95,424 results match your criteria obstructive pulmonary

Perfusion quantification using voxel-wise proton density and median signal decay in PREFUL MRI.

Magn Reson Med 2021 Apr 9. Epub 2021 Apr 9.

Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Lower Saxony, Germany.

Purpose: Contrast-free lung MRI based on Fourier decomposition is an attractive method to monitor various lung diseases. However, the accuracy of the current perfusion quantification is limited. In this study, a new approach for perfusion quantification based on voxel-wise proton density and median signal decay toward the steady state for Fourier decomposition-based techniques is proposed called Q (Q ). Read More

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Chronic breathlessness in advanced cardiorespiratory disease: patient perceptions of opioid use.

BMJ Support Palliat Care 2021 Apr 9. Epub 2021 Apr 9.

The University of Melbourne Faculty of Medicine, Dentistry and Health Sciences, Melbourne, Victoria, Australia

Objective: Low-dose oral opioids may improve severe chronic breathlessness in advanced cardiorespiratory diseases. Prescription of opioids for breathlessness occurs infrequently however, with little known about patients' attitudes towards their use in this setting. The aim of this qualitative study was to explore patients' perceptions regarding opioids for the management of severe chronic breathlessness in people with advanced cardiorespiratory disease. Read More

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There is detectable variation in the lipidomic profile between stable and progressive patients with idiopathic pulmonary fibrosis (IPF).

Respir Res 2021 Apr 9;22(1):105. Epub 2021 Apr 9.

School of Biomedical Science, University of Western Australia, Crawley, WA, Australia.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis and progressive loss of lung function. The pathophysiological pathways involved in IPF are not well understood. Abnormal lipid metabolism has been described in various other chronic lung diseases including asthma and chronic obstructive pulmonary disease (COPD). Read More

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Impact of comorbidity assessment methods to predict non-cancer mortality risk in cancer patients: a retrospective observational study using the National Health Insurance Service claims-based data in Korea.

BMC Med Res Methodol 2021 Apr 9;21(1):66. Epub 2021 Apr 9.

Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, 10408, Republic of Korea.

Background: Cancer patients' prognoses are complicated by comorbidities. Prognostic prediction models with inappropriate comorbidity adjustments yield biased survival estimates. However, an appropriate claims-based comorbidity risk assessment method remains unclear. Read More

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COPD exacerbations are related to poor air quality in Innsbruck: A retrospective pilot study.

Heart Lung 2021 Apr 6;50(4):499-503. Epub 2021 Apr 6.

Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria. Electronic address:

Background: Triggers of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are diverse, potentially including airborne pollutants.

Objectives: To analyze whether daily air pollution levels correlate with AECOPD frequency.

Methods: In this retrospective pilot-study, AECOPD frequency was recorded between 2010 and 2016 at the University Hospital of Innsbruck's emergency department and correlated with daily air quality parameters. Read More

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Bronchiectasis among Australian Aboriginal and non-Aboriginal patients in the regional and remote population of the Northern Territory of Australia.

Rural Remote Health 2021 Apr 10;21(2):6390. Epub 2021 Apr 10.

Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; and Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, Northern Territory, Australia

Introduction: Chronic respiratory disorders are highly prevalent among Australian Aboriginal people living in the Top End Health Service region in the Northern Territory, Australia. Bronchiectasis is a heterogenous disease that features among these chronic respiratory conditions in this population. However, there are sparse comparative data between Aboriginal and non-Aboriginal patients with bronchiectasis from this region. Read More

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Comprehensive profiling of the gut microbiota in patients with chronic obstructive pulmonary disease of varying severity.

PLoS One 2021 9;16(4):e0249944. Epub 2021 Apr 9.

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.

Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that reduces lung and respiratory function, with a high mortality rate. Severe and acute deterioration of COPD can easily lead to respiratory failure, resulting in personal, social, and medical burden. Recent studies have shown a high correlation between the gut microbiota and lung inflammation. Read More

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Are Adults with COPD Vulnerable to Air Pollution and Cardiovascular Risk?

C Arden Pope Iii

Am J Respir Crit Care Med 2021 Apr 9. Epub 2021 Apr 9.

Brigham Young University, Economics, Provo, Utah, United States;

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Sex and Racial Differences in Autopsy-Defined Causes of Presumed Sudden Cardiac Death.

Circ Arrhythm Electrophysiol 2021 Apr 9. Epub 2021 Apr 9.

Office of the Chief Medical Examiner, City & County of San Francisco, San Francisco, CA.

- Sudden cardiac death (SCD) studies report higher incidence in men and Blacks but presume cardiac cause. We sought to identify sex and race differences in rates and causes of presumed SCDs in a prospective postmortem study in San Francisco County. - All incident presumed SCDs meeting World Health Organization definition ages 18-90 were autopsied via active surveillance of consecutive out-of-hospital deaths in the stmortem ystematic Invesigation of udden ardiac eath (POST SCD) Study (2/1/2011 - 3/1/2014). Read More

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[Safety of administration of norepinephrine through peripheral vein line in patients with septic shock].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):276-280

Department of 2nd Intensive Care Unit, Lanzhou University Second Hospital, Lanzhou 730000, Gansu, China.

Objective: To analysis the risk factors and safety of administration of norepinephrine (NE) via peripheral vein line (PVL) in patients with septic shock.

Methods: A single-center retrospective study was conducted. According to the Lanzhou University Second Hospital information system (HIS) and nursing adverse events report cards, patients with septic shock administrated with NE via PVL to correct the hypotension from January 1st 2015 to December 31st, 2019 were enrolled. Read More

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Endobronchial Hamartoma Presenting as Recurrent Pneumonia and Chronic Cough.

Cureus 2021 Mar 5;13(3):e13717. Epub 2021 Mar 5.

Pulmonary and Critical Care, Jersey Shore University Medical Center, Neptune, USA.

Pneumonia is an infection of the lungs that can result from various etiologies, including bronchial obstruction. It is estimated that 5.4% of community-acquired pneumonia occurs as a result of an endobronchial obstruction, classifying them as post-obstructive pneumonia. Read More

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Arginine Therapy for Lung Diseases.

Front Pharmacol 2021 23;12:627503. Epub 2021 Mar 23.

Division of Respiratory Medicine, Department of Paediatrics and Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.

Nitric oxide (NO) is produced by a family of isoenzymes, nitric oxide synthases (NOSs), which all utilize L-arginine as substrate. The production of NO in the lung and airways can play a number of roles during lung development, regulates airway and vascular smooth muscle tone, and is involved in inflammatory processes and host defense. Altered L-arginine/NO homeostasis, due to the accumulation of endogenous NOS inhibitors and competition for substrate with the arginase enzymes, has been found to play a role in various conditions affecting the lung and in pulmonary diseases, such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), pulmonary hypertension, and bronchopulmonary dysplasia. Read More

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The Perception of Physicians on Gender-Specific Differences in the Diagnosis of COPD: Results from a Questionnaire-Based Survey.

Int J Chron Obstruct Pulmon Dis 2021 1;16:901-907. Epub 2021 Apr 1.

Medicines Evaluation Unit, University of Manchester, Manchester University NHS Foundations Trust, Manchester, UK.

Objective: To evaluate the perception of physicians on gender-specific differences in the diagnosis of chronic obstructive pulmonary disease (COPD) using a qualitative and anonymous questionnaire-based survey.

Methods: The survey was conducted amongst respiratory physicians attending a standalone educational conference (29-30 September 2017) using the SpotMe App. The 20-item standardized closed questionnaire had pre-coded responses to questions on physician's profile, and perception of COPD diagnosis and existing comorbidities between genders. Read More

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CircANKRD11 Knockdown Protects HPMECs from Cigarette Smoke Extract-Induced Injury by Regulating miR-145-5p/BRD4 Axis.

Int J Chron Obstruct Pulmon Dis 2021 1;16:887-899. Epub 2021 Apr 1.

Department of Physical Examination Center, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People's Republic of China.

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of death because of its high incidence and mortality, which is chiefly resulted from cigarette smoke exposure. A large number of studies show that circular RNA (circRNA) participates in regulating COPD process. This study aims to reveal the role of circRNA ankyrin repeat domain 11 (circANKRD11) in cigarette smoke extract (CSE)-induced cell apoptosis, inflammation, and oxidative stress. Read More

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The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation.

Int J Chron Obstruct Pulmon Dis 2021 31;16:877-885. Epub 2021 Mar 31.

Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People's Republic of China.

Background: Penehyclidine hydrochloride is a selective antagonist of M1 and M3 receptors. Clinical studies suggest that it is a potential drug for the treatment of chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the effect of penehyclidine hydrochloride on the inflammatory response of lung tissue during mechanical ventilation in rats with COPD and explore the role of the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) signaling pathway. Read More

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Improvement in Lung Function and Patient-Reported Outcomes in Patients with COPD with Comorbid Anxiety and Depression Receiving Nebulized Glycopyrrolate in the GOLDEN 3 and 4 Studies.

Int J Chron Obstruct Pulmon Dis 2021 31;16:865-875. Epub 2021 Mar 31.

Sunovion Pharmaceuticals Inc., Marlborough, MA, USA.

Background: Anxiety and depression (A/D) are common in patients with chronic obstructive pulmonary disease (COPD) and are often associated with lower adherence to treatment and worse patient-related outcomes. However, studies on the impact of comorbid A/D on responses to bronchodilators are limited.

Methods: This post hoc analysis of pooled data (N=861) from the GOLDEN 3 and 4 studies compared the efficacy and safety of nebulized glycopyrrolate (GLY) 25 µg in patients with moderate-to-very-severe COPD, grouped by self-reported A/D. Read More

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Favorable Response to Long-Term Azithromycin Therapy in Bronchiectasis Patients with Chronic Airflow Obstruction Compared to Chronic Obstructive Pulmonary Disease Patients without Bronchiectasis.

Int J Chron Obstruct Pulmon Dis 2021 30;16:855-863. Epub 2021 Mar 30.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Purpose: Long-term macrolide treatment is recommended for patients with chronic obstructive pulmonary disease (COPD) with frequent exacerbations. Bronchiectasis is a common comorbid condition in patients with COPD, for which long-term azithromycin is effective in preventing exacerbation. This study aimed to compare the effect of long-term azithromycin between bronchiectasis patients with chronic airflow obstruction (CAO) and COPD patients without bronchiectasis. Read More

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Mortality and high risk of major adverse events in patients with COVID-19 and history of cardiovascular disease.

Open Heart 2021 Apr;8(1)

Department of Cardiology, University Hospitals of Geneva Department of Medical Specializations, Geneva, Switzerland

Objective: History of cardiovascular diseases (CVDs) may influence the prognosis of patients hospitalised for COVID-19. We investigated whether patients with previous CVD have increased risk of death and major adverse cardiovascular event (MACE) when hospitalised for COVID-19.

Methods: We included 839 patients with COVID-19 hospitalised at the University Hospitals of Geneva. Read More

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Action plans in idiopathic pulmonary fibrosis: a qualitative study-'I do what I can do'.

BMJ Support Palliat Care 2021 Apr 8. Epub 2021 Apr 8.

Palliative/End of Life Care, Continuing Care, Alberta Health Services, Edmonton, Alberta, Canada.

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive, incurable fibrotic lung disease in which patients and caregivers report a high symptom burden. Symptoms are often poorly managed and patients and caregivers struggle to alleviate their distress in the absence of self-management support.

Aim: To explore perceptions of symptoms, symptom management strategies and self-efficacy for patients with IPF and caregivers who received self-management education and action plans created and provided in a Multidisciplinary Collaborative Interstitial Lung Disease (MDC-ILD) Clinic. Read More

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Incidence of emergency calls and out-of-hospital cardiac arrest deaths during the COVID-19 pandemic: findings from a cross-sectional study in a UK ambulance service.

Emerg Med J 2021 Apr 8. Epub 2021 Apr 8.

North East Ambulance Service NHS Trust, Newcastle Upon Tyne, UK.

Background: In response to the COVID-19 pandemic, a national lockdown was introduced on 23 March 2020. In the following weeks, emergency departments in the UK reported a reduction in attendances. We aimed to explore the incidence of emergency calls across North East England, as well as the number of out-of-hospital cardiac arrest (OHCA) deaths. Read More

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Peripheral lung effect of elexacaftor/tezacaftor/ivacaftor in adult cystic fibrosis.

J Cyst Fibros 2021 Apr 6. Epub 2021 Apr 6.

Respiratory Division, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090 Brussels, Belgium.

Despite being an important patient group, adult cystic fibrosis patients with an FEV below 40%predicted have been excluded from clinical trials with elexacaftor/tezacaftor/ivacaftor. We conducted a real-life 3 months follow-up study in 14 adult CF patients (median FEV 34%predicted) demonstrating significant treatment effects in terms of FEV (an increase of 12%predicted at 4 weeks, remaining stable thereafter). Corresponding decreases in lung clearance index LCI (by 31%predicted, down from baseline 247%predicted) and ventilation heterogeneity in the acinar compartment (Sacin) (by 411%predicted, down from baseline 798%predicted) suggest a distinct peripheral lung effect. Read More

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Experiences in responders and non-responders to pulmonary rehabilitation among people with chronic obstructive pulmonary disease: a clinical study with convergent mixed analysis.

Disabil Rehabil 2021 Apr 8:1-9. Epub 2021 Apr 8.

Institute of The Regional Health University of Southern Denmark, Odense, Denmark.

Purpose: This study aims to investigate the experienced and measured development in physical capacity in people with Chronic Obstructive Pulmonary Disease (COPD) undergoing a standard pulmonary rehabilitation programme with a focus on the diverging experiences of responders and non-responders.

Methods: Twenty-one participants in standard pulmonary rehabilitation were included in the study. We measured the participants' change in the six-minute walk test (6MWT) during rehabilitation participation. Read More

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Supraglottic foreign body in a woman with Down's syndrome and congenital heart disease: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25455

Department of Anesthesiology.

Rationale: An impacted foreign body (FB) in the larynx of an adult is a rare but potentially life-threatening occurrence. Patients with Down's syndrome (DS) are vulnerable to airway FB. However, the anesthesia for FB removal can be challenging. Read More

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Effectiveness of thoracic kinesio taping on respiratory function and muscle strength in patients with chronic obstructive pulmonary disease: A protocol of randomized, double-blind placebo-controlled trial.

Medicine (Baltimore) 2021 Apr;100(14):e25269

Pulmonary and Critical Care Medicine, Affiliated Nanhua Hospital, University of South China, HengYang, China.

Background: To our knowledge, only 1 study has investigated the effects of kinesio taping (KT) on pulmonary function and functional capacity of patients with chronic obstructive pulmonary disease (COPD). Therefore, there is still a lack of high-quality evidence to prove the effectiveness of KT for COPD patients. Our purpose was to investigate the effect of KT on respiratory function and muscle strength in the COPD patients who were in stable condition. Read More

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Incident obstructive lung disease and mortality among HIV-positive and negative persons with a history of injecting drugs.

AIDS 2021 Apr 6. Epub 2021 Apr 6.

Department of Family Medicine, University of California, Los Angeles Department of Epidemiology, University of North Carolina, Chapel Hill Department of Pulmonary Diseases and Critical Care Medicine, University of North Carolina, Chapel Hill Department of Epidemiology, Johns Hopkins University.

Objective: People with HIV (PWH) experience increased prevalence of obstructive lung disease (OLD), regardless of greater observed smoking behaviors. We investigated whether the effect of incident OLD on mortality differed by HIV and HIV viral suppression among persons who inject drugs (PWID) and report smoking history.

Design: ALIVE is a longitudinal, observational cohort study of HIV-positive and seronegative PWID. Read More

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Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients.

Respir Med 2021 Apr 2;181:106389. Epub 2021 Apr 2.

Cardiopulmonary Physiotherapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil. Electronic address:

Purpose: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with an elevated risk of cardiovascular events, which can be linked to endothelial dysfunction. In this study, we aimed to investigate whether noninvasive ventilation (NIV) acutely changes endothelial function in hospitalized AECOPD patients.

Methods: Twenty-one AECOPD patients were assessed in a hospital ward setting from 24 to 48 h after admission. Read More

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Leveraging statistical shape modeling in computational respiratory dynamics: Nanomedicine delivery in remodeled airways.

Comput Methods Programs Biomed 2021 Apr 3;204:106079. Epub 2021 Apr 3.

Department of Biomedical Engineering, University of Massachusetts, Lowell, MA, U.S.A. Electronic address:

Background And Objective: Accurate knowledge of the delivered doses to the diseased site in the respiratory tract is crucial to elicit desired therapeutic outcomes. However, such information is still difficult to obtain due to inaccessibility for measurement or visualization, complex network structure, and challenges in reconstructing lung geometries with disease-invoked airway remodeling. This study presents a novel method to simulate the airway remodeling in a mouth-lung geometry extending to G9. Read More

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Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes.

Mol Ther 2021 Apr 5. Epub 2021 Apr 5.

Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic-, Transplantation and Vascular Surgery, REBIRTH - Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany. Electronic address:

Cellular therapies based on induced pluripotent stem cells (iPSCs) come out of age and an increasing number of clinical trials applying iPSC-based transplants are ongoing or in preparation. Recent studies, however, demonstrated a high number of small scale mutations in iPSCs. Although, the mutational load in iPSCs seems to be largely derived from their parental cells, it is still unknown whether reprogramming may enrich for individual mutations that could lead to loss of functionality and tumor formation from iPSC derivatives. Read More

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Improving patient identification for advanced cardiac imaging through machine learning-integration of clinical and coronary CT angiography data.

Int J Cardiol 2021 Apr 5. Epub 2021 Apr 5.

Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700RB Groningen, the Netherlands; Turku PET Centre, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Department of Cardiology, Hart and Lung Division, University Medical Centre Utrecht, Heidelberglaan 100, 3508, GA, Utrecht, the Netherlands. Electronic address:

Background: Standard computed tomography angiography (CTA) outputs a myriad of interrelated variables in the evaluation of suspected coronary artery disease (CAD). But an important proportion of obstructive lesions does not cause significant myocardial ischemia. Nowadays, machine learning (ML) allows integration of numerous variables through complex interdependencies that optimize classification and prediction at the individual level. Read More

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