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Cationic Heterobimetallic Mg(Zn)/Al(Ga) Combinations for Cooperative C-F Bond Cleavage.

Angew Chem Int Ed Engl 2021 May 12. Epub 2021 May 12.

FAU: Friedrich-Alexander-Universitat Erlangen-Nurnberg, chemistry, GERMANY.

Low-valent ( Me BDI)Al and ( Me BDI)Ga act as Lewis bases for complexation of highly Lewis acidic cations in [( tBu BDI)M + ·C 6 H 6 ][(B(C 6 F 5 ) 4 -] (M = Mg or Zn, Me BDI = HC[C(Me)N-DIPP], tBu BDI = HC[C( t Bu)N-DIPP], DIPP = 2,6-diisopropylphenyl) yielding heterobimetallic complexes containing the cations [( tBu BDI)Mg-Al( Me BDI) + ], [( tBu BDI)Mg-Ga( Me BDI) + ] and [( tBu BDI)Zn-Ga( Me BDI) + ]. These cations do not show interaction with B(C 6 F 5 ) 4 - and feature long Mg-Al(or Ga) distances or a short Zn-Ga bond. The complex with the [( tBu BDI)Zn-Al( Me BDI) + ] cation could not be obtained but should, according to DFT calculations, be stable. Read More

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The influence of the antithymocyte globulin dose on clinical outcomes of patients undergoing kidney retransplantation.

PLoS One 2021 12;16(5):e0251384. Epub 2021 May 12.

Division of Nephrology, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.

Optimizing antithymocyte globulin (rATG) dosage is critical for high immunological risk patients undergoing a repeat kidney transplant. This natural retrospective cohort study compared clinical outcomes of two successive cohorts of consecutive recipients of retransplants receiving 5 x 1 mg/kg (rATG-5, n = 100) or a single 3 mg/kg (rATG-3, n = 110) dose of rATG induction therapy. All patients had negative complement-dependent cytotoxicity crossmatch and no anti-HLA A, B, DR donor-specific antibodies (DSA). Read More

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Social mobility and healthy behaviours from a gender perspective in the Spanish multicase-control study (MCC-Spain).

PLoS One 2021 12;16(5):e0251447. Epub 2021 May 12.

Cancer and Public Health Area, Foundation for the Promotion of the Research in Healthcare and Biomedicine (FISABIO-Salud Pública), Valencia, Valencian Community, Spain.

There is evidence for the influence of socioeconomic status (SES) on healthy behaviours but the effect of social mobility (SM) is not yet well known. This study aims to analyse the influence of origin and destination SES (O-SES and D-SES) and SM on healthy behaviours and co-occurrence, from an integrated gender and age perspective. Data were obtained from the controls of MCC-Spain between 2008-2013 (3,606 participants). Read More

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Evaluation of the efficacy of physical therapy on cognitive decline at 6-month follow-up in Parkinson disease patients with mild cognitive impairment: a randomized controlled trial.

Aging Clin Exp Res 2021 May 12. Epub 2021 May 12.

IRCCS Mondino Foundation, Via Mondino 2, 20100, Pavia, Italy.

Background: In Parkinson's disease (PD), physical activity may represent a possible non-pharmacological intervention not only for improving motor symptoms but also for modulating cognitive impairment.

Aims: To evaluate the efficacy of an intensive physical program on cognitive functions in mid-stage PD patients with mild cognitive impairment (PD-MCI) over a 6-month follow-up.

Methods: This is a 6-month randomized controlled follow-up study. Read More

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Inflammatory Response Assessment in Patients with COVID-19 Under Extracorporeal Membrane Oxygenation Support.

Clin Lab 2021 May;67(5)

Background: Extracorporeal membrane oxygenation (ECMO), could be extremely helpful in the management of COVID-19 patients with refractory hypoxemic respiratory failure; however, to date, evidence on the true effecttiveness of ECMO in the COVID19 setting still hangs in the balance.

Methods: This was a prospective cohort study of 39 COVID-19 patients admitted to the intensive care unit (ICU) in an experienced ECMO center at a tertiary hospital during March/April 2020. Among the recruited participants, 10 (25. Read More

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Enantiopure polyradical tetrahedral Pd12L6 cages.

Chemistry 2021 May 12. Epub 2021 May 12.

Indian Institute of Science Education and Research, Pune, Chemistry, Dr. Homi Bhabha Road, Pashan, 411008, Pune, INDIA.

Synthesis of cages with polyradical framework remains a challenging task. Here we report an enantiomeric pair of quinoid-bridged polyradical tetrahedral palladium (II) cages that are stabilized by an unusual dianionic diradical (dhbq·· 2- ) form. These cages have been characterized by electron paramagnetic resonance (EPR) spectroscopy, squid magnetometry and mass spectrometry. Read More

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Toxicological and anti-tumor effects of a linden extract ( Scop.) in a HPV16-transgenic mouse model.

Food Funct 2021 May;12(9):4005-4014

Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Inov4Agro, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.

Tilia platyphyllos Scop. is a popular broad-leaved tree, native to Central and Southern Europe. Hydroethanolic extracts rich in phenolic compounds obtained from T. Read More

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Implants sites with concomitant bone regeneration using a resorbable or non-resorbable membrane result in stable marginal bone levels and similar profilometric outcomes over 5 years.

Clin Oral Implants Res 2021 May 12. Epub 2021 May 12.

Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich, Switzerland.

Objectives: To assess clinical and radiographic outcomes as well as the profilometric contour alterations of peri-implant hard and soft tissues around single implants treated with simultaneous guided bone regeneration (GBR) at 5 years.

Materials And Methods: Twenty-seven patients presenting with a single tooth gap in the esthetic zone received a two-piece implant. GBR was randomly performed using a resorbable (RES) or a non-resorbable membrane (N-RES) combined with a bone substitute material. Read More

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What Atomic Positions Determines Reactivity of a Surface? Long-Range, Directional Ligand Effects in Metallic Alloys.

Adv Sci (Weinh) 2021 May 14;8(9):2003357. Epub 2021 Feb 14.

Department of Chemistry University of Copenhagen København Ø 2100 Denmark.

Ligand and strain effects can tune the adsorption energy of key reaction intermediates on a catalyst surface to speed up rate-limiting steps of the reaction. As novel fields like high-entropy alloys emerge, understanding these effects on the atomic structure level is paramount: What atoms near the binding site determine the reactivity of the alloy surface? By statistical analysis of 2000 density functional theory calculations and subsequent host/guest calculations, it is shown that three atomic positions in the third layer of an fcc(111) metallic structure fourth-nearest to the adsorption site display significantly increased influence on reactivity over any second or third nearest atomic positions. Subsequently observed in multiple facets and host metals, the effect cannot be explained simply through the d-band model or a valence configuration model but rather by favorable directions of interaction determined by lattice geometry and the valence difference between host and guest elements. Read More

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Historical effective population size of North American hoary bat () and challenges to estimating trends in contemporary effective breeding population size from archived samples.

PeerJ 2021 19;9:e11285. Epub 2021 Apr 19.

U.S. Geological Survey, Fort Collins Science Center, Fort Collins, CO, United States of America.

Background: Hoary bats () are among the bat species most commonly killed by wind turbine strikes in the midwestern United States. The impact of this mortality on species census size is not understood, due in part to the difficulty of estimating population size for this highly migratory and elusive species. Genetic effective population size (Ne) could provide an index of changing census population size if other factors affecting Ne are stable. Read More

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The influence of active carbon contaminants on the ozonation mechanism interpretation.

Sci Rep 2021 May 11;11(1):9934. Epub 2021 May 11.

Department of Analytical and Environmental Chemistry, Faculty of Chemistry, Adam Mickiewicz University Poznan, Uniwersytetu Poznańskiego 8, 61-614, Poznań, Poland.

In water treatment technology, activated carbons are used primarily as sorbents to remove organic impurities, mainly natural organic matter, but also as catalysts in the ozonation process. Commercially available activated carbons are usually contaminated with mineral substances, classified into two main groups: alkali metals (Ca, Na, K, Li, Mg) and multivalent metals (Al, Fe, Ti, Si). The presence of impurities on the carbon surface significantly affects the pH values determined for raw and ozonated carbon as well as their acidity and alkalinity. Read More

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[Gemcitabine and Docetaxel for the Treatment of Relapsed and Refractory Malignant Rhabdoid Tumor of Kidney and Atypical Teratoid Rhabdoid Tumor].

Gan To Kagaku Ryoho 2021 Apr;48(4):537-540

Dept. of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan.

Gemcitabine and Docetaxel(GEM/DTX)are well known chemotherapeutic drugs for the treatment of soft tissue sarcomas. However, the efficacy of these drugs in the treatment of malignant rhabdoid tumors(MRTs)has not been well described. We used GEM/DTX as salvage chemotherapy for relapsed and refractory MRTs, including 2 patients with malignant rhabdoid tumor of the kidney(MRTK)and 2 with atypical teratoid rhabdoid tumor(ATRT). Read More

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Evaluation of gas chromatography for the separation of a broad range of isotopic compounds.

Anal Chim Acta 2021 Jun 10;1165:338490. Epub 2021 Apr 10.

Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, 76019, United States. Electronic address:

The separation of deuterated compounds from their protiated counterparts is essential in areas of drug discovery and development, investigating kinetic isotope effects and quantitative methods of non-mass spectrometry-based stable isotope dilution assay (non-MS SIDA). The separations of 47 isotopologue pairs of common compounds and drugs were achieved by gas-liquid chromatography, employing twelve different stationary phases. Polydimethylsiloxane phase, phenyl substituted polydimethylsiloxane phases, wax phases, ionic liquid phases, and chiral stationary phases were selected to encompass a wide polarity range and diverse chemical interactions. Read More

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Human exposure and health risk assessment of an increasingly used antibacterial alternative in personal care products: Chloroxylenol.

Sci Total Environ 2021 May 5;786:147524. Epub 2021 May 5.

Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety, South China Normal University, Guangzhou 510006, China. Electronic address:

The ban of some antibacterial ingredients, such as triclosan (TCS) and triclocarban (TCC), in personal care products (PCPs) in some countries (but not in China) has resulted in the increasing use of antibacterial alternatives, such as chloroxylenol (PCMX). However, the underlying human health risks and environmental impacts of PCMX exposure are largely unknown. Thus, the distribution characteristics of PCMX in PCPs and susceptible populations and the major routes and health risks of human exposure to PCMX were investigated. Read More

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A genetic variant conferred high expression of CAV2 promotes pancreatic cancer progression and associates with poor prognosis.

Eur J Cancer 2021 May 7;151:94-105. Epub 2021 May 7.

Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China. Electronic address:

Aim: This study aimed to identify the functional genes and genetic variants associated with the prognosis of pancreatic ductal adenocarcinoma (PDAC) and reveal the mechanism underlying their prognostic roles.

Methods: First, we implement a two-stage exome-wide association study in a total of 1070 patients to identify the genetic variant correlated with PDAC prognosis. Then we performed fine mapping through bioinformatics analysis and dual-luciferase reporter assays to reveal the causal functional variant and prognostic gene. Read More

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IMPACT OF THE PLACEBO EFFECT ON SYMPTOMS, QUALITY OF LIFE AND FUNCTIONAL OUTCOMES IN ANGINA PECTORIS: A meta-analysis of randomized placebo-controlled trials.

Can J Cardiol 2021 May 8. Epub 2021 May 8.

Division of Cardiology, Department of Internal Medicine, Città della Salute e della Scienza, Torino.

Background: The placebo effect is a well described phenomenon in blinded studies evaluating anti-anginal therapeutics, although its impact on clinical research metrics remains unknown. We conducted a systematic review and meta-analysis to quantify the impact of placebo on endpoints of symptoms, life-quality and functional outcomes in randomized placebo-controlled trials (RCTs) of symptomatic stable coronary artery disease.

Methods: We systematically reviewed MEDLINE, EMBASE, and the Cochrane database for double-blind RCTs of anti-angina therapeutics. Read More

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Worldwide trend in human papillomavirus-attributable cancer incidence rates between 1990 and 2012 and Bayesian projection to 2030.

Cancer 2021 May 11. Epub 2021 May 11.

Hepatobiliary and Pancreatic Interventional Treatment Center, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: There is a paucity of global comparative trend analyses of all human papillomavirus (HPV)-attributable cancers. In addition, most analyses by international sources only describe past trends; few studies have projected the future trend of HPV-attributable cancers.

Methods: Data were used from the Cancer Incidence in Five Continents (CI5plus) database that contains annual incidence by cancer site, age, and sex, as well as corresponding populations. Read More

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Shifting access to pools of shoot water sustains gas exchange and increases stem hydraulic safety during seasonal atmospheric drought.

Plant Cell Environ 2021 May 11. Epub 2021 May 11.

Plant Science Division, Research School of Biology, Australian National University, Acton, Australia.

Understanding how plants acclimate to drought is crucial for predicting future vulnerability, yet seasonal acclimation of traits that improve drought tolerance in trees remains poorly resolved. We hypothesized that dry season acclimation of leaf and stem traits influencing shoot water storage and hydraulic capacitance would mitigate the drought-associated risks of reduced gas exchange and hydraulic failure in the mangrove Sonneratia alba. By late dry season, availability of stored water had shifted within leaves and between leaves and stems. Read More

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Stable isotope evidence (Fe, Cu) suggests that sex, but not aging is recorded in rhesus macaque (Macaca mulatta) bone.

Am J Phys Anthropol 2021 May 11. Epub 2021 May 11.

Department of Anthropology, Rutgers University, New Brunswick, New Jersey, USA.

Objectives: Here, we examine (1) if the sex-related differences in iron (Fe) and copper (Cu) isotope ratios, represented as δ Fe and δ Cu values, respectively observed in humans exist in bulk occipital bone and incisors of male and female non-human primates, and (2) if the variation of Fe and Cu isotope ratios, known to vary in human blood as a factor of age are similar in non-human primate bone.

Materials And Methods: Isotope ratios were measured from the skeletal elements of 20 rhesus macaques (Macaca mulatta) with known life history traits. The metals were purified by column chromatography and their isotope ratios measured by MC-ICP-MS. Read More

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Prosocial and Aggressive Behavior: A Longitudinal Study.

Monogr Soc Res Child Dev 2021 Jun;86(2):7-103

School of Psychology, Cardiff University.

Developmental theorists have made strong claims about the fundamental prosocial or aggressive nature of the human infant. However, only rarely have prosocial behavior and aggression been studied together in the same sample. We charted the parallel development of both behaviors from infancy to childhood in a British community sample, using a two-construct, multimethod longitudinal design. Read More

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Stable leaders pave the way for cooperation under time-dependent exploration rates.

R Soc Open Sci 2021 Feb 3;8(2):200910. Epub 2021 Feb 3.

INESC-ID and Instituto Superior Técnico, Universidade de Lisboa, 2744-016 Porto Salvo, Portugal.

The exploration of different behaviours is part of the adaptation repertoire of individuals to new environments. Here, we explore how the evolution of cooperative behaviour is affected by the interplay between exploration dynamics and social learning, in particular when individuals engage on prisoner's dilemma along the edges of a social network. We show that when the population undergoes a transition from strong to weak exploration rates a decline in the overall levels of cooperation is observed. Read More

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February 2021

Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations.

Cell Discov 2021 May 11;7(1):32. Epub 2021 May 11.

Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, China.

Substitution of lysine 36 with methionine in histone H3.3 (H3.3K36M) is an oncogenic mutation that inhibits SETD2-mediated histone H3K36 tri-methylation in tumors. Read More

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Discovery of novel tripeptide propylene oxide proteasome inhibitors for the treatment of multiple myeloma.

Bioorg Med Chem 2021 May 1;40:116182. Epub 2021 May 1.

College of Life Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210037, PR China; Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd., No. 9 Weidi Road, Nanjing 210046, PR China. Electronic address:

The ubiquitin proteasome pathway (UPP) plays a critical role in the maintenance of cell homeostasis and the development of diseases, such as cancer and neurodegenerative disease. A series of novel tripeptide propylene oxide compounds as proteasome inhibitors were designed, synthesized and biologically investigated in this manuscript. The enzymatic activities of final compounds against 20S human proteasome were investigated and structure-activity relationship (SAR) was summarized. Read More

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E4 Transfer (E = P, As) to Ni Complexes.

Chemistry 2021 May 10. Epub 2021 May 10.

University of Regensburg, Inorganic Chemistry, Universitätsstrasse 31, D-93040, Regensburg, GERMANY.

: The utilization of [Cp''2Zr(η1:1-E4)] (E = P (1a), As (1b), Cp'' = 1,3-di-tertbutyl-cyclopentadienyl) as phosphorus or arsenic source, respectively, gives access to novel stable polypnictogen transition metal complexes at ambient temperatures. The reaction of 1a/1b with [CpRNiBr]2 (CpR = CpBn (1,2,3,4,5-penta-benzyl-cyclopentadienyl), Cp''' (1,2,4-tri-tertbutyl-cyclopentadienyl)) was studied, to yield novel complexes depending on steric effects and stoichiometric ratios. Besides the transfer of the complete En unit, a degradation as well as aggregation can be observed. Read More

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Successful Plasmapheresis and Immunoglobulin treatment for severe lipid storage myopathy: doing the right thing for the wrong reason.

Neuropathol Appl Neurobiol 2021 May 10. Epub 2021 May 10.

Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117, Berlin, Germany.

Lipid myopathies are rare and heterogeneous multi-systemic diseases that may be hereditary or acquired and affect the skeletal muscle [1]. Four types usually demonstrate accumulation of lipids in muscle biopsy specimens that can be visualised using Oil-Red-O (ORO) stain. These comprise (i) Multiple Acyl-CoA Dehydrogenase deficiency (MADD), (ii) Primary Carnitine Deficiency (PCD), (iii) Neutral Lipid Storage Disease with Ichthyosis (NLSDI), and (iv) Neutral Lipid Storage Disease with myopathy (NLSDM) [2]. Read More

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Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity.

Alzheimers Dement (Amst) 2021 2;13(1):e12180. Epub 2021 May 2.

School of Public Health and Preventive Medicine Monash University Melbourne Australia.

Introduction: This study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and the association of these trajectories with dementia.

Methods: Generally healthy older adults (n = 19,114) were followed for up to 7 years, with regular cognitive assessments. Group-based trajectory modeling identified distinct cognitive trajectories. Read More

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Pecking Behavior in Conventional Layer Hybrids and Dual-Purpose Hens Throughout the Laying Period.

Front Vet Sci 2021 23;8:660400. Epub 2021 Apr 23.

Animals in Science and Society, Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

To avoid the killing of surplus male layer chickens, dual-purpose hybrids are suggested as an alternative approach. These strains may offer additional advantages compared to conventional laying hens, for instance, a lower tendency to develop injurious pecking behavior. The aim of this study was to assess the behavior, with focus on pecking behavior, of conventional layers (Lohmann Brown plus, LB+) and dual-purpose hens (Lohmann Dual, LD). Read More

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Agreement of Angiography-Derived and Wire-Based Fractional Flow Reserves in Percutaneous Coronary Intervention.

Front Cardiovasc Med 2021 23;8:654392. Epub 2021 Apr 23.

Department of Cardiology, National Center of Gerontology, Institute of Geriatric Medicine, Beijing Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Coronary angiography-derived fractional flow reserve (caFFR) measurements have shown good correlations and agreement with invasive wire-based fractional flow reserve (FFR) measurements. However, few studies have examined the diagnostic performance of caFFR measurements before and after percutaneous coronary intervention (PCI). This study sought to compare the diagnostic performance of caFFR measurements against wire-based FFR measurements in patients before and after PCI. Read More

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Associations Between Sputum Torque Teno Virus Load and Lung Function and Disease Severity in Patients With Chronic Obstructive Pulmonary Disease.

Front Med (Lausanne) 2021 22;8:618757. Epub 2021 Apr 22.

Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.

Viral load of Torque Teno virus (TTV) is elevated in immunosuppressed patients. The weakened immune response is typical in chronic obstructive pulmonary disease (COPD) patients. However, the relationship between TTV and COPD is still unknown. Read More

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Trends in US emergency department visits and subsequent hospital admission among patients with inflammatory bowel disease presenting with abdominal pain: a real-world study from a national emergency department sample database.

J Mark Access Health Policy 2021 Apr 19;9(1):1912924. Epub 2021 Apr 19.

Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

: This study evaluated emergency department (ED) visit trends, subsequent inpatient admissions for patients with inflammatory bowel disease (IBD) diagnosis and IBD-related abdominal pain (AP), and hospital-level variation in inpatient admission rates in the USA (US). : This population-based, cross-sectional study included data from Nationwide Emergency Department Sample (NEDS, 2006─2013) database. Patients ≥18 years of age with primary ED diagnosis of IBD/IBD-related AP were included. Read More

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