7,497 results match your criteria occluded coronary

Distinct Types of Plexiform Lesions Identified by Synchrotron-Based Phase Contrast Micro-CT.

Am J Physiol Lung Cell Mol Physiol 2021 Apr 21. Epub 2021 Apr 21.

Department of Experimental Medical Science, Lund University, Sweden.

In pulmonary arterial hypertension, plexiform lesions are associated with severe arterial obstruction and right ventricular failure. Exploring their structure and position is crucial for understanding the interplay between hemodynamics and vascular remodeling. The aim of this research was to use synchrotron-based phase contrast micro-CT to study the three-dimensional structure of plexiform lesions. Read More

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Midterm follow up of transcatheter closure of coronary artery fistula with Nit-Occlud® patent ductus arteriosus coil.

BMC Cardiovasc Disord 2021 Apr 20;21(1):192. Epub 2021 Apr 20.

Cardiac Surgery Department, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Coronary artery fistula (CAF) is a rare congenital anomaly with a challenging scenario in children. This study reports our experience in transcatheter closure of CAF with Nit-Occlude PDA coil and midterm clinical and imaging follow-up.

Methods: Twelve children with congenital CAF between 2009 and 2019, mean age 2. Read More

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Pulmonary-to-systemic venous collateral in obstructed supracardiac totally anomalous pulmonary venous connection: Blood finds a way!

J Card Surg 2021 Apr 16. Epub 2021 Apr 16.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

We describe a rare variant of obstructed supracardiac totally anomalous venous connection in a 7-day-old boy where the vertical vein was occluded and the entire pulmonary venous return was draining through a large tortuous pulmonary-systemic venous collateral. The case highlights the importance of computed tomography angiography in demonstrating such complex anatomies in congenital heart diseases. Read More

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Do we really understand how drug eluted from stents modulates arterial healing?

Int J Pharm 2021 Apr 9:120575. Epub 2021 Apr 9.

Division of Biomedical Engineering, University of Glasgow, Glasgow, UK. Electronic address:

The advent of drug-eluting stents (DES) has revolutionised the treatment of coronary artery disease. These devices, coated with anti-proliferative drugs, are deployed into stenosed or occluded vessels, compressing the plaque to restore natural blood flow, whilst simultaneously combating the evolution of restenotic tissue. Since the development of the first stent, extensive research has investigated how further advancements in stent technology can improve patient outcome. Read More

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Fragmentation of Ventricular Extrasystoles: A Potential New Electrocardiographic Window to Uncover Patients at Risk.

Cureus 2021 Mar 7;13(3):e13748. Epub 2021 Mar 7.

Cardiovascular Medicine, University of Missouri Kansas City, Kansas City, USA.

Fragmented QRS (fQRS) is a marker of conduction block due to myocardial scar that presents in electrocardiography (ECG) as an additional one or more R wave (R') or notching in the S wave nadir in contiguous leads. However, fQRS description on premature ventricular contractions (PVCs) has not been previously described. We describe a case of a 67-year-old male with a past medical history of prediabetes, hypertension and coronary artery disease who presented after an ophthalmic procedure with asymptomatic PVCs and episodes of bigeminy. Read More

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Incidence and impact of totally occluded culprit coronary artery in patients with non-ST segment elevation myocardial infarction acute coronary syndrome.

Egypt Heart J 2021 Apr 7;73(1):36. Epub 2021 Apr 7.

Department of Cardiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background: Significance of totally occluded culprit coronary artery in patients presenting with non-ST segment elevation myocardial infarction (NSTEMI) is underestimated. The aim of the study was to evaluate the incidence and impact of totally occluded culprit artery on in-hospital and 6 months follow-up outcomes of NSTEMI acute coronary syndrome (ACS) patients.

Results: We collected retrospectively data of 500 NSTEMI patients who presented to our hospital from June 2016 to June 2017. Read More

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Feasibility and safety of left atrial appendage closure in a patient with previous foramen ovale occlusion: a case report.

Eur Heart J Case Rep 2021 Mar 31;5(3):ytab113. Epub 2021 Mar 31.

Cardiology Division, Sant'Andrea Hospital, Corso Mario Abbiate 21, 13100, Vercelli, Italy.

Background: Left atrial appendage (LAA) closure is an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation (AF) at high bleeding risk. Patients with a previous percutaneous closure of a patent foramen ovale (PFO) present an increased risk for developing AF during their life, and the presence of an atrial septal device renders future percutaneous left atrial access more challenging. Very few cases of LAA occlusion in patients with a preexisting PFO closure device have been previously reported. Read More

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Acute Coronary Syndrome and COVID-19: A Case Report of Refractory Hypercoagulability.

Cureus 2021 Mar 3;13(3):e13675. Epub 2021 Mar 3.

Internal Medicine, St Mary's General Hospital, Passaic, USA.

Novel coronavirus disease 2019 (COVID-19) is known to cause severe bilateral pneumonia and acute respiratory distress syndrome (ARDS), leading to difficulty breathing requiring mechanical ventilation and ICU management. In many patients, it has been found to cause severe hypercoagulability. We present a case of COVID-19 positive patient who developed myocardial infarction (MI) despite being on multiple anticoagulants. Read More

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Coronary endarterectomy in coronary artery disease: Factors affecting graft patency and survival.

Asian Cardiovasc Thorac Ann 2021 Apr 6:2184923211006851. Epub 2021 Apr 6.

Division of Cardiothoracic Surgery, Department of Surgery, 13621Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Hong Kong.

Background: Coronary endarterectomy aims to improve completeness of revascularization in patients with occluded coronary vessels. The benefits of coronary endarterectomy remain uncertain. The aim of this study was to evaluate short-term surgical outcomes and factors affecting graft patency post-coronary endarterectomy. Read More

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Elevated Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 Level in Patients with Acute Coronary Syndrome (ACS): A Biomarker of Disease Severity and Outcome.

Mediators Inflamm 2021 15;2021:8872686. Epub 2021 Mar 15.

Institute of Rheumatology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.

Background And Aims: Plasma levels of soluble triggering receptor expressed on myeloid cells (sTREM-1) reflect innate immune cell activation. We sought to evaluate sTREM-1 levels in patients with acute coronary syndrome (ACS) and their predictive value for disease severity and outcome.

Methods: Plasma sTREM-1 levels were prospectively measured by ELISA in 121 consecutive patients with new-onset (≤24 h) chest pain at arrival to the emergency department (ED) and 73 healthy controls. Read More

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Perforation of an Aortopulmonary Collateral: A Scary Sight in the Lab!

J Invasive Cardiol 2021 Apr;33(4):E312-E313

Department of Cardiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi-110029, India.

A 12-year-old boy with complex cyanotic congenital heart disease with single-ventricle physiology was planned for univentricular repair. Aortopulmonary collateral occlusion using thrombotic embolization coils was planned, but during the procedure, there was perforation of an aortopulmonary collateral arising from the descending thoracic aorta. The teaching point from this case is that all aortopulmonary collaterals do not necessarily need to be occluded; when occlusion is performed, coils must be appropriately sized. Read More

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Inflammation in Pulmonary Arterial Hypertension.

Adv Exp Med Biol 2021 ;1303:351-372

Divisions of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Pulmonary artery hypertension (PAH) is a devastating cardiopulmonary disease characterized by vascular remodeling and obliteration of the precapillary pulmonary arterioles. Alterations in the structure and function of pulmonary vessels result in the resistance of blood flow and can progress to right-sided heart failure, causing significant morbidity and mortality. There are several types of PAH, and the disease can be familial or secondary to an underlying medical condition such as a connective tissue disorder or infection. Read More

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Endovascular revascularization of chronically occluded vertebral artery: single-center experience.

Wideochir Inne Tech Maloinwazyjne 2021 Mar 27;16(1):211-218. Epub 2020 Jul 27.

Department of Neurology, The Second Afliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.

Introduction: Chronic vertebral basilar artery occlusion is one of the most common causes of ischemic stroke, which accounts for roughly 20% of all cases. However, the evidence for the precise clinical effect in treatment of the initial segment of chronic vertebral basilar artery occlusion is not sufficient.

Aim: To evaluate the feasibility and efficacy of endovascular therapy in the initial segment of chronic vertebral basilar artery occlusion. Read More

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Successful Percutaneous Closure of a Large Saphenous Vein Graft Aneurysm With Vascular Plug 4, Optimal Percutaneous Device Selection.

Cureus 2021 Mar 21;13(3):e14016. Epub 2021 Mar 21.

Cardiovascular Surgery, Toho University Sakura Medical Center, Sakura, JPN.

Saphenous vein graft (SVG) aneurysm is one of the late unusual complications of coronary artery bypass grafting (CABG). We report a case of a very large SVG aneurysm successfully treated with a vascular plug 4. A 94-year-old man was referred to our hospital for an expanding aortic aneurysm. Read More

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Primary coronary intervention in ST-elevation myocardial infarction

Orv Hetil 2021 03 28;162(13):497-503. Epub 2021 Mar 28.

1 Semmelweis Egyetem, Városmajori Szív- és Érgyógyászati Klinika, Budapest, Városmajor u. 68., 1122.

Összefoglaló. Bevezetés: Heveny myocardialis infarctusban a szívizommentés sikere, a beteg életkilátása nagymértékben függ a panasz kezdete és az elzáródott koszorúér rekanalizálása között eltelt ischaemiás időtől. Jelenleg az ér nyitása optimális esetben minden betegnél koszorúér-intervencióval történik. Read More

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Increased bleeding events with the addition of apixaban to the dual anti-platelet regimen for the treatment of patients with acute coronary syndrome: A meta-analysis.

Medicine (Baltimore) 2021 Mar;100(12):e25185

Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.

Background: Dual anti-platelet therapy (DAPT) with aspirin and clopidogrel has been the mainstay of treatment for patients with acute coronary syndrome (ACS). However, the recurrence of thrombotic events, potential aspirin and clopidogrel hypo-responsiveness, and other limitations of DAPT have led to the development of newer oral anti-thrombotic drugs. Apixaban, a new non-vitamin K antagonist, has been approved for use. Read More

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MINI OPCAB Operation: Surgical Technique.

Surg Technol Int 2021 03 23;38. Epub 2021 Mar 23.

Invita Science Corp, Port St. Lucie, FL, USA.

Introduction: We describe how to perform left internal mammary artery (LIMA) bypass to the left anterior descending (LAD) artery, the so-called MINI Off-pump Coronary Artery Bypass (MINI OPCAB).

Materials And Methods: We included patients with a demonstrated predominant ischemia related to the LAD territory. Of 70 patients who were operated upon at the Benetti Foundation, 10 received hybrid revascularization. Read More

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Large- and Medium-sized Arteries Remaining in Transmural Scar Distal to Permanent Coronary Ligation Undergo Neointimal Hyperplasia and Inward Remodeling.

Eduard I Dedkov

J Histochem Cytochem 2021 Mar 22:221554211004297. Epub 2021 Mar 22.

Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, New Jersey.

This study aimed to investigate the structural integrity and dynamic changes in chronically occluded residual arteries found in post-myocardial infarction (MI) scar. A transmural MI was induced in middle-aged, male Sprague-Dawley rats by left coronary artery ligation. The rats were euthanized 3 days and 1, 2, 4, 8, and 12 weeks after MI, and their hearts were processed into paraffin for histology, immunohistochemistry, and quantitative morphometry. Read More

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Effect of First-Pass Reperfusion on Outcome After Endovascular Treatment for Ischemic Stroke.

J Am Heart Assoc 2021 Apr 19;10(7):e019988. Epub 2021 Mar 19.

Department of Neurology Erasmus MC, University Medical Center Rotterdam the Netherlands.

Background First-pass reperfusion (FPR) is associated with favorable outcome after endovascular treatment. It is unknown whether this effect is independent of patient characteristics and whether FPR has better outcomes compared with excellent reperfusion (Expanded Thrombolysis in Cerebral Infarction [eTICI] 2C-3) after multiple-passes reperfusion. We aimed to evaluate the association between FPR and outcome with adjustment for patient, imaging, and treatment characteristics to single out the contribution of FPR. Read More

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Subepicardial aneurysm with free wall rupture and its successful surgical intervention: a case report.

Eur Heart J Case Rep 2021 Feb 20;5(2):ytab048. Epub 2021 Feb 20.

Department of Cardiology, Japan Community Healthcare Organization Osaka Hospital, 4-2-78, Fukushima, Fukushima-Ku, Osaka city, Osaka, 553-0003, Japan.

Background: Subepicardial aneurysm (SEA) is an uncommon but potentially fatal complication of acute myocardial infarction (MI) associated with an increased risk of free wall rupture (FWR) leading to sudden death. We describe a rare case of a silent myocardial infarction complicated by SEA and subsequent FWR, resulting in cardiac tamponade.

Case Summary: A 68-year-old man with no previous chest symptoms presented with syncope. Read More

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February 2021

Percutaneous coronary intervention in saphenous vein grafts after coronary artery bypass grafting: a systematic review and meta-analysis.

Scand Cardiovasc J 2021 Mar 18:1-9. Epub 2021 Mar 18.

Department of Cardiothoracic and Vascular Surgery and University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

To investigate the results of percutaneous coronary intervention (PCI) in saphenous vein grafts after coronary artery bypass grafting (CABG). MEDLINE, Embase, and the Cochrane library were searched for relevant articles published between 1 January 2000 and 29 February 2020. The PICO (population, intervention, comparison, outcome) model was applied in constructing the clinical question. Read More

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Polymer Conjugation of Docosahexaenoic Acid Potentiates Cardioprotective Therapy in Preclinical Models of Myocardial Ischemia/Reperfusion Injury.

Adv Healthc Mater 2021 Mar 15:e2002121. Epub 2021 Mar 15.

Polymer Therapeutics Laboratory, Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, Valencia, E-46012, Spain.

While coronary angioplasty represents an effective treatment option following acute myocardial infarction, the reperfusion of the occluded coronary artery can prompt ischemia-reperfusion (I/R) injury that significantly impacts patient outcomes. As ω-3 polyunsaturated fatty acids (PUFAs) have proven, yet limited cardioprotective abilities, an optimized polymer-conjugation approach is reported that improves PUFAs bioavailability to enhance cardioprotection and recovery in animal models of I/R-induced injury. Poly-l-glutamic acid (PGA) conjugation improves the solubility and stability of di-docosahexaenoic acid (diDHA) under physiological conditions and protects rat neonatal ventricular myocytes from I/R injury by reducing apoptosis, attenuating autophagy, inhibiting reactive oxygen species generation, and restoring mitochondrial membrane potential. Read More

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STEMI with flush occlusion of a coronary artery: An interventional dilemma.

J Cardiol Cases 2021 Mar 3;23(3):108-111. Epub 2020 Nov 3.

Rashid Hospital, Dubai, United Arab Emirates.

Flush occlusions of coronary arteries present with multiple challenges during primary percutaneous coronary intervention (PPCI). We describe a case of anterior ST-elevation myocardial infarction in cardiogenic shock, where it was not possible to identify the origin of left anterior descending artery (LAD) as it was flush occluded and initial attempts to place a coronary guidewire in the LAD during PPCI were unsuccessful. After failed attempts with multiple guidewires, a combined pharmacological-mechanical approach resulted in successful timely revascularization and subsequent recovery of the patient. Read More

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A study on eccentric occluder via ultra minimal incision of doubly committed subarterial ventricular septal defects.

J Card Surg 2021 Mar 11. Epub 2021 Mar 11.

Department of Cardiac Surgery and Heart Center, The Childern's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou, China.

Object: To compare the clinical data of sternotomy and left intercostals incision, combined with the literature, to provide the best surgical incision for committed subarterial ventricular septal defect (DCS-VSD).

Methods: From July 2016 to July 2020, a total of 117 cases of occlusion surgeries for DCSVSD, which guided by transoesophagel echocardiography (TEE) were completed, including 34 cases with sternotomy incision and 83 cases with left intercostal incision. Statistics and analysis of the operation and follow-up. Read More

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Left ventricular assist device inflow cannula implantation: Why a "Step sideways" technique can be helpful.

Artif Organs 2021 Mar 9. Epub 2021 Mar 9.

Department of Cardiac Surgery, Tours University Hospital, Tours, France.

Preservation of right ventricle vascularization that is dependent on left coronary network collateral development is essential during left ventricular assist device implantation to avoid postoperative right heart failure. Our technique was performed on a patient who underwent implantation as a bridge to transplantation; the technique is characterized by providing a moderate lateral and inferior displacement of the inflow cannula position, which achieves both the objectives of respecting the apical course of a left anterior descending coronary artery supplying an occluded right coronary and of maintaining a sufficient orientation degree toward the plane of the mitral valve for correct left ventricular unloading. Read More

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Early and mid-term results from a postmarket observational study of Zenith t-Branch thoracoabdominal endovascular graft.

J Vasc Surg 2021 Mar 5. Epub 2021 Mar 5.

Department of Vascular Surgery, St. Franziskus Hospital, Münster, Germany.

Objective: We have reported the short-term outcomes regarding the safety of the off-the-shelf Zenith t-Branch multibranched thoracoabdominal stent-graft (William Cook Europe ApS, Bjaeverskov, Denmark) in a postmarket, multicenter study.

Methods: Patients who had been treated with the t-Branch device from September 2012 to November 2017 at three European centers were either prospectively or retrospectively enrolled in the present study. Device implantation and postprocedural follow-up were performed according to the standard of care at each center. Read More

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Preclinical Feasibility and Patency Analyses of a New Distal Coronary Connector: The ELANA Heart Bypass.

Innovations (Phila) 2021 Mar 7:1556984521991519. Epub 2021 Mar 7.

8124 Department of Cardiothoracic Surgery, University Medical Center Utrecht, The Netherlands.

Objective: This preclinical study determines the feasibility and 6-month patency rates of a new distal coronary connector, the Excimer Laser Assisted Nonocclusive Anastomosis (ELANA) Heart Bypass.

Methods: Twenty Dutch Landrace pigs received either a hand-sewn ( = 8) or an ELANA ( = 12) left internal thoracic artery to left anterior descending artery anastomosis, using off-pump coronary artery bypass grafting. Six-month patency rates were demonstrated by coronary angiography and histological evaluation. Read More

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Incidental Finding and Endovascular Repair of a Left Internal Mammary Artery Aneurysm following a Multivessel Coronary Artery Bypass Graft.

Case Rep Cardiol 2021 17;2021:8831235. Epub 2021 Feb 17.

Vital Heart & Vein, USA.

True aneurysms discovered within the internal mammary artery are extremely rare and typically have an asymptomatic occurrence. Their presentation and management have also been variable due to their low incidence, decreased detection, or lack of documentation. They have a high risk for morbidity or mortality as they can possibly rupture with increasing size and thus become life-threatening. Read More

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February 2021

Prosthetic versus native artery inflow for infrainguinal bypass.

J Vasc Surg 2021 Mar 5. Epub 2021 Mar 5.

Department of Vascular Surgery, Albany Medical College, Albany Medical Center Hospital, Albany, NY. Electronic address:

Background: Infrainguinal bypass performed after previous prosthetic inflow reconstruction offers a choice of where to perform the proximal anastomosis. The hood of a previous inflow bypass might be technically easier to isolate during reoperative surgery. However, the more distal native artery might offer better patency to the outflow revascularization. Read More

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Invasive Management of Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Scientific Statement From the American Heart Association.

Circulation 2021 Apr 4;143(15):e815-e829. Epub 2021 Mar 4.

Cardiogenic shock (CS) remains the most common cause of mortality in patients with acute myocardial infarction. The SHOCK trial (Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock) demonstrated a survival benefit with early revascularization in patients with CS complicating acute myocardial infarction (AMICS) 20 years ago. After an initial improvement in mortality related to revascularization, mortality rates have plateaued. Read More

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