167,665 results match your criteria observational study


Develop a Clinical Prediction Model for Postoperative Cognitive Dysfunction after Major Noncardiac Surgery in Elderly Patients: A Protocol for a Prospective Observational Study.

Gerontology 2021 Jul 27:1-8. Epub 2021 Jul 27.

Department of Anesthesia, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Perioperative neurocognitive disorders (PNDs) refer to cognitive decline identified in the preoperative or postoperative period. It has been reported that the incidence of postoperative neurocognitive impairment after noncardiac surgery in patients older than 65 at 1 week was 25.8∼41. Read More

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Fluorescence-Advanced Videodermoscopy (FAV) - a new method of hairs and scalp evaluation. Comparison with trichoscopy.

J Eur Acad Dermatol Venereol 2021 Jul 27. Epub 2021 Jul 27.

Dermatologic Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Introduction: Non-invasive diagnostic methods in clinical dermatology are widely used to reduce the need for invasive techniques, with great advantages in terms of cost and time. Dermoscopy is the reference test for the in vivo diagnosis of cutaneous lesions, and when it is performed on the scalp region it is named trichoscopy. Fluorescence-Advanced Videodermoscopy (FAV) has been lately proposed as a new non-invasive method for the in vivo skin examination at high magnification, with cell-level resolution. Read More

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Efficacy of diammonium glycyrrhizinate combined with vitamin C for treating hospitalized COVID-19 patients: a retrospective, observational study.

QJM 2021 Jul 26. Epub 2021 Jul 26.

Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Background: The current global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown limited responses to medical treatments.

Aims: To observe the effect of combination treatment of giammonium glycyrrhizinate and vitamin C (DV)on the prognoses of patients with COVID-19.

Methods: This retrospective observational study recruited 207 COVID-19 patients from Tongji Hospital, patients were assigned to DV and non-DV groups on the basis of the DV treatment. Read More

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High sedation needs of critically ill COVID-19 ARDS patients-A monocentric observational study.

PLoS One 2021 27;16(7):e0253778. Epub 2021 Jul 27.

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, Hessen, Germany.

Background: Therapy of severely affected coronavirus patient, requiring intubation and sedation is still challenging. Recently, difficulties in sedating these patients have been discussed. This study aims to describe sedation practices in patients with 2019 coronavirus disease (COVID-19)-induced acute respiratory distress syndrome (ARDS). Read More

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Sleep increases leaks and asynchronies during home noninvasive ventilation: a polysomnographic study.

J Clin Sleep Med 2021 Jul 27. Epub 2021 Jul 27.

Respiratory Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Study Objectives: In patients treated with noninvasive ventilation, sleep-related breathing changes can modify patient-ventilator interactions which could reduce its effectiveness. The aim of this prospective observational study was to determine the impact of sleep/wake state on leaks, upper airway obstructive events, and asynchronies, in patients treated by long-term noninvasive ventilation.

Methods: Stable patients adapted to noninvasive ventilation were considered for nocturnal polysomnography. Read More

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Assessment of an electronic system for research ethics committees document management: an observational study.

Account Res 2021 Jul 27. Epub 2021 Jul 27.

Comité Central de Ética en Investigación, Ministerio de Salud del Gobierno de la Ciudad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina. Dirección General de Docencia, Investigación y Desarrollo Profesional, Ministerio de Salud del Gobierno de la Ciudad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Since January 1st 2020, the Central Research Ethics Committee of the Health Ministry implemented PRIISA.BA, an in-house developed electronic system for online submission of health research applications to the 63 public and private research ethics committees (RECs) of Buenos Aires City, Argentina. This study though to compare the times to first review and the time to approval among applications submitted prior to PRIISA. Read More

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Evaluation of the effect of the severity of diabetic retinopathy on microvascular abnormalities and vascular density using optical coherence tomography angiography.

Acta Diabetol 2021 Jul 27. Epub 2021 Jul 27.

Department of Ophthalmology, Charles Nicolle University Hospital of Tunis, Boulevard du 9-Avril 1938, 1006, Tunis, Tunisia.

Purpose: To quantify and to study the relationship between retinal microvascular changes and different stages of diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA).

Methods: This prospective observational study included the eyes of patients with different stages of DR. OCTA was performed in all eyes using a 9 × 9 mm protocol. Read More

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Hormone therapy formulation, dose, route of delivery, and risk of hypertension: findings from the Women's Health Initiative Observational Study (WHI-OS).

Menopause 2021 Jul 26. Epub 2021 Jul 26.

Department of Obstetrics and Gynecology, Biostatistics and Epidemiology, Family and Preventive Medicine University of Oklahoma Health Sciences Center, Oklahoma City, OK Statistical Research Associate, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Medicine, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA Department of Family Medicine, University of California San Diego School of Medicine, La Jolla, CA The North American Menopause Society Emeritus, Cleveland, OH Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA.

Objective: Using data from the Women's Health Initiative Observational Study (WHI-OS), to determine the role of estrogen formulation, dose, route of delivery, and its combination with different progestogens on the risk for hypertension in the WHI-OS.

Methods: After excluding women with diagnosed hypertension, receiving antihypertensive medication, presenting with elevated blood pressure ( ≥ 140/90), and those not taking menopausal hormone therapy at baseline, 19,986 women remained eligible for the analyses. Using hierarchal modeling, proportional hazard rate calculation, and linear and logistic regression analyses, we evaluated incident treated hypertension and mean systolic and diastolic blood pressure changes at 3 years. Read More

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Age, minimum alveolar concentration and choice of depth of sedation monitor: examining the paradox of age when using the Narcotrend monitor: A secondary analysis of an observational study.

Eur J Anaesthesiol 2021 Jul 26. Epub 2021 Jul 26.

From the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern (DH, CS, MH, FS, HAK) and Department of General Internal Medicine, Canton Hospital Frauenfeld, Frauenfeld, Switzerland (CS).

Background: With an ageing global population, it is important to individualise titration of anaesthetics according to age and by measuring their effect on the brain. A recent study reported that during general surgery, the given concentration of volatile anaesthetics, expressed as a fraction of the minimum alveolar concentration (MAC fraction), decreases by around only 3% per age-decade, which is less than the 6% expected from age-adjusted MAC. Paradoxically, despite the excessive dosing, Bispectral index (BIS) values also increased. Read More

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A Computed Tomography Angiography (CTA): Based score (SGPGI score) to predict level of difficulty, operative, and postoperative outcomes for right-sided radical nephrectomy.

Urologia 2021 Jul 27:3915603211015541. Epub 2021 Jul 27.

Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Objective: With the advent of laparoscopic approach for the large (T1b-T3a ± N1) right renal masses, higher rates of complications and conversion to open surgery are being reported. The role of preoperative angioembolization (PAE), which has increased cost and inherent morbidity but may help in select circumstances has also not been clearly defined in the literature. We therefore devised a scoring system (SGPGI score) based on pre-operative Computed Tomography Angiography (CTA) to predict the level of difficulty of radical nephrectomy and enhance its safety and efficacy which could also be used for the judicious use of PAE in selected cases. Read More

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Context matters: Self-regulation of healthy eating at different eating occasions.

Appl Psychol Health Well Being 2021 Jul 27. Epub 2021 Jul 27.

Wageningen Economic Research, Wageningen University & Research, Wageningen, The Netherlands.

Self-regulation plays an important role in healthy eating behaviors. The current research explores temporary fluctuations in self-regulation next to variations between individuals. In an online observational study, 892 participants (M  = 44. Read More

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A study of the accuracy of the Fitbit Zip in measuring steps both indoors and outdoors in a mixed rehabilitation population.

Clin Rehabil 2021 Jul 27:2692155211035293. Epub 2021 Jul 27.

Clinical Rehabilitation, College of Nursing and Health Sciences, Flinders University, Adelaide, SA, Australia.

Objective: To assess (1) step count accuracy of the Fitbit Zip, compared to manual step count, in people receiving outpatient rehabilitation, in indoor and outdoor conditions, and (2) impact of slow walking speed on Fitbit accuracy.

Design: Observational study.

Setting: A metropolitan rehabilitation hospital. Read More

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Clinical features of ST-segment elevation myocardial infarction in young Chinese patients.

Cardiol J 2021 Jul 27. Epub 2021 Jul 27.

Department of cardiology, the first affiliated hospital of Soochow University, Suzhou City, Jiangsu Province, the People's Republic of China, No.899 Pinghai Road, Gusu District, Suzhou City, Jiangsu Province, the People's Republic of China, 215006 Suzhou, China.

Background: To investigate the clinical characteristics, angiographic findings and clinical outcomes (in-hospital) of young adults with acute myocardium infarction in a Chinese population.

Methods: This was an observational study. Five hundred and forty-nine patients who suffered with ST-segment elevation myocardial infarction (STEMI) firstly between January 2013 and December 2015 were enrolled consecutively. Read More

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Pain Medication and Corticosteroid Use in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis in the United States: A Retrospective Observational Study.

Rheumatol Ther 2021 Jul 26. Epub 2021 Jul 26.

Anthem Inc., Indianapolis, IN, USA.

Objective: We compared pain medication use in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis (RA) versus matched control over 2 years; a subgroup analysis assessed changes in pain medication use in patients who initiated a biologic during 12 months before and after.

Methods: This was a retrospective observational cohort study using an administrative claims database. Newly diagnosed adult patients with AS, PsA, or RA identified between 1/1/2014 and 7/31/2017 were included. Read More

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Temporal Expression Pattern of Hemoxygenase-1 Expression and Its Association with Vasospasm and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.

Neurocrit Care 2021 Jul 26. Epub 2021 Jul 26.

Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: Red blood cell-induced cerebral inflammation and toxicity has been shown to be attenuated by induction of the heme-catalyzing enzyme, hemoxygenase-1 (HO-1), in animal models of subarachnoid hemorrhage (SAH). Although inflammatory mechanisms leading to secondary neuronal injury in SAH are becoming increasingly well understood, markers of cerebral inflammation have so far not been implemented in clinical prediction models of SAH.

Methods: In this biomarker observational study, HO-1 messenger ribonucleic acid (mRNA) expression levels were determined in cerebrospinal fluid (CSF) and blood of 66 patients with aneurysmal SAH on days 1, 7, and 14 after the SAH event. Read More

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Psychometric properties of the Croatian version of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25).

Int Ophthalmol 2021 Jul 26. Epub 2021 Jul 26.

Department of Ophthalmology, University Hospital Center "Zagreb", Kišpatićeva 12, 10 000, Zagreb, Croatia.

Purpose: The purpose of the study was to translate, adapt and validate the Croatian version of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) in participants with visual impairment. This study also aims at evaluating the relationship between visual impairment and health-related quality of life (HRQoL).

Methods: The prospective observational study was conducted at the University Hospital Centre Zagreb, Department of Ophthalmology. Read More

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Reversal of left-sided colostomy utilizing single-port laparoscopy a multicenter European audit and overview of the literature.

Surg Endosc 2021 Jul 26. Epub 2021 Jul 26.

Department of Surgery, Elisabeth-TweeSteden Hospital, Hilvarenbeekseweg 60, 5022GC, Tilburg, The Netherlands.

Background: Stoma reversal surgery can result in considerable morbidity and even mortality. Feasibility of utilizing single-port laparoscopy through the stoma fenestration have been shown before. Aim of the present observational study is to evaluate multicenter experiences of single-port reversal of left-sided colostomy (SPRLC) throughout Europe and to provide an overview of available literature on this topic. Read More

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Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination.

Nat Med 2021 Jul 26. Epub 2021 Jul 26.

Department of Transplant and Infection Immunology, Saarland University, Homburg, Germany.

Heterologous priming with the ChAdOx1 nCoV-19 vector vaccine followed by boosting with a messenger RNA vaccine (BNT162b2 or mRNA-1273) is currently recommended in Germany, although data on immunogenicity and reactogenicity are not available. In this observational study we show that, in healthy adult individuals (n = 96), the heterologous vaccine regimen induced spike-specific IgG, neutralizing antibodies and spike-specific CD4 T cells, the levels of which which were significantly higher than after homologous vector vaccine boost (n = 55) and higher or comparable in magnitude to homologous mRNA vaccine regimens (n = 62). Moreover, spike-specific CD8 T cell levels after heterologous vaccination were significantly higher than after both homologous regimens. Read More

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Profiles for identifying problematic dietary habits in a sample of recreational Spanish cyclists and triathletes.

Sci Rep 2021 Jul 26;11(1):15193. Epub 2021 Jul 26.

Department of Physical Education and Sport, University of Granada, 18071, Granada, Spain.

There is a lack of sufficient information on the dietary intake and nutritional supplementation of recreational endurance athletes throughout the year. The present observational study sought to assess the dietary intake and nutritional supplementation habits of recreational cyclists and triathletes from Spain. 4,037 cyclists and triathletes completed self-report measures. Read More

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Prognostic value of serum soluble ST2 in stable coronary artery disease: a prospective observational study.

Sci Rep 2021 Jul 26;11(1):15203. Epub 2021 Jul 26.

Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Boramae Medical Center, 20, Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, Korea.

The role of ST2 in stable coronary artery disease (CAD) has not yet been well defined. This study was performed to investigate baseline serum soluble ST2 (sST2) level can predict clinical outcomes in patients with stable CAD. A total of 388 consecutive patients with suspected CAD (65 years and 63. Read More

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Clinical outcomes of hospitalized COVID-19 patients with renal injury: a multi-hospital observational study from Wuhan.

Sci Rep 2021 Jul 26;11(1):15205. Epub 2021 Jul 26.

Department of Nephrology, Daping Hospital, Army Medical University, Changjiang Branch Road 10, Yu Zhong district, Chongqing, 400042, China.

Renal injury is common in patients with coronavirus disease 2019 (COVID-19). We aimed to determine the relationship of estimated glomerular filtration rate (eGFR) and acute kidney injury (AKI) with the characteristics, progression, and prognosis of COVID-19 in-patients. We retrospectively reviewed 1851 COVID-19 patients admitted to 3 hospitals in Wuhan, China. Read More

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Impact of SARS-Cov-2 pandemic on Emergency General Surgery. A single-center observational study.

Ann Ital Chir 2021 ;92:317-322

Introduction: Several articles have been published on impact COVID-19 infection about reduction of surgical activity. We have focused on the differences between our surgical activity in an Emergency General Surgery department in "Cardarelli" Hospital in Naples.

Methods: This retrospective study compared the patients treated from March 9, 2020 to April 27, 2020 (Italian lockdown time) and the patients treated in the same period of 2019. Read More

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January 2021

Integrating Physical Therapists Into Primary Care Within A Large Health Care System.

J Am Board Fam Med 2021 Jul-Aug;34(4):866-870

From the University of California, San Francisco (TB); Bellin Health, Green Bay, WI (JK, AT, JJ).

Background: Bellin Health in Wisconsin has pioneered the colocation and integration of physical therapists into primary care pods.

Methods: This is an observational study based on one in-person visit and several interviews.

Results: For patients with musculoskeletal complaints, providers make warm handoffs to the physical therapist, who is a few steps away. Read More

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Development of a healthcare system COVID Hotspotting Score in California: an observational study with prospective validation.

BMJ Open 2021 Jul 26;11(7):e048211. Epub 2021 Jul 26.

Kaiser Permanente Division of Research, Oakland, California, USA.

Objective: To examine the value of health systems data as indicators of emerging COVID-19 activity.

Design: Observational study of health system indicators for the COVID Hotspotting Score (CHOTS) with prospective validation.

Setting And Participants: An integrated healthcare delivery system in Northern California including 21 hospitals and 4. Read More

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What happens after menopause? (WHAM): A prospective controlled study of vasomotor symptoms and menopause-related quality of life 12 months after premenopausal risk-reducing salpingo-oophorectomy.

Gynecol Oncol 2021 Jul 23. Epub 2021 Jul 23.

Centre for Longitudinal and Life Course Research, School of Public Health, University of Queensland, Brisbane, Queensland, Australia.

Objective: To measure menopausal symptoms and quality of life up to 12 months after risk-reducing salpingo-oophorectomy (RRSO) and to measure the effects of hormone therapy.

Methods: Prospective observational study of 95 premenopausal women planning RRSO and a comparison group of 99 who retained their ovaries. Vasomotor symptoms and menopausal-related quality of life (QoL) were measured by the Menopause-Specific QoL Intervention scale at baseline, 3, 6 and 12 months. Read More

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[ω-3 Fatty acids intake level of vegetarians in Shanghai].

Wei Sheng Yan Jiu 2021 Jul;50(4):558-563

Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China.

Objective: To assess the ω-3 fatty acids intake level of vegetarians in Shanghai, and compare with the sex and age matched omnivores.

Methods: The present observational study included 282 vegetarians aged 18 to 60 years old who had been vegetarian for at least one year and 282 sex and age matched omnivores recruited among Shanghai citizens. Daily food consumption was assessed through frequency and average intake of 149 kinds of food by food frequency questionnaire(FFQ) conducted by experienced dietitians. Read More

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Potential drug-drug interactions in patients with cardiovascular diseases: findings from a prospective observational study.

J Pharm Policy Pract 2021 Jul 26;14(1):63. Epub 2021 Jul 26.

Department of Pharmacy Practice, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan.

Background: Patients with cardiovascular diseases (CVD) are at high risk of experiencing drug-drug interactions (DDIs). The objective of this study was to evaluate the frequency, level and risk factors associated with potential-DDIs (pDDIs) in hospitalized CVD patients at cardiology departments of two tertiary care hospitals in Quetta, Pakistan.

Methods: In the current prospective observational study, a total of 300 eligible CVD inpatients were evaluated for pDDIs using Lexicomp Interact®. Read More

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Lower urinary tract signs and symptoms in patients with COVID-19.

BMC Infect Dis 2021 Jul 26;21(1):706. Epub 2021 Jul 26.

Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.

Background: The type of pneumonia that is caused by the new coronavirus (SARS-CoV-2) has spread across the world in a pandemic. It is not clear if COVID-19 patients have any lower urinary tract signs or symptoms.

Methods: The effect of COVID-19 on lower urinary tract function was studied in a prospective multi-centre, observational study including 238 patients who were admitted with symptoms caused by COVID-19 to the university hospital of Aachen in Germany and Tabriz in Iran. Read More

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COVID-19 Clinical Phenotypes and Short-term Outcomes: Differences Between the First and the Second Wave of Pandemic in Italy.

Expert Rev Respir Med 2021 Jul 27. Epub 2021 Jul 27.

Institute of Respiratory Disease, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari, "Aldo Moro", Bari.

Objectives: There are no comparison studies between patients belonging to the first and second waves of the pandemic of the SARS-CoV-2, the virus triggering coronavirus disease 2019 (COVID-19). In this retrospective observational study, we analyzed clinical characteristics and the short-term outcomes of two groups of laboratory-confirmed COVID-19 patients with moderate-to-severe acute respiratory distress syndrome (ARDS) belonging to two different waves of the pandemic.

Methods: We analyzed 97 consecutive patients from 11 March, 2020 to 31 May, 2020 and 52 consecutive patients from 28 August, 2020 to 15 October, 2020. Read More

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