Pediatr Crit Care Med 2021 Sep 24. Epub 2021 Sep 24.
Department of Statistics, University of British Columbia, Vancouver, BC, Canada. Research Institute, BC Children's Hospital, Vancouver, BC, Canada. Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada. Department of Pediatrics, Division of Critical Care, University of British Columbia, Vancouver, BC, Canada.
Objectives: To evaluate the performance of pragmatic imputation approaches when estimating model coefficients using datasets with varying degrees of data missingness.
Design: Performance in predicting observed mortality in a registry dataset was evaluated using simulations of two simple logistic regression models with age-specific criteria for abnormal vital signs (mentation, systolic blood pressure, respiratory rate, WBC count, heart rate, and temperature). Starting with a dataset with complete information, increasing degrees of biased missingness of WBC and mentation were introduced, depending on the values of temperature and systolic blood pressure, respectively. Read More