113 results match your criteria number cres

In silico simulations reveal that RYR distribution affects the dynamics of calcium release in cardiac myocytes.

J Gen Physiol 2021 Apr;153(4)

Department of Cellular Cardiology, Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.

The dyads of cardiac myocytes contain ryanodine receptors (RYRs) that generate calcium sparks upon activation. To test how geometric factors of RYR distribution contribute to the formation of calcium sparks, which cannot be addressed experimentally, we performed in silico simulations on a large set of models of calcium release sites (CRSs). Our models covered the observed range of RYR number, density, and spatial arrangement. Read More

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Evaluation of Smoking as a Modifying Factor in Chronic Rhinosinusitis.

JAMA Otolaryngol Head Neck Surg 2021 02;147(2):159-165

James Paget University Hospital National Health Service (NHS) Foundation Trust, Gorleston, England.

Importance: The negative association of smoking with the respiratory tract is well known; however, the association between smoking and chronic rhinosinusitis (CRS) has not been well characterized.

Objective: To analyze whether active smoking was a risk factor for CRS development, smoking was associated with disease-specific quality of life, and smokers experience an increased symptom burden than nonsmokers.

Design, Setting, And Participants: This subanalysis of the Chronic Rhinosinusitis Epidemiology Study (CRES), a prospective, questionnaire-based case-control study conducted between October 2007 and September 2013 was conducted across 30 UK tertiary/secondary care sites. Read More

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February 2021

The effect of lockdowns and infection rates on supermarket sales.

Econ Hum Biol 2021 01 13;40:100947. Epub 2020 Nov 13.

Department of Economics, Universitat Pompeu Fabra & CRES-UPF, Spain.

In this paper we document the evolution of the supermarket sales in one of the European countries, Spain, that has been most hardly hit by the COVID-19 pandemic. Using a very detailed dataset at the weekly and municipality level on the sales of a supermarket chain, we are able to separately identify the effects on sales for 12 different food products and for three population age groups. Furthermore, we distinguish between the impact of the lockdown, which affected the entire territory by mid-March, from the effect of the number of new confirmed positive COVID-19 cases at the municipal level. Read More

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January 2021

A Social Network Analysis of Tweets Related to Masks during the COVID-19 Pandemic.

Int J Environ Res Public Health 2020 11 7;17(21). Epub 2020 Nov 7.

School of Health Care and Social Work, Seinäjoki University of Applied Sciences, 60100 Seinäjoki, Finland.

Background: High compliance in wearing a mask is a crucial factor for stopping the transmission of COVID-19. Since the beginning of the pandemic, social media has been a key communication channel for citizens. This study focused on analyzing content from Twitter related to masks during the COVID-19 pandemic. Read More

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November 2020

Long-range chromatin interactions in pathogenic gene expression control.

Transcription 2020 10 5;11(5):211-216. Epub 2020 Nov 5.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST) , Daejeon, Republic of Korea.

A large number of distal -regulatory elements (REs) have been annotated in the human genome, which plays a central role in orchestrating spatiotemporal gene expression. Since many REs regulate non-adjacent genes, long-range RE-promoter interactions are an important factor in the functional characterization of the engaged REs. In this regard, recent studies have demonstrated that identification of long-range target genes can decipher the effect of genetic mutations residing within REs on abnormal gene expression. Read More

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October 2020

Efficacy and safety of CD19 chimeric antigen receptor T cells in the treatment of 11 patients with relapsed/refractory B-cell lymphoma: a single-center study.

Ann Transl Med 2020 Sep;8(17):1048

Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Background: No effective treatment exist for patients with relapsed and refractory B-cell lymphoma, until the advent of anti-CD19 chimeric antigen receptor (CAR) T-cells. Therefore, this study aimed to explore the factors affecting the efficacy of anti-CD19 CAR T-cell and the adverse reactions of the therapy.

Methods: We recruited 11 patients with relapsed and refractory B-cell lymphoma. Read More

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September 2020

A saturating mutagenesis CRISPR-Cas9-mediated functional genomic screen identifies and regulatory elements of in murine ESCs.

J Biol Chem 2020 11 29;295(47):15797-15809. Epub 2020 Sep 29.

Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. Electronic address:

Regulatory elements (REs) consist of enhancers and promoters that occupy a significant portion of the noncoding genome and control gene expression programs either in or in Putative REs have been identified largely based on their regulatory features (co-occupancy of ESC-specific transcription factors, enhancer histone marks, and DNase hypersensitivity) in mouse embryonic stem cells (mESCs). However, less has been established regarding their regulatory functions in their native context. We deployed and regulatory elements scanning through saturating mutagenesis and sequencing (ctSCAN-SMS) to target elements within the ∼12-kb -region (REs; CREs) of the gene locus, as well as genome-wide 2,613 high-confidence REs (TREs), in mESCs. Read More

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November 2020

CAR T-Cell Therapy Is Effective but Not Long-Lasting in B-Cell Lymphoma of the Brain.

Front Oncol 2020 4;10:1306. Epub 2020 Aug 4.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Advanced central nervous system (CNS) lymphoma is an exclusion criterion for most chimeric antigen receptor (CAR) T-cell studies due to the associated levels of neurotoxicity. In this study, we described five patients with chemorefractory B-cell CNS lymphoma who received CAR19 and CAR22 T-cell "Cocktail" therapy and follow-up for 6-16 months. All patients experienced cytokine release syndrome (CRS). Read More

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Bayesian spatial analysis of socio-demographic factors influencing pregnancy termination and its residual geographic variation among ever-married women of reproductive age in Bangladesh.

BMC Public Health 2020 Sep 4;20(1):1348. Epub 2020 Sep 4.

Department of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University, 5790 University Avenue, Halifax, B3H 4R2, Nova Scotia, Canada.

Background: Unsafe pregnancy termination is a major public health concern among reproductive-aged women in many developing countries. This study evaluated the socio-demographic characteristics, as well as residual spatial correlation in pregnancy termination among Bangladeshi women.

Methods: Secondary data was obtained from the Bangladesh Demographic and Health Survey for the survey year 2014. Read More

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September 2020

Successful application of anti-CD19 CAR-T therapy with IL-6 knocking down to patients with central nervous system B-cell acute lymphocytic leukemia.

Transl Oncol 2020 Nov 31;13(11):100838. Epub 2020 Jul 31.

Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Suzhou, China; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. Electronic address:

Few studies have described chimeric antigen receptor-modified T cell (CAR-T) therapy for central nervous system (CNS) B-cell acute lymphocytic leukemia (B-ALL) patients due to life-threatening CAR-T-related encephalopathy (CRES) safety issues. In this study, CAR-Ts targeting CD19 with short hairpin RNA (shRNA)-IL-6 gene silencing technology (ssCART-19s) were prepared. We conducted a phase 1 clinical trial (ClinicalTrials. Read More

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November 2020

Novel aspects of Cell Division Cycle and Apoptosis Regulator 1 (CCAR1) protein in : an approach.

Plant Signal Behav 2020 10 21;15(10):1795396. Epub 2020 Jul 21.

Taxonomy and Biosystematic Laboratory, Department of Botany, University of Calcutta , Kolkata, India.

Cell division cycle and apoptosis regulator 1 (CCAR1) is a deleted in breast cancer domain containing protein and their molecular roles in the animal system are well characterized. So far study on CCAR1 protein has not available in the plant system. The domain-based phylogenetic study clearly indicates that the CCAR1 protein has widely distributed throughout the plant kingdom. Read More

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October 2020

Dissection of c-AMP Response Element Architecture by Using Genomic and Episomal Massively Parallel Reporter Assays.

Cell Syst 2020 07 29;11(1):75-85.e7. Epub 2020 Jun 29.

Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

In eukaryotes, transcription factors (TFs) orchestrate gene expression by binding to TF-binding sites (TFBSs) and localizing transcriptional co-regulators and RNA polymerase II to cis-regulatory elements. However, we lack a basic understanding of the relationship between TFBS composition and their quantitative transcriptional responses. Here, we measured expression driven by 17,406 synthetic cis-regulatory elements with varied compositions of a model TFBS, the c-AMP response element (CRE) by using massively parallel reporter assays (MPRAs). Read More

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Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: a systematic review and network meta-analysis.

BMC Geriatr 2020 06 16;20(1):212. Epub 2020 Jun 16.

Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, East Building, Toronto, Ontario, M5B 1W8, Canada.

Background: Prescribing trends suggest that pharmacologic alternatives to antipsychotics are gaining in popularity, but randomized trial (RCT) data of their comparative safety is scarce. Our objective was to describe the comparative safety of pharmacologic interventions for treating neuropsychiatric symptoms in dementia.

Methods: We searched MEDLINE, EMBASE, CENTRAL, CINAHL, and PsycINFO, from inception to May 28, 2019, for studies of pharmacologic interventions used to treat neuropsychiatric symptoms in dementia. Read More

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The Analysis of Teaching of Medical Schools (AToMS) survey: an analysis of 47,258 timetabled teaching events in 25 UK medical schools relating to timing, duration, teaching formats, teaching content, and problem-based learning.

Oliver Patrick Devine Andrew Christopher Harborne Hugo Layard Horsfall Tobin Joseph Tess Marshall-Andon Ryan Samuels Joshua William Kearsley Nadine Abbas Hassan Baig Joseph Beecham Natasha Benons Charlie Caird Ryan Clark Thomas Cope James Coultas Luke Debenham Sarah Douglas Jack Eldridge Thomas Hughes-Gooding Agnieszka Jakubowska Oliver Jones Eve Lancaster Calum MacMillan Ross McAllister Wassim Merzougui Ben Phillips Simon Phillips Omar Risk Adam Sage Aisha Sooltangos Robert Spencer Roxanne Tajbakhsh Oluseyi Adesalu Ivan Aganin Ammar Ahmed Katherine Aiken Alimatu-Sadia Akeredolu Ibrahim Alam Aamna Ali Richard Anderson Jia Jun Ang Fady Sameh Anis Sonam Aojula Catherine Arthur Alena Ashby Ahmed Ashraf Emma Aspinall Mark Awad Abdul-Muiz Azri Yahaya Shreya Badhrinarayanan Soham Bandyopadhyay Sam Barnes Daisy Bassey-Duke Charlotte Boreham Rebecca Braine Joseph Brandreth Zoe Carrington Zoe Cashin Shaunak Chatterjee Mehar Chawla Chung Shen Chean Chris Clements Richard Clough Jessica Coulthurst Liam Curry Vinnie Christine Daniels Simon Davies Rebecca Davis Hanelie De Waal Nasreen Desai Hannah Douglas James Druce Lady-Namera Ejamike Meron Esere Alex Eyre Ibrahim Talal Fazmin Sophia Fitzgerald-Smith Verity Ford Sarah Freeston Katherine Garnett Whitney General Helen Gilbert Zein Gowie Ciaran Grafton-Clarke Keshni Gudka Leher Gumber Rishi Gupta Chris Harlow Amy Harrington Adele Heaney Wing Hang Serene Ho Lucy Holloway Christina Hood Eleanor Houghton Saba Houshangi Emma Howard Benjamin Human Harriet Hunter Ifrah Hussain Sami Hussain Richard Thomas Jackson-Taylor Bronwen Jacob-Ramsdale Ryan Janjuha Saleh Jawad Muzzamil Jelani David Johnston Mike Jones Sadhana Kalidindi Savraj Kalsi Asanish Kalyanasundaram Anna Kane Sahaj Kaur Othman Khaled Al-Othman Qaisar Khan Sajan Khullar Priscilla Kirkland Hannah Lawrence-Smith Charlotte Leeson Julius Elisabeth Richard Lenaerts Kerry Long Simon Lubbock Jamie Mac Donald Burrell Rachel Maguire Praveen Mahendran Saad Majeed Prabhjot Singh Malhotra Vinay Mandagere Angelos Mantelakis Sophie McGovern Anjola Mosuro Adam Moxley Sophie Mustoe Sam Myers Kiran Nadeem Reza Nasseri Tom Newman Richard Nzewi Rosalie Ogborne Joyce Omatseye Sophie Paddock James Parkin Mohit Patel Sohini Pawar Stuart Pearce Samuel Penrice Julian Purdy Raisa Ramjan Ratan Randhawa Usman Rasul Elliot Raymond-Taggert Rebecca Razey Carmel Razzaghi Eimear Reel Elliot John Revell Joanna Rigbye Oloruntobi Rotimi Abdelrahman Said Emma Sanders Pranoy Sangal Nora Sangvik Grandal Aadam Shah Rahul Atul Shah Oliver Shotton Daniel Sims Katie Smart Martha Amy Smith Nick Smith Aninditya Salma Sopian Matthew South Jessica Speller Tom J Syer Ngan Hong Ta Daniel Tadross Benjamin Thompson Jess Trevett Matthew Tyler Roshan Ullah Mrudula Utukuri Shree Vadera Harriet Van Den Tooren Sara Venturini Aradhya Vijayakumar Melanie Vine Zoe Wellbelove Liora Wittner Geoffrey Hong Kiat Yong Farris Ziyada I C McManus

BMC Med 2020 05 14;18(1):126. Epub 2020 May 14.

Research Department of Medical Education, UCL Medical School, Gower Street, London, WC1E 6BT, UK.

Background: What subjects UK medical schools teach, what ways they teach subjects, and how much they teach those subjects is unclear. Whether teaching differences matter is a separate, important question. This study provides a detailed picture of timetabled undergraduate teaching activity at 25 UK medical schools, particularly in relation to problem-based learning (PBL). Read More

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Genome-wide MNase hypersensitivity assay unveils distinct classes of open chromatin associated with H3K27me3 and DNA methylation in Arabidopsis thaliana.

Genome Biol 2020 02 3;21(1):24. Epub 2020 Feb 3.

Department of Plant Biology, Michigan State University, East Lansing, MI, 48824, USA.

Background: Regulation of transcription depends on interactions between cis-regulatory elements (CREs) and regulatory proteins. Active CREs are imbedded in open chromatin that are accessible to nucleases. Several techniques, including DNase-seq, which is based on nuclease DNase I, and ATAC-seq, which is based on transposase Tn5, have been widely used to identify genomic regions associated with open chromatin. Read More

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February 2020

High-performance method to detection of Klebsiella pneumoniae Carbapenemase in Enterobacterales by LC-MS/MS.

Braz J Microbiol 2020 Sep 27;51(3):1029-1035. Epub 2020 Jan 27.

Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Carbapenem-resistant Enterobacterales (CREs) have been recognized as an important threat to global health. CRE cause the majority of the difficult-to-treat infections in health-care settings and are associated with high mortality. Klebsiella pneumoniae carbapenemase (KPC)-producing CREs, in particular Klebsiella pneumoniae, are globally disseminated and responsible for a large number of outbreaks. Read More

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September 2020

A Pretraining-Retraining Strategy of Deep Learning Improves Cell-Specific Enhancer Predictions.

Front Genet 2019 8;10:1305. Epub 2020 Jan 8.

College of Informatics, Hubei Key Laboratory of Agricultural Bioinformatics, Huazhong Agricultural University, Wuhan, China.

Deciphering the code of cis-regulatory element (CRE) is one of the core issues of today's biology. Enhancers are distal CREs and play significant roles in gene transcriptional regulation. Although identifications of enhancer locations across the whole genome [discriminative enhancer predictions (DEP)] is necessary, it is more important to predict in which specific cell or tissue types, they will be activated and functional [tissue-specific enhancer predictions (TSEP)]. Read More

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January 2020

The prevalence, evolution and chromatin signatures of plant regulatory elements.

Nat Plants 2019 12 18;5(12):1250-1259. Epub 2019 Nov 18.

Department of Genetics, University of Georgia, Athens, GA, USA.

Chromatin accessibility and modification is a hallmark of regulatory DNA, the study of which led to the discovery of cis-regulatory elements (CREs). Here, we characterize chromatin accessibility, histone modifications and sequence conservation in 13 plant species. We identified thousands of putative CREs and revealed that distal CREs are prevalent in plants, especially in species with large and complex genomes. Read More

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December 2019

Impact of a Telemedicine Program on the Reduction in the Emission of Atmospheric Pollutants and Journeys by Road.

Int J Environ Res Public Health 2019 11 8;16(22). Epub 2019 Nov 8.

Health Promotion in Rural Areas Research Group, Institut Català de la Salut, 08272 Sant Fruitós de Bages, Spain.

This retrospective study evaluates the effect of a telemedicine program developed in the central Catalan region in lowering the environmental footprint by reducing the emission of atmospheric pollutants, thanks to a reduction in the number of hospital visits involving journeys by road. Between January 2018 and June 2019, a total of 12,322 referrals were made to telemedicine services in the primary care centers, avoiding a total of 9034 face-to-face visits. In total, the distance saved was 192,682 km, with a total travel time saving of 3779 h and a total fuel reduction of 11,754 L with an associated cost of €15,664. Read More

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November 2019

Genome-Wide Computational Identification of Biologically Significant Cis-Regulatory Elements and Associated Transcription Factors from Rice.

Plants (Basel) 2019 Oct 23;8(11). Epub 2019 Oct 23.

Division of Plant Biology, School of Biological Science, Southern Illinois University Carbondale, 1125 Lincoln Ave., Life Science II, Carbondale, IL 62901-6509, USA.

The interactions between transcription factors (TFs) and cis-acting regulatory elements (CREs) provide crucial information on the regulation of gene expression. The determination of TF-binding sites and CREs experimentally is costly and time intensive. An in silico identification and annotation of TFs, and the prediction of CREs from rice are made possible by the availability of whole genome sequence and transcriptome data. Read More

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October 2019

Zebrafish: A Powerful Model for Understanding the Functional Relevance of Noncoding Region Mutations in Human Genetic Diseases.

Biomedicines 2019 Sep 16;7(3). Epub 2019 Sep 16.

MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

Determining aetiology of genetic disorders caused by damaging mutations in protein-coding genes is well established. However, understanding how mutations in the vast stretches of the noncoding genome contribute to genetic abnormalities remains a huge challenge. Cis-regulatory elements (CREs) or enhancers are an important class of noncoding elements. Read More

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September 2019

Genetic Variation in Long-Range Enhancers.

Curr Top Behav Neurosci 2019 ;42:35-50

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Cis-regulatory elements (CREs), including insulators, promoters, and enhancers, play critical roles in the establishment and maintenance of normal cellular function. Within each cell, the 3D structure of chromatin is arranged in specific patterns to expose the CREs required for optimal spatiotemporal regulation of gene expression. CREs can act over large distances along the linear genome, facilitated by looping of the intervening chromatin to allow direct interaction between distal regulatory elements and their target genes. Read More

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January 2020

Cellular therapy: Immune-related complications.

Immunol Rev 2019 07;290(1):114-126

Divisions of Hematology and Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

The advent of chimeric antigen receptor T (CAR-T) and the burgeoning field of cellular therapy has revolutionized the treatment of relapsed/refractory leukemia and lymphoma. This personalized "living therapy" is highly effective against a number of malignancies, but this efficacy is tempered by side effects relatively unique to immunotherapies, including CAR-T. The overwhelming release of cytokines and chemokines by activated CAR-T and other secondarily activated immune effector cells can lead to cytokine release syndrome (CRS), which can have clinical and pathophysiology similarities to systemic inflammatory response syndrome and macrophage activating syndrome/hemophagocytic lymphohistiocytosis. Read More

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The effects of copayment in primary health care: evidence from a natural experiment.

Eur J Health Econ 2019 Nov 26;20(8):1237-1248. Epub 2019 Jul 26.

Center for Research in Health and Economics (CRES), Universitat Pompeu Fabra, Barcelona, Spain.

Objective: Evaluate the effects of the 'euro per prescription' on primary health care services (number of doctor visits), through a retrospective cohort study of health care users in Catalonia (Spain). This policy, implemented in Catalonia on 23 June 2012, only lasted 6 months. This policy was introduced to improve budgetary imbalances in Spain and boost the regional and national governments' budgets. Read More

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November 2019

Treatment of patients with relapsed or refractory CD19+ lymphoid disease with T lymphocytes transduced by RV-SFG.CD19.CD28.4-1BBzeta retroviral vector: a unicentre phase I/II clinical trial protocol.

BMJ Open 2019 05 19;9(5):e026644. Epub 2019 May 19.

Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.

Introduction: Chimeric antigen receptor (CAR) T cells spark hope for patients with CD19+ B cell neoplasia, including relapsed or refractory (r/r) acute lymphoblastic leukaemia (ALL) or r/r non-Hodgkin's lymphoma (NHL). Published studies have mostly used second-generation CARs with 4-1BB or CD28 as costimulatory domains. Preclinical results of third-generation CARs incorporating both elements have shown superiority concerning longevity and proliferation. Read More

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Acute salt stress differentially modulates nitrate reductase expression in contrasting salt responsive rice cultivars.

Protoplasma 2019 Sep 30;256(5):1267-1278. Epub 2019 Apr 30.

Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.

Salt stress response includes alteration in the activity of various important enzymes in plants. Nitrate reductase (NR) is one of the known enzyme affected by salt stress. In this study, contrasting salt responsive cultivars (CVS) (IR64-sensitive and CSR 36-tolerant) were considered to study the regulation of NR genes under salt stress conditions. Read More

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September 2019

The ethnobotany and biogeography of wild vegetables in the Adriatic islands.

J Ethnobiol Ethnomed 2019 Mar 29;15(1):18. Epub 2019 Mar 29.

Department of Agricultural Botany, Faculty of Agriculture, University of Zagreb, Svetošimunska cesta 25, 10000, Zagreb, Croatia.

Background: Archipelagos of islands have played an important role in shaping some of the paradigms of biology, including the theory of the evolution of species. Later, their importance in biology was further emphasised by the theory of island biogeography, which contributed to a better understanding of the shaping of species richness not only on real islands, but on isolated habitat islands as well. Although ethnobotany is a well-established discipline, patterns of knowledge about plant uses in archipelagos have never been quantitatively analysed, and the whole concept has been only briefly mentioned in the ethnobiological context. Read More

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Cost-utility analysis of second-generation direct-acting antivirals for hepatitis C: a systematic review.

Expert Rev Gastroenterol Hepatol 2018 Dec 31;12(12):1251-1263. Epub 2018 Oct 31.

d Real-World Insights , IQVIA , Barcelona , Spain.

Introduction: High prices of second-generation direct-acting antivirals (DAAs) in the treatment of chronic hepatitis C virus (HCV) patients led to reimbursement decisions based on cost per quality-adjusted life year (QALY). Areas covered: We performed a systematic review of cost-utility analyses (CUA) comparing interventions with second-generation DAA therapies with no treatment, and with previous therapies for chronic HCV patients until July 2017. A total of 36 studies were included: 30 studies from the perspective of the healthcare payer, 3 from the societal perspective, and 3 did not report the perspective. Read More

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December 2018

Public finances and tobacco taxation with product variety: Theory and application to Senegal and Nigeria.

PLoS One 2019 14;14(2):e0212015. Epub 2019 Feb 14.

Maastricht University, School of Business and Economics, Maastricht, The Netherlands.

This study endeavors to answer two questions: which category of excise taxes is more appropriate for Senegal and Nigeria and which consequences an increase of the tobacco taxes would have on the price, the demand and the tax revenues in each one of the two countries? To answer these questions, we adopt a double approach: first, a theoretical model of taxation with variety; and second, a simulation model to answer the second question. The results of the theoretical model indicate that, in the context of excise taxation, the number of products variety-or that of cigarette brands-directly affects both the degree of market concentration and the marginal effects of specific and ad valorem excise taxes on the price of tobacco. In addition, the comparison of the marginal effects of ad valorem and specific excise taxes depends on the marginal costs of production of different varieties weighted by the tax rates and the number of varieties. Read More

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November 2019

Food and beverage marketing in primary and secondary schools in Canada.

BMC Public Health 2019 Jan 28;19(1):114. Epub 2019 Jan 28.

Faculty of Health Sciences, Interdisciplinary School of Health Sciences, University of Ottawa, 25 University Private, Ottawa, Ontario, K1N 7K4, Canada.

Background: Unhealthy food marketing is considered a contributor to childhood obesity. In Canada, food marketing in schools is mostly self-regulated by industry though it is sometimes restricted through provincial school policies. The purpose of this study was to document the type of food marketing activities occurring in Canadian schools and examine differences by school characteristics. Read More

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January 2019