328,541 results match your criteria number years


Analysis of Cross-Reactivity and Allergic Symptoms of 19 Allergens: Results from NHANES 2005-2006.

Int Arch Allergy Immunol 2021 Sep 21:1-10. Epub 2021 Sep 21.

Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Introduction: We explored the cross-reactivity among 19 common allergen sources and evaluated the influence of serum IgE concentrations and the number of sensitized allergens on the incidence of allergic symptoms.

Methods: We conducted this cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2006 which is a program of studies designed to assess the health and nutritional status of adults and children in the USA. After excluding participants with missing data from the allergen IgE test, allergy questionnaire, and respiratory health questionnaire, a total of 7,224 participants aged 6 years and older were included, as children younger than 6 years old did not complete all 19 allergen-specific IgE tests. Read More

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September 2021

Relationship Between Lymphaticovenular Anastomosis Outcomes and The Number and Types of Anastomoses.

J Surg Res 2021 Sep 18;269:103-109. Epub 2021 Sep 18.

Department of Plastic and Reconstructive Surgery, Kagawa Rosai Hospital, Kagawa, Japan.

Background: Lymphaticovenular anastomosis (LVA) is the first-line treatment for lymphedema in many hospitals. However, many aspects of its effects remain unclear. This study aimed to analyze problems with regard to the relationship between lymphaticovenular anastomosis and outcomes of surgery for lymphedema in the upper and lower extremities. Read More

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September 2021

Which is the best alternative to estimate muscle mass for sarcopenia diagnosis when DXA is unavailable?

Arch Gerontol Geriatr 2021 Sep 3;97:104517. Epub 2021 Sep 3.

FCNAUP - Faculdade de Ciências da Nutrição e Alimentação, Universidade do Porto, 4150-180 Porto, Portugal; LAETA-INEGI - Faculdade de Engenharia, Universidade do Porto, Porto, Portugal.

Background: Dual x-ray absorptiometry (DXA) is widely adopted to estimate muscle mass for research, but for daily practice is only available in a limited number of facilities.

Aim: To elucidate if it is anthropometry or bioelectrical impedance analysis (BIA) the method more concordant with DXA in estimating muscle mass for sarcopenia diagnosis among older adults, and to investigate the impact of several cut-off points in sarcopenia frequency.

Methods: 159 older adults (≥65 years) were included in a cross-sectional analysis. Read More

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September 2021

A Cost Effectiveness Analysis of Intravitreal Aflibercept for the Prevention of Progressive Diabetic Retinopathy.

Ophthalmol Retina 2021 Sep 18. Epub 2021 Sep 18.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Purpose: To calculate costs required to prevent center-involved diabetic macular edema (CI-DME) or proliferative diabetic retinopathy (PDR), and to improve the diabetic retinopathy severity score (DRSS) with intravitreal anti-VEGF injections as reported for aflibercept in two randomized control trials.

Design: Cost-effectiveness analysis modeling based on published data SUBJECTS: None METHODS: Results from PANORAMA and the Diabetic Retinopathy Clinical Research Network (DRCR.net) Protocol W were analyzed. Read More

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September 2021

Next Generation Sequencing (NGS) to Determine Microbiome of Herniated Intervertebral Disc.

Spine J 2021 Sep 18. Epub 2021 Sep 18.

Programa Locomotor, Hospital Israelita Albert Einstein, Av. Albert Einstein 627, Sao Paulo, SP, Brazil, 05652-900.

Background Context: There is apparent causality between chronic infection of the intervertebral disc and its degenerative process. Although disc is considered a sterile tissue, collected samples of uninfected patients sent to culture testing resulted positive.

Purpose: The purpose of this study was to analyze the microbiome of the intervertebral disc by using and validating the Next Generation Sequencing (NGS) molecular test, controlled with tissue culture and clinical presentation of patients. Read More

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September 2021

Application of commercially available mesoporous silica for drug dissolution enhancement in oral drug delivery.

Eur J Pharm Sci 2021 Sep 18:106015. Epub 2021 Sep 18.

Faculty of Pharmacy, University of Ljubljana, 1000, Ljubljana, Slovenia. Electronic address:

Due to the high number of poorly water-soluble active pharmaceutical ingredients, oral drug delivery development has become challenging. One of the strategies to enhance drug solubility and to achieve high oral bioavailability is to formulate such compounds into amorphous solid dispersions. In recent years, porous materials have been investigated as possible carriers into which a drug can be adsorbed, such as mesoporous silica, in particular. Read More

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September 2021

Indirect effects of social activity on appetite via depressive symptoms in community-dwelling older adults: A cross-sectional study.

Appetite 2021 Sep 18:105705. Epub 2021 Sep 18.

Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe, Japan. Electronic address:

Depressive symptoms have a strong effect on appetite decline in older adults. There is also an association between social activity and decreased depressive symptoms, but the mechanism between appetite and social activity with respect to depressive symptoms is unclear. This cross-sectional study examined the direct and indirect effects of social activity on appetite, via depressive symptoms. Read More

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September 2021

Cost-effectiveness Analysis of the 2019 ASCCP Risk-Based Management Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors.

Am J Obstet Gynecol 2021 Sep 18. Epub 2021 Sep 18.

Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA.

Background: Guidelines for managing abnormal cervical cancer screening tests changed from a results-based approach in 2012 to a risk-based approach in 2019. We estimated the cost-effectiveness and changes in resource utilization of the 2012 and 2019 guidelines.

Methods: We utilized a previously published model of cervical cancer natural history and screening to estimate and compare the lifetime costs and number of screens, colposcopies, precancer treatments, cancer cases, and cancer deaths associated with the 2012 versus 2019 management guidelines. Read More

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September 2021

EFFECTIVENESS OF DIFLUPREDNATE FOR THE TREATMENT OF ANTERIOR SCLERITIS.

Am J Ophthalmol 2021 Sep 18. Epub 2021 Sep 18.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Purpose: To describe the effectiveness and side effect profile of difluprednate therapy in a series of patients with anterior scleritis.

Design: Retrospective, interventional case series.

Methods: Data collected from all patients with anterior scleritis who used difluprednate as a single treatment agent from 1/1/2018 to 1/1/2020 included: demographics, scleritis type, presence of nodules or necrosis, changes in scleritis activity, intraocular pressure (IOP), number of difluprednate drops used, best-corrected visual acuity (BCVA), and lens status. Read More

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September 2021

AMPK: restoring metabolic homeostasis over space and time.

Mol Cell 2021 Sep;81(18):3677-3690

Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

The evolution of AMPK and its homologs enabled exquisite responsivity and control of cellular energetic homeostasis. Recent work has been critical in establishing the mechanisms that determine AMPK activity, novel targets of AMPK action, and the distribution of AMPK-mediated control networks across the cellular landscape. The role of AMPK as a hub of metabolic control has led to intense interest in pharmacologic activation as a therapeutic avenue for a number of disease states, including obesity, diabetes, and cancer. Read More

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September 2021

Automated Insulin Dosing Systems: Advances After a Century of Insulin.

Diabet Med 2021 Sep 21:e14695. Epub 2021 Sep 21.

Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

The daily complexities of insulin therapy and glucose variability in type 1 diabetes still pose significant challenges, despite advancements in modern insulin analogues. Minimising hypoglycaemia and optimising time spent within target glucose range are recommended to reduce the risk of diabetes-related complications and distress. Access to structured education and adjuvant diabetes technologies such as insulin pumps and glucose sensors, are recommended by National Institute for Health and Care Excellence (NICE) to enable people with type 1 diabetes achieve their glycaemic goals. Read More

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September 2021

Effect of School Integrated Pest Management or Classroom Air Filter Purifiers on Asthma Symptoms in Students With Active Asthma: A Randomized Clinical Trial.

JAMA 2021 Sep;326(9):839-850

Harvard University Medical School, Boston, Massachusetts.

Importance: School and classroom allergens and particles are associated with asthma morbidity, but the benefit of environmental remediation is not known.

Objective: To determine whether use of a school-wide integrated pest management (IPM) program or high-efficiency particulate air (HEPA) filter purifiers in the classrooms improve asthma symptoms in students with active asthma.

Design, Setting, And Participants: Factorial randomized clinical trial of a school-wide IPM program and HEPA filter purifiers in the classrooms was conducted from 2015 to 2020 (School Inner-City Asthma Intervention Study). Read More

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September 2021

Prevalence and factors associated with family planning during COVID-19 pandemic in Bangladesh: A cross-sectional study.

PLoS One 2021 21;16(9):e0257634. Epub 2021 Sep 21.

Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States of America.

Background And Objectives: The COVID-19 pandemic has negatively impacted health systems worldwide, including in Bangladesh, limiting access to family planning information (FP) and services. Unfortunately, the evidence on the factors linked to such disruption is limited, and no study has addressed the link among Bangladeshis. This study aimed to examine the socioeconomic, demographic, and other critical factors linked to the use of FP in the studied areas during the COVID-19 pandemic. Read More

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September 2021

Could Commercial Formulations Replace Individualized Prescription in Pediatric Home Parenteral Nutrition?

J Pediatr Gastroenterol Nutr 2021 Oct;73(4):548-554

Pediatric Gastroenterology and Nutrition Unit, Department of Pediatrics, Centro Hospitalar e Universitário de São João, Porto, Portugal.

Objectives: Standard parenteral nutrition (PN) solutions are safe and can meet the nutritional requirements of a significant number of pediatric patients. However, they may not always be adequate for those on long term PN. We aimed to compare the composition of individually tailored prescriptions in a pediatric population on home PN with that of available commercial PN formulations. Read More

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October 2021

Comparing Physician Assistant and Nurse Practitioner Practice in U.S. Emergency Departments, 2010-2017.

West J Emerg Med 2021 Aug 21;22(5):1150-1155. Epub 2021 Aug 21.

University of California, San Francisco, Department of Emergency Medicine, Fresno, California.

Introduction: We sought to compare physician assistant (PA) and nurse practitioner (NP) practice in United States emergency departments (ED) based on ED visits as reported by the National Hospital Ambulatory Medical Care Survey (NHAMCS).

Methods: We performed a retrospective, secondary analysis of the 2010 to 2017 NHAMCS with analysis of ED visits, patient demographics, and hospital characteristics.

Results: Between 2010 to 2017, 21. Read More

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Transdermal Fentanyl Usage in Working-age Patients Undergoing Cancer Treatment: Prescription Pattern Analysis Using Large Claims Data in Japan.

J Pain Palliat Care Pharmacother 2021 Sep 21:1-8. Epub 2021 Sep 21.

The number of working-age individuals undergoing cancer treatment has been increasing. In these patients, transdermal fentanyl is the preferred treatment. However, it is known to have (1) pharmacodynamic interactions with benzodiazepines and (2) fever-induced pharmacokinetic variations. Read More

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September 2021

Autologous Adipose Tissue Injection of Vocal Cords in Presbyphonia.

Otolaryngol Head Neck Surg 2021 Sep 21:1945998211045292. Epub 2021 Sep 21.

Department of Otolaryngology, Hospital Universitario de Fuenlabrada, Madrid, Spain.

Objective: This series evaluates the long-term results of autologous adipose injection (AAI) in patients older than 65 years with presbyphonia.

Study Design: Retrospective cohort study.

Setting: Academic secondary medical center. Read More

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September 2021

Accounting for misclassified and unknown cause of death data in vital registration systems for estimating trends in HIV mortality.

J Int AIDS Soc 2021 Sep;24 Suppl 5:e25791

Institute for Health Metrics and Evaluation, Seattle, Washington, USA.

Introduction: Misclassification of HIV deaths can substantially diminish the usefulness of cause of death data for decision-making. In this study, we describe the methods developed by the Global Burden of Disease Study to account for the misclassified cause of death data from vital registration systems for estimating HIV mortality in 132 countries and territories.

Methods: The cause of death data were obtained from the World Health Organization Mortality Database and official country-specific mortality databases. Read More

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September 2021

Incorporating label correlations into deep neural networks to classify protein subcellular location patterns in immunohistochemistry images.

Proteins 2021 Sep 21. Epub 2021 Sep 21.

Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai, China.

Analysis of protein subcellular localization is a critical part of proteomics. In recent years, as both the number and quality of microscopic images are increasing rapidly, many automated methods, especially convolutional neural networks, have been developed to predict protein subcellular location(s) based on bioimages, but their performance always suffers from some inherent properties of the problem. First, many microscopic images have non-informative or noisy sections, like unstained stroma and unspecific background, which affect the extraction of protein expression information. Read More

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September 2021

The impact of early pregnancy complications on completed family size-A nationwide, registry-based cohort study with 40 years of data.

Acta Obstet Gynecol Scand 2021 Sep 21. Epub 2021 Sep 21.

Recurrent Pregnancy Loss Unit, Fertility Clinic, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.

Introduction: The impact of early pregnancy complications on completed family size is unknown. Here, we hypothesize that early pregnancy complications and adverse outcomes may influence family size.

Material And Methods: In this nationwide, registry-based study we included all 458 475 women born 1957-1972 who lived in Denmark from age 20-45 years with at least one registered pregnancy. Read More

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September 2021

Predictors of drug prescription in nursing home residents: results from the INCUR study.

Intern Emerg Med 2021 Sep 21. Epub 2021 Sep 21.

Geriatric Unit, Fondazione IRCCS Istituti Clinici Scientifici Maugeri, Via Camaldoli 64, 20138, Milan, Italy.

Polypharmacy represents a major clinical and public health issue in older persons. We aimed to measure the prevalence of polypharmacy, and the main predictors of drug prescription in nursing home residents. Post hoc analyses of the "Incidence of pNeumonia and related ConseqUences in nursing home Residents" (INCUR) study were conducted. Read More

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September 2021

Nonsurgical treatment of cerebral ischemia associated with ACTA2 cerebral arteriopathy: a case report and literature review.

Childs Nerv Syst 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurosurgery, Yokohama Brain and Spine Center, Yokohama, Japan.

Mutations in ACTA2 gene can lead to multisystemic smooth muscle dysfunction, including cerebrovascular disease. Treatment strategies for this rare entity remain controversial, and patients are at increasing risk of neurological sequelae. We herein present the case of an 11-year-old boy previously diagnosed with an ACTA2 gene mutation who developed repetitive transient ischemic attacks and treated with bosentan, an oral endothelin receptor antagonist. Read More

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September 2021

Variation in Diagnosis, Treatment, and Outcome of Esophageal Cancer in a Regionalized Care System in Ontario, Canada.

JAMA Netw Open 2021 Sep 1;4(9):e2126090. Epub 2021 Sep 1.

Ontario Health (Cancer Care Ontario), Toronto, Canada.

Importance: Esophageal cancer remains one of the most deadly cancers, ranking sixth highest among cancers leading to the greatest years of life lost.

Objective: To determine how patients with esophageal cancer are diagnosed and treated in Ontario's regionalized thoracic surgery centers.

Design, Setting, And Participants: This cohort study included patients diagnosed with esophageal cancer between January 1, 2010, and December 31, 2018, identified from the Ontario Cancer Registry, in a single-payer health care system with regionalization of thoracic surgery in the province of Ontario, Canada. Read More

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September 2021

Gastrointestinal Cancer Stage at Diagnosis Before and During the COVID-19 Pandemic in Japan.

JAMA Netw Open 2021 Sep 1;4(9):e2126334. Epub 2021 Sep 1.

Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Japan.

Importance: The COVID-19 pandemic has delayed medical consultations, possibly leading to the diagnosis of gastrointestinal cancer at advanced stages.

Objective: To evaluate stage at diagnosis among patients with gastrointestinal cancer in Japan before and during the COVID-19 pandemic.

Design, Setting, And Participants: This retrospective cohort study included patients in a hospital-based cancer registry who were diagnosed with gastrointestinal cancer (ie, esophageal, gastric, colorectal, pancreatic, liver, and biliary tract cancers) between January 2016 and December 2020 at 2 tertiary Japanese hospitals. Read More

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September 2021

Effects of Aging on Human Meibum.

Invest Ophthalmol Vis Sci 2021 Sep;62(12):23

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Purpose: The purpose of this study was to determine if aging affects meibum lipid composition in non-meibomian gland dysfunction (MGD)/non-dry eye (DE) population. Aging has been repeatedly linked to pathological changes in various tissues and organs, including the onset of MGD and DE, in a number of clinical and population-wide surveys. Both conditions have been associated with abnormal meibum secretion and composition, among other factors. Read More

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September 2021

Effectiveness of Ozone Therapy as an Adjunct Treatment for Lower-Limb Ulcers: A Systematic Review.

Adv Skin Wound Care 2021 Oct;34(10):1-9

At the Fundação Universidade Federal de Sergipe, São Cristóvão, Brazil, Tássia Lima Bomfim, MSc, is Nurse, Wound Healing Outpatient Clinic, University Hospital; Isla Alcântara Gomes, MSc, is PhD Student, Pharmaceutical Sciences; Daniele de Vasconcelos Cerqueira Meneses, MSc, is Master's Student, Health Sciences; and Adriano Antunes de Souza Araujo, PhD, is Director, Center of Biological and Health Sciences. Acknowledgments: The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico/CNPq/Brazil and Fundação de Amparo à Pesquisa do Estado de Sergipe/FAPITEC-SE for their financial support. The authors have disclosed no other financial relationships related to this article. Submitted March 22, 2021; accepted in revised form May 10, 2021.

Objective: To evaluate the effectiveness of topical ozone therapy as an adjuvant treatment in the healing of lower limb ulcers through a systematic literature review.

Data Sources: Three databases were used to search for studies conducted in the period up to and including September 2020: PubMed, Scopus, and the Web of Science.

Study Selection: The search identified 44 studies, 7 of which met the eligibility criteria and were evaluated. Read More

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October 2021

Colocating Wound Care for Patients with Sickle Cell Ulcers in a Hematology Clinic.

Adv Skin Wound Care 2021 Oct;34(10):539-541

At the Albert Einstein College of Medicine and Montefiore Health System, Bronx, New York, Anna Flattau, MD, MS, MSc, is Associate Professor and Vice Chair, Department of Family and Social Medicine; Giacomo Vinces, DO, is Assistant Professor, Department of Family and Social Medicine; Shuo You, MD, is Research Coordinator, Division of Hematology, Department of Medicine; Andrew S. Crouch, BA, is Research Coordinator, Division of Hematology, Department of Medicine; and Caterina P. Minniti, MD, is Professor, Division of Hematology, Department of Medicine. Acknowledgment: This work was partially supported by a grant from the FDA (R01FD005729). The authors have disclosed no other financial relationships related to this article. Submitted October 29, 2020; accepted in revised form November 23, 2020.

Objective: Leg ulcers affect 15% of people with sickle cell disease. However, wound centers typically treat few people with this condition, which makes it difficult to concentrate clinical expertise or support the scientific study of this orphan disease. This article describes an initiative to increase engagement in care through a partnership between wound healing and hematology leadership that led to colocating wound services within a sickle cell clinic. Read More

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October 2021

The role of fetal surveillance in monochorionic twins: review of the current findings.

Minerva Obstet Gynecol 2021 Sep 21. Epub 2021 Sep 21.

Department of Women's Health, Albert Einstein School of Medicine, São Paulo-SP, Brazil.

Maternal age has increased significantly over the years and assisted reproduction techniques are becoming more available in less developed countries, contributing to the rising number of multiple gestations. Multiple pregnancy is associated with greater risk for both the mother and the fetus than a singleton pregnancy, and needs well-trained professionals to assist and surveil its progression. This review aims to describe the available evidence and summarize the current recommendations for fetal surveillance and delivery timing for monochorionic gestations. Read More

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September 2021

Effects of Oral Management on Elderly Patients with Pneumonia.

J Nutr Health Aging 2021 ;25(8):979-984

Kazuharu Nakagawa, PhD, Department of Dysphagia Rehabilitation, Division of Gerontology and Gerodontology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan, Tel: +81-3-5803-4560, Fax: +81-3-5803-4560, E-mail:

Objectives: In this study, we examined the factors influencing the presence or absence of dental intervention in patients with pneumonia in an acute-care hospital, focusing on oral intake and its status.

Design: Observational study.

Setting: Teikyo University School of Medicine, Mizonokuchi Hospital. Read More

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January 2021

Functional, Clinical, and Sociodemographic Variables Associated with Risk of In-Hospital Mortality by COVID-19 in People over 80 Years Old.

J Nutr Health Aging 2021 ;25(8):964-970

Isabel Rodríguez-Sánchez. Geriatrics Department. Hospital Universitario Clínico San Carlos. Calle Profesor Martín Lagos s/n. 28040 Madrid. SPAIN. Phone number: (+34) 91 3303000. Email:

Objectives: The objective is to assess the role of functional, clinical, and analytic parameters in predicting mortality in older patients hospitalized due to COVID-19.

Design: Cohort study with a mean follow-up of 12.8 days. Read More

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January 2021