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Altered Fibrinolysis during and after Surgery.

Semin Thromb Hemost 2021 Apr 20. Epub 2021 Apr 20.

Anaesthesia and Critical Care Department, Bellvitge University Hospital, L'Hospitalet de LLobregat, Barcelona, Spain.

Major surgery induces hemostatic changes related to surgical stress, tissue destruction, and inflammatory reactions. These changes involve a shift of volume from extravascular space to intravascular and interstitial spaces, a "physiologic" hemodilution of coagulation proteins, and an increase of plasmatic fibrinogen concentration and platelets. Increases in fibrinogen and platelets together with a simultaneous dilution of pro- and anticoagulant factors and development of a hypofibrinolytic status result in a postoperative hypercoagulable state. Read More

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Neonatal Outcomes after Uterus Transplantation: Dallas Uterus Transplant Study.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, Texas.

Objective:  Limited data are available on the outcome of infants born after uterus transplantation. Our aim was to describe the hospital course and laboratory findings in the first 2 months of life of the 12 infants born in the Dallas UtErus Transplant Study (DUETS).

Study Design:  Based on the trial protocol, information about infants was collected in a prospective fashion, including infant demographics, hospital course, and laboratory values. Read More

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Clinical and Demographic Risk Factors for COVID-19 during Delivery Hospitalizations in New York City.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Division of Maternal-Fetal Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York.

Objective:  This study was aimed to review 4 weeks of universal novel coronavirus disease 2019 (COVID-19) screening among delivery hospitalizations, at two hospitals in March and April 2020 in New York City, to compare outcomes between patients based on COVID-19 status and to determine whether demographic risk factors and symptoms predicted screening positive for COVID-19.

Study Design:  This retrospective cohort study evaluated all patients admitted for delivery from March 22 to April 18, 2020, at two New York City hospitals. Obstetrical and neonatal outcomes were collected. Read More

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Effects of Different Onset Times of Early Caffeine Treatment on Mesenteric Tissue Oxygenation and Necrotizing Enterocolitis: A Prospective, Randomized Study.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Division of Neonatology, Department of Pediatrics, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.

Objective:  Caffeine treatment is routinely used in premature infants to prevent development of apnea and bronchopulmonary dysplasia. Although a limited number of studies have reported that early caffeine treatment may cause development of necrotizing enterocolitis (NEC) by reducing mesenteric blood flow, this issue is still under discussion. The aim of this study is to investigate the possible effect of different onset times of early caffeine treatment on mesenteric tissue oxygen saturation and NEC development in premature infants. Read More

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Association of Rural and Frontier Residence with Very Preterm and Very Low Birth Weight Delivery in Nonlevel III NICUs.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Aurora, Colorado.

Objective:  Delivery of very preterm and very low birth weight neonates (VPT/VLBW) in a nonlevel III neonatal intensive care unit (NICU) increases risk of morbidity and mortality. Study objectives included: (1) Determine incidence of VPT/VLBW delivery (<32 weeks gestational age and/or birth weight <1,500 g), in nonlevel III units in Colorado; (2) Evaluate the independent association between residence and nonlevel III unit delivery; (3) Determine the incidence of and factors associated with postnatal transfer.

Study Design:  This retrospective cohort study used 2007 to 2016 Colorado birth certificate data. Read More

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Tuned AFM-FM coupling by the formation of vacancy complex in Gd0.6Ca0.4MnO3 thin film lattice.

J Phys Condens Matter 2021 Apr 20. Epub 2021 Apr 20.

Department of Physics and Astronomy, University of Turku, FI-20014 Turku, Turku, 20014, FINLAND.

The effect of in situ oxygen and vacuum annealing on the low bandwidth manganite Gd1-xCaxMnO3 (GCMO) thin film with x = 0.4 was investigated. Based on the magnetic measurements, the AFM-FM coupling is suppressed by the vacuum annealing treatment via destroying the double exchange interaction and increasing the unit cell volume by converting the Mn 4+ to the Mn 3+ . Read More

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A novel method to reduce false alarms in ECG diagnostic systems: capture and quantification of noisy signals.

Physiol Meas 2021 Apr 20. Epub 2021 Apr 20.

Soochow University, Suzhou, 215006, CHINA.

Objective: Muscle artifacts (MA) and electrode motion artifacts (EMA) in electrocardiogram (ECG) signals lead to a large number of false alarms from cardiac diagnostic systems. To reduce false alarms, it is necessary to improve the performance of the diagnostic algorithm in noisy environments by removing excessively noisy signals. However, existing methods focus on signal quality assessment and contain too many artificial features. Read More

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Trimodal processing of complex stimuli in inferior parietal cortex is modality-independent.

Cortex 2021 Mar 19;139:198-210. Epub 2021 Mar 19.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Monell Chemical Senses Center, Philadelphia, USA; Department of Psychology, University of Pennsylvania, Philadelphia, USA; Stockholm University Brain Imaging Centre, Stockholm University, Stockholm, Sweden. Electronic address:

In humans, multisensory mechanisms facilitate object processing through integration of sensory signals that match in their temporal and spatial occurrence as well as their meaning. The generalizability of such integration processes across different sensory modalities is, however, to date not well understood. As such, it remains unknown whether there are cerebral areas that process object-related signals independently of the specific senses from which they arise, and whether these areas show different response profiles depending on the number of sensory channels that carry information. Read More

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Opioid prescribing practices in academic otolaryngology: A single institutional survey.

Am J Otolaryngol 2021 Apr 15;42(5):103038. Epub 2021 Apr 15.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.

Objectives: Opioids are highly addictive medications and otolaryngologists have a responsibility to practice opioid stewardship. We investigated postoperative opioid prescribing patterns among resident and attending physicians as an educational platform to underscore the importance of conscientious opioid prescribing.

Methods: This quality improvement study was designed as a cross-sectional electronic survey. Read More

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CD163 macrophages suppress T cell response by producing TGF-β in pediatric colorectal polyps.

Int Immunopharmacol 2021 Apr 17;96:107644. Epub 2021 Apr 17.

Department of Gastroenterology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China. Electronic address:

The local immune response plays an important role in the pathogenesis of colorectal carcinoma. Patients with colorectal polyps are at increased risk of colorectal cancer. However, the immunoregulation of early-stage colorectal polyps remain unknown. Read More

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Mast cells and Kurloff cells - Their detection throughout the oestrous cycle in normal guinea pig ovaries and in guinea pigs with cystic rete ovarii.

Res Vet Sci 2021 Apr 14;136:512-518. Epub 2021 Apr 14.

Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Kożuchowska 1/3, 51-631 Wrocław, Poland. Electronic address:

Mast cells (MCs) and Kurloff cells (KCs) were detected in guinea pig ovaries in the follicular and luteal phases of the oestrous cycle. The samples of ovaries were fixed in Mota's basic lead acetate. Toluidine blue was used for detection of MCs and periodic acid-Schiff for detection of KCs. Read More

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Oxytocin and social anxiety: Interactions with sex hormones.

Psychoneuroendocrinology 2021 Apr 17;128:105224. Epub 2021 Apr 17.

Department of General Psychiatry, Center for Psychosocial Medicine, Heidelberg University Hospital, Heidelberg, Germany; Department of Psychology, Ludwig-Maximilians-University Munich, Munich, Germany.

Oxytocin has been associated with anxiolytic and stress reducing effects in a number of studies. Less is known about the associations of endogenous oxytocin concentrations and their interaction with other hormones such as sex hormones in relation to self-reported anxiety levels. In this study, endogenous oxytocin and sex hormone levels were analyzed in 99 high (51 women) and 100 low (50 women) socially anxious individuals. Read More

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Estimating perceived parental substance use disorder: Using register data to adjust for non-participation in survey research.

Addict Behav 2021 Mar 8;119:106897. Epub 2021 Mar 8.

Centre for Alcohol and Drug Research, Aarhus University, Denmark.

Aims: To estimate the prevalence of parental substance use disorder (PSUD) in the general population based on young adults' reports adjusted for non-participation using register-based indicators of PSUD.

Design: A national sample survey study combined with a retrospective register-based study. Setting Denmark. Read More

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Dilution and amplification effects in Lyme disease: Modeling the effects of reservoir-incompetent hosts on Borrelia burgdorferi sensu stricto transmission.

Ticks Tick Borne Dis 2021 Apr 13;12(4):101724. Epub 2021 Apr 13.

Department of Mathematics, Dartmouth College, Hanover, NH, United States.

The literature on Lyme disease includes a lively debate about the paradoxical role of changing deer populations. A decrease in the number of deer will both (1) reduce the incidence of Lyme disease by decreasing the host populations for ticks and therefore tick populations, and (2) enhance the incidence of Lyme disease by offering fewer reservoir-incompetent hosts for ticks, forcing the vector to choose reservoir-competent, and therefore possibly diseased, hosts to feed on. A review of field studies exploring the net impact of changing deer populations shows mixed results. Read More

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Dietary restrictions modulate the gut microbiota: Implications for health and disease.

Nutr Res 2021 Mar 21;89:10-22. Epub 2021 Mar 21.

Institute of Nutritional Medicine, University of Hohenheim, D-70593 Stuttgart, Germany. Electronic address:

The health benefits of carefully restricting the energy intake in a strategic manner whilst avoiding malnutrition are widely discussed. In the recent years, the great impact of the gut microbiota on its host has been clarified more and more. Since the gut microbiota produces a number of metabolites and molecules that can affect host metabolism, modulating it with dietary restriction can influence the health and the progression of disease of its host on various levels. Read More

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First-in-class and best-in-class dendrimer nanoplatforms from concept to clinic: Lessons learned moving forward.

Eur J Med Chem 2021 Apr 17;219:113456. Epub 2021 Apr 17.

Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, 31077, Toulouse Cedex 4, France. Electronic address:

Research to develop active dendrimers by themselves or as nanocarriers represents a promising approach to discover new biologically active entities that can be used to tackle unmet medical needs including difficult diseases. These developments are possible due to the exceptional physicochemical properties of dendrimers, including their biocompatibility, as well as their therapeutic activity as nanocarriers and drugs themselves. Despite a large number of academic studies, very few dendrimers have crossed the 'valley of death' between. Read More

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Technical Note: Post-burial alteration of bones: Quantitative characterization with solid-state H MAS NMR.

Forensic Sci Int 2021 Apr 10;323:110783. Epub 2021 Apr 10.

National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia.

The identification of markers of the modifications occurring in human bones after death and of the sedimentary and post-sedimentary processes affecting their state of preservation, is of interest for several scientific disciplines. A new index, obtained from spectral deconvolution of the H MAS NMR spectra of bones, relating the number of organic protons to the amount of hydrogen nuclei in the OH groups of bioapatite, is proposed as indicator of the state of preservation of the organic fraction. In the osteological material from three different archaeological sites, this index resulted positively correlated with the extent of collagen loss derived from infrared spectroscopy. Read More

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Effects of estradiol treatments on PGF release in beef heifers submitted to estrous resynchronization 14 days after timed-AI.

Domest Anim Endocrinol 2021 Mar 23;76:106625. Epub 2021 Mar 23.

Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga, São Paulo, Brazil. Electronic address:

The effects of 17β-estradiol (E2) or estradiol benzoate (EB) on PGF2α release were studied in bred-non-pregnant and pregnant Nelore beef heifers. The day of timed artificial insemination (TAI) was designated day 0 (D0), and a single treatment was given on D14. All heifers also received an intravaginal P4 device on D14, and were randomly assigned to three groups: Control (C, P4 device only, n = 12); E2 (1 mg E2 + 9 mg P4, n = 10); or EB (1 mg, n = 10). Read More

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Identification and validation of autophagy-related prognostic signature for head and neck squamous cell carcinoma.

Transl Oncol 2021 Apr 17;14(7):101094. Epub 2021 Apr 17.

Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430000, China. Electronic address:

Background: Many studies have demonstrated that autophagy plays a significant role in regulating tumor growth and progression. However, the effect of autophagy-related genes (ARGs) on the prognosis have rarely been analyzed in head and neck squamous cell carcinoma (HNSCC).

Methods: We obtained differentially expressed ARGs from HNSCC mRNA data in The Cancer Genome Atlas (TCGA) database. Read More

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Defining the risk profile of women with stage 1 hypertension: A time to event analysis.

Am J Obstet Gynecol MFM 2021 Apr 17:100376. Epub 2021 Apr 17.

Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO.

Background: Chronic hypertension complicates up to 5% of pregnancies and is increasing in prevalence. Women with hypertension have increased risks of serious maternal morbidity and mortality in pregnancy including the development of preeclampsia. In 2017, new guidelines reclassified blood pressure into four categories: normal (<120/<80 mmHg), elevated (120-129/<80 mmHg), stage 1 hypertension (130-139/80-89 mmHg), and stage 2 hypertension (>140/>90 mmHg). Read More

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Long-term follow-up of the three-ligament tenodesis for scapholunate ligament lesions: 9-year results.

Hand Surg Rehabil 2021 Apr 17. Epub 2021 Apr 17.

UZ Leuven, Department of Orthopedic Surgery, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

We report on a retrospective cohort of 50 cases of three-ligament tenodesis for scapholunate instability. Fifteen cases (30% of our cohort) needed salvage surgery (11 proximal row carpectomies, 2 partial and 2 total wrist fusions) at an average of 33 months and are considered "failures". Of the 35 remaining cases ("success"), 16 (32% of our cohort) were reviewed at average 111 months and had good functional outcomes (QuickDASH 18/100, PRWE 11/100, pain 1/10, satisfaction 9/10). Read More

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Curculigoside attenuates oxidative stress and osteoclastogenesis via modulating Nrf2/NF-κB signaling pathway in RAW264.7 cells.

J Ethnopharmacol 2021 Apr 17:114129. Epub 2021 Apr 17.

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China; School of Pharmacy, Second Military Medical University, Shanghai, 200433, China. Electronic address:

Ethnopharmacological Relevance: Curculigo orchioides Gaertn is used for the treatment of impotence, atrophic debility of bones (osteoporosis), limb limpness, and arthritis of the lumbar and knee joints in traditional Chinese medicine and Ayurvedic medical system. Curculigoside (Cur) from Curculigo orchioides Gaertn has been shown to have regulatory effects on bone metabolism via anti-oxidative activities in rats and osteoblasts. However, little is known about the molecular pharmacological activity of Cur in osteoclastic bone resorption. Read More

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Bacillus subtilis BSH has a protective effect on Salmonella infection by regulating the intestinal flora structure in chickens.

Microb Pathog 2021 Apr 17:104898. Epub 2021 Apr 17.

College of Animal Science and Technology, College of Veterinary Medicine, Jilin Agricultural University, Changchun, China; Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Agricultural University, Changchun, China; Key Laboratory of Animal Production and Product Quality Safety of Ministry of Education, Jilin Agricultural University, Changchun, China. Electronic address:

Salmonellosis is a worldwide zoonotic disease that poses a serious threat to the reproduction of livestock and poultry and the health of young animals. Probiotics including Bacillus species, have received increasing attention as a substitute for antibiotics. In this study, chicks infected with Salmonella were fed feed supplemented with the BSH to observe the pathological changes in the liver, detect the number of viable bacteria in the liver and spleen, and record the death of the chicks. Read More

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Galactose in human metabolism, glycosylation and congenital metabolic diseases: Time for a closer look.

Biochim Biophys Acta Gen Subj 2021 Apr 17:129898. Epub 2021 Apr 17.

Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands; Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

Galactose is an essential carbohydrate for cellular metabolism, as it contributes to energy production and storage in several human tissues while also being a precursor for glycosylation. Galactosylated glycoconjugates, such as glycoproteins, keratan sulfate-containing proteoglycans and glycolipids, exert a plethora of biological functions, including structural support, cellular adhesion, intracellular signaling and many more. The biological relevance of galactose is further entailed by the number of pathogenic conditions consequent to defects in galactosylation and galactose homeostasis. Read More

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Brain network mechanisms of visual shape completion.

Neuroimage 2021 Apr 17:118069. Epub 2021 Apr 17.

Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Ave, 07102, USA.

Visual shape completion recovers object shape, size, and number from spatially segregated edges. Despite being extensively investigated, the process's underlying brain regions, networks, and functional connections are still not well understood. To shed light on the topic, we scanned (fMRI) healthy adults during rest and during a task in which they discriminated pac-man configurations that formed or failed to form completed shapes (illusory and fragmented condition, respectively). Read More

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