392,713 results match your criteria obese controls


Maternal Factors Predicting Loss to Follow-Up from Newborn Hearing Screenings in New Jersey.

Health Soc Work 2021 Jun;46(2):115-124

MSW student, Montclair State University, Montclair, NJ.

Because hearing loss in children can result in developmental deficits, early detection and intervention are critical. This article identifies a constellation of maternal factors that predict loss to follow-up (LTF) at the point of rescreening-the first follow-up for babies who did not pass the hearing screening performed at birth-through New Jersey's early hearing detection and intervention program. Maternal factors are critical to consider, as mothers are often the primary decision makers around children's health care. Read More

View Article and Full-Text PDF

Endotrophin: Nominated for best supporting actor in the fibro-inflammatory saga.

EBioMedicine 2021 Jun 18;69:103447. Epub 2021 Jun 18.

Touchstone Diabetes Center, Department of Internal Medicine, the University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

View Article and Full-Text PDF

Maximum intravenous alteplase dose for obese stroke patients is not associated with greater likelihood of worse outcomes.

Thromb Res 2021 Jun 7;204:76-80. Epub 2021 Jun 7.

Miami Neuroscience Institute, Baptist Health South Florida, 8900 North Kendall Drive, 2 Clarke Pavilion, Miami, FL 33176, USA. Electronic address:

Background: IV alteplase is a primary treatment for acute ischemic stroke (AIS) at a weight-based dose (WBD) of 0.9 mg/kg and maximum dose (MD) of 90 mg. There are conflicting data regarding outcomes for those weighing ≥100 kg. Read More

View Article and Full-Text PDF

HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue.

Mol Metab 2021 Jun 18:101276. Epub 2021 Jun 18.

Institute of Nutritional Science, Department of Molecular and Experimental Nutritional Medicine, University of Potsdam, 14558, Nuthetal, Germany; German Institute of Human Nutrition, Junior Research Group Central Regulation of Metabolism; D-14558, Nuthetal, Germany; German Center for Diabetes Research (DZD), D-85764, München-Neuherberg, Germany. Electronic address:

Objective: Insulin regulates mitochondrial function, thereby propagating efficient metabolism. Conversely, diabetes and insulin resistance are linked to mitochondrial dysfunction with decreased expression of the mitochondrial chaperone HSP60. The aim of this investigation was to determine the effect of a reduced HSP60 expression on the development of obesity and insulin resistance. Read More

View Article and Full-Text PDF

Exploring overweight and obesity beyond body mass index: A body composition analysis in people with and without patellofemoral pain: Body composition in patellofemoral pain.

J Sport Health Sci 2021 Jun 18. Epub 2021 Jun 18.

La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC 3086, Australia.

Purpose: To compare body mass index (BMI), body fat, and skeletal muscle mass between (i) a mixed-sex non-athletic cohort of people with patellofemoral pain (PFP) and pain-free people, and (ii) a non-athletic cohort of people with PFP and pain-free people subgrouped by sex (i.e., men and women with PFP vs. Read More

View Article and Full-Text PDF

Beneficial effects of dietary supplementation with olive oil, oleic acid, or hydroxytyrosol in metabolic syndrome: systematic review and meta-analysis.

Free Radic Biol Med 2021 Jun 18. Epub 2021 Jun 18.

Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS & IDISBA, E-07122 Palma de Mallorca, Spain; CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain. Electronic address:

Background And Aims: Olive oil and components might have a beneficial effect on Metabolic Syndrome (MetS). The aim of this review and meta-analysis was to assess whether those effects are related to hydroxytyrosol or oleic acid contents, or the combination of them as olive oil, and how powerful is this effect.

Methods: A systematic literature search was performed in MEDLINE via Pubmed, Web of Science (WOS) core collection, and Virtual Health Library (VHL) via LILACS and IBECS (Spain). Read More

View Article and Full-Text PDF

How to promote healthy eating in preschool children: Evidence from an associative conditioning procedure with non-food stimuli.

Appetite 2021 Jun 18:105472. Epub 2021 Jun 18.

Department of Psychology, University of Trier, Universitätsring 15, 54296, Trier, Germany.

Given the increasing rates and severe consequences of childhood obesity, how to encourage children to eat low-calorie and healthy foods is an important question. Building on evaluative conditioning research, this study investigated how associating fruits and vegetables with positive, non-food stimuli influences preschool children's food choice and consumption. Consistent with this idea, it was found in two experiments that 3- to 6-year-old children's healthy food choice and consumption increased by pairing a healthy food's picture systematically with a positive, non-food image. Read More

View Article and Full-Text PDF

Examining patterns of postnatal feeding in relation to Infant's weight during the first year.

Appetite 2021 Jun 18:105473. Epub 2021 Jun 18.

Background: There is mixed evidence regarding specific infant feeding behaviors and later risk for overweight and obesity. We sought to detect underlying patterns in duration of breastfeeding, introduction of solid foods and sweetened beverages, in order to understand the relation to later weight.

Methods: Patterns of postnatal feeding were examined among infants enrolled in the Infant Feeding Practices Study II (N = 3033). Read More

View Article and Full-Text PDF

Bilirubin: the yellow hormone?

J Hepatol 2021 Jun 18. Epub 2021 Jun 18.

Fondazione Italiana Fegato, Trieste, Italy. Electronic address:

Bilirubin is a tetrapyrrolic compound originating from heme catabolism. Although originally considered only a waste product, potentially dangerous for human health, it becomes now increasingly evident that this molecule represents an important modulator of various biological functions in the human body. Bilirubin appears to have versatile functions, from cell signaling (behaving almost as a ¨real¨ hormonal substance), modulation of metabolism, to immune system affecting biological activities with apparent clinical and even therapeutic consequences. Read More

View Article and Full-Text PDF

Unravelling the impacts of western-style diets on brain, gut microbiota and cognition.

Neurosci Biobehav Rev 2021 Jun 18. Epub 2021 Jun 18.

School of Medical Sciences, UNSW Sydney, NSW, 2052, Australia. Electronic address:

The steady rise in the prevalence of obesity has been fostered by modern environments that reduce energy expenditure and encourage consumption of 'western'-style diets high in fat and sugar. Obesity has been consistently associated with impairments in executive function and episodic memory, while emerging evidence indicates that high-fat, high-sugar diets can impair aspects of cognition within days, even when provided intermittently. Here we review the detrimental effects of diet and obesity on cognition and the role of inflammatory and circulating factors, compromised blood-brain barrier integrity and gut microbiome changes. Read More

View Article and Full-Text PDF

Circulating α-klotho regulates metabolism via distinct central and peripheral mechanisms.

Metabolism 2021 Jun 18:154819. Epub 2021 Jun 18.

East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North, Carolina, USA; Department of Kinesiology, East Carolina University, Greenville, North, Carolina, USA; Human Performance Laboratory, College of Human Performance and Health, East Carolina University, Greenville, North, Carolina, USA; Department of Physiology, East Carolina University, Greenville, North, Carolina, USA. Electronic address:

Emerging evidence implicates the circulating α-klotho protein as a prominent regulator of energy balance and substrate metabolism, with diverse, tissue-specific functions. Despite its well-documented ubiquitous role inhibiting insulin signaling, α-klotho elicits potent antidiabetic and anti-obesogenic effects. α-Klotho facilitates insulin release and promotes β cell health in the pancreas, stimulates lipid oxidation in liver and adipose tissue, attenuates hepatic gluconeogenesis, and increases whole-body energy expenditure. Read More

View Article and Full-Text PDF

Short- and Long-Term Adaptation to Altered Levels of Glucose: Fifty Years of Scientific Adventure.

Authors:
Kosaku Uyeda

Annu Rev Biochem 2021 Jun;90:31-55

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; email:

My graduate and postdoctoral training in metabolism and enzymology eventually led me to study the short- and long-term regulation of glucose and lipid metabolism. In the early phase of my career, my trainees and I identified, purified, and characterized a variety of phosphofructokinase enzymes from mammalian tissues. These studies led us to discover fructose 2,6-P, the most potent activator of phosphofructokinase and glycolysis. Read More

View Article and Full-Text PDF

A Community Jury on initiating weight management conversations in primary care.

Health Expect 2021 Jun 21. Epub 2021 Jun 21.

Centre for Research in Evidence-Based Practice, Bond University, Gold Coast, Qld, Australia.

Background: Current guidelines recommend that patients attending general practice should be screened for excess weight, and provided with weight management advice.

Objective: This study sought to elicit the views of people with overweight and obesity about the role of GPs in initiating conversations about weight management.

Methods: Participants with a body mass index ≥25 were recruited from a region in Australia to take part in a Community Jury. Read More

View Article and Full-Text PDF

Fitness vs. fatness as determinants of survival in non-institutionalized older adults: The EXERNET multi-center study.

J Gerontol A Biol Sci Med Sci 2021 Jun 21. Epub 2021 Jun 21.

GENUD (Growth, Exercise, NUtrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain.

Background: Physical fitness and body composition are important health indicators, nevertheless their combined pattern inter-relationships and their association with mortality are poorly investigated.

Methods: This longitudinal study is part of the Spanish EXERNET-Elder project. Person-months follow-up were calculated from the interview date, performed between June 2008 and November 2009, until date of death or censoring on March 2018 (whichever came first). Read More

View Article and Full-Text PDF

Association between Body Weight and Telomere Length is Predominantly Mediated through C-Reactive Protein.

J Clin Endocrinol Metab 2021 Jun 21. Epub 2021 Jun 21.

Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, USA.

Background: To dissect the direct effect of body mass index (BMI) and its indirect effect through C-reactive protein (CRP) on leukocyte telomere length (LTL) to determine the mediation effect of CRP on the BMI-LTL association.

Methods: The study cohort included 5,451 adults (1,404 Mexican Americans, 3,114 Whites and 933 Blacks; 53.5% males; mean age=49. Read More

View Article and Full-Text PDF

Magnitude, components and predictors of metabolic syndrome in Northern Ethiopia: Evidences from regional NCDs STEPS survey, 2016.

PLoS One 2021 21;16(6):e0253317. Epub 2021 Jun 21.

Tigray Health Research Institute, Mekelle, Tigray, Ethiopia.

Background: Individuals with metabolic syndrome are five times more susceptible to chronic diseases. Assessment of its magnitude, components, and risk factors is essentials to deploy visible interventions needed to avoid further complications. The study aimed to assess magnitude, components, and predictors of metabolic syndrome in Tigray region northern Ethiopia, 2016. Read More

View Article and Full-Text PDF

Cerebrovascular Disease Correlates With Longitudinal Brain Atrophy in Virally Suppressed Older People Living With HIV.

J Acquir Immune Defic Syndr 2021 Aug;87(4):1079-1085

Department of Neurology, Memory and Aging Center, University of California San Francisco, CA.

Background: Mild cognitive difficulties and progressive brain atrophy are observed in older people living with HIV (PLWH) despite persistent viral suppression. Whether cerebrovascular disease (CVD) risk factors and white matter hyperintensity (WMH) volume correspond to the observed progressive brain atrophy is not well understood.

Methods: Longitudinal structural brain atrophy rates and WMH volume were examined among 57 HIV-infected participants and 40 demographically similar HIV-uninfected controls over an average (SD) of 3. Read More

View Article and Full-Text PDF

Differential Perioperative Outcomes in Patients With Obstructive Sleep Apnea, Obesity, or a Combination of Both Undergoing Open Colectomy: A Population-Based Observational Study.

Anesth Analg 2021 Jun 21. Epub 2021 Jun 21.

Departments of Orthopaedic Surgery, Population Health Science & Policy, and Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: An increasing body of evidence demonstrates an association between obstructive sleep apnea (OSA) and adverse perioperative outcomes. However, large-scale data on open colectomies are lacking. Moreover, the interaction of obesity with OSA is unknown. Read More

View Article and Full-Text PDF

Childhood maltreatment predicts physical health in college students.

J Am Coll Health 2021 Jun 21:1-10. Epub 2021 Jun 21.

School of Psychological Sciences, University of Northern Colorado, Greeley, Colorado, USA.

Objective: Childhood maltreatment (CM) is associated with physical health problems throughout the lifespan, yet more research is needed regarding the trajectory of health problems (e.g., onset of health risk indicators) in young adults. Read More

View Article and Full-Text PDF

Metabolic Syndrome and Related Inflammation, Prevalence, and Predictive Value of C-Reactive Protein in South Asian Youths.

Metab Syndr Relat Disord 2021 Jun 21. Epub 2021 Jun 21.

Centennial Medical Center, Nashville, Tennessee, USA.

Metabolic syndrome (MetS) is widely prevalent in the South Asian (SA) population. The syndrome leads to a high risk of premature atherosclerosis and diabetes. Obesity, specifically abdominal obesity, is a central pathological mechanism of disease in this population. Read More

View Article and Full-Text PDF

Association of SNPs in Lipid Metabolism Gene Single Nucleotide Polymorphism with the Risk of Obesity in Children.

Genet Test Mol Biomarkers 2021 Jun;25(6):419-425

Animal and Human Genetics Laboratory, Department of Genetics, Southern Federal University, Rostov-on-Don, Russia.

Obesity is one of the most common metabolic disorders in the world, which develops due to an imbalance in energy consumption and expenditure, and both genetic and environmental factors are of great importance. We investigated the potential interactions of single nucleotide polymorphisms that might contribute to the development of polygenic obesity in children. The study involved 367 children and adolescents of both sexes aged from 4 to 18 years. Read More

View Article and Full-Text PDF

Is Food Addictive? A Review of the Science.

Annu Rev Nutr 2021 Jun 21. Epub 2021 Jun 21.

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email:

As ultraprocessed foods (i.e., foods composed of mostly cheap industrial sources of dietary energy and nutrients plus additives) have become more abundant in our food supply, rates of obesity and diet-related disease have increased simultaneously. Read More

View Article and Full-Text PDF

Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging.

Anal Chem 2021 Jun 21. Epub 2021 Jun 21.

State Key Laboratory of Natural Medicines and School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

Few matrices have the potential to be universally applicable for imaging vast endogenous compounds ranging from micro to macromolecules. In this article, we present hydralazine (HZN) as a versatile and universal matrix for matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) of a wide range of endogenous compounds between 50.0 and 20,000. Read More

View Article and Full-Text PDF

Prevalence and factors associated with hypertension among school children and adolescents in urban and semi-urban areas in Cameroon.

J Clin Hypertens (Greenwich) 2021 Jun 21. Epub 2021 Jun 21.

Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.

Few data to date exist on pediatric hypertension (PH) prevalence and risk factors in semi-urban areas in Cameroon, and they are believed to be the same as urban areas. These data are needed to design targeted preventive strategies and contribute to reducing the burden of PH in Cameroon and countries with equivalent standards of care. The authors conducted a cross-sectional study, from November, 2017 to June, 2018, in primary and secondary schools, from semi-urban (Bamboutos, West Region) and urban (Mfoundi, Center Region) settings in Cameroon, including children and adolescent aged between 3 and 19 years, recruited on a stratified probability sampling. Read More

View Article and Full-Text PDF

Effect of a High-calorie Diet and Constant Light Exposure on Female Reproduction, Metabolism and Immune Inflammation: A Comparative Study of Different Mouse Models.

Am J Reprod Immunol 2021 Jun 21:e13479. Epub 2021 Jun 21.

Department of Gynecology, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, 200011, China.

Problem: Excess caloric intake and irregular circadian rhythm could severely impair female reproductive, metabolic and immune function. However, the similarities and differences between their individual and combined effects and mechanisms have not been fully elucidated. Due to limitations and confounding factors in clinical research, we used these two kinds of unhealthy factors to intervene the mice singly or in combination to explore their effects on individuals. Read More

View Article and Full-Text PDF

Food Insecurity and Cardiometabolic Conditions: a Review of Recent Research.

Curr Nutr Rep 2021 Jun 21. Epub 2021 Jun 21.

Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Purpose Of Review: To understand recent literature that examines associations between food insecurity and cardiometabolic conditions and risk factors. We included original research, systematic reviews, and meta-analyses on the topic of food insecurity and cardiometabolic risk published from January 1, 2017, to December 31, 2020. Editorials, perspectives, and case reports were excluded. Read More

View Article and Full-Text PDF

BMI and dissatisfaction with life: contextual factors and socioemotional costs of obesity.

Qual Life Res 2021 Jun 21. Epub 2021 Jun 21.

Institute of Philosophy and Sociology, Polish Academy of Sciences, Nowy Świat 72, 00-330, Warsaw, Poland.

Purpose: In this study, we investigate whether individuals' BMI categories are associated with being dissatisfied with one's life, how this association is affected by the social comparison that individuals make, and what the role of the overall BMI levels in this process is.

Methods: We use data for 21,577 men and 27,415 women, collected in 2016 by the European Bank for Reconstruction and Development, from 34 countries in Europe, the Middle East, and Central Asia. To understand the moderating effect of contextual environment, we use multilevel mixed effect logistic regression models and data for national, regional, and cohort-specific BMI levels. Read More

View Article and Full-Text PDF

The Changes in Body Composition in Obese Patients with Polycystic Ovary Syndrome after Laparoscopic Sleeve Gastrectomy:a 12-Month Follow-up.

Obes Surg 2021 Jun 19. Epub 2021 Jun 19.

Department of Endocrinology & Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.

Objectives: To investigate the changes in body fat distribution and predicting factors of these changes in polycystic ovary syndrome (PCOS) patients with obesity, after laparoscopic sleeve gastrectomy (LSG).

Methods: This study consecutively enrolled 153 patients with obesity aged 18-45 years (83 with PCOS and 70 control patients) who underwent LSG from May 2013 to September 2020 at the Department of Endocrinology, Shanghai Tenth People's Hospital, with a 12-month follow-up. Dual-energy X-ray absorptiometry (DEXA) was used to assess body fat distribution. Read More

View Article and Full-Text PDF

Sleeve Gastrectomy Attenuates the Severity of Cerulein-Induced Acute Pancreatitis in Obese Rats.

Obes Surg 2021 Jun 21. Epub 2021 Jun 21.

Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People's Republic of China.

Purpose: Obesity is one of the most important risk factors for acute pancreatitis. Based on the effect of sleeve gastrectomy (SG) on improving body weight and blood lipids, we investigated whether SG is beneficial in improving pancreatitis in obese rats.

Materials And Methods: Two studies were used to evaluate the effect of SG on the first onset of pancreatitis and acute episodes of recurrent pancreatitis in obese rats. Read More

View Article and Full-Text PDF

Effects of cereal fibers on short-chain fatty acids in healthy subjects and patients: a meta-analysis of randomized clinical trials.

Food Funct 2021 Jun 21. Epub 2021 Jun 21.

State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

Short-chain fatty acids (SCFAs) are involved in the regulation of a wide array of diseases. However, the effect of cereal dietary fibers on SCFA production remains unclear. We reviewed relevant clinical studies between 1950 and 2021 and aimed to evaluate the effect of cereal fiber consumption on SCFA production in healthy subjects and patients. Read More

View Article and Full-Text PDF