16 results match your criteria observed iups

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Effect of progestogen-only contraception on premenopausal fracture risk: a case-control study.

Osteoporos Int 2020 Sep 6;31(9):1801-1806. Epub 2020 May 6.

Philipps University of Marburg, Marburg, Germany.

Our study demonstrated that progestogen-only oral and intrauterine contraceptives are not associated with fracture risk independent from age.

Purpose: The use of progestogen-only contraception, resulting in a hypoestrogenic state, has been associated with impaired bone acquisition and increased fracture risk. The aim of this large population-based study was to assess the fracture risk in association with the use of progestogen-only contraceptives (progestogen-only pills (POPs) and progestogen-containing IUDs (LNG-IUD)). Read More

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September 2020

Risk/benefit perceptions underlying lower African American Students' illicit stimulant use.

Addict Behav 2020 01 9;100:106118. Epub 2019 Sep 9.

Department of Psychology, Mississippi State University, P.O. Box 6161, MS 39762-6161, United States of America. Electronic address:

Researchers have documented lower illicit use of prescription stimulants (IUPS) in African American (AA) populations but have not provided empirically-based explanations for this finding. Four gender-balanced groups of AA and Caucasian male/female college students (n = 120/group, mean age of 19.23, SD = 1. Read More

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January 2020

Distinct mutational landscape of inverted urothelial papilloma.

J Pathol 2019 09 2;249(1):3-5. Epub 2019 Jul 2.

Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.

A recent study has identified gene mutations involving the MAPK/ERK pathway, particularly the HRAS gene, in all inverted urothelial papillomas (IUPs), in the absence of pathway mutations in TERT promoter, FGFR3, and TP53/RB1genes. Neither recurrence nor progression was observed in IUPs. These data support several longstanding hypotheses: (1) IUPs are benign and do not recur or progress; (2) they harbor mutations that are different from those of urothelial carcinoma; and (3) they arise through different molecular mechanisms than low- or high-grade urothelial carcinoma. Read More

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September 2019

Use of double decidual sac sign to confirm intrauterine pregnancy location prior to sonographic visualization of embryonic contents.

Ultrasound Obstet Gynecol 2017 May 2;49(5):643-648. Epub 2017 Apr 2.

Nurture Fertility, The East Midlands Fertility Clinic, Nottingham, UK.

Objectives: To determine the diagnostic accuracy of the double decidual sac sign (DDSS) for predicting an intrauterine pregnancy (IUP) prior to visualization of embryonic contents, using modern high-resolution transvaginal sonography (TVS).

Methods: The study was conducted following STARD guidelines and participants were recruited prospectively from Nurture Fertility, Nottingham, UK, following in-vitro fertilization/intracytoplasmic sperm injection treatment between 1 January 2015 and 31 October 2015. Women were excluded if there was no evidence of intrauterine fluid collection during the index test, a yolk sac or fetal pole was visible during the index test, no outcome data were available or pregnancy location could not be determined by the reference standard. Read More

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The Illicit Use of Prescription Stimulants on College Campuses: A Theory-Guided Systematic Review.

Health Educ Behav 2015 Dec 1;42(6):719-29. Epub 2015 Jun 1.

Oregon State University, Corvallis, OR, USA.

The illicit use of prescription stimulants (IUPS) is a substance use behavior that remains prevalent on college campuses. As theory can guide research and practice, we provide a systematic review of the college-based IUPS epidemiological literature guided by one ecological framework, the theory of triadic influence (TTI). We aim to assess prevalence, elucidate the behavior's multietiological nature, and discuss prevention implications. Read More

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December 2015

Diffusive oxygen shunting between vessels in the preglomerular renal vasculature: anatomic observations and computational modeling.

Am J Physiol Renal Physiol 2012 Sep 6;303(5):F605-18. Epub 2012 Jun 6.

School of Computer Science and Software Engineering, The Univ. of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.

To understand how geometric factors affect arterial-to-venous (AV) oxygen shunting, a mathematical model of diffusive oxygen transport in the renal cortex was developed. Preglomerular vascular geometry was investigated using light microscopy (providing vein shape, AV separation, and capillary density near arteries) and published micro-computed tomography (CT) data (providing vessel size and AV separation; Nordsletten DA, Blackett S, Bentley MD, Ritman EL, Smith NP. IUPS Physiome Project. Read More

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September 2012

BQP35 is a novel member of the intrinsically unstructured protein (IUP) family which is a potential antigen for the sero-diagnosis of Babesia sp. BQ1 (Lintan) infection.

Vet Parasitol 2012 Jul 21;187(3-4):421-30. Epub 2012 Jan 21.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Xujiaping 1, Lanzhou, Gansu 730046, PR China.

A new gene of Babesia sp. BQ1 (Lintan) (BQP35) was cloned by screening a merozoite cDNA expression library with infected sheep serum and using rapid amplification of cDNA ends (RACE). The nucleotide sequence of the cDNA was 1140bp with an open reading frame (ORF) of 936bp encoding a 35-kDa predicted polypeptide with 311 amino acid residues. Read More

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Performance of human chorionic gonadotropin curves in women at risk for ectopic pregnancy: exceptions to the rules.

Fertil Steril 2012 Jan;97(1):101-6.e2

Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Objective: To investigate the accuracy of serial hCG to predict outcome of a pregnancy of unknown location in an ethnically and geographically diverse setting.

Design: Multisite cohort study.

Setting: University hospital. Read More

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January 2012

Tight regulation of unstructured proteins: from transcript synthesis to protein degradation.

Science 2008 Nov;322(5906):1365-8

Medical Research Council (MRC) Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

Altered abundance of several intrinsically unstructured proteins (IUPs) has been associated with perturbed cellular signaling that may lead to pathological conditions such as cancer. Therefore, it is important to understand how cells precisely regulate the availability of IUPs. We observed that regulation of transcript clearance, proteolytic degradation, and translational rate contribute to controlling the abundance of IUPs, some of which are present in low amounts and for short periods of time. Read More

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November 2008

The use of serial human chorionic gonadotropin levels to establish a viable or a nonviable pregnancy.

Semin Reprod Med 2008 Sep 29;26(5):383-90. Epub 2008 Sep 29.

Division of Reproductive Endocrinology and Infertility, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA.

Measurement of serial human chorionic gonadotropin (hCG) concentrations facilitates the diagnosis of normal or abnormal early gestation, as deviations from expected rates of rise or decline prompt intervention and/or treatment of abnormal pregnancies. Recently, the expected rise in hCG levels for normal intrauterine pregnancies (IUPs) was well characterized, and based on a 95% confidence interval, it was determined that the slowest rise in a normal IUP was 53% in 2 days. When the hCG level is decreasing, it is clear that the pregnancy is not viable. Read More

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September 2008

A robust approach for analyzing a heterogeneous structural ensemble.

Proteins 2008 Dec;73(4):918-28

Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Life Science South, Moscow, Idaho 83844-3052, USA.

Intrinsically unstructured proteins (IUP) are widespread in eukaryotes and participate in numerous cellular processes, but a structural explanation of the mechanisms they use to recognize and bind their diverse targets has proved elusive. Transcriptional activator domains are one class of IUP that function by recruiting other factors into basal transcription complexes. Transcriptional activator domains are known to use electrostatic interactions for recognition, but it is unclear how this could be accomplished by a structurally heterogeneous ensemble. Read More

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December 2008

Solution NMR studies of an intrinsically unstructured protein within a dilute, 75 kDa eukaryotic protein assembly; probing the practical limits for efficiently assigning polypeptide backbone resonances.

Chembiochem 2005 Dec;6(12):2242-6

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

This paper describes an efficient NMR strategy for assigning the backbone resonances of an intrinsically unstructured protein (IUP), p21-KID, bound to its biological target, Cdk2/cyclin A. In order to overcome the challenges associated with the high molecular weight (75 kDa) and low solubility of the ternary complex (0.2 mM), we used perdeuteration, TROSY, and high-sensitivity cryogenic NMR probes at high magnetic-field strengths (i. Read More

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December 2005

Mother's prior intrauterine position affects the sex ratio of her offspring in house mice.

Proc Natl Acad Sci U S A 1994 Nov;91(23):11055-9

Department of Zoology, North Carolina State University, Raleigh 27695-7617.

Sex ratio alterations related to environmental factors occur in several mammals, but no mechanism has been identified to explain the adjustment. Intrauterine position (IUP) may provide the context in which such alterations occur. Previous studies on house mice and gerbils reveal that the position of a fetus in the uterus in relation to the sex of its neighbors influences its later anatomy, physiology, and behavior. Read More

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November 1994

Transvaginal color Doppler study of blood flow in ectopic pregnancies.

Fertil Steril 1992 Jan;57(1):68-73

Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, London, United Kingdom.

Objective: To compare Doppler indices of blood flow in the uterine and spiral arteries and the corpus luteum (CL), in ectopic and intrauterine pregnancies (IUPs).

Design: A prospective study of women with an ectopic or singleton IUP at the corresponding stage of gestation.

Setting: The Gynaecological Ultrasound Clinic, King's College Hospital. Read More

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January 1992

Effect of intrauterine position and social density on age of first reproduction in wild-type female house mice (Mus musculus).

J Comp Psychol 1991 Jun;105(2):134-9

Department of Zoology, North Carolina State University, Raleigh 27695-7617.

In laboratory strains of mice, reproductive maturation is influenced by both the fetal and the peripubertal social environments experienced by females. Intrauterine position (IUP) for female fetuses is identified by the number of adjacent males; where 0M have zero, 1M have one, and 2M have two male neighbors. We sought to confirm, using wild-type female house mice (Mus musculus), the previous finding in the CF-1 strain of laboratory mouse that males prefer 0M over 2M females as mates. Read More

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Value of the yolk sac in evaluating early pregnancies.

J Ultrasound Med 1988 Mar;7(3):129-35

Department of Radiology, University of Washington Hospital, Seattle, Washington.

To determine the potential value in identifying a yolk sac in women with suspected ectopic pregnancies, 211 consecutive women who were referred to pelvic sonography with this clinical indication were prospectively studied. Of the 211 patients examined, 104 proved to have a normal intrauterine pregnancy (IUP), 59 had an abnormal (nonviable) IUP, and 48 had a surgically-proven ectopic pregnancy. Considering only intrauterine "sacs" that lacked a visible embryo, a yolk sack was identified in 16 of 26 (62%) normal IUPs, and 3 of 19 (16%) abnormal IUPs, but was not seen in any of six pseudo-gestational sacs in women with ectopic pregnancies. Read More

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