37,638 results match your criteria observed recommended


Comparison of the polarization contrast of gelatinous zooplankton and a transparent single-use plastic bag-Implications for marine animals.

Mar Pollut Bull 2021 May 12;168:112438. Epub 2021 May 12.

University of Texas at Austin, Department of Integrative Biology, Austin, TX 78712, USA.

Plastic pollution in the ocean is an increasingly detrimental issue for marine organisms. As a form of polarized light pollution, transparent plastic debris may be more visible and pose additional threats to organisms that can detect and interpret polarized light. Plastic can mimic the visual features of common marine prey items, such as transparent gelatinous zooplankton, which may lead to more significant plastic ingestion. Read More

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Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial.

Lancet 2021 May 12. Epub 2021 May 12.

MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.

Background: Ovarian cancer continues to have a poor prognosis with the majority of women diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) to determine if population screening can reduce deaths due to the disease. We report on ovarian cancer mortality after long-term follow-up in UKCTOCS. Read More

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High-risk individuals for gastric cancer would be missed for surveillance without subtyping of intestinal metaplasia.

Virchows Arch 2021 May 14. Epub 2021 May 14.

Institute of Clinical and Preventive Medicine, Faculty of Medicine, University of Latvia, 19 Raina Blvd, Riga, 1006, Latvia.

The use of Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis Assessment based on Intestinal Metaplasia (OLGIM) staging system is recommended for identifying subjects at risk for developing gastric cancer; usually high-risk lesions are considered only as stages III and IV. Accumulating evidence suggests that incomplete intestinal metaplasia (IM) is important in the development of gastric cancer. Our aim has been to identify the prevalence of incomplete IM in patients with low-risk OLGA/OLGIM stages among a high-risk general population. Read More

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Efficacy and Safety of Intrathecal Pemetrexed Combined with Dexamethasone for Treating TKI-failed Leptomeningeal Metastases from EGFR-mutant NSCLC-A Prospective Open-label Single-arm Phase I/II Clinical Trial (unique identifier: ChiCTR1800016615).

J Thorac Oncol 2021 May 11. Epub 2021 May 11.

Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address:

Introduction: We aimed to examine the efficacy and safety of intrathecal pemetrexed (IP) for treating EGFR-mutant leptomeningeal metastases (LM) from EGFR-mutant non-small cell lung cancer (NSCLC).

Methods: EGFR-mutant NSCLC patients with LM who had failed tyrosine-kinase inhibitors (TKIs) were recruited. The dose of IP was escalated from 15 mg to 80 mg using an accelerated titration design in a Phase I study. Read More

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Meningiomas in patients with long-term exposition to progestins: Characteristics and outcome.

Neurochirurgie 2021 May 11. Epub 2021 May 11.

Aix Marseille Univ, APHM, INSERM, MMG, Department of Neursurgery, CHU Timone, Marseille, France.

Objective: The aim of this study was to describe progestin-associated meningiomas' characteristics, outcome and management.

Material And Methods: We included 53 patients operated on and/or followed in the department for meningioma with progestin intake longer than one year and with recent drug discontinuation.

Results: Cyproterone acetate (CPA), nomegestrol acetate (NomA), and chlormadinone acetate (ChlA) were involved in most cases. Read More

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Reporting of Differences in Taste Between Branded and Unbranded Cigarettes by Smokers Blinded to Cigarette Branding: Within-Person, Randomized Crossover Study.

JMIR Form Res 2021 May 14;5(5):e24446. Epub 2021 May 14.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Background: Saudi Arabia implemented a plain tobacco packaging regulation, one of the World Health Organization's recommended initiatives to help reduce smoking rates, in August 2019. A few weeks after implementation, a large number of smokers complained via various media channels, especially social media (eg, Twitter), that an extreme change in cigarette taste had occurred, frequency of coughing had increased, and for some, shortness of breath had led to hospitalization.

Objective: The main objective is to determine whether smokers blinded to cigarette branding report differences in taste between branded and unbranded cigarettes. Read More

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Impact of Applying a Skin Compression with the Ultrasound Probe on Carotid Artery Strain Elastography.

J Ultrasound Med 2021 May 14. Epub 2021 May 14.

Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center (CRCHUM), Montréal, Québec, Canada.

Objective: To study the impact of varying the external compression exerted by the ultrasound probe when performing a carotid strain elastography exam.

Methods: Nine healthy volunteers (mean age 43 years ±13 years; 6 men) underwent a vascular ultrasound elastography exam using a custom made sound feedback handle embedding the probe, and allowing the sonographer to adjust the applied compression. A clinical standard practice (SP) force was first recorded, and then predetermined compression (PDC) forces were applied, ranging from 0 to 5 N for the left common carotid artery (CCA) or 2-12 N for the left internal carotid artery (ICA). Read More

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Treatment of Hydatid Liver Cyst With Double Percutaneous Aspiration and Ethanol Injection Under Ultrasound Guidance: 6.5-Year Median Follow-up Analysis.

Cardiovasc Intervent Radiol 2021 May 13. Epub 2021 May 13.

Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Purpose: Although hydatid liver cyst (HLC) is a benign disease, treatment is recommended to avoid life-threatening complications. There are several treatment options for HLC: "wait-and-watch," medical or surgical or percutaneous treatment. The purpose of this study was to assess the long-term effectiveness of an alternative of the traditional percutaneous PAIR procedure, called double percutaneous aspiration and ethanol injection (D-PAI). Read More

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Effects of hot-melt extruded nano-copper on the Cu bioavailability and growth of broiler chickens.

J Anim Sci Technol 2021 Mar 31;63(2):295-304. Epub 2021 Mar 31.

College of Animal Life Sciences, Kangwon National University, Chuncheon, 24341, Korea.

This study was aimed to investigate the Cu bioavailability, growth response, digestibility of nutrients, and blood metabolites of broiler chicks fed CuSO in nano or common forms. A total of 720 broiler chickens were distributed between eight treatments according to a completely randomized design. There were 8 treatments and 6 replicates in each treatment with 15 birds/replicate. Read More

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Features Associated With Quality of Life Impairment in Hidradenitis Suppurativa Patients.

Front Med (Lausanne) 2021 27;8:676241. Epub 2021 Apr 27.

Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with an adverse impact on patients' quality of life (QoL). To quantify QoL impairment in patients in Germany suffering from HS and to identify the parameters associated with QoL impairment. A non-interventional, cross-sectional, mono-centric study with 500 HS patients. Read More

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Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.

Clin Nutr Res 2021 Apr 27;10(2):127-139. Epub 2021 Apr 27.

Food and Beverages Safety Research Center, Department of Nutrition, School of Medicine, Urmia University of Medical Sciences, Urmia 32770-397, Iran.

Migraine is a widespread incapacitating neurologic disorder with debilitating headaches which are usually throbbing due to inefficacy and several side effects, complementary therapies recommended as possible alternatives. The current randomized controlled trial was carried out to evaluate the effect of zinc gluconate supplementation on migraine-related symptoms, serum level of high sensitivity C-reactive protein (hs-CRP) and lipid profile in migraineurs. Present study was designed as randomized double-blind, placebo-controlled trial. Read More

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Skip decompression surgeries in the treatment of holospinal epidural abscess: a case report.

Spinal Cord Ser Cases 2021 May 13;7(1):38. Epub 2021 May 13.

Department of Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan.

Introduction: Holospinal epidural abscess (HEA) extending from the cervical to the lumbosacral spine is an extremely rare condition. Surgical treatment of HEA, which involves extensive decompression of the spinal lesion is difficult in emergency settings. However, the authors successfully treated a case of HEA in critical condition with severe neurological deficits through a combination of skip decompression surgeries and catheter irrigation. Read More

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Bioaccumulation and human health risk assessment of trace metals in the freshwater mussel Cristaria plicata in Dongting Lake, China.

J Environ Sci (China) 2021 Jun 28;104:335-350. Epub 2020 Dec 28.

State Key Laboratory of Eco-hydraulic in Northwest Arid Region of China, Xi'an University of Technology, Xi'an 710048, Shaanxi, China.

Trace metal contamination in water and bioaccumulation in aquatic organisms are human health risks of increasing concern. However, the bioaccumulation of trace metals in the organs of the mussel Cristaria plicata in Dongting Lake, China and the human health risks of mussel consumption are largely unknown. We investigated the concentrations of 15 trace metals and metalloids in surface water, sediments, and C. Read More

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Rupture of contralateral mainstem bronchus during uniportal video-assisted thoracoscopy surgery lobectomy and 3 successful cases of repair.

J Cardiothorac Surg 2021 May 13;16(1):129. Epub 2021 May 13.

Department of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.

Background: Our goal was to discuss the treatment for rupture of contralateral mainstem bronchus during uniportal video-assisted thoracoscopy surgery (uniportal VATS) lobectomy.

Case Presentation: We analyzed clinical data of 3 cases of rupture of contralateral mainstem bronchus during uniportal VATS. Surgical repair was performed immediately under an uniportal VATS during operation, as a result, 3 cases of bronchial rupture all were repaired successfully, and we continued to complete lobectomy and systemic lymph node dissection. Read More

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Simulating trophic impacts of fishing scenarios on two oceanic islands using Ecopath with Ecosim.

Mar Environ Res 2021 Apr 28;169:105341. Epub 2021 Apr 28.

I.U. EcoAqua, Universidad de Las Palmas de Gran Canaria, Edf. Ciencias Básicas, Campus de Tafira, Gran Canaria, Spain.

The ecological system conformed by the islands of Tenerife and La Gomera (Canary Islands) is characterized though the trophic network. The indicators obtained by the Ecopath model show a stressed and still developing ecosystem, probably related to inadequate management of the fisheries that takes place in this area, focused on high trophic level species. The Ecosim and Ecospace modules have been used to provide comparative assessment of three management scenarios addressed to evaluate the impact of fishing, both professional and recreational, on the marine ecosystem, as well as the spatial evolution of the fishing effort in a projection period going from 2021 to 2030, that can be applied in decision-making and planning in the short and medium term. Read More

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Assessment of predictive performance of caries risk assessment models based on a systematic review and meta-analysis.

J Dent 2021 May 10:103664. Epub 2021 May 10.

Department of Social Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amasterdam and VU University, the Netherlands.

Objectives: To assess the predictive performance of caries risk assessment (CRA) models for prediction of caries increment for individuals based on a systematic review and meta-analyses.

Data/sources: We included external validation studies assessing the predictive performance of CRA models for prediction of caries increment for individuals, using discrimination and calibration as the outcome parameters. PubMed, EMBASE, and CINAHL were searched electronically on 10 September 2020 to identify prediction modeling studies on external validation of CRA models. Read More

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Activity of Fosfomycin and Nitrofurantoin Against Contemporary Pathogens Isolated from Indian Tertiary Care Hospitals.

Microb Drug Resist 2021 May 13;27(5):678-684. Epub 2020 Oct 13.

Wockhardt Research Centre, D4 MIDC, Aurangabad, India.

In India, multidrug resistance in community and hospital associated Gram-negative pathogens has increased sharply over the past few years. In the absence of novel oral multidrug resistant-pathogen active therapies, the therapeutic situation with regard to community infections is even more challenging. Hence, the focus is now shifting toward potentially expanding the utility of older antibiotics such as fosfomycin and nitrofurantoin beyond their approved pathogen coverage. Read More

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Impact of Postshock Transcutaneous Pacing on Chest Compression Quality during Resuscitation: A Simulation-Based Pilot Study.

Emerg Med Int 2021 22;2021:5584632. Epub 2021 Apr 22.

Department of Medical Rescue, Poznan University of Medical Sciences, 7 Rokietnicka Street, Poznan 60-608, Poland.

Background: Successful defibrillation is commonly followed by a transient nonperfusing state. To provide perfusion in this stagnant phase, chest compressions are recommended irrespective of arrhythmia termination. Implantable cardioverters-defibrillators (ICD) used immediately after delivery of the shock are capable of pacing the heart, and this feature is commonly activated in these devices. Read More

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HER2 in situ hybridization test in breast cancer: quantifying margins of error and genetic heterogeneity.

Mod Pathol 2021 May 12. Epub 2021 May 12.

Department of Pathology, Ipatimup Diagnostics, Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.

The aim of the present study was to evaluate the effect of counting increasing number of invasive cancer cells in the result of the HER2 in situ hybridization (ISH) test in breast cancer as well as to compare two different approaches of measuring genomic heterogeneity (single cell and population based). A cohort of 100 consecutive breast cancer cases (primary and metastatic) were evaluated for HER2 gene amplification with bright-field ISH. The evaluation of the samples included scoring 20 nuclei, in five different areas, measuring the margins of error for each case. Read More

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Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19-Convalescent Donors.

J Immunol 2021 May 12. Epub 2021 May 12.

Department of Transfusion Medicine, Ulm University, Ulm, Germany.

The current SARS-CoV-2 pandemic has triggered the development of various SARS-CoV-2 neutralization tests. A wild-type virus (using African green monkey VeroE6 cells), a pseudovirus (using human Caco-2 cells), and a surrogate neutralization test platform were applied to characterize the SARS-CoV-2 neutralization potential of a cohort of 111 convalescent plasma donors over a period of seven months after diagnosis. This allowed an in-depth validation and assay performance analysis of these platforms. Read More

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Skin necrosis and calcifications after extravasation of vancomycin: a localised form of calciphylaxis?

J Wound Care 2021 May;30(5):390-393

Grenoble University Hospital, Department of Vascular Medicine, F-38000 Grenoble, France.

Vancomycin is a tricyclic glycopeptide antibiotic produced from . There is much variation in the literature with regard to the recommended dose, dilution rate and type of infusion. Given the vesicant properties of vancomycin at supratherapeutic doses (>10mg/ml), tissue damage including blistering and necrosis have been reported. Read More

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Newborn Hearing Screening: association between coverage, and the availability of speech therapists and equipment in Brazil.

Codas 2021 3;33(2):e20190259. Epub 2021 May 3.

Departamento de Fonoaudiologia, Universidade Federal da Paraíba - UFPB - João Pessoa (PB), Brasil.

Purpose: To determine the coverage of newborn hearing screening (NHS) and its association with the availability of speech therapists in the National Health System (SUS) and equipment in the states of Brazil in 2012 and 2018.

Methods: This is a descriptive ecological time series study with the Brazilian states and live births as units of analysis. An exploratory analysis of newborn hearing screening coverage and descriptive data analysis were performed. Read More

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Expanding role of radiotherapy in adenoid cystic carcinoma of the tracheobronchial tree: a new horizon.

Tumori 2021 May 12:3008916211012461. Epub 2021 May 12.

Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: Primary adenoid cystic carcinomas (ACCs) of central trachea-bronchi system are rare and heterogeneous tumors. Definitive radiotherapy (RT) is the recommended treatment in surgically unresectable or incomplete resection or in the presence of severe comorbidities.

Objective: To evaluate the clinical features and outcomes of patients with ACC of trachea-bronchi treated with radiotherapy. Read More

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Uso de la prueba Lens culinaris Med como bioindicador ambiental para identificar el efecto citogenotóxico del pesticida paraquat.

Environ Sci Pollut Res Int 2021 May 12. Epub 2021 May 12.

Departamento de Matemáticas y Estadística , Universidad Francisco de Paula Santander , San José , de Cúcuta, Colombia.

Paraquat is the most widely used herbicide and the third most sold pesticide in the world, applied in more than 120 countries despite being banned in the European Union. It is a risk to ecosystems. The genotoxic effect of paraquat was evaluated using the Lens culinaris test. Read More

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Adults Hospitalized with COVID-19 -United States, March-June and October-December 2020: Implications for the Potential Effects of COVID-19 Tier-1 Vaccination on Future Hospitalizations and Outcomes.

Clin Infect Dis 2021 May 12. Epub 2021 May 12.

CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Because of the increased risk for severe coronavirus disease 2019 (COVID-19), the Advisory Committee on Immunization Practices (ACIP) initially prioritized COVID-19 vaccination for persons in long-term care facilities (LTCF), persons aged ≥65 years, and persons aged 16-64 years with high-risk medical conditions when there is limited vaccine supply. We compared characteristics and severe outcomes of hospitalized patients with COVID-19 in the United States between early and later in the pandemic categorized by groups at higher risk of severe COVID-19.

Methods: Observational study of sampled patients aged ≥18 years who tested positive for SARS-CoV-2 and admitted to one of 14 academic hospitals in the United States during March-June and October-December 2020. Read More

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Variation in hypertension clinical practice guidelines: a global comparison.

BMC Med 2021 May 12;19(1):117. Epub 2021 May 12.

Centre for Mathematics of Precision Healthcare, Department of Mathematics, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.

Background: Hypertension is the largest single contributor to the global burden of disease, affecting an estimated 1.39 billion people worldwide. Clinical practice guidelines (CPGs) can aid in the effective management of this common condition, however, inconsistencies exist between CPGs, and the extent of this is unknown. Read More

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Medial subtalar dislocation from a low-energy trauma. A case report and review of the literature.

Int J Surg Case Rep 2021 May 6;83:105954. Epub 2021 May 6.

Department of Clinical Science and Translational Medicine, Section of Orthopedics and Traumatology, University of Rome "Tor Vergata", Italy. Electronic address:

Introduction: Subtalar dislocation is a rare injury characterized by a simultaneous dislocation of the talocalcaneal and talonavicular joints. The most common type is caused by high-energy trauma with medial dislocation of the foot. This injury is frequently associated with fractures, but isolated dislocations are also reported. Read More

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Effect of different rearing system on eggs production, hatchability, and offspring quality in layer breeders.

Poult Sci 2021 Mar 11;100(6):101101. Epub 2021 Mar 11.

Department of Biotechnology and Nutrigenomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Jastrzębiec 36 A, Magdalenka, Poland.

This study analyzed the influence of an aviary system, in comparison with battery cages, on rearing and reproduction of parent-stock (PS) laying-type chickens. ISA Brown PS chicks were reared for 16 wk in battery cages or in an aviary system. Chickens reared in cages were kept there throughout the rearing period, whereas those reared in the aviary were released after 7 wk. Read More

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Detection of Translocation of Cochlear Implant Electrode Arrays by Intracochlear Impedance Measurements.

Ear Hear 2021 Apr 8. Epub 2021 Apr 8.

1ENT-Department, Leiden University Medical Centre, RC Leiden, the Netherlands 2Leiden Institute for Brain and Cognition, RC Leiden, the Netherlands.

Objectives: Misplacement of the electrode array is associated with impaired speech perception in patients with cochlear implants (CIs). Translocation of the electrode array is the most common misplacement. When a CI is translocated, it crosses the basilar membrane from the scala tympani into the scala vestibuli. Read More

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Two-year follow-up after a six-week high-intensity training intervention study with breast cancer patients: physiological, psychological and immunological differences.

Disabil Rehabil 2021 May 11:1-8. Epub 2021 May 11.

Division of Sports and Rehabilitation Medicine, Ulm University Hospital, Ulm, Germany.

Purpose: Previously we demonstrated the feasibility of a six-week-long combination of high-intensity interval endurance and strength training (HIT/HIRT) for women with nonmetastatic breast cancer leading to improvements in psychological well-being and performance. Now we report results of a 24-month follow-up.

Methods: Previous intervention (IG,  = 10; 58. Read More

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