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Incidence, risk factors and management of post cesarean section surgical site infection (SSI) in a tertiary hospital in Egypt: a five year retrospective study.

BMC Pregnancy Childbirth 2021 Sep 18;21(1):634. Epub 2021 Sep 18.

Minia Maternity and Children University Hospital, Obstetrics and Gynecology Department, Faculty of Medicine, Minia University, Minia, Egypt.

Background: Surgical site infection (SSI) is one of the commonest complications following cesarean section (CS) with a reported incidence of 3-20%. SSI causes massive burdens on both the mother and the health care system. Moreover, it is associated with high maternal morbidity and mortality rate of up to 3%. Read More

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September 2021

Computed-tomography based scoring system predicts outcome for clinical lymph node-positive patients undergoing radical cystectomy.

Int Braz J Urol 2021 Sep 10;47. Epub 2021 Sep 10.

Department of Urology, Ludwig-Maximilians-University, Munich, Germany.

Purpose: Contrast-enhanced CT scan is the standard staging modality for patients with bladder cancer undergoing radical cystectomy (RC). Involvement of lymph nodes (LN) determines prognosis of patients with bladder cancer. The detection of LN metastasis by CT scan is still insufficient. Read More

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September 2021

The association between physical activity, sedentary time and health-related quality of life in cancer survivors.

Health Qual Life Outcomes 2021 Sep 6;19(1):213. Epub 2021 Sep 6.

Institute of Clinical Epidemiology, Key Laboratory of Public Health Safety, Ministry of Education, Key Lab of Health Technology Assessment of Ministry of Health, School of Public Health, Fudan University, 130 Dong-An Road, Shanghai, 200032, China.

Background: Although physical activity (PA) and sedentary time in cancer survivors (CSs) were associated with health-related quality of life (HRQOL), it was not clear whether their associations were similar among CSs with different number of comorbid chronic diseases (CCDs). This study aimed to investigate the associations between PA, sedentary time and HRQOL in CSs with different number of CCDs.

Methods: A cross-sectional study was conducted among 1546 CSs between June and September 2018 in Shanghai, China. Read More

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September 2021

Ethnic Differences in Survival Among Lung Cancer Patients: A Systematic Review.

JNCI Cancer Spectr 2021 Oct 7;5(5):pkab062. Epub 2021 Jul 7.

Department of Psychology, University of Arizona, Tucson, AZ, USA.

Background: Despite a substantially worse risk factor profile, Hispanics in the United States experience lower incidence of many diseases and longer survival than non-Hispanic Whites (NHWs), an epidemiological phenomenon known as the Hispanic Health Paradox (HHP). This systematic review evaluated the published longitudinal literature to address whether this pattern extends to lung cancer survival.

Methods: Searches of Medline, PubMed, Embase, Web of Science, and the Cochrane Library were conducted for publications dated from January 1, 2000, to July 18, 2018. Read More

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October 2021

Association of Polypharmacy with Colorectal Cancer Survival Among Older Patients.

Oncologist 2021 Sep 3. Epub 2021 Sep 3.

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.

Background: In geriatric oncology, polypharmacy is often assessed during a comprehensive geriatric assessment. Previous studies about its association with survival among patients with colorectal cancer (CRC) were inconclusive and had high risk for indication bias.

Patients And Methods: A cohort study was conducted with 3,239 patients with CRC, aged ≥65 years, who were recruited in Germany between 2003 and 2016, while being hospitalized for CRC surgery. Read More

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September 2021

Salvage Radical Prostatectomy for Radio-Recurrent Prostate Cancer: An Updated Systematic Review of Oncologic, Histopathologic and Functional Outcomes and Predictors of Good Response.

Curr Oncol 2021 Jul 29;28(4):2881-2892. Epub 2021 Jul 29.

Department of Urology, Medical University of Vienna, 1090 Vienna, Austria.

A valid treatment option for recurrence after definite radiotherapy (RT) for localized prostate cancer (PC) is salvage radical prostatectomy (SRP). However, data on SRP are scarce, possibly resulting in an underutilization. A systematic review was performed using MEDLINE (Pubmed), Embase, and Web of Science databases including studies published between January 1980 and April 2020. Read More

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Changing perception and improving knowledge of leprosy: An intervention study in Uttar Pradesh, India.

PLoS Negl Trop Dis 2021 Aug 23;15(8):e0009654. Epub 2021 Aug 23.

Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Introduction: Since ancient times leprosy has had a negative perception, resulting in stigmatization. To improve the lives of persons affected by leprosy, these negative perceptions need to change. The aim of this study is to evaluate interventions to change perceptions and improve knowledge of leprosy. Read More

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A national assessment of elective cesarean sections in Bangladesh and the need for health literacy and accessibility.

Sci Rep 2021 Aug 19;11(1):16854. Epub 2021 Aug 19.

Transport and Road Safety (TARS) Research Centre, School of Aviation, University of New South Wales, Sydney, Australia.

There has been a gradual rise in the number of cesarean sections (CSs) in Bangladesh. The present study identified the cohort of women, who were more likely to opt for an elective CS based on their sociodemographic characteristics, pre-delivery care history, and media exposure, using the Bangladesh Multiple Indicator Cluster Survey-2019. The survey stratification adjusted logistic regression model and interpretable machine learning method of building classification trees were utilized to analyze a sample of 9202 women, alongside district-wise heat maps. Read More

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Chronic constipation is negatively associated with colonic diverticula.

Scand J Gastroenterol 2021 Aug 19:1-7. Epub 2021 Aug 19.

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Objectives: Constipation has been considered the key risk factor for diverticulosis occurrence, but the underlying mechanism is unclear. We investigated the factors associated with diverticulosis, focusing on the association of constipation severity with the localization and number of diverticula.

Materials And Methods: We analyzed consecutive patients who underwent colonoscopy between March and December 2019. Read More

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The Cancers-Specific Survival of Metastatic Pulmonary Carcinoids and Sites of Distant Metastasis: A Population-Based Study.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211036528

Department of Thoracic Surgery, 89657The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Background: Lung cancer is the leading cause of cancer-related deaths and pulmonary carcinoids (PCs) account for almost 2% of all pulmonary malignancies. However, few published articles have reported prognosis and related factors of pulmonary carcinoid patients.

Material And Method: The Surveillance, Epidemiology, and End Results (SEER) database was used to collect data of patients diagnosed with metastatic PCs from 2010 to 2016. Read More

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Mental Health Symptoms, Binge Drinking, and the Experience of Abuse During the COVID-19 Lockdown in Mexico.

Front Public Health 2021 22;9:656036. Epub 2021 Jul 22.

Sección mexicana de la Comisión de Salud Fronteriza México-Estados Unidos, Mexico City, Mexico.

The health crisis associated with the COVID-19 pandemic is causally linked to negative mental health symptoms in the same way as other diseases such as Ebola. The purpose of this paper is to describe the relationship between mental health symptoms, binge drinking, and the experience of abuse during the COVID-19 lockdown. We surveyed 9,361 participants, all Mexican, with an average age of 33 years old ( = 10. Read More

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Optimal Cut-Off Values of the Positive Lymph Node Ratio and the Number of Removed Nodes for Patients Receiving Resection of Bronchopulmonary Carcinoids: A Propensity Score-Weighted Analysis of the SEER Database.

Front Oncol 2021 21;11:696732. Epub 2021 Jul 21.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Although lymph node dissection (LND) has been commonly used for patients with bronchopulmonary carcinoids (PCs), the prognostic values of the positive lymph node ratio (PLNR) and the number of removed nodes (NRN) remain unclear.

Methods: Patients with resected PCs were identified in the Surveillance, Epidemiology, and End Results (SEER) database (2010-2015). The optimal cut-off values of the PLNR and NRN were determined by X-tile. Read More

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Cerebrovascular Risk Factors in Possible or Probable Cerebral Amyloid Angiopathy, Modifier or Bystander?

Front Neurol 2021 21;12:676931. Epub 2021 Jul 21.

Department of Neurology, University of Regensburg, Regensburg, Germany.

Cerebral amyloid angiopathy (CAA) is a frequent cause of atypical intracerebral hemorrhage (ICH) in the elderly. Stroke risk factors such as arterial hypertension (AHT), atrial fibrillation (AFib), diabetes mellitus (DM), and renal dysfunction (RD) are increasingly apparent in these patients. In this retrospective study, we analyzed the presence of these stroke risk factors in different initial CAA presentations comprising cerebral microbleeds (CMB), acute ischemic stroke (AIS), cortical superficial hemosiderosis (cSS), or lobar ICH (LICH) and evaluated their influence on the initial clinical presentation of patients with CAA. Read More

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Validation of a prognostic model including the number of harvested lymph-nodes in the setting of non-small cell lung cancer patients undergoing curative resection: a multicentre analysis.

Minerva Surg 2021 Aug 2. Epub 2021 Aug 2.

Thoracic Surgery, Regina Elena National Cancer Institute-IRCCS, Rome, Italy.

Background: The prognostic role of the extension of lymphadenectomy in Non-small-cell lung cancer is still a debated and intriguing issue. The aim of this study is to validate a prognostic score including the number of resected lymph-nodes previously reported using a large multicentre dataset.

Methods: From 01/2002 to 12/2012, data on 4858 NSCLC patients undergoing curative-intent surgery in six Institutions were retrospectively reviewed. Read More

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Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Front Oncol 2021 12;11:683825. Epub 2021 Jul 12.

State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Objectives: A significant number of recently published research has outlined the contribution of perineural invasion (PNI) to clinical outcomes in oral tongue squamous cell carcinoma (OTSCC), but some results remain conflicting. This study aimed to determine whether patients with OTSCC with PNI have a worse prognosis than those without PNI.

Materials And Methods: PubMed, Embase, and the Cochrane Library were queried for potentially eligible articles published up to December 2020. Read More

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Impact of Surgical Wait Time on Survival in Patients With Upper Urinary Tract Urothelial Carcinoma With Hydronephrosis.

Front Oncol 2021 5;11:698594. Epub 2021 Jul 5.

Department of Urology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Background And Objectives: Due to the inevitability of waiting time for surgery, this problem seems to have become more pronounced since the outbreak of COVID-19, and due to the high incidence of preoperative hydronephrosis in upper urinary tract urothelial carcinoma (UTUC) patients, it is particularly important to explore the impact of preoperative waiting time and hydronephrosis on upper urinary urothelial carcinoma.

Methods: 316 patients with UTUC who underwent radical surgery at a high-volume center in China between January 2008 and December 2019 were included in this study. We retrospectively collected the clinicopathologic data from the medical records, including age, sex, smoking history, ECOG performance status (ECOG PS), body mass index (BMI), tumor location and size, number of lesions, T stage, N stage, surgical approach and occurrence of hydronephrosis, lymph node invasion, lymph node dissection, surgical margin, tumor necrosis, infiltrative tumor architecture, lymphovascular invasion and concomitant bladder cancer. Read More

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A Scoping Review of Cross-Sectional Studies on Traditional Chinese Medicine.

Am J Chin Med 2021 14;49(6):1275-1296. Epub 2021 Jul 14.

Hong Kong Chinese Medicine Clinical Study Center, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, P. R. China.

Cross-sectional studies on traditional Chinese medicine (TCM-CSs) have become the most published type of TCM observational study; however, the research scope of current TCM-CSs is unknown. A scoping review of the literature was performed. A descriptive approach to summarize the core study characteristics was prepared, along with structured tables and figures to identify salient points of similarities and differences noted across studies. Read More

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Governor vessel acupuncture for acute ischemic stroke: a systematic review and meta-analysis.

Ann Palliat Med 2021 Jul 14;10(7):7236-7246. Epub 2021 Jul 14.

School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.

Background: Acute ischemic stroke (AIS) is the major type of stroke, which highly risks human health and life quality. Governor vessel acupuncture (GV Ac) is one specific acupoint selection treatment. This study aimed to systematically evaluate the clinical value of GV Ac in AIS patients. Read More

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Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy.

Future Sci OA 2021 Aug 20;7(7):FSO709. Epub 2021 Apr 20.

Department of Emergency & Organ Transplantation-Urology, Andrology & Kidney Transplantation Unit, University of Bari, Bari, Italy.

Aim: To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC).

Patients & Methods: 213 patients were included.

Inclusion Criteria: Nonmetastatic, MIBC (cT2-T4aN0M0), at least three cycles of NAC, undergone RC and with blood count within 30 days before NAC. Read More

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Prognostic factors for survival in advanced thymomas: The role of the number of involved structures.

J Surg Oncol 2021 Oct 12;124(5):858-866. Epub 2021 Jul 12.

Università Cattolica del Sacro Cuore, Rome, Italy.

Background And Objectives: The Masoka-Koga and tumor node metastases staging systems for thymoma are based on structures involved, but the prognostic role of the number of infiltrated/involved structures is still debated. We analyzed the prognostic role of involved structures and their combinations in locally advanced thymomas patients.

Methods: Data on 174 surgically treated locally advanced thymoma patients from 1/01/1990 to 31/12/2015 were reviewed. Read More

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October 2021

Prognostic value of circulating tumor cells in patients with bladder cancer: A meta-analysis.

PLoS One 2021 9;16(7):e0254433. Epub 2021 Jul 9.

Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Background: Circulating tumor cells (CTCs) have been considered diagnostic and prognostic biomarkers for urothelial cancer. However, the prognostic role of CTCs in bladder cancer (BC) remains controversial. Here, we conducted a meta-analysis to evaluate the prognostic significance of CTCs for patients with BC. Read More

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Frailty is associated with poor prognosis after resection for pancreatic cancer.

Int J Clin Oncol 2021 Oct 7;26(10):1938-1946. Epub 2021 Jul 7.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Background: With population aging, the number of frail patients with pancreatic cancer has increased. The Clinical Frailty Scale (CFS) is a simple and validated tool to assess frailty, and higher scores predict worse clinical outcomes after cardiovascular surgery. In this retrospective study, we aimed to examine the association of preoperative frailty with prognosis after resection for pancreatic cancer. Read More

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October 2021

The impact of Health Transformation Plan on natural vaginal delivery and cesarean section frequency in Iran: an interrupted time series analysis.

BMC Res Notes 2021 Jul 3;14(1):257. Epub 2021 Jul 3.

School of Health Management and Information Sciences, Health Human Resources Research Center, Shiraz University of Medical Sciences, Almas Building, Alley 29, Qasrodasht Ave, P.O. code: 71336-54361, Shiraz, Iran.

Objective: This study was conducted to evaluate the effect of the Iran's Health Transformation Plan on the frequency of natural vaginal deliveries (NVDs), cesarean sections (CSs), and total deliveries in the Fars province of Iran.

Results: Average number of total deliveries before and after the reform were 3946 and 3810, respectively (p  =  0.164). Read More

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The effects of presenting additional stimuli resembling the CS+ during extinction on extinction retention and generalisation to novel stimuli.

Behav Res Ther 2021 Sep 25;144:103921. Epub 2021 Jun 25.

School of Psychology, Curtin University, Australia.

Recent studies have shown that extinction training including the conditional stimulus (CS+) and stimuli similar to the CS + enhances extinction retention and generalisation to novel stimuli. The aim of the present study was to confirm that these effects are specific to presenting stimuli similar to the CS+ during extinction and not merely an effect of additional trials or additional stimuli unrelated to the CS+. In an experiment conducted in a single session on the same day, participants (134 adults; 70. Read More

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September 2021

Multi-microphone Complex Spectral Mapping for Utterance-wise and Continuous Speech Separation.

IEEE/ACM Trans Audio Speech Lang Process 2021 26;29:2001-2014. Epub 2021 May 26.

Department of Computer Science and Engineering & the Center for Cognitive and Brain Sciences, The Ohio State University, Columbus, OH 43210-1277 USA.

We propose multi-microphone complex spectral mapping, a simple way of applying deep learning for time-varying non-linear beamforming, for speaker separation in reverberant conditions. We aim at both speaker separation and dereverberation. Our study first investigates offline utterance-wise speaker separation and then extends to block-online continuous speech separation (CSS). Read More

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Genotype-Phenotype Correlations in 208 Individuals with Coffin-Siris Syndrome.

Genes (Basel) 2021 06 19;12(6). Epub 2021 Jun 19.

Division of Medical Genetics and Metabolism, Children's Hospital of The King's Daughters, Norfolk, VA 23507, USA.

Coffin-Siris syndrome (CSS, MIM 135900) is a multi-system intellectual disability syndrome characterized by classic dysmorphic features, developmental delays, and organ system anomalies. Genes in the BRG1(BRM)-associated factors (BAF, Brahma associated factor) complex have been shown to be causative, including , , , , , , , , , and . In order to describe more robust genotype-phenotype correlations, we collected data from 208 individuals from the CSS/BAF complex registry with pathogenic variants in seven of these genes. Read More

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Interpreting Testosterone and Concomitant Prostate Specific Antigen Values during Androgen Deprivation Therapy for Recurrent Prostate Cancer.

J Urol 2021 Jun 29:101097JU0000000000001946. Epub 2021 Jun 29.

Department of Surgery, Faculty of Medicine, Université Laval; Centre de recherche CHU de Québec-Université Laval, Oncology Division, Quebec City, Quebec, Canada.

Purpose: Measurement of testosterone levels during androgen deprivation therapy (ADT) is broadly recommended, but how therapy should be altered in response to testosterone values during ADT remains controversial Our objective was therefore to evaluate the relation between testosterone and concomitant prostate specific antigen (PSA) levels during ADT on clinical outcomes.

Materials And Methods: Patients from the continuous androgen deprivation arm of the PR.7 trial of intermittent ADT for biochemically recurrent prostate cancer following radiotherapy were included. Read More

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Patient-reported symptom burden in routine oncology care: Examining racial and ethnic disparities.

Cancer Rep (Hoboken) 2021 Jun 24:e1478. Epub 2021 Jun 24.

Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida, USA.

Background: Racial and ethnic disparities are well-documented in cancer outcomes such as disease progression and survival, but less is known regarding potential disparities in symptom burden.

Aims: The goal of this retrospective study was to examine differences in symptom burden by race and ethnicity in a large sample of cancer patients. We hypothesized that racial and ethnic minority patients would report greater symptom burden than non-Hispanic and White patients. Read More

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CheSPI: chemical shift secondary structure population inference.

J Biomol NMR 2021 Jul 19;75(6-7):273-291. Epub 2021 Jun 19.

Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000, Aarhus C, Denmark.

NMR chemical shifts (CSs) are delicate reporters of local protein structure, and recent advances in random coil CS (RCCS) prediction and interpretation now offer the compelling prospect of inferring small populations of structure from small deviations from RCCSs. Here, we present CheSPI, a simple and efficient method that provides unbiased and sensitive aggregate measures of local structure and disorder. It is demonstrated that CheSPI can predict even very small amounts of residual structure and robustly delineate subtle differences into four structural classes for intrinsically disordered proteins. Read More

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