J Trauma Acute Care Surg 2021 Jul 6. Epub 2021 Jul 6.
Department of Acute Critical Care and Disaster Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan (K.N., Y.O.) Department of Acute Critical Care and Disaster Medicine, Tokyo Medical and Dental University Hospital of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan (K.N., K.M., A.S., J.A., Y.O.) Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan (S.D., A.W., N.I., T.K.) Emergency Medicine and Acute Care Surgery, Matsudo City General Hospital, Chiba, Japan (M.Y.) Emergency and Critical Care Center, Tokyo Women's Medical University Medical Center East, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan (M.K.) Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan (K.Y.) Department of Surgery, Riverside University Health System Medical Center, Loma Linda University School of Medicine, CA 92354, USA (R.C).
Background: Inflammatory lipid mediators in mesenteric lymph (ML), including arachidonic acid (AA), are considered to play an important role in the pathogenesis of multiple organ dysfunction (MOD) after hemorrhagic shock. A previous study suggested vagus nerve stimulation (VNS) could relieve shock-induced gut injury and abrogate ML toxicity, resulting in the prevention of MOD. However, the detailed mechanism of VNS in lymph toxicity remains unclear. Read More