Front Behav Neurosci 2019 9;13:101. Epub 2019 May 9.
Developmental Neuropsychobiology Laboratory, Department of Psychology, Northeastern University, Boston, MA, United States.
Early life stress (ELS) is a potent developmental disruptor and increases the risk for psychopathology. Various forms of ELS have been studied in both humans and rodents, and have been implicated in altered DNA methylation, gene transcription, stress hormone levels, and behavior. Although recent studies have focused on stress-induced epigenetic changes, the extent to which ELS alters HPA axis function and stress responsivity across generations, whether these effects are sex-specific, and how lineage interacts with upbringing to impact these effects, remain unclear. Read More