2,335 results match your criteria obesity imbalance

Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women.

Breast Cancer Res 2021 Jul 30;23(1):77. Epub 2021 Jul 30.

Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Background: The mechanistic target of rapamycin (mTOR) pathway promoted by positive energy imbalance and insulin-like growth factors can be a mechanism by which obesity influences breast cancer risk. We evaluated the associations of body fatness with the risk of breast cancer varied with phosphorylated (p)-mTOR protein expression, an indication of the pathway activation.

Methods: Women with newly diagnosed breast cancer (n = 715; 574 [80%] Black and 141 [20%] White) and non-cancer controls (n = 1983; 1280 [64%] Black and 713 [36%] White) were selected from the Women's Circle of Health Study. Read More

View Article and Full-Text PDF

Bariatric Surgery-Associated Myelopathy.

Obes Facts 2021 Jul 26:1-9. Epub 2021 Jul 26.

Department of Pediatrics, Ruth Children's Hospital, Rambam Medical Center, Haifa, Israel.

Bariatric surgery is gaining acceptance as an efficient treatment modality for adults and adolescents with morbid obesity. The early postbariatric period has the potential to induce an immunomodulatory imbalance due to the development or worsening of nutritional deficiencies, changes in hormonal balance (specifically after sleeve gastrectomy), and a shift in the proinflammatory cytokine profile along with a major change in the gut microbiome and permeability. These changes may induce encephalomyelitic T cell activity, change neural barrier permeability, and induce gut dysbioisis, favoring a proinflammatory metabolic profile. Read More

View Article and Full-Text PDF

Polycystic ovary syndrome in pediatric obesity and diabetes.

Minerva Pediatr (Torino) 2021 Jul 21. Epub 2021 Jul 21.

Metabolic Disorders and Genetic Unit, Giovanni XXIII Children Hospital, Bari, Italy -

Introduction: Polycystic ovary syndrome is characterized by anovulation (amenorrhea, oligomenorrhea, irregular menstrual cycles) combined with symptoms of androgen excess (hirsutism, acne, alopecia). The clear definition and diagnosis in adolescents could be challenging considering that most of symptoms occur as part of the expected physiological hormonal imbalance of puberty. Therefore, different diagnostic criteria have been elaborated. Read More

View Article and Full-Text PDF

Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review.

Int J Environ Res Public Health 2021 07 4;18(13). Epub 2021 Jul 4.

Laboratory of Neuroscience, Department of Psychology, Instituto de Neurociencias del Principado de Asturias (INEUROPA), University of Oviedo, 33003 Oviedo, Spain.

In recent years, the worldwide prevalence of overweight and obesity among adults and children has dramatically increased. The conventional model regarding the onset of obesity is based on an imbalance between energy intake and expenditure. However, other possible environmental factors involved, such as the exposure to chemicals like pesticides, cannot be discarded. Read More

View Article and Full-Text PDF

A novel model of obesity prediction: Neurobehaviors as targets for treatment.

Behav Neurosci 2021 Jun;135(3):426-442

Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech.

Obesity is a worldwide epidemic that is on the rise, with approximately 30% of the world population classified as either overweight or obese. The United States has some of the highest rates of obesity, and in most countries in the world, obesity now poses more of a serious health concern than malnutrition. Obesity is a chronic, relapsing disorder that is both preventable and treatable; however, traditional interventions that target eating less and exercising more have low success rates, especially in the long term. Read More

View Article and Full-Text PDF

Sesamol promotes browning of white adipocytes to ameliorate obesity by inducing mitochondrial biogenesis and inhibition mitophagy via β3-AR/PKA signaling pathway.

Food Nutr Res 2021 10;65. Epub 2021 May 10.

Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.

Background: Obesity is defined as an imbalance between energy intake and expenditure, and it is a serious risk factor of non-communicable diseases. Recently many studies have shown that promoting browning of white adipose tissue (WAT) to increase energy consumption has a great therapeutic potential for obesity. Sesamol, a lignan from sesame oil, had shown potential beneficial functions on obesity treatment. Read More

View Article and Full-Text PDF

A Food Supplement with Antioxidative Santa Herba Extract Modulates Energy Metabolism and Contributes to Weight Management.

J Med Food 2021 Jul 13. Epub 2021 Jul 13.

Mibelle Group Biochemistry, Aargau, Switzerland.

The plant Santa herba () contains high flavonoids, thus potentially exerting beneficial effects in context of obesity, often accompanied by inflammation and metabolic imbalance. The study assessed the impact of Santa herba on oxidative stress, energy metabolism, weight reduction, and eating behavior, combining models with clinical data. Santa herba binding of the adenosine receptor A2A (ADORA2A) was assessed using a radioligand binding assay. Read More

View Article and Full-Text PDF

Is the habit system altered in individuals with obesity? A systematic review.

Neurosci Biobehav Rev 2021 09 9;128:621-632. Epub 2021 Jul 9.

Departamento de Psicología Básica, Universidad Autónoma de Madrid, Spain; Departamento de Psicología Básica, Universidad de Málaga, Spain. Electronic address:

Habit-like eating behavior is repeatedly pointed to as a key cognitive mechanism contributing to the emergence and maintenance of obesity. Here, we conducted a systematic review of the literature to assess the existent behavioral evidence for the Habit Hypothesis for Overeating (HHO) which states that obesity is the consequence of an imbalance between the habit and goal-directed reward learning systems, leading to overconsumption of food. We found a total of 19 studies implementing a variety of experimental protocols (i. Read More

View Article and Full-Text PDF
September 2021

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update.

Front Cell Dev Biol 2021 24;9:686173. Epub 2021 Jun 24.

Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Obesity prevalence became a severe global health problem and it is caused by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major site of mammalian non-shivering thermogenesis or energy dissipation. Thus, modulation of BAT thermogenesis might be a promising application for body weight control and obesity prevention. Read More

View Article and Full-Text PDF

Hypothalamic microinflammation.

Handb Clin Neurol 2021 ;181:311-322

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States.

Over the past decade, hypothalamic microinflammation has been studied and appreciated as a core mechanism involved in the advancement of metabolic syndrome and aging. Accumulating evidence suggests that atypical microinflammatory insults disturb hypothalamic regulation resulting in metabolic imbalance and aging progression, establishing a common causality for these two pathophysiologic statuses. Studies have causally linked these changes to activation of key proinflammatory pathways, especially NF-κB signaling within the hypothalamus, which leads to hypothalamic neuronal dysregulation, astrogliosis, microgliosis, and loss of adult hypothalamic neural stem/progenitor cells. Read More

View Article and Full-Text PDF

Predicting Obesity in Adults Using Machine Learning Techniques: An Analysis of Indonesian Basic Health Research 2018.

Front Nutr 2021 21;8:669155. Epub 2021 Jun 21.

Department of Health Promotion, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia.

Obesity is strongly associated with multiple risk factors. It is significantly contributing to an increased risk of chronic disease morbidity and mortality worldwide. There are various challenges to better understand the association between risk factors and the occurrence of obesity. Read More

View Article and Full-Text PDF

Diagnosis and Management of Infertility: A Review.

JAMA 2021 Jul;326(1):65-76

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut.

Importance: In the US, approximately 12.7% of reproductive age women seek treatment for infertility each year. This review summarizes current evidence regarding diagnosis and treatment of infertility. Read More

View Article and Full-Text PDF

Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress.

Front Microbiol 2021 11;12:656372. Epub 2021 Jun 11.

School of Stomatology, Anhui Medical University, Hefei, China.

Periodontitis is a type of systemic immune inflammation that is caused by the complex infection of a variety of microorganisms in the subgingival plaque and the imbalance of the microbial ecological environment in the mouth. Periodontitis and chronic kidney disease (CKD) share many risk factors, such as obesity, smoking, and age. A growing body of data supports a strong correlation between periodontitis and kidney disease. Read More

View Article and Full-Text PDF

Hypothalamic primary cilium: A hub for metabolic homeostasis.

Exp Mol Med 2021 Jul 1. Epub 2021 Jul 1.

Departments of Oral Biology and Applied Biological Science, BK21 Four, Yonsei University College of Dentistry, Seoul, 03722, Korea.

Obesity is a global health problem that is associated with adverse consequences such as the development of metabolic disorders, including cardiovascular disease, neurodegenerative disorders, and type 2 diabetes. A major cause of obesity is metabolic imbalance, which results from insufficient physical activity and excess energy intake. Understanding the pathogenesis of obesity, as well as other metabolic disorders, is important in the development of methods for prevention and therapy. Read More

View Article and Full-Text PDF

The Arcuate Nucleus of the Hypothalamus and Metabolic Regulation: An Emerging Role for Renin-Angiotensin Pathways.

Int J Mol Sci 2021 Jun 30;22(13). Epub 2021 Jun 30.

Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Obesity is a chronic state of energy imbalance that represents a major public health problem and greatly increases the risk for developing hypertension, hyperglycemia, and a multitude of related pathologies that encompass the metabolic syndrome. The underlying mechanisms and optimal treatment strategies for obesity, however, are still not fully understood. The control of energy balance involves the actions of circulating hormones on a widely distributed network of brain regions involved in the regulation of food intake and energy expenditure, including the arcuate nucleus of the hypothalamus. Read More

View Article and Full-Text PDF

Impaired Leptin Signalling in Obesity: Is Leptin a New Thermolipokine?

Int J Mol Sci 2021 Jun 16;22(12). Epub 2021 Jun 16.

Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.

Leptin is a principal adipose-derived hormone mostly implicated in the regulation of energy balance through the activation of anorexigenic neuronal pathways. Comprehensive studies have established that the maintenance of certain concentrations of circulating leptin is essential to avoid an imbalance in nutrient intake. Indeed, genetic modifications of the leptin/leptin receptor axis and the obesogenic environment may induce changes in leptin levels or action in a manner that accelerates metabolic dysfunctions, resulting in a hyperphagic status and adipose tissue expansion. Read More

View Article and Full-Text PDF

The Peculiar Trialogue between Pediatric Obesity, Systemic Inflammatory Status, and Immunity.

Biology (Basel) 2021 Jun 9;10(6). Epub 2021 Jun 9.

Department of Pediatrics III, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Gheorghe Marinescu Street No 38, 540136 Târgu Mureș, Romania.

Pediatric obesity is not only an energetic imbalance, but also a chronic complex multisystem disorder that might impair both the life length and quality. Its pandemic status should increase worldwide awareness regarding the long-term life-threatening associated complications. Obesity related complications, such as cardiovascular, metabolic, or hepatic ones, affect both short and long-term wellbeing, and they do not spare pediatric subjects, defined as life-threatening consequences of the systemic inflammatory status triggered by the adipose tissue. Read More

View Article and Full-Text PDF

β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis.

Biomedicines 2021 Jun 22;9(7). Epub 2021 Jun 22.

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

As a kind of metabolically triggered inflammation, obesity influences the interplay between the central nervous system and the enteral environment. The present study showed that β-elemene, which is contained in various plant substances, had effects on recovering the changes in metabolites occurring in high-fat diet (HFD)-induced obese C57BL/6 male mice brains, especially in the prefrontal cortex (PFC) and hippocampus (HIP). β-elemene also partially reversed HFD-induced changes in the composition and contents of mouse gut bacteria. Read More

View Article and Full-Text PDF

Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications.

Int J Mol Sci 2021 Jun 6;22(11). Epub 2021 Jun 6.

State Key Laboratory of Natural Medicines and School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China.

Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely related to oxidative stress-induced mitochondrial dysfunction, ectopic fat accumulation, and the impairment of the antioxidant system, which in turn further aggravates the intracellular oxidative imbalance and inflammatory response. As enriched anti-inflammatory and antioxidant components in plants, natural polyphenols exhibit beneficial effects, including improving liver fat accumulation and dyslipidemia, reducing blood pressure. Read More

View Article and Full-Text PDF

Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health.

Nutrients 2021 Jun 23;13(7). Epub 2021 Jun 23.

Natural Products for Neuroprotection and Anti-Ageing Research Unit, Chulalongkorn University, Bangkok 10330, Thailand.

Tea is one of the most popular and widely consumed beverages worldwide, and possesses numerous potential health benefits. Herbal teas are well-known to contain an abundance of polyphenol antioxidants and other ingredients, thereby implicating protection and treatment against various ailments, and maintaining overall health in humans, although their mechanisms of action have not yet been fully identified. Autophagy is a conserved mechanism present in organisms that maintains basal cellular homeostasis and is essential in mediating the pathogenesis of several diseases, including cancer, type II diabetes, obesity, and Alzheimer's disease. Read More

View Article and Full-Text PDF

Seaweed Components as Potential Modulators of the Gut Microbiota.

Mar Drugs 2021 Jun 23;19(7). Epub 2021 Jun 23.

Food Biosciences, Teagasc Food Research Centre, Ashtown, D15 KN3K Dublin, Ireland.

Macroalgae, or seaweeds, are a rich source of components which may exert beneficial effects on the mammalian gut microbiota through the enhancement of bacterial diversity and abundance. An imbalance of gut bacteria has been linked to the development of disorders such as inflammatory bowel disease, immunodeficiency, hypertension, type-2-diabetes, obesity, and cancer. This review outlines current knowledge from and studies concerning the potential therapeutic application of seaweed-derived polysaccharides, polyphenols and peptides to modulate the gut microbiota through diet. Read More

View Article and Full-Text PDF

The Link between Obesity, Microbiota Dysbiosis, and Neurodegenerative Pathogenesis.

Diseases 2021 Jun 23;9(3). Epub 2021 Jun 23.

Centre of Biotechnology, University of Allahabad, Prayagraj 211002, India.

Current research in medicine in several parts of the world has attempted to establish a link between the occurrence of neurodegenerative pathologies, microbiota dysbiosis, and the incidence of obesity. The body's response to different physicochemical factors has also been influenced by the proper assimilation of bioactive compounds contained in the food that is ingested. Oxidative stress is one of the major factors that directly affects the functioning of the human microbiota. Read More

View Article and Full-Text PDF

Physiological and Psychological Effects of Treadmill Overtraining Implementation.

Biology (Basel) 2021 Jun 10;10(6). Epub 2021 Jun 10.

Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei 11219, Taiwan.

Overtraining in athletes usually causes profound and lasting deleterious effects on the maintenance of health and exercise capacity. Here, we established an overtraining animal model to investigate the physiological modulation for future strategic applications in vivo. We subjected C57BL/6 mice to exhaustive treadmill exercises daily for 8 weeks (the exhaustive exercise group). Read More

View Article and Full-Text PDF

Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity.

Children (Basel) 2021 Jun 27;8(7). Epub 2021 Jun 27.

Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milano, Italy.

In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders, including impaired glucose metabolism. In particular, Treg and Th17 cells are dynamically balanced under healthy conditions, but imbalance occurs in inflammatory and pathological states, such as obesity. Read More

View Article and Full-Text PDF

Endothelial impairment evaluation by peripheral arterial tonometry in pediatric endocrinopathies: A narrative review.

World J Diabetes 2021 Jun;12(6):810-826

Pediatric Clinic and Endocrinology, IRCCS Istituto Giannina Gaslini, Genoa16147, Italy.

Endothelial dysfunction (ED) is characterized by an imbalance between vasodilator and vasoconstriction agents. Several pathological conditions clinically diagnosed in childhood and adolescence are characterized by ED and increased risk for early development of microangiopathic and macroangiopathic impairment, in particular type 1 diabetes mellitus (T1DM), T2DM, obesity, metabolic syndromeand pituitary dysfunction associated to various endocrinopathies. More recently insulin resistance following chemotherapy or radiotherapy for tumors, bone marrow transplantation for hematological malignancies (, cancer survivors), or immunosuppressive treatment for solid organ transplantation has been observed. Read More

View Article and Full-Text PDF

Complement in metabolic disease: metaflammation and a two-edged sword.

B C King A M Blom

Semin Immunopathol 2021 Jun 22. Epub 2021 Jun 22.

Department of Translational Medicine, Lund University, Lund, Sweden.

We are currently experiencing an enduring global epidemic of obesity and diabetes. It is now understood that chronic low-grade tissue inflammation plays an important role in metabolic disease, brought upon by increased uptake of a so-called Western diet, and a more sedentary lifestyle. Many evolutionarily conserved links exist between metabolism and the immune system, and an imbalance in this system induced by chronic over-nutrition has been termed 'metaflammation'. Read More

View Article and Full-Text PDF

Association of SNPs in Lipid Metabolism Gene Single Nucleotide Polymorphism with the Risk of Obesity in Children.

Genet Test Mol Biomarkers 2021 Jun;25(6):419-425

Animal and Human Genetics Laboratory, Department of Genetics, Southern Federal University, Rostov-on-Don, Russia.

Obesity is one of the most common metabolic disorders in the world, which develops due to an imbalance in energy consumption and expenditure, and both genetic and environmental factors are of great importance. We investigated the potential interactions of single nucleotide polymorphisms that might contribute to the development of polygenic obesity in children. The study involved 367 children and adolescents of both sexes aged from 4 to 18 years. Read More

View Article and Full-Text PDF

Metformin Improves Autonomic Nervous System Imbalance and Metabolic Dysfunction in Monosodium L-Glutamate-Treated Rats.

Front Endocrinol (Lausanne) 2021 4;12:660793. Epub 2021 Jun 4.

Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Brazil.

Metformin is an antidiabetic drug used for the treatment of diabetes and metabolic diseases. Imbalance in the autonomic nervous system (ANS) is associated with metabolic diseases. This study aimed to test whether metformin could improve ANS function in obese rats. Read More

View Article and Full-Text PDF

Metabolic Syndrome in an Aging Society - Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis.

Clin Interv Aging 2021 9;16:1057-1070. Epub 2021 Jun 9.

Department of Internal Medicine, Medical University of Silesia in Katowice, Bytom, Poland.

Introduction: The prevalence of metabolic syndrome among the elderly population is growing. The elements of metabolic syndrome in an aging society are currently being researched. Atherosclerosis is a slow process in which the first symptoms may be observed after many years. Read More

View Article and Full-Text PDF

Sarcopenic obesity as a determinant of cardiovascular disease risk in older people: a systematic review.

Postgrad Med 2021 Jul 12:1-12. Epub 2021 Jul 12.

Department of Geriatric Medicine, Rotherham General Hospital, Rotherham UK.

Background: Aging is associated with body composition changes that include a reduction of muscle mass or sarcopenia and an increase in visceral obesity. Thus, aging involves a muscle-fat imbalance with a shift toward more fat and less muscle. Therefore, sarcopenic obesity, defined as a combination of sarcopenia and obesity, is a global health phenomenon due to the increased aging of the population combined with the increased epidemic of obesity. Read More

View Article and Full-Text PDF