136,174 results match your criteria observational cohort


Initial therapy of chronic graft vs. host disease: Analysis of practice variation and failure-free survival.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

Fred Hutchinson Cancer Research Center, SEATTLE, Washington, United States.

Prior clinical trials largely considered prednisone 1mg/kg/day with or without calcineurin inhibitor as standard initial therapy for chronic graft vs. host disease (cGVHD) but uncertainty remains regarding the extent of practice variation and whether this affects subsequent outcomes. We assembled a cohort of 745 cGVHD patients treated with initial systemic immune suppressive (IS) therapy from three prior Chronic GVHD Consortium observational studies. Read More

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September 2021

Medication administration behaviors in prelicensure nursing students: A longitudinal, cohort study.

Nurse Educ Pract 2021 Sep 6;56:103189. Epub 2021 Sep 6.

School of Nursing, University of Maryland, Baltimore. Electronic address:

Aim: This longitudinal study identified changes in safe medication administration behaviors in a single cohort of students followed over four semesters of nursing school.

Background: Over 40% of a nurse's shift is dedicated to the processes of medication administration, placing them in a position to interrupt costly medication errors. Yet, despite efforts to decrease medication errors, including electronic medical records, smart pumps, and standardized processes, 5% of hospitalized patients experience adverse drug events and the sequela costs billions of dollars annually. Read More

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September 2021

Fruit and vegetable intake and risk of frailty: A systematic review and dose response meta-analysis.

Ageing Res Rev 2021 Sep 14:101460. Epub 2021 Sep 14.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Purpose: This systematic review and dose-response meta-analysis of observational studies was conducted to summarize available findings on the association between fruits and vegetables (FVs) consumption and risk of frailty.

Methods: Online databases including Medline, Scopus, and Embase were searched to detect related publications up to February 2021. Study selection and data extraction were performed by two investigators working in parallel. Read More

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September 2021

Phenotype and genotype of 197 British patients with McArdle disease: an observational single-centre study.

J Inherit Metab Dis 2021 Sep 17. Epub 2021 Sep 17.

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK.

Objective: McArdle disease is caused by recessive mutations in PYGM gene. The condition is considered to cause a 'pure' muscle phenotype with symptoms including exercise intolerance, inability to perform isometric activities, contracture, acute rhabdomyolysis leading to acute renal failure.

Methods: This is a retrospective observational study aiming to describe phenotypic and genotypic features of a large cohort of patients with McArdle disease between 2011-2019. Read More

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September 2021

Ipsilateral internal carotid artery web and acute ischemic stroke: A cohort study, systematic review and meta-analysis.

PLoS One 2021 17;16(9):e0257697. Epub 2021 Sep 17.

Division of Vascular Neurology, Department of Neurology, Vidant Medical Center, Greenville, North Carolina, United States of America.

Introduction: The carotid web is a compelling potential mechanism of embolic ischemic stroke. In this study, we aim to determine the prevalence of ipsilateral carotid web in a cohort of ischemic stroke patients and to perform a systematic review and meta-analysis of similar cohorts.

Patients & Methods: We performed a retrospective, observational, cohort study of acute ischemic stroke patients admitted to a comprehensive stroke center from June 2012 to September 2017. Read More

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September 2021

Immune Profiling Demonstrates a Common Immune Signature of Delayed Acquired Immunodeficiency in Patients With Various Etiologies of Severe Injury.

Crit Care Med 2021 Sep 16. Epub 2021 Sep 16.

Pathophysiology of Injury-Induced Immunosuppression (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux), Joint Research Unit HCL-bioMérieux, Immunology Laboratory & Anesthesia and Critical Care Medicine Department, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France. BIOASTER, Lyon, France. Sanofi Pasteur, Marcy l'Etoile, France. GSK, GSK Medicines Research Centre, Stevenage, United Kingdom. Laboratoire de Biochimie (LBC), ESPCI Paris, PSL Université, CNRS UMR8231, Paris, France.

Objectives: The host response plays a central role in the pathophysiology of sepsis and severe injuries. So far, no study has comprehensively described the overtime changes of the injury-induced immune profile in a large cohort of critically ill patients with different etiologies.

Design: Prospective observational cohort study. Read More

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September 2021

Moderate obstructive sleep apnea and cardiovascular outcomes in older adults: a propensity score matched multicenter study (CPAGE-MODE Study).

J Clin Sleep Med 2021 Sep 17. Epub 2021 Sep 17.

Hospital Universitario Ramon y Cajal, Sleep Unit, Respiratory Department.

Study Objectives: Obstructive sleep apnea (OSA) has been associated with cardiovascular events (CVE) although recent randomized controlled trials have not demonstrated that long-term continuous positive airway pressure (CPAP) prevents CVEs. Our objective was to determine the effect of CPAP on older adults with moderate OSA regarding CVE reduction.

Methods: An observational and multicentric study of a cohort of older adults (>70 years of age) diagnosed with moderate OSA (apnea hypopnea index 15. Read More

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September 2021

More than half of opioids prescribed to pediatric patients after ambulatory knee surgery are unused.

J Opioid Manag 2021 Jul-Aug;17(4):311-320

Department of Pediatric Orthopedics, Hospital for Special Surgery, New York, New York.

Objective: To determine the number of opioid pills remaining after pediatric ambulatory knee surgery to provide insight into how many pills are actually used.

Design: Prospective observational cohort study. Participants who were expected to be prescribed 20 (Group 1) versus 40 (Group 2) opioid pills according to the institutional policy (based on the type of surgery) were studied. Read More

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September 2021

Migraine Characteristics, Comorbidities, Healthcare Resource Utilization, and Associated Costs of Early Users of Erenumab in the USA: A Retrospective Cohort Study Using Administrative Claims Data.

Pain Ther 2021 Sep 17. Epub 2021 Sep 17.

Global Health Economics, Amgen Inc., 1 Amgen Center Dr, Thousand Oaks, CA, 91320, USA.

Introduction: Erenumab is indicated for migraine preventive treatment in adults. The objective of this study was to provide descriptive information on real-world use of erenumab including patient profile and treatment patterns.

Methods: We completed a retrospective review of US data (through May 2019) from the IBM MarketScan Early View Databases, identifying adult patients newly treated with erenumab with a migraine claim in the year prior to first erenumab claim (index) and at least 1 year of continuous pre-index medical and pharmacy insurance coverage, to assess pre- and post-erenumab migraine characteristics, comorbidities, healthcare resource utilization, and associated costs. Read More

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September 2021

Long-term outcome after surgical treatment of Scheuermann's Kyphosis (SK).

Spine Deform 2021 Sep 17. Epub 2021 Sep 17.

Park Hospital, Nottingham, UK.

Study Design: A retrospective observational cohort study with a minimum follow-up of 10 years of patients who underwent surgery for Scheurmann Kyphosis (SK).

Objective: Evaluate the long-term clinical and radiological outcome of patients with SK who either underwent combined anterior-posterior surgery or posterior instrumented fusion alone. There is paucity of literature for long-term outcome studies on SK. Read More

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September 2021

Increased risk of death from COVID-19 in multiple sclerosis: a pooled analysis of observational studies.

J Neurol 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurology, S. Camillo-Forlanini Hospital, C.ne Gianicolense 87, 00152, Rome, Italy.

Objective: To estimate whether the risk of death from COVID-19 in patients with multiple sclerosis (MS) exceeds that of the general population.

Methods: We conducted a pooled analysis of cohort studies on COVID-19 in patients with MS published until July 31, 2021. We calculated the pooled crude death rate (CDR) and estimated the indirectly-adjusted age-standardized lethality ratio (SLR) to assess the risk of death from COVID-19 in patients with MS as compared to general population. Read More

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September 2021

Microvascular Breakdown Due to Retinal Neurodegeneration in Ataxias.

Mov Disord 2021 Sep 17. Epub 2021 Sep 17.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

Background: Neurodegenerative ataxias are devastating disorders of the cerebellum and spinal cord, accompanied by death of retinal ganglion cells, leading to relentlessly progressive decline of motor coordination and permanent disability. Retinal microvascular affection has not yet been determined.

Objectives: The aim of this study is to assess whether retinal microvascular alterations occur and, if so, whether they are concurrent with or follow cell death in the retina in neurodegenerative diseases. Read More

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September 2021

Comparison of Routine Replacement With Clinically Indicated Replacement of Peripheral Intravenous Catheters.

JAMA Intern Med 2021 Sep 17. Epub 2021 Sep 17.

Infection Control Program and World Health Organization Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland.

Importance: Peripheral intravenous catheters (PVCs) are the most frequently used indwelling devices in hospitals worldwide. Peripheral intravenous catheter bloodstream infections (PVC-BSIs) are rare, but severe and preventable, adverse events.

Objective: To investigate the incidence of PVC-BSIs after changing the policy of routine PVC replacement every 96 hours to clinically indicated replacement. Read More

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September 2021

The prognostic value of respiratory symptoms and performance status in ambulatory cancer patients and unsuspected pulmonary embolism; analysis of an international, prospective, observational cohort study.

J Thromb Haemost 2021 Sep 16. Epub 2021 Sep 16.

Department of Medicine and Ageing Sciences, University G. D'Annunzio, Chieti, Italy.

Background: Optimal risk stratification of unsuspected pulmonary embolism (UPE) in ambulatory cancer patients (ACPs) remains unclear. Existing clinical predictive rules (CPRs) are derived from retrospective databases and have limitations. The UPE registry is a prospective international registry with pre-specified characteristics of ACPs with a recent UPE. Read More

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September 2021

Diagnosis of acute respiratory distress syndrome (DARTS) by bedside exhaled breath octane measurements in invasively ventilated patients: protocol of a multicentre observational cohort study.

Ann Transl Med 2021 Aug;9(15):1262

Department of Intensive Care, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Acute respiratory distress syndrome (ARDS) is currently diagnosed by the Berlin Definition. Diagnosis is subjective and often late. Untargeted metabolomics analysis of exhaled breath with gas chromatography and mass spectrometry (GC-MS) showed that the breath concentration of octane has a high diagnostic accuracy for ARDS. Read More

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High Central Venous Pressure and Right Ventricle Size Are Related to Non-decreased Left Ventricle Stroke Volume After Negative Fluid Balance in Critically Ill Patients: A Single Prospective Observational Study.

Front Med (Lausanne) 2021 31;8:715099. Epub 2021 Aug 31.

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Optimal adjustment of cardiac preload is essential for improving left ventricle stroke volume (LVSV) and tissue perfusion. Changes in LVSV caused by central venous pressure (CVP) are the most important concerns in the treatment of critically ill patients. This study aimed to clarify the changes in LVSV after negative fluid balance in patients with elevated CVP, and to elucidate the relationship between the parameters of right ventricle (RV) filling state and LVSV changes. Read More

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Venovenous extracorporeal membrane oxygenation for treating very severe pneumonia in Aotearoa New Zealand: a 16-year experience.

N Z Med J 2021 Sep 17;134(1542):56-66. Epub 2021 Sep 17.

Anaesthetist and Intensivist, The Cardiothoracic and Vascular Intensive Care Unit, Auckland District Health Board, Auckland.

Aim: We sought to describe the aetiology, demographics and outcomes of patients with pneumonia undergoing venovenous extracorporeal membrane oxygenation (VV-ECMO) in Aotearoa New Zealand.

Methods: Retrospective observational study.

Results: Between January 2004 and August 2020, 133 patients underwent VV-ECMO for pneumonia. Read More

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September 2021

Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit.

Sci Rep 2021 Sep 16;11(1):18467. Epub 2021 Sep 16.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.

Proton pump inhibitors (PPIs), followed by histamine 2 receptor antagonists (H2RAs), are the most commonly used drugs to prevent gastrointestinal bleeding in critically ill patients through stress ulcer prophylaxis. The relative efficacy and drug-related adverse events of PPIs and H2RAs remain unclear. In this retrospective, observational, comparative cohort study, PPIs and H2RAs for stress ulcer prophylaxis in critically ill patients were compared using a common data model. Read More

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September 2021

Late stage 3 chronic kidney disease is an independent risk factor for sarcopenia, but not proteinuria.

Sci Rep 2021 Sep 16;11(1):18472. Epub 2021 Sep 16.

Division of Nephrology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang, Gyeonggi-do, 14068, Republic of Korea.

Most epidemiologic studies assessing the relationship between chronic kidney disease (CKD) and sarcopenia have been performed in dialysis patients. This study aimed to evaluate the relationship between estimated glomerular filtration rate (eGFR), proteinuria, and sarcopenia in patients with non-dialysis-dependent CKD. A total of 892 outpatients who did not show any rapid changes in renal function were enrolled in this observational cohort study. Read More

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September 2021

Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study.

Neurology 2021 Sep 16. Epub 2021 Sep 16.

Hospital Universitario 12 de Octubre, Madrid, Spain.

Background And Objectives: To investigate the natural history and outcomes following treatment for spontaneous amyloid-related imaging abnormalities (ARIA)-like in cerebral amyloid angiopathy-related inflammation (CAA-ri).

Methods: A multicenter, hospital-based, longitudinal, prospective observational study of inpatients meeting CAA-ri diagnostic criteria, recruited through the iCAβ International Network, in the period January 2013 - March 2017. A protocol for systematic data collection at first-ever presentation and at subsequent in-person visits, including T1-weighted, GRE-T2*, fluid-suppressed T2-weighted (FLAIR), and T1 post-gadolinium contrast-enhancement images aquired on 1. Read More

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September 2021

Usefulness of rheumatology consultancy in situ: Analysis of a long-term experience.

Reumatol Clin (Engl Ed) 2021 Sep 13. Epub 2021 Sep 13.

Centro de Salud Cervantes, Gerencia de Atención Integrada, Guadalajara, Spain.

Objective: To report the long-term experience of a rheumatologist consultant "in situ" (RCI) in a primary care centre (PCC).

Material And Methods: Observational retrospective study analysing the complete cohort of the patients seen by the RCI between 2013 and 2019. Rheumatology patients' clinical characteristics and course of care were collected to estimate the diagnoses that were most likely to be monitored by a primary care physician (PCP). Read More

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September 2021

Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19.

Eur J Med Res 2021 Sep 16;26(1):107. Epub 2021 Sep 16.

Medical Faculty, University of Dusseldorf, Dusseldorf, Germany.

Background: COVID-19, the pandemic disease caused by infection with SARS-CoV-2, may take highly variable clinical courses, ranging from symptom-free and pauci-symptomatic to fatal disease. The goal of the current study was to assess the association of COVID-19 clinical courses controlled by patients' adaptive immune responses without progression to severe disease with patients' Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, and the presence or absence of near-loss-of-function delta 32 deletion mutant of the C-C chemokine receptor type 5 (CCR5).

Patient And Methods: An exploratory observational study including 157 adult COVID-19 convalescent patients was performed with a median follow-up of 250 days. Read More

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September 2021

Impact of imposed social isolation and use of face masks on asthma course and mental health in pediatric and adult patients with recurrent wheeze and asthma.

Allergy Asthma Clin Immunol 2021 Sep 16;17(1):93. Epub 2021 Sep 16.

Institut Für Asthma- Und Allergieprävention (IAP), Helmholtz Zentrum Munich, Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GmbH), Munich, Germany.

Background: There is currently a dramatic increase in the number of COVID-19 cases worldwide, and further drastic restrictions in our daily life will be necessary to contain this pandemic. The implications of restrictive measures like social-distancing and mouth-nose protection on patients with chronic respiratory diseases have hardly been investigated.

Methods: Our survey, was conducted within the All Age Asthma Cohort (ALLIANCE), a multicenter longitudinal observational study. Read More

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September 2021

Neurological manifestations in people living with HIV/AIDS in the late cART era: a prospective observational study at a tertiary healthcare center in São Paulo, Brazil.

HIV Res Clin Pract 2021 Sep 16:1-9. Epub 2021 Sep 16.

Departamento de Infectologia, Instituto de Infectologia Emílio Ribas, São Paulo, SP, Brazil.

The aim of this study was to evaluate the frequency, spectrum, in-hospital mortality rate, and factors associated with death in people living with HIV/AIDS (PLWHA) presenting with neurological diseases from a middle-income country, as well as estimate its one-year global death rate.This prospective observational cohort study was conducted at a Brazilian tertiary health center between January and July 2017. HIV-infected patients above 18 years of age who were admitted due to neurological complaints were consecutively included. Read More

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September 2021

Chronotype and wellbeing in adults with established type 2 diabetes - cross-sectional study.

Diabet Med 2021 Sep 16:e14690. Epub 2021 Sep 16.

Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust.

Aims: 'Chronotype' describes an individual's sleep-wake schedule, and can be classified into morning, intermediate, or evening types. Evening chronotype has been widely associated with increased cardiometabolic risk and mortality in people with type 2 diabetes. We explored associations between chronotype and markers of wellbeing in people with type 2 diabetes. Read More

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September 2021

Antibiotic Prescriptions Targeting Bacterial Respiratory Infections in Admitted Patients with COVID-19: A Prospective Observational Study.

Infect Dis Ther 2021 Sep 16. Epub 2021 Sep 16.

Department of Internal Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090, Brussels, Belgium.

Introduction: Although bacterial co- and superinfections are rarely present in patients with COVID-19, overall antibiotic prescribing in admitted patients is high. In order to counter antibiotic overprescribing, antibiotic stewardship teams need reliable data concerning antibiotic prescribing in admitted patients with COVID-19.

Methods: In this prospective observational cohort study, we performed a quantitative and qualitative evaluation of antibiotic prescriptions in patients admitted to the COVID-19 ward of a 721-bed Belgian university hospital between 1 May and 2 November 2020. Read More

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September 2021

Antirheumatic Drug Intake Influence on Occurrence of COVID-19 Infection in Ambulatory Patients with Immune-Mediated Inflammatory Diseases: A Cohort Study.

Rheumatol Ther 2021 Sep 16. Epub 2021 Sep 16.

Adolphe de Rothschild Foundation Hospital, 29 Rue Manin, Paris, France.

Introduction: We aimed to study the prevalence of a history of COVID-19 infection among patients suffering from systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome (SjS) or psoriatic arthritis (PsA), and the potential influence of long-term hydroxychloroquine (HCQ) intake.

Methods: We performed an observational monocentric cohort study at the Adolphe de Rothschild Foundation Hospital ophthalmology division (Paris, France). Electronic medical records (EMR) data were searched for keywords associated with SLE, RA, SjS, or PsA. Read More

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September 2021

Soluble angiotensin-converting enzyme levels in heart failure or acute coronary syndrome: revisiting its modulation and prognosis value.

J Mol Med (Berl) 2021 Sep 16. Epub 2021 Sep 16.

Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Travesía da Choupana S/N, 15706, Santiago de Compostela, A Coruña, Spain.

The main objective was to compare the meaning of soluble angiotensin-converting enzyme-2 (sACE2) plasma levels modulation on the prognosis of two cohorts of heart failure (HF) and acute coronary syndrome (ACS). We conducted an observational clinical study where sACE2 was measured in two cohorts of HF or ACS (102 patients each), matched by age and gender. The primary endpoint (cardiac death) and the secondary endpoints (non-fatal myocardial infarction or HF readmission) were registered during a 5-year follow-up period. Read More

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September 2021

Association of Care Environment With HIV Incidence and Death Among Orphaned, Separated, and Street-Connected Children and Adolescents in Western Kenya.

JAMA Netw Open 2021 Sep 1;4(9):e2125365. Epub 2021 Sep 1.

Department of Biostatistics, Brown University School of Public Health, Providence, Rhode Island.

Importance: In 2015, there were nearly 140 million orphaned children globally, particularly in low- and middle-income regions, and millions more for whom the street is central to their everyday lives. A total of 16.6 million children were orphaned because of deaths associated with HIV/AIDS, of whom 90% live in sub-Saharan Africa. Read More

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September 2021

Risk of Pancreatic Cancer Among Individuals With Pathogenic Variants in the ATM Gene.

JAMA Oncol 2021 Sep 16. Epub 2021 Sep 16.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.

Importance: Pathogenic germline variants in the ATM gene have been associated with pancreatic cancer risk. Although genetic testing identifies these variants in approximately 1% to 3% of unselected patients with pancreatic cancer, the lifetime risk of pancreatic cancer among individuals with pathogenic ATM variants has not been well estimated.

Objective: To estimate age-specific penetrance of pancreatic cancer in individuals with a pathogenic variant in the ATM gene. Read More

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September 2021