2,825,531 results match your criteria observed presumed


Association of the apoptotic marker APO1/Fas with children's predisposing factors for metabolic syndrome and with mean platelet volume.

J Pediatr Endocrinol Metab 2021 Aug 2. Epub 2021 Aug 2.

Laboratory of Biology and Biochemistry, Faculty of Health Sciences, Department of Nursing, University of Peloponnese, Tripoli, Greece.

Background: Apoptosis antigen 1/FAS receptor (APO1/Fas) signaling in endothelial cells plays a significant role in angiogenesis while increased mean platelet volume (MPV) is an important marker for platelet activation. We investigated the possible correlation between APO1/Fas and both metabolic parameters and platelet activity (indicated by the MPV) in a healthy pediatric population.

Methods: One hundred and eighty-five children, aged 5-17 years old, were enrolled in the study. Read More

View Article and Full-Text PDF

Removed heavy metal ions from wastewater reuse for chemiluminescence: Successive application of lignin-based composite hydrogels.

J Hazard Mater 2021 Jul 24;421:126722. Epub 2021 Jul 24.

Liaoning Key Laboratory of Lignocellulosic Chemistry and Biomaterials, College of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian 116034, China. Electronic address:

The novel sulfomethylated lignin-grafted-polyacrylic acid (SL-g-PAA) hydrogel was fabricated in this work via a facile and green synthetic strategy for the efficient removal of heavy metal ions from wastewater, and then successively reused for chemiluminescence (CL). The sulfomethylation of lignin was first performed to improve its water solubility and introduce numerous active sites for adsorption of heavy metal ions. The as-synthesized SL-g-PAA hydrogel with high content of lignin exhibited the highly efficient and rapid removal of various metal ions from simulated wastewater. Read More

View Article and Full-Text PDF

Inflammation-associated pulmonary microbiome and metabolome changes in broilers exposed to particulate matter in broiler houses.

J Hazard Mater 2021 Jul 21;421:126710. Epub 2021 Jul 21.

Research Centre for Livestock Environmental Control and Smart Production, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:

The particulate matter (PM) in livestock houses, one of the primary sources of atmospheric PM, is not only detrimental to the respiratory health of animals and farmworkers but also poses a threat to the public environment and public health and warrants increased attention. In this study, we investigated the variation in the pulmonary microbiome and metabolome in broiler chickens exposed to PM collected from a broiler house. We examined the pulmonary microbiome and metabolome in broilers, observing that PM induced a visible change in α and β diversity. Read More

View Article and Full-Text PDF

Post-embolization outcomes of splenic artery pseudoaneurysms: A single-center experience.

Clin Imaging 2021 Jul 26;80:160-166. Epub 2021 Jul 26.

Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, IL, USA. Electronic address:

Purpose: Splenic artery pseudoaneurysms (PSA) are relatively rare but associated with high mortality/morbidity when presenting acutely. Embolization has emerged as the treatment of choice. We aim to evaluate the outcomes of embolization for the treatment of splenic artery PSAs. Read More

View Article and Full-Text PDF

Multiple sclerosis incidence and prevalence in Poland: Data from administrative health claims.

Mult Scler Relat Disord 2021 Jul 22;55:103162. Epub 2021 Jul 22.

Department of Neurology, Jagiellonian University Medical College, Krakow, Poland; Department of Neurology, University Hospital in Krakow, Krakow, Poland.

Background: The detailed data concerning multiple sclerosis (MS) epidemiology in Poland are based on studies from few and less populated provinces. Therefore, we evaluated MS incidence and prevalence in Poland using electronic administrative health claims (AHCs) from the National Health Fund.

Methods: We retrospectively analyzed the AHC financial database collected from 2009 to 2019, encompassing all patients using public health resources. Read More

View Article and Full-Text PDF

Inflation of residually stressed Fung-type membrane models of arteries.

J Mech Behav Biomed Mater 2021 Jul 13;122:104699. Epub 2021 Jul 13.

Department of Mechanical Engineering, Texas A&M University, College Station, TX 77845, USA.

Elastic arteries are idealised as being incompressible orthotropic nonlinearly elastic cylinders. They are further idealised as being membranes in order to analyse the effect of the experimentally observed pre-stressing of arterial tissue on inflation. The pre-stress is modelled here using the opening-angle method. Read More

View Article and Full-Text PDF

Enhanced biogas production from Lantana camara via bioaugmentation of cellulolytic bacteria.

Bioresour Technol 2021 Jul 24;340:125652. Epub 2021 Jul 24.

Department of Environmental Studies, Siksha -Bhavana, Visva-Bharati, Santiniketan, West Bengal, 731235, India. Electronic address:

A study was designed to isolate cellulolytic bacteria from termite-gut and soil, optimizing their cellulase production to enhance biogas generation, using Lantana camara as a substrate. Out of 57 bacteria screened, two isolates DSB1 and DSB12, showed significant cellulolytic activity. 16S rRNA based methods identified these isolates as Microbacterium sp. Read More

View Article and Full-Text PDF

Changes of neurocognitive status in patients with the first-episode psychosis after 18 months of treatment-A prospective cohort study.

Psychiatry Res 2021 Jul 19;304:114131. Epub 2021 Jul 19.

Department of Psychiatry, Zagreb University Hospital Centre, Kispaticeva 12, Zagreb HR-10000, Croatia; Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia. Electronic address:

Neurocognitive symptoms exert the most influence on treatment outcomes over the course of schizophrenia, starting from the first-episode of psychosis (FEP) onwards. Our aim was to analyze the neurocognitive status of FEP compared to healthy controls (HC), and its change after 18 months of treatment. We performed a study in a sample of 159 patients with FEP and 100 HC. Read More

View Article and Full-Text PDF

Dental microstructure records life history events: A histological study of mandrills (Mandrillus sphinx) from Gabon.

J Hum Evol 2021 Jul 27;158:103046. Epub 2021 Jul 27.

Department of Anthropology, Durham University, South Road, Durham, DH1 3LE, UK. Electronic address:

Accentuated lines in dental microstructure are hypothesized to correlate with potentially stressful life history events, but our understanding of when, how and why such accentuated lines form in relation to stressful events is limited. We examined accentuated line formation and life history events in the teeth of three naturally deceased mandrills (Mandrillus sphinx, Cercopithecidae), for whom we had detailed life history information. We determined the ages at formation of accentuated lines in histological tooth sections and used dates of birth and death to calibrate dental histology to calendar time and individual age. Read More

View Article and Full-Text PDF

Softness mapping of the concentration dependence of the dynamics in model soft colloidal systems.

J Colloid Interface Sci 2021 Jul 21;605:398-409. Epub 2021 Jul 21.

Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409, United States. Electronic address:

The dynamics of a series of soft colloids comprised of polystyrene cores with poly(N-isopropylacrylamide) (PNIPAM) coronas was investigated by diffusing wave spectroscopy (DWS). The modulus of the coronas was varied by changing the cross-link density and we were able to interpret the results within a hard-soft mapping framework. The soft, swellable particle properties were modeled using an extended Flory-Rehner theory and a Hertzian pair potential. Read More

View Article and Full-Text PDF

Specific locations of blue and green-emitting units in dual emissive carbon dots and their reversible emitting properties due to switchable inter-chromophoric interactions.

J Colloid Interface Sci 2021 Jul 26;605:364-372. Epub 2021 Jul 26.

Indian Institute of Science Education and Research, Govt. ITI Building (transit campus), Engg. School Road, Berhampur, Odisha 760010 India. Electronic address:

Carbon dots (CDs) are the unique class of luminescent nanomaterials consist of various chromophoric units heterogeneously distributed throughout the nanoparticle, resulting intriguing multistate emissive properties. Herein, we have critically investigated the specific locations of the blue and green-emitting centers inside dual emissive CDs by steady-state and time-resolved polarized emission study. It is further clarified by a temperature-dependent fluorescence study for both the emitting domains. Read More

View Article and Full-Text PDF

ZNF326 promotes colorectal cancer epithelial-mesenchymal transition.

Pathol Res Pract 2021 Jul 22;225:153554. Epub 2021 Jul 22.

Department of Pathology, College of Basic Medical Science, and the First Affiliated Hospital of China Medical University, Shenyang, China. Electronic address:

Zinc-finger protein 326 (ZNF326) activity has been reported in different tumors, but its expression and possible mechanism of action in colorectal cancer are not known. In this study, we applied immunohistochemistry to detect the expression of ZNF326 in colorectal tissues. Next, we used a ZNF326 expression plasmid and small interfering (si) RNA-ZNF326 (siZNF326) to transfect colorectal cancer cell lines in order to determine the effect of ZNF326 on cell migration and as well as its potential role in promoting epithelial-mesenchymal transition (EMT). Read More

View Article and Full-Text PDF

Long-term semi-continuous production of carbohydrate-enriched microalgae biomass cultivated in low-loaded domestic wastewater.

Sci Total Environ 2021 Jul 22;798:149227. Epub 2021 Jul 22.

Instituto de Energías Renovables, Universidad Nacional Autónoma de México, Priv. Xochicalco s/n, Col. Centro, Temixco, Morelos CP 62580, Mexico. Electronic address:

The production of carbohydrate-enriched biomass from waste streams as a sustainable biofuel precursor is a noteworthy endeavor. This study investigates the long-term microalgae cultivated under low domestic wastewater loads and different hydraulic retention times (HRT) in a semi-continuous photobioreactor. The influence of operational conditions, the microalgae interaction with carbon, nutrients availability, and microbial population in terms of carbohydrate content were elucidated. Read More

View Article and Full-Text PDF

Continuous input of organic ultraviolet filters and benzothiazoles threatens the surface water and sediment of two major rivers in the Pearl River Basin.

Sci Total Environ 2021 Jul 27;798:149299. Epub 2021 Jul 27.

Environmental Research Institute, School of Environment, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety, MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China.

The extensive usage of organic ultraviolet filters (UV filters) and benzothiazoles (BTs) has caused continuous and widespread pollution in the aquatic environment. This study investigated the occurrence of nine organic UV filters and eight BTs in the surface water and sediment of two major drinking water source rivers in the Pearl River Basin (PRB). The detection frequencies of six organic UV filters and seven BTs were above 50% in surface water, while eight target compounds were as high as 100%. Read More

View Article and Full-Text PDF

A positron emission tomography study of the serotonin1B receptor effect of electroconvulsive therapy for severe major depressive episodes.

J Affect Disord 2021 Jul 17;294:645-651. Epub 2021 Jul 17.

Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Background: Electroconvulsive therapy (ECT) is an effective treatment for depressive disorders, although its molecular mechanism of action is unknown. The serotonin 1B (5-HT) receptor is a potential target for treatment of depression and low 5-HT receptor binding in limbic regions has been reported in previous positron emission tomography (PET) studies of depression.

Methods: The objective of this longitudinal PET study was to examine the effect of ECT for depression on 5-HT receptor binding. Read More

View Article and Full-Text PDF

Stress management versus cognitive restructuring in trauma-affected refugees - A follow-up study on a pragmatic randomised trial.

J Affect Disord 2021 Jul 16;294:628-637. Epub 2021 Jul 16.

Competence Centre for Transcultural Psychiatry, Mental Health Centre Ballerup, Mental Health Services of the Capital Region, Ballerup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Background: There is a lack of research and consensus with respect to long-term effective treatments for trauma-affected refugees. The purpose of this follow-up study of a randomised clinical trial was to investigate the effectiveness of Stress Management (SM) versus Cognitive Restructuring (CR) in treating trauma-affected refugees, six and 18 months post-treatment, respectively.

Methods: From a total of 126 refugees with PTSD, the intention-to-treat sample in the original trial, 74 patients were present at the six-month follow-up (SM; n = 37, CR; n = 37) and 34 patients at the 18-month follow-up (SM; n = 14, CR; n = 20). Read More

View Article and Full-Text PDF

Considerable interlaboratory variation in PD-L1 positivity in a nationwide cohort of non-small cell lung cancer patients.

Lung Cancer 2021 Jul 22;159:117-126. Epub 2021 Jul 22.

Department of Pathology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.

Objectives: Immunohistochemical expression of programmed death-ligand 1 (PD-L1) is used as a predictive biomarker for prescription of immunotherapy to non-small cell lung cancer (NSCLC) patients. Accurate assessment of PD-L1 expression is therefore crucial. In this study, the extent of interlaboratory variation in PD-L1 positivity in the Netherlands was assessed, using real-world clinical pathology data. Read More

View Article and Full-Text PDF

Genetic insights into the paternal admixture history of Chinese Mongolians via high-resolution customized Y-SNP SNaPshot panels.

Forensic Sci Int Genet 2021 Jul 20;54:102565. Epub 2021 Jul 20.

Institute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, China. Electronic address:

The Mongolian people, one of the Mongolic-speaking populations, are native to the Mongolian Plateau in North China and southern Siberia. Many ancient DNA studies recently reported extensive population transformations during the Paleolithic to historic periods in this region, while little is known about the paternal genetic legacy of modern geographically different Mongolians. Here, we genotyped 215 Y-chromosomal single nucleotide polymorphisms (Y-SNPs) and 37 Y-chromosomal short tandem repeats (Y-STRs) among 679 Mongolian individuals from Hohhot, Hulunbuir, and Ordos in North China using the AGCU Y37 kit and our developed eight Y-SNP SNaPshot panels (including two panels first reported herein). Read More

View Article and Full-Text PDF

A five-dimensional data collection strategy for multicomponent discovery and characterization in Traditional Chinese Medicine: Gastrodia Rhizoma as a case study.

J Chromatogr A 2021 Jul 14;1653:462405. Epub 2021 Jul 14.

Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address:

Establishing the identity of bioactive compounds to control the quality of Traditional Chinese Medicines is made more challenging by the complexity of the metabolite matrix, the existence of isomers, and the range of compound concentration and polarity observed between individual samples of the same plant in a multicomponent preparation. In addition, LC-MS analysis has limited capability for the separation and analysis of potentially important trace compounds and isomers, which hinders the comprehensive metabolite characterization of functional foods and Traditional Natural Medicine. To facilitate and improve the chemical composition characterization and enhance metabolite discernment, a comprehensive strategy was developed which integrates ion mobility mass spectrometry (IMS) with offline two-dimensional liquid chromatography based on hydrophilic interaction chromatography (HILIC) and conventional reversed phase (RP) C18 chromatography. Read More

View Article and Full-Text PDF

Serological response in health care workers after a single dose of SARS-CoV-2 vaccine using six automated SARS-CoV-2 antibody assays.

Diagn Microbiol Infect Dis 2021 Jul 10;101(2):115486. Epub 2021 Jul 10.

University Hospital Antwerp, Laboratory Medicine, Edegem, Belgium. Electronic address:

Spike (S)- and nucleocapsid (N)-specific serological assay responses were determined before and/or after first dose SARS-CoV-2 vaccination in 22 individuals. S-specific assays quantified antibodies after vaccination with significant higher levels in participants with a previous infection. Be cautious combining N-/S-specific assay results, potentially differentiating post-infection/vaccination immunization as assay-specific N-antibody waning was observed. Read More

View Article and Full-Text PDF

Identification of plant-based multitargeted leads for Alzheimer's disease: In-vitro and in-vivo validation of Woodfordia fruticosa (L.) Kurz.

Phytomedicine 2021 Jul 21;91:153659. Epub 2021 Jul 21.

Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India. Electronic address:

Background: Alzheimer's disease (AD) is a complex neurodegenerative disease with no availability of disease-modifying therapeutics. The complex etiology and recent failures in clinical trials indicate the need for multitargeted agents.

Purpose: The present study aims to discover new plant-based multitargeted anti-AD leads. Read More

View Article and Full-Text PDF

Topical treatment with mastic (resin from Pistacia lentiscus) elicits anti-inflammatory and anti-pruritic responses by modulating keratinocyte activation in a mouse model of allergic dermatitis.

Phytomedicine 2021 Jul 19;91:153679. Epub 2021 Jul 19.

Laboratory of Veterinary Pharmacology, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa, Japan. Electronic address:

Background: As the number of patients with skin allergies, including atopic dermatitis, has increased rapidly, therapeutic options such as anti-IL-31 antibody and Janus kinase inhibitor have been developed recently. However, many concerns remain regarding the adverse effects and cost of these drugs; therefore, development of supplements that could support the effect of therapeutic agents is always required.

Purpose: The aim of this study was to develop preventive and supportive options for skin allergies by focusing on a natural product called "Mastic". Read More

View Article and Full-Text PDF

PCR-based rapid diagnostic tools for the authentication of medicinal mistletoe species.

Phytomedicine 2021 Jul 16;91:153667. Epub 2021 Jul 16.

Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju, Jeollanam-do 58245, Republic of Korea. Electronic address:

Background: Taxilli Herba (TH) and Visci Herba (VH), defined as the leaves and branches of the mistletoe species Taxillus chinensis and Viscum coloratum, respectively, are popular herbal medicines in East Asia. However, commercial TH and VH products are frequently adulterated with related inauthentic mistletoe species, posing efficacy and safety concerns. Accurate species identification of herbal medicinal products is a prerequisite for quality control, but traditional morphological identification methods are hampered by difficulties in discriminating among closely related species and in identifying the source materials in processed products. Read More

View Article and Full-Text PDF

Oral and manual automatisms elicited by electrical stimulation of the pars opercularis cortex in a patient with frontal lobe epilepsy.

Clin Neurol Neurosurg 2021 Jul 20;208:106784. Epub 2021 Jul 20.

Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Clinical Research Center for Refractory Epilepsy of Shaanxi Province, Xi'an, China. Electronic address:

Oral automatism (OA) and manual automatism (MA) are common signs during initiation of temporal seizures. However, the precise symptomatogenic zones for OA and MA remains largely unclear. In this study, we presented a case of intractable frontal lobe epilepsy (FLE) in which the patient received intracranial EEG monitoring with subdural electrodes. Read More

View Article and Full-Text PDF

Infants Oscillatory Frequencies change during Free-Play.

Infant Behav Dev 2021 Jul 28;64:101612. Epub 2021 Jul 28.

Department of Psychology, Lancaster University, Bailrigg, UK; School of Psychology, The University of Waikato, New Zealand.

Social interactions are known to be an essential component of infant development. For this reason, exploring functional neural activity while infants are engaged in social interactions will enable a better understanding of the infant social brain. This in turn, will enable the beginning of disentangling the neural basis of social and non-social interactions as well as the influence that maternal engagement has on infant brain function. Read More

View Article and Full-Text PDF

Reactive astrocytes contribute to epileptogenesis in patients with cavernous angioma.

Epilepsy Res 2021 Jul 26;176:106732. Epub 2021 Jul 26.

Department of Pathology, Brain Research Institute, Niigata University, Japan.

Objective: Patients with cavernous angioma (CA) often suffer from severe epilepsy, and surgical resection is often performed to attenuate these epileptic seizures. Several studies have suggested that surgical removal of the surrounding hemosiderin-pigmented tissues adjacent to CA achieves better seizure control than restricted lesionectomy. Pathological examination of the resected foci reveals not only hemosiderin pigmentation but also various degrees of inflammatory change, such as hemosiderin-laden macrophages, gliosis and fibrosis. Read More

View Article and Full-Text PDF

Melatonin mitigated circadian disruption and cardiovascular toxicity caused by 6-benzylaminopurine exposure in zebrafish.

Ecotoxicol Environ Saf 2021 Jul 28;223:112555. Epub 2021 Jul 28.

State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China. Electronic address:

As a highly effective plant hormone, the overuse of 6-benzylaminopurine (6-BA) may pose potential threats to organisms and the environment. Melatonin is widely known for its regulation of sleep rhythm, and it also shows a beneficial effect in a variety of adverse situations. In order to investigate the harm of 6-BA to vertebrates and whether melatonin can reverse the toxicity induced by 6-BA, we analyzed the circadian rhythm and cardiovascular system of zebrafish, and further clarified the role of the thyroid endocrine system. Read More

View Article and Full-Text PDF

Spectroscopic characterization of samples from different environments in a Volcano-Glacial region in Iceland: Implications for in situ planetary exploration.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 23;263:120205. Epub 2021 Jul 23.

Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD 21010, USA. Electronic address:

Raman spectroscopy and laser induced breakdown spectroscopy (LIBS) are complementary techniques that together can provide a comprehensive characterization of geologic environments. For landed missions with constrained access to target materials on other planetary bodies, discerning signatures of life and habitability can be daunting, particularly where the preservation of organic compounds that contain the building blocks of life is limited. The main challenge facing any spectroscopy measurements of natural samples is the complicated spectra that often contain signatures for multiple components, particularly in rocks that are composed of several minerals with surfaces colonized by microbes. Read More

View Article and Full-Text PDF

Fluorescent detection mechanism of CO-releasing molecule-3: Competition of inter-/intra-molecular hydrogen bonds.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 26;263:120227. Epub 2021 Jul 26.

Henan Key Laboratory of Infrared Materials & Spectrum Measures and Applications, School of Physics, Henan Normal University, Xinxiang 453007, China. Electronic address:

The fluorescent detection mechanism of 2-(4-nitro-1,3-dioxoisoindolin-2-yl) acetic acid (CORM3-green) on CO-Releasing Molecule-3 (CORM-3) is theoretically studied. Upon reaction with CORM-3, the non-fluorescent CORM3-green is transferred to the keto form of 2-(4-amino-1,3-dioxoisoindolin-2-yl)acetic acid (PTI) to produce strong fluorescence peak located at 423 nm. This peak red-shifts to 489 nm, which is induced by the strengthening of intermolecular hydrogen bond (HB) between PTI and water molecules and attributed to the experimentally observed fluorescence emission at 503 nm. Read More

View Article and Full-Text PDF

Identification, characterization and evaluation of novel antifungal cyclic peptides from Neobacillus drentensis.

Bioorg Chem 2021 Jul 17;115:105180. Epub 2021 Jul 17.

Organic Synthesis and Process Chemistry Department, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India; School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi 110 062, India. Electronic address:

Marine microbes secrete exopolymeric substances (EPS), which surrounds the biofilm and inhibits the fungal growth. Elucidation of the structure and function of the extracellular exopolymeric substances is of vital relevance therapeutically. The active compound responsible for bioactivity was purified and characterized using TLC, LC/MS/MS, GC/MS and FT-IR. Read More

View Article and Full-Text PDF