings were used to monitor cells from the endocardial surface of each preparation in tissue bath. All coronary ligated preparations displayed accelerated spontaneous activity compared to normal and sham operated preparations. Read More

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Citalopram, a selective serotonin reuptake inhibitor: clinical antidepressive and long-term effect--a phase II study.

Psychopharmacology (Berl) 1982 ;77(3):199-204

In a phase II study the antidepressive effect of citalopram, a selective and potent serotonin reuptake inhibitor, was examined in 20 endogenously and three non-endogenously depressed hospitalized patients. Four endogenously depressed patients dropped out due to deterioration early in the treatment period. The remaining 19 patients completed a 4-6 week treatment schedule. Read More

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December 1982

Changes of water-relation characteristics and levels of organic cytoplasmic solutes during salinity induced transition of Mesembryanthemum crystallinum from C-photosynthesis to crassulacean acid metabolism.

Oecologia 1981 Aug;50(1):66-72

Adran Biocemeg A Gwyddor Pridd, Coleg Prifysgol Gogledd Cymru, Ffordd Deiniol, UK, LL57 2UW, Bangor, Gwynedd, United Kingdom.

NaCl was added to the nutrient solution of 4-6-week old Mesembryanthemum crystallinum plants so that the concentration rose by 50 mM per day. Ten to fifteen days after a concentration of 400 mM was reached, pronounced diurnal oscillations of malate levels indicated that plants had changed from C-photosynthesis to crassulacean acid metabolism (CAM). Due to the NaCl-treatment the solute potential (Ψ) decreased from about -6 bar to -25 bar, and the water potential (Ψ) changed from about -5 bar to -23 bar on average. Read More

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TRH test as an index of suppression compared with the thyroid radioiodine uptake in euthyroid goitrous patients treated with thyroxine.

J Clin Endocrinol Metab 1978 Jul;47(1):78-83

To determine an index of adequate suppression of pituitary TSH secretion in euthyroid goitrous patients treated with sodium levothyroxine (T4), TSH responses to 500 micrograms TRH given iv were compared with thyroid 24-h radioiodine uptakes during therapy with T4 in 12 euthyroid goitrous patients. The patients received sequentially 100, 150, 200, 250, and 300 micrograms T4 with the doses increased at 4-6 week intervals. The mean dose of T4 that reduced the peak TSH response to TSH to the lower limit of normal (TSH = 5 microU/ml) was 130 micrograms; the mean T4 dose that suppressed the TSH response to one-half the lower limit of normal (TSH = 2. Read More

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[Results of a trial of a coronary therapeutic agent, Adalat (author's transl)].

Authors:
M Wildenhues

MMW Munch Med Wochenschr 1977 Feb;119(7):233-4

This report concerns data on 54 patients with coronary heart disease. With a 4-6 week treatment with 3 X 1 capsule Adalat daily, the attacks of angina pectoris fell from 1-7 daily to 1-2 per week. In more than 50% of the subjects, no more attacks occurred. Read More

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February 1977
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