23,679 results match your criteria obese diabetic


Gestational diabetes mellitus - A metabolic and reproductive disorder.

Biomed Pharmacother 2021 Sep 21;143:112183. Epub 2021 Sep 21.

Department of Bio-Medical Sciences, School of Biosciences and Technology, VIT University, Vellore 632 014, Tamil Nadu, India. Electronic address:

Maternal health associated with Gestational Diabetes Mellitus (GDM) has been gaining significant research attention due to its severe risk and adverse health effects. GDM is the leading health disease in pregnant women. It is the most common metabolic disease and it can affect up to 25% of women during pregnancy. Read More

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September 2021

Diabetes is not protective against the formation of unruptured cerebral aneurysm.

Clin Neurol Neurosurg 2021 Sep 15;209:106944. Epub 2021 Sep 15.

Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University College of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: Diabetes appears to decrease the risk of subarachnoid hemorrhage. However, it is not clear whether diabetes decreases the risk of aneurysm formation. The aim of our study to evaluate the risk of unruptured cerebral aneurysm in patients with diabetes mellitus. Read More

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September 2021

Hemin attenuates response of primary rat adipocytes to adrenergic stimulation.

PeerJ 2021 2;9:e12092. Epub 2021 Sep 2.

Department of Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, Poznań, Poland.

Hemin is an activator of heme oxygenase-1 (HO-1), an enzyme catalyzing heme degradation. Up-regulation of HO-1 is observed in response to various pathological conditions. Moreover, pharmacological activation of HO-1 is associated with numerous beneficial effects in the organism. Read More

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September 2021

Combination of Metformin and Exercise in Management of Metabolic Abnormalities Observed in Type 2 Diabetes Mellitus.

Authors:
Filip Jevtovic

Diabetes Metab Syndr Obes 2021 16;14:4043-4057. Epub 2021 Sep 16.

Department of Kinesiology, College of Health and Human Performance, East Carolina University, Greenville, NC, USA.

Excess nutrient intake and lack of exercise characterize the problem of obesity and are common factors in insulin resistance (IR). With an increasing number of prediabetic, and type 2 diabetic populations, metformin is still the most prescribed glucose-lowering drug and is often accompanied by recommendations for regular physical exercise. Metformin, by the inhibition of complex 1 of the electron transport chain, and exercise, by increasing energy expenditure, both elicit a low cellular energy state that leads to improvements in glucose control via activation of adenosine 5' monophosphate-activated protein kinase (AMPK). Read More

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September 2021

Syntaxin 4 enrichment in β-cells prevents conversion to autoimmune diabetes in non-obese diabetic (NOD) mice.

Diabetes 2021 Sep 23. Epub 2021 Sep 23.

Department of Molecular and Cellular Endocrinology, Arthur Riggs Diabetes& Metabolism Research Institute, City of Hope Beckman Research Institute, Duarte CA

Syntaxin 4 (STX4), a plasma membrane-localized SNARE protein, regulates human islet β-cell insulin secretion and preservation of β-cell mass. We found that human type 1 diabetic (T1D) and non-obese diabetic (NOD) mouse islets show reduced β-cell STX4 expression, consistent with decreased STX4 expression as a potential driver of T1D phenotypes. To test this hypothesis, we generated inducible β-cell-specific STX4-expressing NOD mice (NOD-iβSTX4). Read More

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September 2021

Evaluation of quality of life in diabetic pregnant women.

Prim Care Diabetes 2021 Sep 20. Epub 2021 Sep 20.

Department of Public Health, Firoozabad Branch, Islamic Azad University, Firoozabad, Iran.

Aims: Gestational diabetes is the most common clinical complication during pregnancy. Women with gestational diabetes face many problems in their personal, family and social lives that affect their quality of life. The aim of this study was to evaluate the quality of life of diabetic pregnant women. Read More

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September 2021

Adipocyte function and the development of cardiometabolic disease.

J Physiol 2021 Sep 23. Epub 2021 Sep 23.

Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, 81377, Germany.

Key Points: Obesity and the associated adipocyte pathology are risk factors for cardiovascular disease Translational research is possible but strongly depends on the mouse model used White adipose tissue inflammation contributes to metabolic and vascular dysfunction Brown adipose tissue thermogenesis supports metabolic and vascular function ABSTRACT: Obesity is a medical disorder caused by multiple mechanisms of dysregulated energy balance. A major consequence of obesity is an increased risk to develop diabetes, diabetic complications, and cardiovascular disease. While a better understanding of the molecular mechanisms linking obesity, insulin resistance, and cardiovascular disease is needed, translational research of the human pathology is hampered by the available cellular and rodent model systems. Read More

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September 2021

Noncommunicable diseases risk factors in Bhutan: A secondary analysis of data from Bhutan's nationwide STEPS survey 2014.

PLoS One 2021 23;16(9):e0257385. Epub 2021 Sep 23.

Sydney School of Public Health, The University of Sydney, Sydney, NSW, Australia.

Background: Bhutan is facing an epidemic of noncommunicable diseases; they are responsible for 53% of all deaths. Four main modifiable risk factors, including tobacco use, harmful use of alcohol, physical inactivity, and unhealthy diet, are the causes of most noncommunicable diseases (NCDs). This study aimed to assess 1) the prevalence of NCDs modifiable risk factors in Bhutan's adult population and 2) associations between the sociodemographic factors and the NCDs modifiable risk factors with overweight or obesity, hypertension, and diabetes. Read More

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September 2021

Insulin and the insulin receptor collaborate to promote human gastric cancer.

Gastric Cancer 2021 Sep 23. Epub 2021 Sep 23.

Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, University of Newcastle-upon-Tyne, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK.

Background: Gastric adenocarcinoma is common and consequent mortality high. Presentation and mortality are increased in obese individuals, many of whom have elevated circulating insulin concentrations. High plasma insulin concentrations may promote, and increase mortality from, gastric adenocarcinoma. Read More

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September 2021

miR-21 mimic blocks obesity in mice: A novel therapeutic option.

Mol Ther Nucleic Acids 2021 Dec 2;26:401-416. Epub 2021 Jul 2.

Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario, Universidad de Málaga, Campus Teatinos, 29010 Málaga, Spain.

MicroRNAs (miRNAs) are promising drug targets for obesity and metabolic disorders. Recently, miRNA mimics are providing a unique mechanism of action that guides the process for drug development and sets out the context of their therapeutic application. miRNA (miR)-21 expression in white adipose tissue (WAT) has been associated with obesity. Read More

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December 2021

Hypofibrinolysis in type 2 diabetes and its clinical implications: from mechanisms to pharmacological modulation.

Cardiovasc Diabetol 2021 Sep 22;20(1):191. Epub 2021 Sep 22.

Institute of Cardiology, Jagiellonian University Medical College, 80 Prądnicka St., 31-202, Kraków, Poland.

A prothrombotic state is a typical feature of type 2 diabetes mellitus (T2DM). Apart from increased platelet reactivity, endothelial dysfunction, hyperfibrinogenemia, and hypofibrinolysis are observed in T2DM. A variety of poorly elucidated mechanisms behind impaired fibrinolysis in this disease have been reported, indicating complex associations between platelet activation, fibrin formation and clot structure, and fibrinolysis inhibitors, in particular, elevated plasminogen antigen inhibitor-1 levels which are closely associated with obesity. Read More

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September 2021

Relationship between Type 2 Diabetes Mellitus and Lumbar Bone Mineral Density in Postmenopausal Women.

Asian Spine J 2021 Sep 28. Epub 2021 Sep 28.

Department of Orthopaedic Surgery, Master Yonsei Orthopedic Clinic, Seoul, Korea.

Study Design: Cross-sectional study using radiological measurements.

Purpose: To analyze the relationship between type 2 diabetes mellitus (DM) and bone mineral density (BMD) in postmenopausal women and to assess risk factors of osteoporotic vertebral compression fracture (OVCF) in postmenopausal diabetic women.

Overview Of Literature: Type 2 DM has negative effects on the quality of bone. Read More

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September 2021

Impact of BMI on Left Atrial Strain and Abnormal Atrioventricular Interaction in Patients With Type 2 Diabetes Mellitus: A Cardiac Magnetic Resonance Feature Tracking Study.

J Magn Reson Imaging 2021 Sep 22. Epub 2021 Sep 22.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Type 2 diabetes mellitus (T2DM) and obesity often coexist and together contribute to left atrial (LA) functional abnormalities. However, little is known about the impact of body mass index (BMI) on LA strains measured using cardiac magnetic resonance feature tracking (MR-FT).

Purpose: To investigate the additive effect of BMI on LA functional remodeling using MR-FT as well as to explore abnormal atrioventricular interaction in T2DM patients. Read More

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September 2021

The effect of N-acetylcysteine and ascorbic acid-2-phosphate supplementation on Mesenchymal Stem Cell function in B6.C-Lepob/J type 2 diabetic mice.

Stem Cells Dev 2021 Sep 21. Epub 2021 Sep 21.

Stellenbosch University Faculty of Medicine and Health Sciences, 121470, Medicine, Fransie van Zijl drive, Tygerberg Campus, Clinical building, Cape Town, South Africa, 7500;

Diabetes is a complex multifactorial disorder associated with hyperglycaemia, oxidative stress and inflammation. The pathological microenvironment impairs MSC viability and dysregulates their pro-regenerative and immune-modulatory function causing maladaptive tissue damage. Targeting stem cells to protect them against impairment could thus delay the onset of complications and enhance the quality of life in DM patients. Read More

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September 2021

Gentamicin-Containing Collagen Implant May Reduce Surgical Site Infections After Open Infrainguinal Arterial Revascularisation.

Ann Vasc Surg 2021 Sep 17. Epub 2021 Sep 17.

School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, Mailbox Drop Point 509, 35 Stirling Hwy, Nedlands, 6009, Western Australia, Australia; Department of Vascular and Endovascular Surgery, Sir Charles Gairdner Hospital, Level 6, G Block, QEII Medical Centre, Hospital Avenue, Nedlands, 6009 Western Australia, Australia; Curtin Medical School, Faculty of Health Sciences, Curtin University Level 4 Building 400, GPO Box U1987, Perth, Western Australia 6845 Australia; Heart and Vascular Research Institute, Level 2 Harry Perkins Institute of Medical Research, 6 Verdun Street, Nedlands, Western Australia, Australia 6009. Electronic address:

Objectives: Deep-space surgical site infections carry significant morbidity and mortality. The evidence for gentamicin-containing collagen implants at reducing surgical site infections in open infrainguinal arterial surgery is limited. This study examined whether gentamicin-containing collagen implants reduces 30-day surgical site infections and their severity following open infrainguinal arterial surgery. Read More

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September 2021

Prevalence of diabetic foot among adults with diabetes mellitus in northern Sudan: a cross-sectional study.

Int J Clin Pract 2021 Sep 19:e14892. Epub 2021 Sep 19.

Department of Obstetrics and Gynecology, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia.

Objective: The aim of this study was to determine the prevalence and associated factors for diabetic foot (DF) among patients with diabetes Mellites (DM) in Nahr an Nil State (River Nile State), Sudan.

Methods: We conducted across-sectional study between May and August 2018. DM patients were examined for DF, and clinical data were collected through a questionnaire. Read More

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September 2021

Teratoma Formation Assay for Assessing Pluripotency and Tumorigenicity of Pluripotent Stem Cells.

Bio Protoc 2017 Aug 20;7(16):e2518. Epub 2017 Aug 20.

Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan.

Pluripotent stem cells such as induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) form teratomas when transplanted into immunodeficient mice. As teratomas contain all three germ layers (endoderm, mesoderm, ectoderm), teratoma formation assay is widely used as an index of pluripotency (Evans and Kaufman, 1981; Hentze , 2009 ; Gropp , 2012 ). On the other hand, teratoma-forming tumorigenicity also represents a major risk factor impeding potential clinical applications of pluripotent stem cells ( Miura , 2009 ; Okano , 2013 ). Read More

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Obesity, diabetes, hypertension and severe outcomes among inpatients with COVID-19: a nationwide study.

Clin Microbiol Infect 2021 Sep 16. Epub 2021 Sep 16.

Department of Public Health, University Hospital of Nice, Nice, France; Université Côte d'Azur, CHU Nice, Nice, France.

Objectives: Initial studies of COVID-19 patients revealed that obesity, diabetes and hypertension were associated with severe outcomes. Subsequently, some authors showed that the risk could vary according to age, gender, comorbidities and medical history. In a nationwide retrospective cohort, we studied the association between these comorbidities and patients' requirement for invasive mechanical ventilation (IMV) or their death. Read More

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September 2021

Associations between obesity, weight change and decreased renal function in Korean type 2 diabetic patients: a longitudinal follow-up study.

BMC Endocr Disord 2021 Sep 17;21(1):188. Epub 2021 Sep 17.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon, 14584, Republic of Korea.

Background: We aimed to examine the associations between the risk of decreased renal function, obesity, and weight changes in Korean type 2 diabetic patients with normal renal function.

Methods: Type 2 diabetic patients (n = 1060) who visited the diabetic clinic at Soonchunhyang University Bucheon Hospital between 2001 and 2007 with follow up surveys completed in 2016 to 2017 were recruited into the study. Decreased renal function was defined as an estimated glomerular filtration rate < 60 mL/min/1. Read More

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September 2021

Why the diabetic heart is energy inefficient: A ketogenesis and ketolysis perspective.

Am J Physiol Heart Circ Physiol 2021 Sep 17. Epub 2021 Sep 17.

Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, United States.

Lack of glucose uptake compromises metabolic flexibility and reduces energy efficiency in the diabetes mellitus (DM) heart. Although increased utilization of fatty acid to compensate glucose substrate has been studied, less is known about ketone body metabolism in the DM heart. Ketogenic diet reduces obesity, a risk factor for T2DM. Read More

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September 2021

Impact of COVID-19 in Liver Disease Progression.

Hepatol Commun 2021 Jul 31;5(7):1138-1150. Epub 2021 May 31.

IrsiCaixa, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus disease 19 (COVID-19), which has infected millions of people worldwide in only a few months. A minority, but significant number, of infected individuals require hospitalization and intensive care. From the start of this new virus pandemic, it was apparent that obese and/or diabetic individuals had a bad prognosis for COVID-19 progression, strongly suggesting an association between liver disease and severe COVID-19. Read More

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Does Losing 5-7% of Prediabetic Body Weight from a Diabetes Prevention Program decrease Cardiovascular Risks?

Spartan Med Res J 2021 30;6(2):27627. Epub 2021 Aug 30.

Beaumont Farmington Hills.

Introduction: According to the Centers for Disease Control and Prevention (CDC), one-third of adults have prediabetes (i.e., at risk for developing type 2 diabetes), a leading risk factor for cardiovascular disease. Read More

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Biochanin A from Chinese Medicine: An Isoflavone with Diverse Pharmacological Properties.

Am J Chin Med 2021 Sep 16:1-21. Epub 2021 Sep 16.

Department of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery, System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced, Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China.

Biochanin A (BCA) is a dietary isoflavone, isolated from the leaves and stems of L and many other herbs of Chinese medicine. Recent findings indicated BCA as a promising drug candidate with diverse bioactive effects. On the purpose of evaluating the possibility of BCA in clinical application, this review is trying to provide a comprehensive summary of the pharmacological actions of BCA. Read More

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September 2021

SYSTEMATIC REVIEW WITH META-ANALYSIS: NON-ALCOHOLIC FATTY LIVER DISEASE AND THE ASSOCIATION WITH PREGNANCY OUTCOMES.

Clin Mol Hepatol 2021 Sep 17. Epub 2021 Sep 17.

Department of Gastroenterology and Hepatology, Nepean Hospital, Penrith, New South Wales, Australia.

Background And Aims: Maternal and fetal outcomes in pregnant patients with NAFLD have been largely unexplored. To determine the level of evidence associated with both maternal and fetal outcomes in pregnant women with NAFLD.

Method: We conducted a comprehensive literature search. Read More

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September 2021

Quercetin and its role in modulating endoplasmic reticulum stress: A review.

Phytother Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

The endoplasmic reticulum (ER) is the place where proteins and lipids are biosynthesized and where transmembrane proteins are folded. Both pathological and physiological situations may disturb the function of the ER, resulting in ER stress. Under stress conditions, the cells initiate a defensive procedure known as the unfolded protein response (UPR). Read More

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September 2021

Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes.

Biochem Biophys Rep 2021 Dec 6;28:101127. Epub 2021 Sep 6.

Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.

Methylglyoxal (MG) is a metabolite derived from glycolysis whose levels in the blood and tissues of patients with diabetes are higher than those of healthy individuals, suggesting that MG is associated with the development of diabetic complications. However, it remains unknown whether high levels of MG are a cause or consequence of diabetes. Here, we show that MG negatively affects the expression of uncoupling protein 1 (UCP1), which is involved in thermogenesis and the regulation of systemic metabolism. Read More

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December 2021

Protects against Diabetes-Associated Endothelial Dysfunction: Comparison between Ethanolic Extract and Total Saponin.

Oxid Med Cell Longev 2021 4;2021:4722797. Epub 2021 Sep 4.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.

Previous studies revealed a cardioprotective potential of to relieve acute myocardial infarction and focal cerebral ischemia-reperfusion. However, whether protects endothelial function in diabetes and the underlying mechanisms remain to be explored. contains several chemical components including saponins, which are commonly believed as the major bioactive ingredients. Read More

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September 2021

Obese patients with higher TSH levels had an obvious metabolic improvement after bariatric surgery.

Endocr Connect 2021 Sep 1. Epub 2021 Sep 1.

G Wang, Beijing, 100020, China.

Objective: Bariatric surgery has become the most effective treatment for morbid obesity. Increasing evidence showed that bariatric surgery can alleviate insulin resistance and influence thyroid function. This study aimed to investigate the relationship between changes in thyroid function and adipose tissue insulin resistance (adipo-IR) after bariatric surgery. Read More

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September 2021

Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.

J Cachexia Sarcopenia Muscle 2021 Sep 15. Epub 2021 Sep 15.

College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Goyang-si, Gyeonggi-Do, South Korea.

Background: Skeletal muscle as a metabolic consumer determines systemic energy homeostasis by regulating myofibre type conversion and muscle mass control. Perturbation of the skeletal muscle metabolism elevates the risk of a variety of diseases including metabolic disorders. However, the regulatory pathways and molecules are not completely understood. Read More

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September 2021

Sex Difference in the Associations among Obesity-Related Indices with Metabolic Syndrome in Patients with Type 2 Diabetes Mellitus.

Int J Med Sci 2021 13;18(15):3470-3477. Epub 2021 Aug 13.

Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

The aim of this study was to investigate the associations among obesity-related indices and MetS in diabetic patients, and explore sex differences in these associations. Patients with type 2 DM were included from two hospitals in southern Taiwan. The Adult Treatment Panel III criteria for an Asian population were used to define MetS. Read More

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