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Motor Learning Promotes the Coupling between Fast Spindles and Slow Oscillations Locally over the Contralateral Motor Network.

Cereb Cortex 2021 Oct 14. Epub 2021 Oct 14.

IFIBIO Houssay, Department of Physiology, School of Medicine, University of Buenos Aires, C1121ABG, Argentina.

Recent studies from us and others suggest that traditionally declarative structures mediate some aspects of the encoding and consolidation of procedural memories. This evidence points to the existence of converging physiological pathways across memory systems. Here, we examined whether the coupling between slow oscillations (SO) and spindles, a mechanism well established in the consolidation of declarative memories, is relevant for the stabilization of human motor memories. Read More

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October 2021

Phase 2 multicenter trial of ofatumumab and prednisone as initial therapy of chronic graft-vs-host disease.

Blood Adv 2021 Oct 14. Epub 2021 Oct 14.

H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States.

Standard initial therapy of chronic graft vs. host disease (cGVHD) with glucocorticoids results in suboptimal and transient responses in a significant number of patients. Safety and feasibility of anti-CD20 directed B-cell therapy with ofatumumab (1000 mg IV on days 0 and 14) and prednisone (1 mg/kg/day) was previously established in our phase I trial (n=12). Read More

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October 2021

Does probiotics work for bacterial vaginosis and vulvovaginal candidiasis.

Curr Opin Pharmacol 2021 Oct 11;61:83-90. Epub 2021 Oct 11.

The Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Nanjing, Jiangsu, China. Electronic address:

The different Lactobacillus strains of probiotics have been applied to the treatment and prevention of bacterial vaginosis and vulvovaginal candidiasis. The experimental data demonstrated that it works well via reducing the number of harmful bacteria, maintaining the acidic microenvironment, inhibiting the immune response, and so on, to restore the vaginal microecology. However, the clinical data indicated that it is not sufficient to support the use of probiotics in the intervention of vulvovaginal candidiasis rather than bacterial vaginosis. Read More

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October 2021

Discussing mental health difficulties in a "diagnosis free zone".

Soc Sci Med 2021 Sep 2;289:114364. Epub 2021 Sep 2.

Tampere University, Faculty of Information Technology and Communication Sciences, 33014, Tampere University, Finland. Electronic address:

Being identified as "mentally ill" is a complicated social process that may be stigmatizing and socially problematic, as a mental illness diagnosis determines the criteria for what is considered normal. This has given rise to a number of anti-stigma campaigns designed to create awareness of the way stigmas affect people with mental health difficulties and to normalize those difficulties in society. One such campaign is the "diagnosis-free zone", which declares that those with mental health difficulties should not be categorized on the basis of their diagnosis; rather, they should be encountered as full individuals. Read More

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September 2021

Seizure recurrence after prolonged seizure control: Patterns and risk factors.

Epilepsy Behav 2021 Oct 11;124:108330. Epub 2021 Oct 11.

Department of Neurology, George Washington University, School of Medicine and Health Sciences, United States.

Objective: To identify the patterns and possible predictors of seizure recurrence after durable seizure freedom during maintenance of anti-seizure medication (ASM) treatment.

Methods: We conducted a retrospective longitudinal study that identified all adult individuals with epilepsy (IWE) at the George Washington University outpatient epilepsy clinic between 1/1/2014 and 12/31/2016 who had been seizure free for at least 2 years. We followed up the patients until 5/30/2020 for seizure recurrence. Read More

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October 2021

Developing a maturity model for cancer multidisciplinary teams.

Int J Med Inform 2021 Oct 4;156:104610. Epub 2021 Oct 4.

Sydney West Translational Cancer Research Centre, Western Sydney Local Health District, Westmead NSW 2145, Australia; Western Sydney Local Health District, Westmead NSW 2145, Australia. Electronic address:

Background: Multidisciplinary teams (MDTs) are considered the "gold standard" of care for patients with cancer but how well they function and the role they play in decision making varies widely. Although several observational tools have been developed to evaluate MDT performance, they are resource intensive and only assess MDT performance at a static point in time. The aim of this study was to develop a validated maturity model as a self-assessment instrument for MDTs to evaluate their performance and monitor improvement over time. Read More

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October 2021

CHML targeted by miR-199a-3p promotes non-small cell lung cancer cell growth via binding to Rab5A.

Pathol Res Pract 2021 Sep 22;227:153626. Epub 2021 Sep 22.

Department of Thoracic Surgery, Nanjing Chest Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province 210029, China. Electronic address:

Choroideremia-like (CHML) has been demonstrated to be related to the development of urothelial carcinoma, multiple myeloma, and hepatocellular carcinoma. Whereas, the association between CHML and lung cancer remains dimness. CHML expression was analyzed in NSCLC patients from TCGA dataset and evaluated in our collected NSCLC tissues and NSCLC cell lines. Read More

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September 2021

Elevated CO concentration increases photosynthetic sensitivity to nitrogen supply of sorghum in a genotype-dependent manner.

Plant Physiol Biochem 2021 Oct 5;168:202-210. Epub 2021 Oct 5.

Centre for Crop Systems Analysis, Department of Plant Sciences, Wageningen University and Research, Wageningen, Netherlands.

We hypothesized that elevated [CO] only increases sorghum photosynthesis under low nitrogen availability and evaluated whether cultivars BRS373 (grain), BRS511 (saccharine) and BRS655 (forage) differ in their sensitivity to nitrogen and [CO]. Plants were grown in growth chambers where air [CO] was 400 (a[CO]) or 800 (e[CO]) μmol CO mol and supplied with nutrient solution containing 211 (HN) or 48 (LN) ppm N for 45 days. Photosynthetic traits were measured in fully expanded leaves as well as leaf nitrogen and biomass accumulation. Read More

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October 2021

CT intraoperative scan for C1-C2 stabilization by Harms: analysis on clinical efficacy and a novel classification of screw placement accuracy.

World Neurosurg 2021 Oct 11. Epub 2021 Oct 11.

Section of Neurosurgery, Department of Neuroscience, University of Turin, Turin, Italy.

Background: The introduction of the intraoperative Computed Tomography (iCT) could improve the surgical results of C1-C2 stabilization by Goel-Harms, especially in patients with complex deformities. This study aims to investigate the impact of iCT on the accuracy of C1-C2 screw positioning and to develop a score based on multiparametric analysis of imaging data (Cervical Screw Placement Accuracy score [CSPAs]).

Methods: 21 patients were retrospectively evaluated. Read More

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October 2021

Screening patients at admission to Copenhagen hospitals for carriage of resistant bacteria after contact with health care systems abroad, 2016-2019.

Int J Antimicrob Agents 2021 Oct 11:106452. Epub 2021 Oct 11.

Department of Clinical Microbiology, Copenhagen University Hospital - Herlev and Gentofte, Borgmester Ib Juuls Vej 1, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, Denmark.

Objectives: Patients with previous contact with health care systems abroad are routinely screened for resistant bacteria at admission to Copenhagen hospitals. The aim of this study was to present carriage prevalence and geographic risk stratification as well as pheno- and genotypic characterisation of resistant isolates.

Methods: We included screening samples analysed at one department of clinical microbiology in Copenhagen from 2016-2019. Read More

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October 2021

Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-κB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo.

J Ethnopharmacol 2021 Oct 11:114739. Epub 2021 Oct 11.

Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China. Electronic address:

Ethnopharmacological Relevance: Panax ginseng C.A. Meyer is a type of herbal plant that has frequently been used in many Asian countries to treat a variety of diseases. Read More

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October 2021

Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice.

J Ethnopharmacol 2021 Oct 11;283:114737. Epub 2021 Oct 11.

Division of Pharmacology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand. Electronic address:

Ethnopharmacological Relevance: ECa 233 is a standardized extract of Centella asiatica (L.) Urban, a herb traditionally used to treat a number of diseases including neurological disorders. Accordingly, ECa 233 showed benefits on animal models of cognitive deficits, chronic stress and Parkinson's disease. Read More

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October 2021

Moderate intensity functional training as adjuvant treatment in patients with peripheral arterial disease: a case report.

Ann Vasc Surg 2021 Oct 11. Epub 2021 Oct 11.

i+HeALTH, European University Miguel de Cervantes, Valladolid, Spain.

Background: Traditional aerobic training and muscle resistance ('strength') training have been shown to be effective for improving functional and health-related quality of life (HRQoL) outcomes in peripheral arterial disease (PAD). However, the transfer of the current resistance exercise modes proposed to other activities of daily living (ADLs) is questionable. Moderate intensity functional training (MIFT) has emerged with the aim of achieving cardiovascular and neuromuscular adaptations simultaneously with functional exercises typical of ADLs. Read More

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October 2021

HIV PrEP is more than ART-lite: Longitudinal study of real-world PrEP services data identifies missing measures meaningful to HIV prevention programming.

J Int AIDS Soc 2021 Oct;24(10):e25827

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Introduction: Evidence indicates HIV oral pre-exposure prophylaxis (PrEP) is highly efficacious and effective. Substantial early discontinuation rates are reported by many programs, which may be misconstrued as program failure. However, PrEP use may be non-continuous and still effective, since HIV risk fluctuates. Read More

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October 2021

Diagnostic radiological examinations and risk of intracranial tumours in adults-findings from the Interphone Study.

Int J Epidemiol 2021 Oct 14. Epub 2021 Oct 14.

International Agency for Research on Cancer, Lyon, France.

Background: Exposure to high doses of ionizing radiation is among the few well-established brain tumour risk factors. We used data from the Interphone study to evaluate the effects of exposure to low-dose radiation from diagnostic radiological examinations on glioma, meningioma and acoustic neuroma risk.

Methods: Brain tumour cases (2644 gliomas, 2236 meningiomas, 1083 neuromas) diagnosed in 2000-02 were identified through hospitals in 13 countries, and 6068 controls (population-based controls in most centres) were included in the analysis. Read More

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October 2021

Changes in antibiotic consumption, AMR and Clostridioides difficile infections in a large tertiary-care center following the implementation of institution-specific guidelines for antimicrobial therapy: A nine-year interrupted time series study.

PLoS One 2021 14;16(10):e0258690. Epub 2021 Oct 14.

Division of Infectious Diseases and Tropical Medicine, Department of Medicine II, Leipzig University Hospital, Leipzig, Germany.

Background: Institution-specific guidelines (ISGs) within the framework of antimicrobial stewardship programs offer locally tailored decision support taking into account local pathogen and resistance epidemiology as well as national and international guidelines.

Objectives: To assess the impact of ISGs for antimicrobial therapy on antibiotic consumption and subsequent changes in resistance rates and Clostridioides difficile infections (CDIs).

Methods: The study was conducted at the Leipzig University Hospital, a 1,451-bed tertiary-care medical center, and covered the years 2012 to 2020. Read More

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October 2021

Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination.

PLoS Comput Biol 2021 Oct 14;17(10):e1009468. Epub 2021 Oct 14.

Department of Biology, Emory University, Atlanta, Georgia, United States of America.

Understanding how immunological memory lasts a lifetime requires quantifying changes in the number of memory cells as well as how their division and death rates change over time. We address these questions by using a statistically powerful mixed-effects differential equations framework to analyze data from two human studies that follow CD8 T cell responses to the yellow fever vaccine (YFV-17D). Models were first fit to the frequency of YFV-specific memory CD8 T cells and deuterium enrichment in those cells 42 days to 1 year post-vaccination. Read More

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October 2021

The genomic ecosystem of transposable elements in maize.

PLoS Genet 2021 Oct 14;17(10):e1009768. Epub 2021 Oct 14.

Center for Population Biology and Department of Evolution and Ecology, University of California, Davis, California, United States of America.

Transposable elements (TEs) constitute the majority of flowering plant DNA, reflecting their tremendous success in subverting, avoiding, and surviving the defenses of their host genomes to ensure their selfish replication. More than 85% of the sequence of the maize genome can be ascribed to past transposition, providing a major contribution to the structure of the genome. Evidence from individual loci has informed our understanding of how transposition has shaped the genome, and a number of individual TE insertions have been causally linked to dramatic phenotypic changes. Read More

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October 2021

Bimetallic Janus Nanocrystals: Syntheses and Applications.

Adv Mater 2021 Oct 14:e2102591. Epub 2021 Oct 14.

The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.

Bimetallic Janus nanocrystals have received considerable interest in recent years owing to their unique properties and niche applications. The side-by-side distribution of two distinct metals provides a flexible platform for tailoring the optical and catalytic properties of nanocrystals. First, a brief introduction to the structural features of bimetallic Janus nanocrystals, followed by an extensive discussion of the synthetic approaches, is given. Read More

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October 2021

The evolutionary trajectories of the individual amygdala nuclei in the common shrew, guinea pig, rabbit, fox and pig: A consequence of embryological fate and mosaic-like evolution.

J Anat 2021 Oct 14. Epub 2021 Oct 14.

Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

The amygdala primarily evolved as a danger detector that regulates emotional behaviours and learning. However, it is also engaged in stress responses as well as olfactory/pheromonal and reproductive functions. All of these functions are processed by a set of nuclei which are derived from different telencephalic sources (pallial and subpallial) and have a unique cellular structure and specific connections. Read More

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October 2021

Reversible conduction block of peroneal nerve associated with SARS-CoV-2.

Neurol Sci 2021 Oct 14. Epub 2021 Oct 14.

Department of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, Via Faggiana 34, 04100, Latina, Italy.

Background: The ongoing SARS-CoV-2 pandemic, which is dramatically spreading worldwide, is well known for its respiratory sequelae. Besides cases of Guillain-Barré Syndrome, encephalitis, hyposmia, the whole range of neurological complications due to SARSCoV-2 is still not well known.

Methods And Findings: Herein, we report a new case of COVID-19, associated with mononeuropathy with reversible conduction block (CB). Read More

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October 2021

Activation of Abl1 Kinase Explored Using Well-Tempered Metadynamics Simulations on an Essential Dynamics Sampled Path.

J Chem Theory Comput 2021 Oct 14. Epub 2021 Oct 14.

Department of Chemistry and Biomedical Sciences, Faculty of Health and Life Sciences, Linnæus University, 391 82 Kalmar, Sweden.

Well-tempered metadynamics (wT-metaD) simulations using path collective variables (CVs) have been successfully applied in recent years to explore conformational transitions in protein kinases and other biomolecular systems. While this methodology has the advantage of describing the transitions with a limited number of predefined path CVs, it requires as an input a reference path connecting the initial and target states of the system. It is desirable to automate the path generation using approaches that do not rely on the choice of geometric CVs to describe the transition of interest. Read More

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October 2021

Discrimination of adhesion and viscoelasticity from nanoscale maps of polymer surfaces using bimodal atomic force microscopy.

Nanoscale 2021 Oct 14. Epub 2021 Oct 14.

School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907, USA.

The simultaneous excitation and measurement of two eigenmodes in bimodal atomic force microscopy (AFM) during sub-micron scale surface imaging augments the number of observables at each pixel of the image compared to the normal tapping mode. However, a comprehensive connection between the bimodal AFM observables and the surface adhesive and viscoelastic properties of polymer samples remains elusive. To address this gap, we first propose an algorithm that systematically accommodates surface forces and linearly viscoelastic three-dimensional deformation computed Attard's model into the bimodal AFM framework. Read More

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October 2021

The combination of chemical, structural, and functional indicators to evaluate the anthropogenic impacts on agricultural stream ecosystems.

Environ Sci Pollut Res Int 2021 Oct 14. Epub 2021 Oct 14.

RiverLy, INRAE, Villeurbanne, France.

Freshwater contamination by pesticides in agricultural landscapes is of increasing concern worldwide, with strong pesticide impacts on biodiversity, ecosystem functions, and ultimately human health (drinking water, fishing). In addition, the excessively large number of substances, as well as their low - and temporally variable - concentrations in water, make the chemical monitoring by grab sampling very demanding and not fully representative of the actual contamination. Tools that integrate temporal variations and that are ecologically relevant are clearly needed to improve the monitoring of freshwater contamination and assess its biological effects. Read More

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October 2021

Plasticity in induced resistance to sequential attack by multiple herbivores in Brassica nigra.

Oecologia 2021 Oct 13. Epub 2021 Oct 13.

Laboratory of Entomology, Wageningen University and Research Center, Droevendaalsesteeg 1, 6708 PB, Wageningen, The Netherlands.

In nature, plants interact with multiple insect herbivores that may arrive simultaneously or sequentially. There is extensive knowledge on how plants defend themselves against single or dual attack. However, we lack information on how plants defend against the attack of multiple herbivores that arrive sequentially. Read More

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October 2021

The intestinal flora of patients with GHPA affects the growth and the expression of PD-L1 of tumor.

Cancer Immunol Immunother 2021 Oct 13. Epub 2021 Oct 13.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Context: Pituitary adenoma (PA) is a common intracranial tumor. The evidence indicates that the tumor immune microenvironment (TIME) is associated with PA and that the intestinal flora influences other tumors' growth through interacting with the TIME. However, how the intestinal microbial flora contributes to the development of PA through the immune response is unknown. Read More

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October 2021

Access to the Emergency Contraceptive Pill and Women's Reproductive Health: Evidence From Public Reform in Chile.

Demography 2021 Oct 14. Epub 2021 Oct 14.

Institute of Sociology, Pontificia Universidad Católica de Chile, Santiago, Chile.

We examine the sharp expansion in availability of the emergency contraceptive pill in Chile following legalized access through municipal public health care centers. We study the period 2002-2016 and a broad rollout of the emergency contraceptive pill occurring between 2008 and 2011. By combining a number of administrative data sets on health outcomes and pharmaceutical use, and using event-study and difference-in-differences methods, we document that this expansion improved certain classes of women's reproductive health outcomes, notably reducing rates of abortion-related morbidity. Read More

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October 2021

Traumatic Lateral Knee Dislocation of a Well-Functioning Total Knee Arthroplasty: A Case of Medial Collateral Ligament Rupture.

Arthroplast Today 2021 Oct 30;11:168-172. Epub 2021 Sep 30.

Department of Orthopedic Surgery, Willis-Knighton Health System, Shreveport, LA, USA.

Tibiofemoral dislocation can be a devastating complication after total knee arthroplasty. Much of the literature on tibiofemoral dislocations state they result from iatrogenic causes, with a very limited number of case reports on traumatic dislocation. Most of the time, these cases will require surgical revision and increased constraint to treat the inherent instability. Read More

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October 2021

A dataset of the food self-sufficiency assessment of Bristol and Vienna based on a foodshed approach.

Data Brief 2021 Oct 28;38:107434. Epub 2021 Sep 28.

Leibniz Center for Agricultural Landscape Research, Eberswalder Str. 84, Müncheberg 15374, Germany.

The food self-sufficiency assessment of Bristol and Vienna was developed by applying the Metropolitan Foodshed and Self-sufficiency scenario (MFSS) model [1] in the proposed respective foodsheds. In the case of Vienna 25 surrounding districts (i.e. Read More

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October 2021

Bone Regeneration in Load-Bearing Segmental Defects, Guided by Biomorphic, Hierarchically Structured Apatitic Scaffold.

Front Bioeng Biotechnol 2021 27;9:734486. Epub 2021 Sep 27.

Institute of Science and Technology for Ceramics, National Research Council, Faenza, Italy.

The regeneration of load-bearing segmental bone defects remains a significant clinical problem in orthopedics, mainly due to the lack of scaffolds with composition and 3D porous structure effective in guiding and sustaining new bone formation and vascularization in large bone defects. In the present study, biomorphic calcium phosphate bone scaffolds (GreenBone™) featuring osteon-mimicking, hierarchically organized, 3D porous structure and lamellar nano-architecture were implanted in a critical cortical defect in sheep and compared with allograft. Two different types of scaffolds were tested: one made of ion-doped hydroxyapatite/β-tricalcium-phosphate (GB-1) and other made of undoped hydroxyapatite only (GB-2). Read More

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September 2021