826 results match your criteria obese dams

L-Leucine Improves Metabolic Disorders in Mice With Cigarette Smoke Exposure.

Front Physiol 2021 1;12:700246. Epub 2021 Jul 1.

Faculty of Science, School of Life Sciences, University of Technology Sydney, NSW, Australia.

Maternal cigarette smoke exposure (SE) causes intrauterine undernutrition, resulting in increased risk for metabolic disorders and type 2 diabetes in the offspring without sex differences. L-leucine supplementation has been shown to reduce body weight and improve glucose metabolism in both obese animals and humans. In this study, we aimed to determine whether postnatal L-leucine supplementation in female offspring can ameliorate the detrimental impact of maternal SE. Read More

View Article and Full-Text PDF

Maternal Microbiota Transfer Programs Offspring Eating Behavior.

Front Microbiol 2021 15;12:672224. Epub 2021 Jun 15.

UN, INRAE, UMR 1280, PhAN, IMAD, Nantes, France.

Understanding the link between mother's obesity and regulation of the child's appetite is a prerequisite for the design of successful preventive strategies. Beyond the possible contributions of genetic heritage, family culture, and hormonal and metabolic environment during pregnancy, we investigate in the present paper the causal role of the transmission of the maternal microbiotas in obesity as microbiotas differ between lean and obese mothers, maternal microbiotas are the main determinants of a baby's gut colonization, and the intestinal microbiota resulting from the early colonization could impact the feeding behavior of the offspring with short- and long-term consequences on body weight. We thus investigated the potential role of vertical transfers of maternal microbiotas in programming the eating behavior of the offspring. Read More

View Article and Full-Text PDF

A mouse model of prenatal exposure to Interleukin-6 to study the developmental origin of health and disease.

Sci Rep 2021 Jun 24;11(1):13260. Epub 2021 Jun 24.

Midwest Veterans' Biomedical Research Foundation (MVBRF), Kansas City, MO, USA.

Systemic inflammation in pregnant obese women is associated with 1.5- to 2-fold increase in serum Interleukin-6 (IL-6) and newborns with lower kidney/body weight ratio but the role of IL-6 in increased susceptibility to chronic kidney (CKD) in adult progeny is not known. Since IL-6 crosses the placental barrier, we administered recombinant IL-6 (10 pg/g) to pregnant mice starting at mid-gestation yielded newborns with lower body (p < 0. Read More

View Article and Full-Text PDF

Magnesium lithospermate B supplementation improved prenatal Bisphenol A exposure-induced metabolic abnormalities in male offspring.

Environ Toxicol 2021 Jun 24. Epub 2021 Jun 24.

Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan.

Obesity is closely linked with metabolic diseases, while life and prenatal exposure to endocrine-disrupting chemicals has been implicated in the development of obesity. Magnesium lithospermate B (MLB), an active compound of Salvia miltiorrhiza (Danshen), has beneficial effects on insulin resistance and metabolic abnormalities in diet-induced obese rodents. Since exposure to endocrine-disrupting chemical Bisphenol A (BPA) during pregnancy mimics the effects of high fat diet-induced alterations of glucose and lipid metabolism in adult male offspring, the effects of daily MLB supplementation for 4 weeks on metabolic abnormalities in rats weaning from prenatal BPA-exposed dams were investigated. Read More

View Article and Full-Text PDF

Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model.

Sci Rep 2021 Jun 21;11(1):12977. Epub 2021 Jun 21.

Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.

The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and developing metabolic disease later in life. Our group has utilized a macaque model to study the metabolic effects of consumption of a calorically-dense, Western-style diet (WSD; 36. Read More

View Article and Full-Text PDF

Effects of maternal taurine supplementation on maternal dietary intake, plasma metabolites and fetal growth and development in cafeteria diet fed rats.

PeerJ 2021 3;9:e11547. Epub 2021 Jun 3.

Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara, Türkiye.

Background: Maternal obesity may disrupt the developmental process of the fetus during gestation in rats. Recent evidence suggests that taurine can exert protective role against detrimental influence of obesogenic diets. This study aimed to examine the effect of maternal cafeteria diet and/or taurine supplementation on maternal dietary intake, plasma metabolites, fetal growth and development. Read More

View Article and Full-Text PDF

Offspring of Obese Dams Exhibit Sex-Differences in Pancreatic Heparan Sulfate Glycosaminoglycans and Islet Insulin Secretion.

Front Endocrinol (Lausanne) 2021 24;12:658439. Epub 2021 May 24.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States.

Offspring of obese mothers suffer higher risks of type 2 diabetes due to increased adiposity and decreased β cell function. To date, the sex-differences in offspring islet insulin secretion during early life has not been evaluated extensively, particularly prior to weaning at postnatal day 21 (P21). To determine the role of maternal obesity on offspring islet insulin secretion, C57BL/6J female dams were fed chow or western diet from 4 weeks prior to mating to induce maternal obesity. Read More

View Article and Full-Text PDF

Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers.

Cells 2021 May 19;10(5). Epub 2021 May 19.

Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, D-50937 Cologne, Germany.

Maternal obesity is associated with an increased risk of hepatic metabolic dysfunction for both mother and offspring and targeted interventions to address this growing metabolic disease burden are urgently needed. This study investigates whether maternal exercise (ME) could reverse the detrimental effects of hepatic metabolic dysfunction in obese dams and their offspring while focusing on the AMP-activated protein kinase (AMPK), representing a key regulator of hepatic metabolism. In a mouse model of maternal western-style-diet (WSD)-induced obesity, we established an exercise intervention of voluntary wheel-running before and during pregnancy and analyzed its effects on hepatic energy metabolism during developmental organ programming. Read More

View Article and Full-Text PDF

Milk Polar Lipids Supplementation to Obese Rats During Pregnancy and Lactation Benefited Skeletal Outcomes of Male Offspring.

Mol Nutr Food Res 2021 May 19:e2001208. Epub 2021 May 19.

Key Laboratory of Precision, Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.

Scope: Dietary intervention to obese dams during pregnancy and lactation period provides avenues for improving metabolic profiles of the offspring. In the current study, the effects of polar lipids-enriched milk fat globule membrane (MFGM-PL) supplementation to obese dams during pregnancy and lactation on the skeletal outcomes of male offspring are investigated.

Methods And Results: MFGM-PL is supplemented to obese rats induced by high-fat diet during pregnancy and lactation at a dose of 400 mg kg body weight. Read More

View Article and Full-Text PDF

Pregnancy and lactation after Roux-en-Y gastric bypass worsen nonalcoholic fatty liver disease in obese rats and lead to differential programming of hepatic lipogenesis in offspring.

J Dev Orig Health Dis 2021 May 17:1-11. Epub 2021 May 17.

Laboratório de Fisiologia Endócrina e Metabolismo (LAFEM), Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Oeste do Paraná (UNIOESTE), Cascavel, PR, Brazil.

Maternal obesity increases the risk of nonalcoholic fatty liver disease (NAFLD) in offspring. The Roux-en-Y gastric bypass (RYBG) is effective for achieving weight loss and ameliorates NAFLD. To determine whether these benefits are maintained after pregnancy and/or lactation, and whether they modulate hepatic morphofunction in the next generation, we evaluated hepatic lipid metabolism in Western diet (WD)-obese female rats that underwent RYGB and in their F1 offspring at adulthood. Read More

View Article and Full-Text PDF

Açaí (Euterpe oleracea Martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes' gene expression in offspring.

Biomed Pharmacother 2021 Jul 6;139:111627. Epub 2021 May 6.

Nucleus of Research in Biological Sciences (NUPEB), Universidade Federal de Ouro Preto, Minas Gerais, Brazil; School of Nutrition, Universidade Federal de Ouro Preto, Minas Gerais, Brazil. Electronic address:

Lipids excess from an uterine environment can increase free radicals production of and thus induce oxidative status imbalance, a key factor for progression of non-alcoholic fatty liver disease (NAFLD) in offspring. Food antioxidant components in maternal diet may play an important role in preventing offspring metabolic disorders. The objective of the study was to evaluate the effects of açaí pulp supplementation on maternal high-fat diet, by assessing activity and expression of antioxidant enzymes and biomarkers of oxidative stress in the liver. Read More

View Article and Full-Text PDF

Obesity modifies the implantation window and disrupts intrauterine embryo positioning in rats.

Reproduction 2021 May 31;162(1):61-72. Epub 2021 May 31.

Universidad de Buenos Aires (UBA), Facultad de Ciencias Exactas y Naturales (FCEN), Buenos Aires, Argentina.

Obesity is a chronic disease that impairs female reproduction. When gestation is achieved, maternal obesity can cause offspring's health complications. We intended to evaluate the effects of maternal pre-conceptional obesity on uterine contractile activity, embryo implantation and offspring development. Read More

View Article and Full-Text PDF

Adult rats from undernourished dams show sex-dependent impaired expression in taste papillae and hypothalamus of genes responsible for sweet and fat detection and signalling.

Nutr Neurosci 2021 Apr 30:1-12. Epub 2021 Apr 30.

UMR Physiologie des Adaptations Nutritionnelles, INRAE - Université de Nantes, 44096 Nantes France.

Aim: Individuals undernourished in utero or during early life are at high risk of developing obesity and metabolic disorders and show an increased preference for consuming sugary and fatty food. This study aimed at determining whether impaired taste detection and signalling in the lingual epithelium and the brain might contribute to this altered pattern of food intake.

Methods: The preference for feeding fat and sweet food and the expression in circumvallate papillae and hypothalamus of genes coding for sweet and fat receptors and transducing pathways were evaluated in adult rats born to control or calorie-restricted dams. Read More

View Article and Full-Text PDF

Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet.

Nutrients 2021 Apr 9;13(4). Epub 2021 Apr 9.

Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, Japan.

Quercetin has been shown to have anti-obesity effects, but it is unknown whether these effects can be transmitted from mothers to their progeny. In this study, we investigated whether maternal quercetin consumption during pregnancy has a protective effect on high-fat diet-induced hyper lipid levels and overweight in progeny. Female mice consumed a control diet or a diet containing 1. Read More

View Article and Full-Text PDF

MicroRNA Let-7 targets AMPK and impairs hepatic lipid metabolism in offspring of maternal obese pregnancies.

Sci Rep 2021 Apr 26;11(1):8980. Epub 2021 Apr 26.

Laboratory of Metabolic Disorders (Labdime) - Faculty of Applied Sciences (FCA), University of Campinas (UNICAMP), 1300, Pedro Zaccaria St, Limeira, SP, 13484-350, Brazil.

Nutritional status during gestation may lead to a phenomenon known as metabolic programming, which can be triggered by epigenetic mechanisms. The Let-7 family of microRNAs were one of the first to be discovered, and are closely related to metabolic processes. Bioinformatic analysis revealed that Prkaa2, the gene that encodes AMPK α2, is a predicted target of Let-7. Read More

View Article and Full-Text PDF

Cesarean section delivery is a risk factor of autism-related behaviors in mice.

Sci Rep 2021 Apr 26;11(1):8883. Epub 2021 Apr 26.

Department of Pharmacology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.

Cesarean section (C/S) is one way of delivering babies, and is chosen when mothers or babies are facing problems or life-threatening conditions during pregnancy. Many meta-analyses have suggested an etiological relationship between C/S delivery and autism spectrum disorders (ASDs). However, as a risk factor for ASDs, C/S delivery has not yet been well studied. Read More

View Article and Full-Text PDF

Leptin Supplementation During Lactation Restores Key Liver Metabolite Levels Malprogrammed by Gestational Calorie Restriction.

Mol Nutr Food Res 2021 Apr 26:e2001046. Epub 2021 Apr 26.

Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics and obesity), University of the Balearic Islands (UIB), Palma de Mallorca, 07122, Spain.

Scope: Perinatal nutritional factors can program offspring metabolic phenotype and risk to obesity. We investigated the potential role of leptin supplementation (during lactation) in ameliorating the malprogrammed effects caused by mild maternal calorie restriction during gestation, on young rat offspring liver metabolic response.

Methods And Results: Untargeted and targeted metabolomics studies on liver samples were performed by NMR and GC-MS, respectively. Read More

View Article and Full-Text PDF

Caloric restriction or cafeteria diet from birth to adulthood increases the sensitivity to ephedrine in anxiety and locomotion in Wistar rats.

Physiol Behav 2021 07 15;236:113430. Epub 2021 Apr 15.

Laboratório de Nutrição Experimental, Departamento de Nutrição, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rodovia MGT 367 (Km 583), Campus JK, n 5000, Alto da Jacuba, Diamantina, Brasil; Programa de Pós-graduação em Ciências da Nutrição, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rodovia MGT 367 (Km 583), Campus JK, n 5000, Alto da Jacuba, Diamantina, Brasil. Electronic address:

Introduction: Obesity and undernutrition, consequences of malnutrition, have been linked to the development of mental illnesses. Both states have been linked to increased sensitivity to some drugs, but there are few data for this association considering drugs with noradrenergic-dopaminergic action.

Objective: To evaluate the nutritional status of animals treated with either a caloric restriction (CR) or cafeteria (CAF) diet from birth and their behavior after ephedrine application. Read More

View Article and Full-Text PDF

Long-term functional alterations following prenatal GLP-1R activation.

Neurotoxicol Teratol 2021 Apr 20;87:106984. Epub 2021 Apr 20.

Department of Biomedical Sciences and Center for Brain Repair, Florida State University College of Medicine, Tallahassee, FL 32306, United States of America. Electronic address:

Evidence supporting the use of glucagon-like peptide-1 (GLP-1) analogues to pharmacologically treat disorders beyond type 2 diabetes and obesity is increasing. However, little is known about how activation of the GLP-1 receptor (GLP-1R) during pregnancy affects maternal and offspring outcomes. We treated female C57Bl/6 J mice prior to conception and throughout gestation with a long-lasting GLP-1R agonist, Exendin-4. Read More

View Article and Full-Text PDF

Impact of maternal obesity and prebiotic supplementation on select maternal milk microRNA levels and correlation with offspring outcomes.

Br J Nutr 2021 Apr 5:1-9. Epub 2021 Apr 5.

Faculty of Kinesiology, University of Calgary, 2500 University Drive NW, Calgary, AB, CanadaT2N 1N4.

Breast milk composition varies with maternal factors including diet and confers health benefits to the neonate; however, the mechanisms mediating this protection remain incompletely understood. Our aim was to investigate the effects of supplementing a maternal high-fat/sucrose (HFS) diet with prebiotic oligofructose (OFS) on milk composition in rats and associations with offspring body composition and gut microbiota. Obese Sprague-Dawley dams consumed a control, HFS, HFS + OFS (10 % wt/wt) or HFS diet weight-matched to the HFS + OFS group (HFS-WM) during pregnancy and lactation. Read More

View Article and Full-Text PDF

Increasing breast milk betaine modulates abundance in mammalian neonates and improves long-term metabolic health.

Sci Transl Med 2021 03;13(587)

Endocrinology Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain.

Accelerated postnatal growth is a potentially modifiable risk factor for future obesity. To study how specific breast milk components contribute to early growth and obesity risk, we quantified one-carbon metabolism-related metabolites in human breast milk and found an inverse association between milk betaine content and infant growth. This association was replicated in an independent and geographically distinct cohort. Read More

View Article and Full-Text PDF

Supplementation of milk polar lipids to obese dams improves neurodevelopment and cognitive function in male offspring.

FASEB J 2021 04;35(4):e21454

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, China Agricultural University, Beijing, China.

Milk contains about 4% fat globules with its surface covered by polar lipids. Despite the abundant consumption of dairy products, the biological effects of dietary milk polar lipids on metabolic health have only been sparsely examined. Maternal obesity results in neurodevelopmental disorders and cognitive impairment in offspring. Read More

View Article and Full-Text PDF

Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet.

PLoS One 2021 18;16(3):e0248854. Epub 2021 Mar 18.

Renal Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia.

Background: Maternal high fat diet (HFD) promotes chronic kidney disease (CKD) in offspring. This is in accordance with the theory of fetal programming, which suggests adverse conditions occurring in utero predispose offspring to chronic conditions later in life. DNA methylation has been proposed as a key mechanism by which fetal programming occurs and is implicated in CKD progression. Read More

View Article and Full-Text PDF

High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis.

Cell Metab 2021 May 1;33(5):923-938.e6. Epub 2021 Mar 1.

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address:

Maternal obesity has been reported to be related to neurodevelopmental disorders in the offspring. However, the underlying mechanisms and effective interventions remain unclear. This cross-sectional study with 778 children aged 7-14 years in China indicated that maternal obesity is strongly associated with children's lower cognition and sociality. Read More

View Article and Full-Text PDF

Late effects of early weaning on food preference and the dopaminergic and endocannabinoid systems in male and female rats.

J Dev Orig Health Dis 2021 Mar 2:1-11. Epub 2021 Mar 2.

Laboratory of Endocrine Physiology, Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Early weaning (EW) is associated with obesity later in life. Here, using an EW model in rats, we investigated changes in feeding behavior and the dopaminergic and endocannabinoid systems (ECS) in the adult offspring. Lactating Wistar rats were divided into two groups: EW, dams were wrapped with a bandage to interrupt suckling during the last 3 days of breastfeeding; CONT; dams fed the pups throughout the period without hindrances. Read More

View Article and Full-Text PDF

Dysregulated appetitive leptin signaling in male rodent offspring from post-bariatric dams.

Curr Res Physiol 2020 Dec 8;3:50-58. Epub 2020 Dec 8.

Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Bariatric surgery produces significant positive benefits to recipients such as significant body fat loss and resolution of the various obesity-related comorbidities, such as reduced reproductive function. Females of childbearing age seek bariatric surgical remedies to improve their chance of successful pregnancy; however, limited knowledge exists on the impact of surgical weight loss to subsequently born offspring. We previously reported that circulating leptin levels were reduced in pregnant females having previously received vertical sleeve gastrectomy (VSG) in comparison to control dams having received Sham surgery. Read More

View Article and Full-Text PDF
December 2020

Maternal obesity interrupts the coordination of the unfolded protein response and heat shock response in the postnatal developing hypothalamus of male offspring in mice.

Mol Cell Endocrinol 2021 05 24;527:111218. Epub 2021 Feb 24.

Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address:

Maternal obesity malprograms offspring obesity and associated metabolic disorder. As a common phenomenon in obesity, endoplasmic reticulum (ER) stress also presents early prior to the development. Here, we investigate metabolic effect of early activated hypothalamic ER stress in offspring exposed to maternal obesogenic environment and the underlying mechanism in ICR mice model. Read More

View Article and Full-Text PDF

An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses.

mBio 2021 02 2;12(1). Epub 2021 Feb 2.

Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland

Antibiotic exposure early in life and other practices impacting the vertical transmission and ordered assembly of a diverse and balanced gut microbiota are associated with a higher risk of immunological and metabolic disorders such as asthma and allergy, autoimmunity, obesity, and susceptibility to opportunistic infections. In this study, we used a model of perinatal exposure to the broad-spectrum antibiotic ampicillin to examine how the acquisition of a dysbiotic microbiota affects neonatal immune system development. We found that the resultant dysbiosis imprints in a manner that is irreversible after weaning, leading to specific and selective alteration of the colonic CD4 T-cell compartment. Read More

View Article and Full-Text PDF
February 2021

Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark.

Diabetologia 2021 Apr 27;64(4):890-902. Epub 2021 Jan 27.

University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Aims/hypothesis: Levels of the microRNA (miRNA) miR-126-3p are programmed cell-autonomously in visceral adipose tissue of adult offspring born to obese female C57BL/6J mice. The spectrum of miR-126-3p targets and thus the consequences of its dysregulation for adipocyte metabolism are unknown. Therefore, the aim of the current study was to identify novel targets of miR-126-3p in vitro and then establish the outcomes of their dysregulation on adipocyte metabolism in vivo using a well-established maternal obesity mouse model. Read More

View Article and Full-Text PDF

Effects of high fat diet-induced obesity and pregnancy on prepartum and postpartum maternal mouse behavior.

Psychoneuroendocrinology 2021 Apr 19;126:105147. Epub 2021 Jan 19.

Department of Physiology & Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Obesity before and during pregnancy negatively affects the mental and physical health of the mother. A diet high in fat also increases the risk for anxiety, depression and cognitive dysfunction. We examined the effects of high fat diet (HFD) -induced obesity and pregnancy on maternal behavior, cognitive function and anxiety- and depression-like behaviors in mice. Read More

View Article and Full-Text PDF