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Legg-Calvé-Perthes disease following Ender nail fixation of a pediatric femoral fracture.

Int J Surg Case Rep 2021 Jul 17;85:106209. Epub 2021 Jul 17.

Department of Orthopaedic Surgery, Jichi Medical University, Tochigi, Japan.

Introduction And Importance: Legg-Calvé-Perthes disease (LCPD) sometimes occur in children, however it is difficult to diagnose it at the early stage especially in the cases there are no complaints of symptoms. Femoral shaft fractures in children cause various complications such as leg-length discrepancy, nonunion and malunion, refracture, and osteonecrosis of the femoral head. We presented a rare case in which a pediatric patient developed LCPD after femoral shaft fracture. Read More

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Deletion of muscle Igf1 exacerbates disuse atrophy weakness in mice.

J Appl Physiol (1985) 2021 07 22. Epub 2021 Jul 22.

Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, United States.

Muscle atrophy occurs as a result of prolonged periods of reduced mechanical stimulation associated with injury or disease. The growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and load sensing pathways can both aid in recovery from disuse through their shared downstream signaling, but their relative contributions to these processes are not fully understood. The goal of this study was to determine if reduced muscle IGF-1 altered the response to disuse and reloading. Read More

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AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.

Blood 2021 Jul;138(3):246-258

Research Laboratory on Chronic Lymphocytic Leukemia, Institut Pasteur de Montevideo, Montevideo, Uruguay.

Most cancers become more dangerous by the outgrowth of malignant subclones with additional DNA mutations that favor proliferation or survival. Using chronic lymphocytic leukemia (CLL), a disease that exemplifies this process and is a model for neoplasms in general, we created transgenic mice overexpressing the enzyme activation-induced deaminase (AID), which has a normal function of inducing DNA mutations in B lymphocytes. AID not only allows normal B lymphocytes to develop more effective immunoglobulin-mediated immunity, but is also able to mutate nonimmunoglobulin genes, predisposing to cancer. Read More

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Exsanguination From Superficial Lower Extremity Trauma.

Am J Forensic Med Pathol 2021 Jul 21. Epub 2021 Jul 21.

From the Philadelphia College of Osteopathic Medicine-South Georgia, Moultrie, GA Department of General Surgery, Huntington Memorial Hospital, University of Southern California, Pasadena, CA Department of Pathology, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI.

Abstract: Deaths related to exsanguination are not rare; however, most are related to large-caliber blood vessel or organ disruption. This article reports 2 deaths from external hemorrhage arising from superficial lower extremity trauma in persons with peripheral vascular disease and anticoagulant therapy. The first involved a 78-year-old woman who was found unconscious in her home by a relative, with a plastic bag tied around her left foot and evidence of profuse hemorrhage arising from a left great toenail partial avulsion injury. Read More

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Response of gene regulatory networks after infection of H3N2 virus.

J Bioinform Comput Biol 2021 Jul 21:2150017. Epub 2021 Jul 21.

Department of Systems Science, University of Shanghai for Science and Technology, Jungong Road, No. 516, Shanghai 200093, P. R. China.

Viral infection is a complicated dynamic process, in which viruses intrude into cells to duplicate themselves and trigger succeeding biological processes regulated by genes. It may lead to a serious disaster to human's health. A scheme is proposed to monitor the response of cells after being infected by viruses. Read More

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Disseminated intravascular coagulation complicating diagnosis of ROS1-mutant non-small cell lung cancer: A case report and literature review.

Thorac Cancer 2021 Jul 22. Epub 2021 Jul 22.

Department of Medical Oncology, St George Cancer Care Centre, Kogarah, New South Wales, Australia.

Disseminated intravascular coagulation (DIC) is a rare paraneoplastic complication in advanced solid malignancies, with success of treatment and survival dependent on treatment of the underlying malignancy. Best estimates suggest an incidence of 1.6-6. Read More

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Osteonecrosis of the jaw: a rare but possible side effect in thyroid cancer patients treated with tyrosine-kinase inhibitors and bisphosphonates.

J Endocrinol Invest 2021 Jul 21. Epub 2021 Jul 21.

Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

Osteonecrosis of the jaw (ONJ) is a rare but very serious disease that can affect both jaws. It is defined as exposed bone in the maxillofacial region that does not heal within 8 weeks after a health care provider identification. ONJ can occur spontaneously or can be due to drugs like bisphosphonates (BPS) and anti-RANK agents, in patients with no history of external radiation therapy in the craniofacial region. Read More

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Possible Vertical Transmission From an Unsuspected SARS-CoV-2-Infected Mother to Her Newborn.

Cureus 2021 Jun 17;13(6):e15717. Epub 2021 Jun 17.

Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, USA.

Although the Coronavirus Disease 2019 (COVID-19) has been found to have multiple routes of transmission, limited data exist on whether the vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur from asymptomatic infected mothers to their newborns during pregnancy. We report a full-term newborn girl who was found to be positive for COVID-19 at 24 hours of life and subsequently symptomatic with fever, tachycardia, tachypnea, elevated lactate dehydrogenase, and elevated total bilirubin. The newborn was delivered by a mother who was not suspected of having COVID-19 before giving birth, but who developed fever and dyspnea five hours after delivery and was found to be positive for COVID-19. Read More

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Identification of Causal Genes of COVID-19 Using the SMR Method.

Authors:
Yan Zong Xiaofei Li

Front Genet 2021 5;12:690349. Epub 2021 Jul 5.

Department of Infectious Diseases, Yiwu Central Hospital, Jinhua, China.

Since the first report of COVID-19 in December 2019, more than 100 million people have been infected with SARS-CoV-2. Despite ongoing research, there is still limited knowledge about the genetic causes of COVID-19. To resolve this problem, we applied the SMR method to analyze the genes involved in COVID-19 pathogenesis by the integration of multiple omics data. Read More

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Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review.

Front Endocrinol (Lausanne) 2021 29;12:681649. Epub 2021 Jun 29.

Endocrine and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

Background: Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be partially accountable for the observed phenotypic variability. Read More

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I Feel Like I Am Flying and Full of Life: Contemporary Dance for Parkinson's Patients.

Front Psychol 2021 5;12:623721. Epub 2021 Jul 5.

The School of Creative Arts Therapies, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.

Parkinson's is a neurodegenerative disease characterized by motor and non-motor symptoms which are strongly associated with patients' quality of life, affecting social skills and support. It strikes not only the motor abilities but may harm cognitive and emotional functioning. For the past 15 years, contemporary dance has been employed as an intervention to help people diagnosed with Parkinson's disease cope physically and mentally by way of motor, vestibular, and sensory stimulation as well as social interaction. Read More

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Diabetic Retinopathy in the Aging Population: A Perspective of Pathogenesis and Treatment.

Clin Interv Aging 2021 15;16:1367-1378. Epub 2021 Jul 15.

Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University, Indianapolis, IN, USA.

The elderly population in the United States is projected to almost double by the year 2050. In addition, the numbers of diabetics are rising, along with its most common complication, diabetic retinopathy (DR). To effectively treat DR within the elderly population, it is essential first to consider the retinal changes that occur due to aging, such as decreased blood flow, retinal thinning, and microglial changes, and understand that these changes can render the retina more vulnerable to oxidative and ischemic damage. Read More

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Clinical characteristics of Rocky Mountain spotted fever in the United States: A literature review.

J Vector Borne Dis 2020 Apr-Jun;57(2):114-120

Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background And Objectives: Rocky Mountain spotted fever (RMSF) is a rapidly progressive and potentially fatal tickborne disease caused by Rickettsia rickettsii. Despite current recommendations and information on the severity of RMSF, studies show that delayed recognition and treatment continues to occur.

Methods: A literature search was performed on cases published in English between 1990-2017. Read More

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Avapritinib: an emerging new therapy for systemic mastocytosis.

Expert Rev Hematol 2021 Jul 21. Epub 2021 Jul 21.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Introduction: Systemic mastocytosis (SM) is a rare myeloid neoplasm driven in ≈95% of cases by activating mutations, usually D816V. SM can be indolent (ISM), smoldering (SSM) and advanced (AdvSM), the latter characterized by organ damage resulting from infiltrating neoplastic mast cells. The vast majority of cases are indolent, with near-normal life expectancy, although symptoms can be severe. Read More

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Catheter-related blood stream infection in hemodialysis patients with symmetric tunneled non-side-hole hemodialysis catheters.

J Vasc Access 2021 Jul 21:11297298211027058. Epub 2021 Jul 21.

Department of Medicine, University of Michigan, Ann Arbor, MI, USA.

Background: Tunneled hemodialysis catheter-related bloodstream infection is a major cause of morbidity and mortality in end-stage renal disease patients. Side holes positioned near the tip of catheters have been linked to formation of thrombi, which, in turn, have been implicated in predisposition to infection. In addition, side holes allow spillage of catheter locking solution, including antibiotics, thereby minimizing the lock solution's effect on the catheter tip. Read More

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Late presentation of chronic hepatitis C patients in the era of direct acting antivirals - Data from the German Hepatitis C-Registry.

J Viral Hepat 2021 Jul 21. Epub 2021 Jul 21.

Leberstiftungs-GmbH Deutschland, Hannover.

Late presentation for care in chronic viral hepatitis has been estimated to occur in approximately 25% of patients initiating treatment with direct acting antivirals. We evaluated the extent of late presentation since the implementation of direct acting antivirals and established differences between HCV monoinfected and HIV/HCV coinfected patients. The German Hepatitis C Registry is a multicenter non-interventional registry study. Read More

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Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice.

Am J Physiol Cell Physiol 2021 07 21. Epub 2021 Jul 21.

Division of Hematology/Oncology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, Rhode Island, United States.

Rheumatoid arthritis (RA) is a debilitating autoimmune disease of unknown cause, characterized by infiltration and accumulation of activated immune cells in the synovial joints where cartilage and bone destructions occur. Myeloid-derived suppressor cells (MDSCs) are of myeloid origin and are able to suppress T cell responses. Src homology 2 domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) was shown to be involved in the regulation of MDSC differentiation. Read More

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A simplified diagnostic pathway for the differential diagnosis of iron deficiency anaemia and anaemia of chronic disease.

Int J Lab Hematol 2021 Jul 20. Epub 2021 Jul 20.

Centre for Bioscience, Manchester Metropolitan University, Manchester, UK.

Introduction: Iron deficiency anaemia (IDA) and anaemia of chronic disease (ACD) are common causes of anaemia with similar clinical and laboratory features. IDA is caused by low iron stores while ACD is due to iron-restricted erythropoiesis occurring in inflammatory states. Differential diagnosis requires analysis of multiple biochemical and haematological parameters. Read More

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Articular cartilage thickness changes differ between males and females four years following anterior cruciate ligament reconstruction.

J Orthop Res 2021 Jul 20. Epub 2021 Jul 20.

Department of Rehabilitation and Movement Science, College of Nursing and Health Sciences, Univ of Vermont.

Anterior cruciate ligament injury and reconstruction (ACLR) affects articular cartilage thickness profiles about the tibial, femoral, and patellar surfaces; however, it's unclear whether the magnitudes of change in cartilage thickness, as well as the locations and areas over which these changes occur, differ between males and females. This is important to consider as differences exist between the sexes with regard to knee biomechanics, patellofemoral pain, and anatomic alignment, which influence risk of an index and repeated injury. Subjects underwent ACLR with a bone-patella tendon-bone autograft. Read More

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The Tele-STELLA protocol: Telehealth-based support for families living with later-stage Alzheimer's disease.

J Adv Nurs 2021 Jul 20. Epub 2021 Jul 20.

Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland, OR, USA.

Aims: We aim to establish the feasibility and acceptability of the Tele-STELLA (Support via Telehealth: Living and Learning with Advancing Alzheimer's Disease and Related Dementias) intervention. We will also assess the efficacy of the intervention in reducing the frequency of behavioural symptoms of dementia as well as family Care Partner reactivity to the symptoms.

Design: This is a multi-component, quasi-experimental study that focuses on facilitating effective management of behavioural symptoms that occur in the later stages of dementia. Read More

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Prevalence of Malaria and Leptospirosis Co-Infection among Febrile Patients: A Systematic Review and Meta-Analysis.

Trop Med Infect Dis 2021 Jul 3;6(3). Epub 2021 Jul 3.

Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat 80161, Thailand.

Malaria and leptospirosis are important cosmopolitan infections that have emerged with overlapping geographic distribution, especially in tropical and subtropical regions. Therefore, co-infection with malaria and leptospirosis may occur in overlapping areas. The present study aimed to quantify the prevalence of malaria and leptospirosis co-infection among febrile patients. Read More

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Current Evidence for Stereotactic Body Radiotherapy in Lung Metastases.

Curr Oncol 2021 Jul 15;28(4):2560-2578. Epub 2021 Jul 15.

Princess Margaret Cancer Centre, Radiation Medicine Program, University Health Network, Toronto, ON M5G2M9, Canada.

Lung metastases are the second most common malignant neoplasms of the lung. It is estimated that 20-54% of cancer patients have lung metastases at some point during their disease course, and at least 50% of cancer-related deaths occur at this stage. Lung metastases are widely accepted to be oligometastatic when five lesions or less occur separately in up to three organs. Read More

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Primary Localized Cutaneous Nodular Amyloidosis and Limited Cutaneous Systemic Sclerosis: Additional Cases with Dermatoscopic and Histopathological Correlation of Amyloid Deposition.

Dermatopathology (Basel) 2021 Jul 2;8(3):229-235. Epub 2021 Jul 2.

Dermatology Clinic, Department Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy.

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare condition due to the plasma cell proliferation and skin deposition of immunoglobulin light chains, without systemic amyloidosis or hematological dyscrasias. The association with autoimmune connective tissue diseases has been reported, especially with Sjogren's syndrome, and in a few cases with systemic sclerosis. Herein, we describe three cases of PLCNA occurring in women with a diagnosis of limited cutaneous systemic sclerosis and review the literature on the topic to highlight a stereotypical presentation. Read More

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Design and fabrication of a novel passive hand tremor attenuator.

J Med Eng Technol 2021 Jul 21:1-9. Epub 2021 Jul 21.

The Heart Valve Performance Laboratory, School of Engineering, Faculty of Applied Science, University of British Columbia, Kelowna, BC, Canada.

Parkinson's disease is most highly recognised by tremors of the hands that occur in those afflicted with the disease. Though the symptoms of Parkinson's disease involving motor function begin with very slight tremors of the hands, they further develop into issues such as difficulty swallowing, severe postural problems and extremely limited mobility. In this study, a method of reducing these tremors that appear during the early stages of the disease is developed by creating a wearable passive device that reduces vibrations of the hand and arm through the use of magnetic actuators. Read More

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Inactivation of SARS-CoV-2 by Simulated Sunlight on Contaminated Surfaces.

Microbiol Spectr 2021 Jul 21:e0033321. Epub 2021 Jul 21.

DGA CBRN Defence Center, Vert-le-Petit, France.

We studied the stability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) under different simulated outdoor conditions by changing the temperature (20°C and 35°C), the illuminance (darkness, 10 klx, and 56 klx), and/or the cleanness of the surfaces at 50% relative humidity (RH). In darkness, the loss of viability of the virus on stainless steel is temperature dependent, but this is hidden by the effect of the sunlight from the first minutes of exposure. The virus shows a sensitivity to sunlight proportional to the illuminance intensity of the sunlight. Read More

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What's New? Improving Home Medication Lists for Patients on Outpatient Dialysis.

Nephrol Nurs J 2021 May-Jun;48(3):251-252

Adjunct Professor, the University of Hartford, Hartford, CT.

Nursing working in outpatient hemodialysis centers face a unique set of challenges working with patients with end stage kidney disease who carry a high medication burden for their multiple chronic conditions. Patient medication lists may not always accurately reflect the entirety of medications prescribed or taken; therefore, nurses are not aware of medication changes that occur in between dialysis treatments. This places patients at risk for medication-related problems or adverse events during treatment. Read More

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Fine needle aspiration in COVID-19 vaccine-associated lymphadenopathy.

Swiss Med Wkly 2021 07 20;151:w20557. Epub 2021 Jul 20.

Department of Pathology and Molecular Pathology, University Hospital, University of Zurich, Switzerland.

Aims: With ongoing intensive vaccination programme against COVID-19, numerous cases of adverse reactions occur, some of which represent rare events. Enlargement of the injection site’s draining lymph nodes is increasingly reported, but is not yet widely recognised as being possibly associated with recent vaccination. As patients at risk of a severe course of COVID-19, indicated by their medical history such as a previous diagnosis of malignancy, receive priority vaccination, newly palpable lymph nodes raise concerns of disease progression. Read More

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Development of Machine Learning Models and the Discovery of a New Antiviral Compound against Yellow Fever Virus.

J Chem Inf Model 2021 Jul 21. Epub 2021 Jul 21.

Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States.

Yellow fever (YF) is an acute viral hemorrhagic disease transmitted by infected mosquitoes. Large epidemics of YF occur when the virus is introduced into heavily populated areas with high mosquito density and low vaccination coverage. The lack of a specific small molecule drug treatment against YF as well as for homologous infections, such as zika and dengue, highlights the importance of these flaviviruses as a public health concern. Read More

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