64,324 results match your criteria occur age

Functional connectivity of the attention networks is altered and relates to neuropsychological outcomes in children with prenatal alcohol exposure.

Dev Cogn Neurosci 2021 Apr 3;48:100951. Epub 2021 Apr 3.

Department of Radiology, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Canada.

Cognitive and functional brain alterations can occur in children with prenatal alcohol exposure (PAE). We examined the functional connectivity (FC) among regions within and between attention networks, and whether inter- and intranetwork FC moderated cognition in children with PAE (n = 37; age 12.8 ± 2. Read More

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Unique Complications and Failure Modes of Iliac Branch Devices.

Ann Vasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Department of Surgery, Division of Vascular & Endovascular Surgery, Stanford University School of Medicine, Stanford, CA.

Objectives: Iliac branch devices (IBDs) are modular, bifurcated endografts designed to preserve hypogastric flow during endovascular aortoiliac aneurysm repair. We report our single center outcomes, and describe the unique complications of these devices: inability to cannulate the hypogastric artery (technical failure), occlusion of the internal branch, and type III endoleak from separation of components between the main body and IBD.

Methods: A prospectively maintained institutional database of patients undergoing IBD implantation between 2014 and 2019 was reviewed. Read More

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A Case of Dominant Dystrophic Epidermolysis Bullosa with a G2043R Mutation in the Type VII Collagen Gene.

Acta Dermatovenerol Croat 2020 Dec;28(4):251-252

Sayaka Yamaguchi, MD, PhD, Department of Dermatology Graduate School and Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0125, Japan;

Dear Editor, Dystrophic epidermolysis bullosa (DEB) is a subepidermal bulla, characterized by severe itching, lichenoid or nodular prurigo-like lesions, skin erosion, scars, milia, and nail dystrophy, resulting from COL7A1 mutation. Herein, we report a case of dominant DEB with a G2043R mutation in COL7A1. A-25-year-old Japanese woman was referred to our clinic for recurrent intense pruritis and hypertrophic scars on the abdomen (Figure 1, a). Read More

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December 2020

Feel the Burn! Fireworks-related Otolaryngologic Trauma.

Ann Otol Rhinol Laryngol 2021 Apr 9:34894211008100. Epub 2021 Apr 9.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.

Objectives: Fireworks are used commonly for celebrations in the United States, but can lead to severe injury to the head and neck. We aim to assess the incidence, types, and mechanisms of head and neck injuries associated with fireworks use from 2010 to 2019.

Methods: A retrospective cross-sectional study, using data from the National Electronic Injury Surveillance System, of individuals presenting to United States Emergency Departments with head and neck injuries caused by fireworks and flares from 2010 to 2019. Read More

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[Training of higher qualification Specialists in children and adolescent psychiatry in Russia and other countries].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(3):98-103

Union of Specialists for Mental Health, Moscow, Russia.

Most mental disorders occur before the age of 25 years, and if left without intervention, they can transform into more severe mental disorders. Despite the great need to protect the mental health of children and adolescents, in Russia and most countries of the world, there is a shortage of qualified personnel in this area. The article presents data on the availability of personnel in different countries of the world, including Russia. Read More

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January 2021


Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):35-38. Epub 2021 Apr 8.

Cardiothoracic Surgery Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal; Faculdade de Medicina da Universidade do Porto, Portugal.

Background: Placement of chest drain following thoracoscopic procedures has been the gold standard. Nevertheless, a drainless approach may be safe and feasible in selected patients and procedures. In this study we aim to report our clinical experience after drainless video-assisted thoracoscopic surgery. Read More

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[Frontometaphyseal dysplasia 1 caused by variant of FLNA gene in a case].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Apr;38(4):355-358

Shanghai Chindren's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

Objective: To explore the clinical and genetic characteristics of a child with frontometaphyseal dysplasia 1 (FMD1) due to variant of FLNA gene.

Methods: Clinical phenotype of the patient was analyzed. Whole exome sequencing (WES) was carried out to detect pathogenic genetic variants. Read More

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Corrective osteotomy for malunion of distal diaphyseal/metaphyseal radius or ulna fracture affecting stability of the distal radioulnar joint.

Injury 2021 Apr 1. Epub 2021 Apr 1.

Department of Orthopedic Surgery, Regional Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.

Background: We postulated that residual distal radioulnar joint (DRUJ) instability after distal diaphyseal or metaphyseal fracture in the radius or ulna may occur due to malaligned or malunited bony structures as well as primary or secondary soft issue stabiliser. Here, we report the outcomes of corrective osteotomy in a retrospective study.

Methods: Patients undergoing the osteotomy for DRUJ instability between March 2000 and February 2018 were included in the study. Read More

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How do colorectal cancer patients rate their GP: a mixed methods study.

BMC Fam Pract 2021 Apr 8;22(1):67. Epub 2021 Apr 8.

Medical Research Centre, University of Waikato, Hamilton, New Zealand.

Background: New Zealand (NZ) has a high incidence of colorectal cancer (CRC) and low rates of early diagnosis. With screening not yet nationwide, the majority of CRC is diagnosed through general practice. A good patient-general practitioner (GP) relationship can facilitate prompt diagnosis, but when there is a breakdown in this relationship, delays can occur. Read More

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Intimate Partner Violence Perpetration Among Military Spouses.

J Interpers Violence 2021 Apr 9:8862605211004139. Epub 2021 Apr 9.

Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Military spouses are an understudied population with respect to intimate partner violence (IPV) perpetration. Due to the unique demands of service members' jobs, military couples are documented to experience particular individual, couple, and family-level risk factors that may lead to IPV perpetration. Using the frustration-aggression hypothesis and considering the possibility of mutual violence, we examined (a) the direct effects of stressful events, marital discord, and work-family conflict on IPV perpetration among military spouses and (b) the indirect effect of anger arousal between stressful events, marital discord, and work-family conflict on IPV perpetration. Read More

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Comparison of single and double dorsal wires in the extension block technique for mallet fractures: Retrospective observational study.

Medicine (Baltimore) 2021 Apr;100(14):e25419

Department of Orthopaedic and Traumatology, Ağri Training and Research Hospital, Ağri.

Abstract: Mallet fractures are avulsion fractures of the extensor tendon from the distal phalanx base and often occur due to sudden flexion or axial loading. In this study, we aimed to compare the clinical and radiological results of patients treated with single and double dorsal wires from the dorsal in the extension block method.Patients to whom a single wire from dorsal was applied were assigned to Group 1 (n: 22), and those to whom double wires were applied were assigned to Group 2 (n: 23). Read More

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Renal function-adjusted contrast medium volume is a major risk factor in the occurrence of acute kidney injury after endovascular aneurysm repair.

Medicine (Baltimore) 2021 Apr;100(14):e25381

Division of Vascular and Endovascular Surgery, Department of Surgery, Pusan National University Yangsan Hospital, Yangsan.

Abstract: Acute kidney injury (AKI) is a complication that can occur during endovascular aneurysm repair (EVAR), increasing postoperative mortality and disease-related death. We therefore evaluated the incidence of AKI after elective EVAR, as well as related factors affecting AKI occurrence, investigating the volume of contrast medium (CV)/estimated glomerular filtration rate (eGFR) ratio as a predictive factor.We retrospectively reviewed the data of patients who underwent EVAR for infrarenal abdominal aorta aneurysm at a single center between April 2011 and December 2018. Read More

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Physical Activity, Menstrual History, and Bone Microarchitecture in Female Athletes with Multiple Bone Stress Injuries.

Med Sci Sports Exerc 2021 Apr 7. Epub 2021 Apr 7.

Massachusetts General Hospital, Boston, MA United States Army Research Institute of Environmental Medicine, Natick MA Harvard Medical School, Boston MA Spaulding Rehabilitation Hospital, Cambridge MA Boston Children's Hospital, Boston MA Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA.

Bone stress injuries (BSIs) occur in up to 20% of runners and military recruits and those with a history of BSI have a 5-fold higher risk for a subsequent BSI. Yet, little is known about prior training, menstrual status and bone structure in runners who experience multiple BSIs.

Purpose: To determine differences in health and physical activity history, bone density, microarchitecture, and strength among female athletes with a history of multiple BSI, athletes with ≤1 BSI, and non-athletes. Read More

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Profile of diabetic ketoacidosis at the National Diabetes and Endocrine Center in Tripoli, Libya, 2015.

Diabetes Metab Syndr 2021 Mar 27;15(3):771-775. Epub 2021 Mar 27.

Biotechnology Research Center, Libyan Authority For Scientific Research, Tripoli, Libya.

Background: Diabetic ketoacidosis (DKA) is a major acute metabolic complication of type I diabetes mellitus but may occur in type II diabetes during severe stressful conditions.

Aim: The aim of this study was to describe the clinical profile of DKA patients admitted to the National Diabetes and Endocrine Center in Tripoli, Libya, during 2015.

Patients And Methods: The profiles of 490 patients admitted with DKA were retrospectively studied. Read More

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Factors influencing place of delivery: Evidence from three south-Asian countries.

PLoS One 2021 8;16(4):e0250012. Epub 2021 Apr 8.

Institute for Physical Activity and Nutrition, Deakin University, Burwood, VIC, Australia.

Background: High maternal mortality is still a significant public health challenge in many countries of the South-Asian region. The majority of maternal deaths occur due to pregnancy and delivery-related complications, which can mostly be prevented by safe facility delivery. Due to the paucity of existing evidence, our study aimed to examine the factors associated with place of delivery, including women's preferences for such in three selected South-Asian countries. Read More

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Current Analysis of Skeletal Phenotypes in Down Syndrome.

Curr Osteoporos Rep 2021 Apr 8. Epub 2021 Apr 8.

Department of Biology, Indiana University-Purdue University Indianapolis, 723 West Michigan Street, SL 306, Indianapolis, IN, 46202-3275, USA.

Purpose: Down syndrome (DS) is caused by trisomy 21 (Ts21) and results in skeletal deficits including shortened stature, low bone mineral density, and a predisposition to early onset osteoporosis. Ts21 causes significant alterations in skeletal development, morphology of the appendicular skeleton, bone homeostasis, age-related bone loss, and bone strength. However, the genetic or cellular origins of DS skeletal phenotypes remain unclear. Read More

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Hyponatraemia in Adult Patients with Pneumonia in a Medical College Hospital of Bangladesh.

Mymensingh Med J 2021 Apr;30(2):267-273

Dr Mohammed Amdad Ullah Khan, Assistant Professor, Department of Medicine, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:

Pneumonia is an acute on chronic infection involving the pulmonary parenchyma. Most cases are caused by microbial pathogens usually bacteria or viruses and less often fungi or parasites. Hyponatraemia on admission is associated with greater risk of death and increased length of hospital stays. Read More

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Deformed Complex Vertebral Osteotomy Technique for Management of Severe Congenital Spinal Angular Kyphotic Deformity.

Orthop Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Spine Surgery and Orthopaedics, Xiangya Hospital of Central-South University, Changsha, China.

Objectives: To (i) introduce the deformed complex vertebral osteotomy (DCVO) technique for the treatment of severe congenital angular spinal kyphosis; (ii) evaluate the sagittal correction efficacy of the DCVO technique; and (iii) discuss the advantages and limitations of the DCVO technique.

Methods: Multiple malformed vertebrae were considered a malformed complex, and large-range and angle wedge osteotomy was performed within the complex using the DCVO technique. Patients with local kyphosis greater than 80° who were treated with DCVO and did not have tumors, infections, or a history of surgery were included. Read More

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Time to event analysis for post-hypospadias repair complications: a single-surgeon experience.

World J Urol 2021 Apr 8. Epub 2021 Apr 8.

Department of Urology, University of Wisconsin, Madison, WI, USA.

Objective: The optimal follow-up duration and frequency following hypospadias repair is unclear within the pediatric urology community. This analysis aims to delineate the time to various complications following primary hypospadias repairs.

Materials And Methods: A retrospective review of a single-surgeon hypospadias database over 2001-2017 was performed. Read More

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Mitochondrial-targeted methionine sulfoxide reductase overexpression increases the production of oxidative stress in mitochondria from skeletal muscle.

Aging Pathobiol Ther 2020 27;2(1):45-51. Epub 2020 Mar 27.

The Sam and Ann Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio TX, USA.

Objective: Mitochondrial dysfunction comprises part of the etiology of myriad health issues, particularly those that occur with advancing age. Methionine sulfoxide reductase A (MsrA) is a ubiquitous protein oxidation repair enzyme that specifically and catalytically reduces a specific epimer of oxidized methionine: methionine sulfoxide. In this study, we tested the ways in which mitochondrial bioenergetic functions are affected by increasing MsrA expression in different cellular compartments. Read More

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Combination of Quantitative MRI Fat Fraction and Texture Analysis to Evaluate Spastic Muscles of Children With Cerebral Palsy.

Front Neurol 2021 22;12:633808. Epub 2021 Mar 22.

Division of Radiological Physics, Department of Radiology, University Hospital of Basel, Basel, Switzerland.

Cerebral palsy (CP) is the most common cause of physical disability in childhood. Muscle pathologies occur due to spasticity and contractures; therefore, diagnostic imaging to detect pathologies is often required. Imaging has been used to assess torsion or estimate muscle volume, but additional methods for characterizing muscle composition have not thoroughly been investigated. Read More

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Music-Evoked Nostalgia and Wellbeing During the United Kingdom COVID-19 Pandemic: Content, Subjective Effects, and Function.

Front Psychol 2021 22;12:647891. Epub 2021 Mar 22.

York Music Psychology Group, Department of Music, University of York, York, United Kingdom.

Nostalgic music is defined as that which evokes feelings of nostalgia through reminders of certain periods of life, places or people. Feelings of nostalgia are said to occur during times of hardship and difficult transitionary periods, such as the first COVID-19 lockdown in the United Kingdom in 2020. Here, the reassurance of the past might have held certainty that could sustain a sense of meaning and purpose in life and influence wellbeing. Read More

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COVID-19 Pandemic on Fire: Evolved Propensities for Nocturnal Activities as a Liability Against Epidemiological Control.

Front Psychol 2021 22;12:646711. Epub 2021 Mar 22.

Department of Experimental Psychology, Institute of Psychology, University of São Paulo, São Paulo, Brazil.

Humans have been using fire for hundreds of millennia, creating an ancestral expansion toward the nocturnal niche. The new adaptive challenges faced at night were recurrent enough to amplify existing psychological variation in our species. Night-time is dangerous and mysterious, so it selects for individuals with higher tendencies for paranoia, risk-taking, and sociability (because of security in numbers). Read More

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The Prevalence of Prescribing Medications Associated with Geriatric Syndromes among Discharged Elderly Patients.

J Pharm Bioallied Sci 2020 Nov 5;12(Suppl 2):S747-S751. Epub 2020 Nov 5.

Department of Pharmacy Practice, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.

Introduction: A geriatric syndrome is a group of signs and symptoms that occur in older people and do not fit into a discrete disease. Several medications were reported to be associated with the incidence of geriatric syndromes.

Objective: The objective of this study was to investigate the prevalence and pattern of medications associated with geriatric syndromes (MAGSs) among the discharged elderly patients (≥65 years old). Read More

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November 2020

Modulation of Retinal Atrophy With Rituximab in Multiple Sclerosis.

Neurology 2021 Apr 7. Epub 2021 Apr 7.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Objective: To investigate the effects of rituximab on retinal atrophy in patients with relapsing-remitting multiple sclerosis (RRMS), we performed serial optical coherence tomography (OCT) scans among a cohort of RRMS patients on rituximab, and compared rates of ganglion cell+inner plexiform layer (GCIPL) atrophy to those observed among age- and sex-matched glatiramer acetate (GA)- and natalizumab-treated RRMS patients, and healthy controls (HCs).

Methods: In this observational study, patients with RRMS treated with a single disease-modifying therapy, and HCs, were followed with serial OCT for a median duration of 2.8 years. Read More

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Examining the association between childhood autistic traits and adolescent hypomania: a longitudinal twin study.

Psychol Med 2021 Apr 8:1-10. Epub 2021 Apr 8.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: There is evidence that autism spectrum disorders (ASDs) co-occur with bipolar disorder (BD) relatively frequently. Individuals with BD often report symptoms of mania and hypomania during adolescence, prior to the age of onset for BD. It is unknown whether these symptoms are associated with ASDs. Read More

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Young adult cancer risk behaviours originate in adolescence: a longitudinal analysis using ALSPAC, a UK birth cohort study.

BMC Cancer 2021 Apr 7;21(1):365. Epub 2021 Apr 7.

Department of Population Health Sciences, Population Health Sciences, Bristol Medical School, University of Bristol, BF4, Barley House, Oakfield Grove, Bristol, BS8 2BN, UK.

Background: An estimated 40% of cancer cases in the UK in 2015 were attributable to cancer risk behaviours. Tobacco smoking, alcohol consumption, obesity, and unprotected sexual intercourse are known causes of cancer and there is strong evidence that physical inactivity is associated with cancer. These cancer risk behaviours co-occur however little is known about how they pattern longitudinally across adolescence and early adulthood. Read More

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20 Years of Radiographic Imaging: Crystalline Deposits Causing Severe Arthropathy and Erosions.

Mil Med 2021 Apr 7. Epub 2021 Apr 7.

Department of Rheumatology, Tripler Army Medical Center, Honolulu, HI 96859, USA.

Urate crystal gout arthritis and calcium pyrophosphate deposition disease (CPPD) are crystalline arthropathies seen in middle age to elderly patients, but are also seen in the active duty military population. Flares of either can be identified by acute joint pain, associated swelling, tenderness, and warmth. Definitive diagnosis involves synovial analysis from arthrocentesis. Read More

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An update on the occurrence of Paracoccidioides species in the Midwest region, Brazil: Molecular epidemiology, clinical aspects and serological profile of patients from Mato Grosso do Sul State.

PLoS Negl Trop Dis 2021 Apr 7;15(4):e0009317. Epub 2021 Apr 7.

Laboratório de Biociência (LaBio), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

Background: Paracoccidioidomycosis (PCM) is a systemic and endemic fungal infection in Latin American, mainly in Brazil. The majority of PCM cases occur in large areas in Brazil, comprising the South, Southeast and Midwest regions, with the latter demonstrating a higher incidence of the species Paracoccidioides lutzii.

Methodology And Main Findings: This study presents clinical, molecular and serological data of thirteen new PCM cases during 2016 to 2019 from the state of Mato Grosso do Sul, located in the Midwest region, Brazil. Read More

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