642,555 results match your criteria observed data

Childhood trauma is linked to decreased temporal stability of functional brain networks in young adults.

J Affect Disord 2021 May 2;290:23-30. Epub 2021 May 2.

Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Mental Health Institute of Central South University, Changsha, Hunan, China; China National Clinical Research Center on Mental Disorders, Changsha, Hunan, China. Electronic address:

Background: Both childhood trauma and disruptions in brain functional networks are implicated in the development of psychiatric disorders in early adulthood. However, the relationships between these two factors remain unclear. This study aimed to investigate whether and how childhood trauma would relate to changes of functional network dynamics in young adults. Read More

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Reduced sexual motivation of diabetic female rats: Restoration with insulin.

Horm Behav 2021 May 12;132:104992. Epub 2021 May 12.

Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, México City, Mexico. Electronic address:

The aim of this study was to evaluate female rat sexual motivation in a model of diabetes mellitus type 1. Severe hyperglycemia was induced in ovariectomized Wistar rats by injecting streptozotocin [STZ, 100 mg/kg, i.p. Read More

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Not so social after all: Video-based acquisition of observational stimulus-response bindings.

Acta Psychol (Amst) 2021 May 12;217:103330. Epub 2021 May 12.

Trier University, Trier, Germany.

Merely observing how another person responds to a stimulus results in incidental stimulus-response (SR) bindings in memory. These observationally acquired SR bindings can be retrieved on a later occasion. Retrieval will bias current behavioral response tendencies towards re-execution of the observed response. Read More

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A Gratton-like effect concerning task order in dual-task situations.

Acta Psychol (Amst) 2021 May 12;217:103328. Epub 2021 May 12.

Martin-Luther University Halle-Wittenberg, Halle, Germany.

Performing two tasks simultaneously involves the coordination of their processing. Task coordination is particularly required in dual-task situations with varying order of the component tasks. When task order switches between subsequent trials, task-order coordination leads to order switch costs in comparison to task order repetitions (i. Read More

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Can Results-Based Financing improve health outcomes in resource poor settings? Evidence from Zimbabwe.

Soc Sci Med 2021 May 7;279:113959. Epub 2021 May 7.

Department of Global Health and Development, London School of Hygiene and Tropical Medicine, UK.

Result Based Financing (RBF) has been implemented in health systems across low and middle-income countries (LMICs), with the objective of improving population health. Most evaluations of RBF schemes have focused on average programme effects for incentivised services. There is limited evidence on the potential effect of RBF on health outcomes, as well as on the heterogeneous effects across socio-economic groups and time periods. Read More

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An integrated approach of PCA and PROMETHEE in spatial assessment of circular economy indicators.

Waste Manag 2021 May 12;128:154-166. Epub 2021 May 12.

University of Priština, Faculty of Agriculture, 38219 Lešak, Kosovo and Metohija. Electronic address:

In order to ensure environmental sustainability, reducing the consumption of renewable resources, finding adequate substitutes for non-renewable resources, and reducing the generation of waste and pollution are necessities. The concept of circular economy one of the possible and good responses to improve the sustainability of the system, as it places particular emphasis on the reduction, reutilization and recycling of its elements. The paper presents a comparative analysis of the circular economy development in European Union countries based on the dataset encompasses 11 indicators, covering the seven-year period with biennial data. Read More

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Tropical cyclone effects on water and sediment chemistry and the microbial community in estuarine ecosystems.

Environ Pollut 2021 May 5;286:117228. Epub 2021 May 5.

Department of Civil and Environmental Engineering, Princeton University, Princeton, NJ, 08544, USA. Electronic address:

Frequent and intense storm disturbances can have widespread and strong effects on the nitrogen and iron cycles and their associated microbial communities in estuary systems. A three-year investigation was conducted in the Pearl River and Zhanjiang estuaries in Guangdong Province, China through repeated sampling at three timepoints, defined as pre-storm (<1 month before storm), post-storm (<1 month after storm), and non-storm (6-8 months after storm). Increased nutrient concentrations (total organic carbon, nitrate, nitrite, ammonium, and sulfate) in both the sediment and water column were observed immediately after storm. Read More

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Subjective value, not a gridlike code, describes neural activity in ventromedial prefrontal cortex during value-based decision-making.

Neuroimage 2021 May 12:118159. Epub 2021 May 12.

Department of Psychology, University of Pennsylvania, Philadelphia, PA, 19104 USA.

Across many studies, ventromedial prefrontal cortex (vmPFC) activity has been found to correlate with subjective value during value-based decision-making. Recently, however, vmPFC has also been shown to reflect a hexagonal gridlike code during navigation through physical and conceptual space, and such gridlike codes have been proposed to enable value-based choices between novel options. Here, we first show that, in theory, a hexagonal gridlike code can in some cases mimic vmPFC activity previously attributed to subjective value, raising the possibility that the subjective value correlates previously observed in vmPFC may have actually been a misconstrued gridlike signal. Read More

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Case analysis of kinetics investigations in toxicity studies of pesticides to identify the nonlinearity of internal exposure and the influences of nonlinearity on the toxicological interpretation of pesticide residue.

Regul Toxicol Pharmacol 2021 May 12:104958. Epub 2021 May 12.

School of Pharmacy, Iwate Medical University 2-1-1 Nishitokuta, Yahaba-cho, Shiwa-gun, Iwate, 028-3684, Japan. Electronic address:

The nonlinearity of internal exposure to 8 pesticides was investigated in toxicity studies using kinetics to identify nonlinearity visually and to investigate the influence of nonlinearity on toxicological evaluation. Data were obtained from risk assessment reports published by the Food Safety Commission (FSCJ). Nonlinearity was defined using 2 indicators: the lowest visual inflection point (LVIP) and the second lowest visual inflection point (SVIP) of kinetics by drawing a linear distribution chart. Read More

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Nurr1 deficiency shortens free running period, enhances photoentrainment to phase advance, and disrupts circadian cycling of the dopamine neuron phenotype.

Behav Brain Res 2021 May 12:113347. Epub 2021 May 12.

East Carolina University, Department of Anatomy and Cell Biology, Brody School of Medicine, Greenville, NC, USA. Electronic address:

Neurological and neuropsychiatric disorders, including addiction, schizophrenia, and Parkinson's disease (PD), involve dysfunction in midbrain dopamine (DA) neurotransmission with severity of disease symptoms and progression associated with disrupted circadian rhythms. The nuclear transcription factor Nurr1, essential for DA neuron (DAN) development, survival, and maintenance, is also known to interact with circadian rhythm regulating clock proteins. In the Nurr1-null heterozygous (+/-) mice, a Nurr1 deficient model which reproduces some of the alterations in DA function found in schizophrenia and PD, we measured, using wheel-running activity, the free running period (tau) and photoperiod entrainment. Read More

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The Role of Temperature Change, Ambient Temperature, and Relative Humidity in Allergic Conjunctivitis in a US Veteran Population.

Am J Ophthalmol 2021 May 12. Epub 2021 May 12.

Environmental Health Division, University of Miami, Miami, FL, USA.

Purpose: Studies have implicated temperature and humidity in the pathogenesis of allergic conjunctivitis (AC), as these conditions facilitate air particulate and aeroallergen dispersion and tear film instability. Research also suggests that variation in temperature associates with risk of asthma, but similar data are limited for AC. This study examined associations between several meteorological conditions, including temperature variation, and AC visit risk. Read More

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Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice.

Physiol Rep 2021 May;9(9):e14853

Department of Anesthesiology & Perioperative Medicine, Penn State University College of Medicine, Hershey, PA, USA.

Previously, we demonstrated that global knockout (KO) of the gene encoding myelin protein zero-like 3 (Mpzl3) results in reduced body weight and adiposity, increased energy expenditure, and reduced hepatic lipid synthesis in mice. These mice also exhibit cyclic and progressive alopecia which may contribute to the observed hypermetabolic phenotype. The goal of the current study was to determine if acute and peripherally restricted knockdown of Mpzl3 could ameliorate the negative metabolic effects of exposure to a high-fat and sucrose, energy-dense (HED) diet similar to what was observed in global Mpzl3 KO mice in the absence of a skin phenotype. Read More

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Comparative efficacy and safety of systemic therapies used in moderate-to-severe atopic dermatitis: a systematic literature review and network meta-analysis.

J Eur Acad Dermatol Venereol 2021 May 15. Epub 2021 May 15.

Pfizer Inc, New York, NY, USA.

Given the lack of head-to-head studies of systemic therapies in moderate-to-severe atopic dermatitis (AD), network meta-analyses (NMAs) can provide comparative efficacy and safety data to inform clinical decision making. In this NMA, eligible randomized controlled trials (RCTs) published before October 24, 2019 were identified by a systematic literature review. Short-term (12-16 weeks) efficacy (Investigator's Global Assessment [IGA] and Eczema Area and Severity Index [EASI] responses), patient-reported outcomes (PROs), and safety data from each trial were abstracted and analyzed separately for monotherapy and combination-therapy (systemic plus topical anti-inflammatory therapy). Read More

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Population Pharmacokinetic Analysis of Bedaquiline-Clarithromycin for Dose Selection Against Pulmonary Nontuberculous Mycobacteria Based on a Phase 1, Randomized, Pharmacokinetic Study.

J Clin Pharmacol 2021 May 15. Epub 2021 May 15.

Johnson and Johnson Services, Inc, New Brunswick, NJ, USA.

Based on in vitro profile of bedaquiline against mycobacterial species, it is being investigated for clinical efficacy against pulmonary nontuberculous mycobacteria (PNTM). Being a cytochrome P450 (CYP) 3A substrate, pharmacokinetic interactions of bedaquiline are anticipated with clarithromycin (a CYP3A inhibitor), which is routinely used in PNTM treatment. This Phase 1, randomized, crossover study assessed the impact of steady-state clarithromycin (500 mg every 12 hours; 14 days) on the pharmacokinetics of bedaquiline and its metabolite (M2) after single-dose bedaquiline (100 mg; n  =  16). Read More

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Impact of low luminance conditions on quality of life for the visually impaired: development of the Low Luminance Questionnaire Japanese version.

Jpn J Ophthalmol 2021 May 15. Epub 2021 May 15.

Department of Ophthalmology, Aichi Medical University, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Purpose: This study aimed to develop a Japanese version of the Low Luminance Questionnaire (LLQ-J) and to evaluate its reliability and validity.

Study Design: Cross-sectional study.

Methods: LLQ-J was developed by standardized methods. Read More

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Endoscopic third ventriculostomy and choroid plexus cauterization (ETV/CPC) for hydrocephalus of infancy: a technical review.

Childs Nerv Syst 2021 May 15. Epub 2021 May 15.

Division of Neurosurgery, Hospital for Sick Children (SickKids), Rooms 1504 & 1503, Hill Wing, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.

In the twenty-first century, choroid plexus cauterization (CPC) in combination with endoscopic third ventriculostomy (ETV) has emerged as an effective treatment for some infants with hydrocephalus, leading to the favourable condition of 'shunt independence'. Herein we provide a narrative technical review considering the indications, procedural aspects, morbidity and its avoidance, postoperative care and follow-up. The CP has been the target of hydrocephalus treatment for more than a century. Read More

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Maribacter hydrothermalis sp. nov., Isolated from Shallow-Sea Hydrothermal Systems Off Kueishantao Island.

Curr Microbiol 2021 May 15. Epub 2021 May 15.

State Key Laboratory of Marine Environmental Science, Fujian Key Laboratory of Marine Carbon Sequestration, Xiamen University, Xiamen, China.

A Gram-stain-negative, strictly aerobic, yellow-pigmented bacterial strain, designated as T28, was isolated from seawater of the shallow-sea hydrothermal system, Kueishantao Islet, Taiwan, China. Cells were oxidase-negative and catalase-positive rods without gliding motility. Growth was observed at 10-40 °C (optimum, 30 °C), at pH 5. Read More

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Modelling Public Sentiments about Juul Flavors on Twitter through Machine Learning.

Nicotine Tob Res 2021 May 15. Epub 2021 May 15.

FIMM Institute of Molecular Medicine, Helsinki University, Helsinki, Finland.

Introduction: The availability of a variety of e-cigarettes flavors is one of the frequently cited reasons for their adoption. An active stream of discussion about flavoring can be observed online. Analyzing these real-time conversations offers nuanced insights into key factors related to the adoption of flavors, subsequently supporting public health interventions. Read More

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High school seniors who used e-cigarettes may have otherwise been cigarette smokers: Evidence from Monitoring the Future (United States, 2009-2018).

Nicotine Tob Res 2021 May 15. Epub 2021 May 15.

FXB Center for Health and Human Rights, Harvard University, Boston, MA.

Introduction: Studies have indicated that youth who use e-cigarettes are more likely to progress to cigarette smoking; however, the likelihood that these youth would have used tobacco products in the pre-vaping era is unclear. This study sought to determine whether youth who used e-cigarettes in 2014-2018 would have likely been smokers in the period preceding e-cigarette availability.

Methods: Analyzing Monitoring the Future 12 th grade data (USA, 2009-2018), we forecasted the prevalence of current smoking with logistic regression-derived propensity scores. Read More

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Long-term analgesic effects of peripheral nerve block in patients with central post-stroke pain: A Retrospective Series.

Pain Pract 2021 May 15. Epub 2021 May 15.

Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: Central post-stroke pain (CPSP) has a detrimental effect on the quality of life of post-stroke patients. However, no definitive and effective method has been established yet for the treatment of CPSP.

Objective: We aimed to examine the applicability of single-injection peripheral nerve blocks (PNB) for the treatment of CPSP. Read More

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Physiological sleep measures predict time to 15-year mortality in community adults: Application of a novel machine learning framework.

J Sleep Res 2021 May 15:e13386. Epub 2021 May 15.

Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA.

Clarifying whether physiological sleep measures predict mortality could inform risk screening; however, such investigations should account for complex and potentially non-linear relationships among health risk factors. We aimed to establish the predictive utility of polysomnography (PSG)-assessed sleep measures for mortality using a novel permutation random forest (PRF) machine learning framework. Data collected from the years 1995 to present are from the Sleep Heart Health Study (SHHS; n = 5,734) and the Wisconsin Sleep Cohort Study (WSCS; n = 1,015), and include initial assessments of sleep and health, and up to 15 years of follow-up for all-cause mortality. Read More

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One-year results of the Variation of Orthokeratology Lens Treatment Zone (VOLTZ) Study: a prospective randomised clinical trial.

Ophthalmic Physiol Opt 2021 May 15. Epub 2021 May 15.

Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.

Purpose: To present the 1-year results of the Variation of Orthokeratology Lens Treatment Zone (VOLTZ) Study, which aims to investigate the myopia control effect of orthokeratology (ortho-k) lenses with different back optic zone diameters (BOZD).

Method: Children, aged 6 to <11 years, having myopia -4.00 D to -0. Read More

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Clinical characteristics and long-term outcomes of 97 Korean patients with mycosis fungoides.

Int J Dermatol 2021 May 15. Epub 2021 May 15.

Department of Dermatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Background: Mycosis fungoides (MF) shows racial and regional differences in terms of clinical features. The availability of therapeutic options as well as drugs differs from one country to another. There are only limited data on the clinical characteristics and treatment experience of MF from South Korea. Read More

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Prediction of Dermal Exposure to Chemical Substances Using a Fluorescence Method within the SysDEA Project.

Ann Work Expo Health 2021 May 15. Epub 2021 May 15.

Department Risk Analysis for Products in Development (RAPID), TNO, Princetonlaan 6, 3584 CB Utrecht, the Netherlands.

Dermal exposure is an important exposure route for occupational exposure and risk assessment. A fluorescence method has been developed to quantify occupational dermal exposure based on a visualization technique, using Tinopal SWN as a fluorescent tracer. The method was developed within the framework of a large experimental study, the SysDEA project. Read More

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covid19census: U.S. and Italy COVID-19 metrics and other epidemiological data.

Database (Oxford) 2021 May;2021

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA.

Since the beginning of the coronavirus disease-2019 (COVID-19) pandemic in 2020, there has been a tremendous accumulation of data capturing different statistics including the number of tests, confirmed cases and deaths. This data wealth offers a great opportunity for researchers to model the effect of certain variables on COVID-19 morbidity and mortality and to get a better understanding of the disease at the epidemiological level. However, in order to draw any reliable and unbiased estimate, models also need to take into account other variables and metrics available from a plurality of official and unofficial heterogenous resources. Read More

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Risk factors for return to work in colorectal cancer survivors.

Cancer Med 2021 May 14. Epub 2021 May 14.

Division of Environmental Health and Occupational Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: The increasing incidence of colorectal cancer among individuals in the productive age-group has adversely affected the labor force and increased healthcare expenses in recent years. Return to work (RTW) is an important issue for these patients. In this study, we explored the factors that influence RTW and investigated the influence of RTW on survival outcomes of patients with colorectal cancer. Read More

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Characteristics of emergency patients admitted to hospital with asthma: A population-based cohort study in Queensland, Australia.

Emerg Med Australas 2021 May 15. Epub 2021 May 15.

School of Biomedical Sciences, Institute for Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

Objective: Patient characteristics with exacerbation of asthma accessing care in the ED who are at risk of hospital admission have not been determined in subtropical climates. The objective of the study was to investigate the spatiotemporal burden of asthma hospital admissions across Queensland (QLD) and model risk factors for asthma hospital admission following an ED visit.

Methods: Six years of routinely collected data (2012-2017) from 28 QLD public hospitals were extracted from Queensland Health's Emergency Data Collection. Read More

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Real life Study on the Pharmacokinetic of Remdesivir in ICU patients admitted for Severe COVID-19 Pneumonia.

Br J Clin Pharmacol 2021 May 14. Epub 2021 May 14.

Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Italy.

Remdesivir is one of the most encouraging treatments against SARS-CoV-2 infection. After intravenous infusion, RDV is rapidly metabolized (T 1h) within the cells to its active adenosine triphosphate analogue form (GS-443902) and, then, it can be found in plasma in its nucleoside analogue form (GS-441524). In this real life study we describe the Remdesivir and GS-441524 concentrations at 3 time points in nine ICU patients, through a validated UHPLC-MS/MS method. Read More

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Feasibility, efficacy, and safety of ethanol infusion into the vein of Marshall for atrial fibrillation: a meta-analysis.

Pacing Clin Electrophysiol 2021 May 14. Epub 2021 May 14.

Heart Center, the First Hospital of Lanzhou University, Lanzhou, China.

Background: Contemporary radiofrequency catheter ablation (RFCA) approaches for atrial fibrillation (AF) have reached an efficacy "ceiling". Ethanol infusion into the vein of Marshall (EI-VOM) has shown potential in preliminary studies. Data on EI-VOM are largely limited to small single-center reports, and clinical benefits and risks have not been systematically examined. Read More

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Safety, pharmacokinetics and pharmacodynamics of TAK-418, a novel inhibitor of the epigenetic modulator lysine-specific demethylase 1A.

Br J Clin Pharmacol 2021 May 14. Epub 2021 May 14.

Takeda Pharmaceuticals U.S.A., Inc., Cambridge, MA, USA.

Aim: Dysregulation of histone methylation epigenetic marks may result in intellectual and developmental disability, as seen in Kabuki syndrome. Animal data suggest that increasing histone methylation by inhibiting lysine-specific demethylase 1A (LSD1) may improve cognitive outcomes in a model of Kabuki syndrome. TAK-418 is a novel LSD1 inhibitor, developed as a potential therapeutic agent for central nervous system disorders such as Kabuki syndrome. Read More

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