43,909 results match your criteria nps


"Walking the nitrogen around the ring"; Chemical synthesis and spectroscopic characterization of novel 4-, 5-, 6, and 7-azaindazole analogs of the synthetic cannabinoid receptor agonist MDMB-PINACA.

Drug Test Anal 2021 Oct 15. Epub 2021 Oct 15.

Analytical & Biological Chemistry Research Facility (ABCRF), University College Cork, Cork, Ireland.

Over the past decade, synthetic cannabinoid receptor agonists (SCRAs) have rapidly evolved to encompass a wide range of structurally diverse new psychoactive substances (NPS), including derivatives which incorporate indole, indazole, 7-azaindole, γ-carbolinone, or carbazole heterocyclic scaffolds. The introduction of legislative measures seeking to control the availability of NPS on the recreational drug scene has likely contributed to the continued emergence of novel SCRA analogs which often evade regulatory control. However, the detection and/or identification of azaindazole-type SCRAs in seized material has not yet been reported (September, 2021). Read More

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October 2021

A baseline study on the impact of nanoplastics on the portals of entry of xenobiotics in fish.

Mar Pollut Bull 2021 Oct 12;173(Pt A):113018. Epub 2021 Oct 12.

Centre for Environmental and Marine Studies (CESAM), Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.

Mediterranean waters are particularly vulnerable to plastic pollution, with plastic particles concentrations comparable to those found in oceanic gyres. This work aimed to assess the impact of polymethylmethacrylate nanoplastics (PMMA-NPs) on the most important mucosal barriers of the gilthead seabream (Sparus aurata), a highly consumed fish species in the Mediterranean area. Fish were waterborne exposed to NPs (0. Read More

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October 2021

Mitochondrial Ca-overloading by oxygen/glutathione depletion-boosted photodynamic therapy based on a CaCO nanoplatform for tumor synergistic therapy.

Acta Biomater 2021 Oct 12. Epub 2021 Oct 12.

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing 211816, China. Electronic address:

The Ca buffering capacity of mitochondria maintains the balance of cell physiological activities. The exogenous reactive oxygen species (ROS) can be used to break the balance, resulting in mitochondrial dysfunction and irreversible cell apoptosis. Herein, the CaCO-based tumor microenvironment (TME) responsive nanoplatform ([email protected]) was designed for oxygen/GSH depletion-boosted photodynamic therapy (PDT) and mitochondrial Ca-overloading synergistic therapy. Read More

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October 2021

A combination of hybrid polydopamine-human keratinocyte growth factor nanoparticles and sodium hyaluronate for the efficient prevention of postoperative abdominal adhesion formation.

Acta Biomater 2021 Oct 12. Epub 2021 Oct 12.

Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China; Department of Talent Highland, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China. Electronic address:

Postoperative abdominal adhesion (PAA) is one of the more universal complications of abdominal surgery with a frequent incidence. Currently available keratinocyte growth factor (KGF)-based glues for the prevention of adhesions remain a great bottleneck since their long-term biological activity in vivo is insufficient. In this study, we fabricated hybrid polydopamine (PDA)-KGF nanoparticles (PDA-KGF NPs) by using an in situ self-assembly and polymerization method. Read More

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October 2021

Role of scavenger receptors in silica nanoparticle-induced cytokine responses in bronchial epithelial cells.

Toxicol Lett 2021 Oct 12. Epub 2021 Oct 12.

Section of Air Quality and Noise, Department of Environmental Health, Norwegian Institute of Public Health, PO Box 222 Skøyen, N-0213, Oslo, Norway.

A major challenge in nanoparticle (NP) research is to elucidate how NPs activate initial targets in cells, leading to cytotoxicity and inflammation. We have previously shown that silica (Si)NPs induce pro-inflammatory responses in bronchial epithelial cells (BEAS-2B) via mechanisms involving transforming growth factor (TGF)-α release, and activation of MAP-kinase p38 and JNK besides NF-κB (p65). In the present study, the roles of scavenger receptors (SRs) in SiNP-induced cytokine responses in BEAS-2B cells were examined by siRNA silencing. Read More

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October 2021

Dose dependent safety implications and acute intravenous toxicity of aminocellulose-grafted-polycaprolactone coated gelatin nanoparticles in mice.

Int J Biol Macromol 2021 Oct 12. Epub 2021 Oct 12.

Chemical Biology Unit, Institute of Nano Science and Technology (INST), Sector-81, Knowledge City, Sahibzada Ajit Singh Nagar, Punjab Pin 140306, India. Electronic address:

Polymeric nanoparticles are the most widely researched nanoformulations and gained broad acceptance in nanotherapeutics for targeted drug delivery and theranostics. However, lack of regulations, guidelines, harmonized standards, and limitations with their employability in clinical circumstances necessitates an in-depth understanding of their toxicology. Here, we examined the in-vivo toxicity of core-shell polymeric nanoparticles made up of gelatin core coated with an outer layer of aminocellulose-grafted polycaprolactone (PCL-AC) synthesized for drug delivery purposes in inflammatory disorders. Read More

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October 2021

In vitro investigation of zinc oxide nanoparticle toxic effects in spermatogonial cells at the molecular level.

Chem Biol Interact 2021 Oct 12:109687. Epub 2021 Oct 12.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. Electronic address:

Because spermatogonia transmit genetic information across generations, their DNA must be protected from environmental damages, including exposure to zinc oxide nanoparticles (ZnO NPs), which are frequently used in modern technology. Here, we used an in vitro system enriched for spermatogonia and exposed them to 10 and 20 μg/ml ZnO NPs for one/seven days. We did not detect any significant cell death, chromosomal instability, or DNA fragmentation in the spermatogonia treated with the ZnO NPs following one-day treatment with 10 or 20 μg/ml ZnO NPs. Read More

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October 2021

Severity of both neuropsychiatric symptoms and dementia is associated with quality of life in nursing home residents.

Eur Geriatr Med 2019 Oct 5;10(5):793-800. Epub 2019 Jul 5.

Department of General Practice, University of Helsinki, Helsinki, Finland.

Purpose: The primary focus in long-term care is to maintain quality of life. The aim of this study was to investigate the association of severity of neuropsychiatric symptoms (NPS) and health-related quality of life (HRQoL) and their interaction with dementia severity among institutionalized older people with dementia.

Methods: 352 long-term care residents aged 65 years or over with dementia participated in this cross-sectional study. Read More

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October 2019

Role of Structural Morphology of Commodity Polymers in Microplastics and Nanoplastics Formation: Fragmentation, Effects and Associated Toxicity in the Aquatic Environment.

Rev Environ Contam Toxicol 2021 Oct 16. Epub 2021 Oct 16.

Department of Chemistry, Trent University, Peterborough, ON, Canada.

With the continued growth in plastic production, its ubiquitous use and insufficient waste management and disposal, the increased levels of plastics in the environment have led to growing ecological concerns. The breakdown of these plastic macromolecules to smaller micro and nanosized particles and their detection in the aerial, aquatic, marine and terrestrial environments has been reviewed extensively, especially for thermoplastics. However, the formation of micro and nanoplastics has typically been explained as a physical abrasion process, largely overlooking the underlying chemical structure-morphology correlations to the degradation mechanisms of the plastics. Read More

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October 2021

A policy analysis of nurse practitioner scope of practice in Massachusetts.

J Am Assoc Nurse Pract 2021 Oct 13. Epub 2021 Oct 13.

University of Massachusetts Boston, Boston, MA Department of Nursing, University of Massachusetts Boston, Boston, MA UMass Medical School, Tan Chingfen Graduate School of Nursing, Boston, MA.

Abstract: Nurse practitioner (NP) practice has evolved since inception of the role in 1965. Educational requirements have been standardized requiring a master's degree, yet variation in NPs scope of practice exists across the United States. As the population ages and more Americans have health insurance coverage, the demand for health care continues to increase. Read More

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October 2021

A ladder that matters: Conceptual development of a clinical ladder program for nurse practitioners and physician assistants.

J Am Assoc Nurse Pract 2021 Oct 13. Epub 2021 Oct 13.

Department of Surgery and the Department of Clinical Education, Johns Hopkins All Children's Hospital, St. Petersburg, Florida College of Nursing, University of Florida, Gainesville, Florida.

Abstract: Clinical ladders are professional enhancement models that encourage and reward participants for continued professional engagement and leadership development. They have the potential to affect patient care through improved provider retention, advanced and refined clinical skills, and increased engagement. Recent literature has demonstrated development and implementation of clinical ladder models for nurse practitioners (NPs) in the acute care setting. Read More

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October 2021

Dissolution and Retention Process of CeO Nanoparticles in Soil with Dynamic Redox Conditions.

Environ Sci Technol 2021 Oct 15. Epub 2021 Oct 15.

Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

The time-course association of soil physicochemical properties and fate of CeO nanoparticles (NPs) is not well understood. This study for the first time investigated the dissolution and retention of CeO NPs (<25 nm) during soil short-term (6 h) and long-term (30 d) aging processes with dynamic redox conditions. Under the additional reductant-induced initial reductive condition, theoretically, up to 220‰ of Ce(IV) was temporarily reductively dissolved within 10 min, accompanied by a slow retention process (180 min) of Ce species in soil solutions. Read More

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October 2021

Promoting Electrocatalytic Oxygen Evolution of Ultrasmall NiFe (Hydr)oxide Nanoparticles by Graphene-Support Effects.

ChemSusChem 2021 Oct 15. Epub 2021 Oct 15.

Heilongjiang University, School of Chemistry and Materials Science, No.74 Xuefu Road, Nangang District, Harbin, China, 150080, Harbin, CHINA.

Although the activity of electrocatalysts towards oxygen evolution reaction (OER) has achieved considerable improvement by modulating the intrinsic electron structure, the role of supports to OER performance, often being summed to enhancing the conductivity, is not fully explored. In this paper, a proof-of-concept study based on a series of hybrids of nickel iron (hydr)oxide nanoparticles (NiFeO NPs) and carbon-supports with different oxidation level compares the motivation of supports for OER activity. The key to implementation lies in anchoring and growing of NiFeO NPs on the various carbon-supports by the first electrostatic assembly and the succedent in-situ reduction. Read More

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October 2021

Anchoring Group Mediated Radiolabeling for Achieving Robust Nanoimaging Probes.

Small 2021 Oct 15:e2104977. Epub 2021 Oct 15.

Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China.

Radiolabeling counts for much in the functionalization of inorganic nanoparticles (NPs) because it endows NPs with high-sensitive imaging capacities apart from providing accurate pharmacokinetic information on the labeled particles, which makes the development of relevant radiolabeling chemistry highly desirable. Herein, a novel Ligand Anchoring Group MEdiated RAdioLabeling (LAGMERAL) method is reported, in which a polyethylene glycol (PEG) ligand with a diphosphonate (DP) terminal group plays a key role. It offers possibilities to radiolabel NPs through the spare coordination sites of the DP anchoring group. Read More

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October 2021

Changes in the nanoparticle uptake and distribution caused by an intramacrophagic parasitic infection.

Nanoscale 2021 Oct 15. Epub 2021 Oct 15.

ISTUN Institute of Tropical Health, University of Navarra, Irunlarrea 1, 31008, Pamplona, Spain.

This study investigates if visceral leishmaniasis (VL) infection has some effects on the organ and cellular uptake and distribution of 100-200 nm near-infrared fluorescently labelled non-biodegradable polystyrene latex beads (PS NPs) or biodegradable polylactic--glycolic nanoparticles (PLGA NPs), as this parasitic infection produces morphological alterations in liver, spleen and bone marrow, organs highly involved in NP sequestration. The results showed that the magnitude of the effect was specific for each organ and type of NP. With the exception of the liver, the general trend was a decrease in NP organ and cellular uptake, mostly due to immune cell mobilization and/or weight organ gain, as vascular permeability was increased. Read More

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October 2021

Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration.

Proc Natl Acad Sci U S A 2021 Oct;118(42)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

Nanoparticle (NP) stiffness has been shown to significantly impact circulation time and biodistribution in anticancer drug delivery. In particular, the relationship between particle stiffness and tumor accumulation and penetration in vivo is an important phenomenon to consider in optimizing NP-mediated tumor delivery. Layer-by-layer (LbL) NPs represent a promising class of multifunctional nanoscale drug delivery carriers. Read More

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October 2021

Accessibility to SARS-CoV-2 swab test during the Covid-19 pandemic: Did age make the difference?

Health Policy 2021 Oct 6. Epub 2021 Oct 6.

Unit of Geriatrics, Department of Medicine, Biomedical Campus of Rome, via Alvaro del Portillo, 21, 00128 Rome, Italy.

Although COVID-19 affects older people more severely, health policies during the first wave of the pandemic often prioritized younger individuals. We investigated whether age had influenced the access to a diagnostic test for SARS-CoV-2 infection and whether clinical complexity and healthcare resources availability could have impacted such differences. This work included 126,741 Italian participants in the EPICOVID19 web-based survey, who reported having had contacts with known/suspected COVID-19 cases (epidemiological criterion) and/or COVID-19-like signs/symptoms (clinical criterion) from February to June 2020. Read More

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October 2021

Rational formulations of sustainable polyurethane/chitin/rosin composites reinforced with ZnO-doped-SiO nanoparticles for green packaging applications.

Food Chem 2021 Sep 20;371:131193. Epub 2021 Sep 20.

Packaging Materials Department, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, Giza, P.O. 12622, Egypt. Electronic address:

Polysaccharide chitin (CH) was modified by antimicrobial natural gum rosin as a biocompatible agent within the thermoplastic polyurethane (TPU) elastomer to form the TPU/CH composite. This blend was then mixed with different ratios of ZnO-doped-SiO nanoparticles (ZnO-SiO-NPs) to chelate chitin and to improve the properties of TPU nanocomposites. The topology and surface roughness of chitin and nanoparticles within the TPU matrix, besides their effect on the crystallinity degree of TPU were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray diffraction (XRD). Read More

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September 2021

Current trends and future prospective in nanoremediation of heavy metals contaminated soils: A way forward towards sustainable agriculture.

Ecotoxicol Environ Saf 2021 Oct 11;227:112888. Epub 2021 Oct 11.

State Key Laboratory of Rice Biology and Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects and Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province. Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China. Electronic address:

Heavy metals (HMs) contamination in agricultural soils is a major concern for global food safety and human health. Although, various in-situ and ex-situ remediation methods have been used for the treatment of HMs contaminated soils, however, they also have many drawbacks viz., capital investment, toxicity, and environmental health hazards. Read More

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October 2021

Chitosan-tripolyphosphate nanoparticles-mediated co-delivery of MTHFD1L shRNA and 5-aminolevulinic acid for combination photodynamic-gene therapy in oral cancer.

Photodiagnosis Photodyn Ther 2021 Oct 11:102581. Epub 2021 Oct 11.

Department of Stomatology, PLA Strategic Support Force Medical Center, Beijing, 100101, China;; PLA 306 Clinical College of Anhui Medical University, Hefei, 230001, China.. Electronic address:

Background: Rationally designed nanostructured materials can produce ideal drug carriers that plays an increasingly important role in cancer treatment. In comparison with conventional drug combination approaches, using co-delivery systems of multiple drugs achieves sophisticated targeting strategies and multifunctionality.

Methods: First, a nano-co-delivery of chitosan/tripolyphosphate (CS-TPP) was synthesized and characterized combining 5-aminolevulinic acid photodynamic therapy (ALA-PDT) with methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) shRNA. Read More

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October 2021

One-Step and Facile Synthesis of Poly(phenylalanine) as a Robust Drug Carrier for Enhanced Cancer Therapy.

Authors:
Yabin Meng Jun Wu

ACS Appl Mater Interfaces 2021 Oct 14. Epub 2021 Oct 14.

School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, P. R. China.

In recent decades, many poly(amino acid)s have been successfully prepared for various biomedical applications. To date, the synthesis and purification procedures used to generate these poly(amino acid)s have generally been complicated and costly. Here, a one-step synthesis strategy was developed and optimized via direct polymerization using thionyl chloride to easily and economically obtain poly(amino acid)s. Read More

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October 2021

Nudging Primary Care Providers to Expand the Opioid Use Disorder Workforce.

Health Serv Res 2021 Oct 14. Epub 2021 Oct 14.

UNC Gillings School of Global Public Health, Cecil G. Sheps Center for Health Services Research, 404 Rosenau Hall, Chapel Hill, NC.

Objective: To examine the responsiveness of primary care providers to pro-social and financial incentives to participate in a learning collaborative for the treatment of opioid use disorder.

Study Setting: We conducted a statewide experiment in North Carolina from January 2019 - November 2019 to expand access to support for providers learning to treat opioid use disorder using different types of messaging and incentives.

Study Design: We randomly assigned 15,835 primary care providers (physicians, nurse practitioners, and physician assistants) in North Carolina to receive one of four letters recruiting providers to participate in an on-line learning collaborative for providers learning to treat opioid use disorder. Read More

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October 2021

Interaction of nanoparticles with lipid films: the role of symmetry and shape anisotropy.

Phys Chem Chem Phys 2021 Oct 14. Epub 2021 Oct 14.

Department of Chemistry, University of Florence and CSGI, Florence, Italy.

The bioactivity, biological fate and cytotoxicity of nanomaterials when they come into contact with living organisms are determined by their interaction with biomacromolecules and biological barriers. In this context, the role of symmetry/shape anisotropy of both the nanomaterials and biological interfaces in their mutual interaction, is a relatively unaddressed issue. Here, we study the interaction of gold nanoparticles (NPs) of different shapes (nanospheres and nanorods) with biomimetic membranes of different morphology, flat membranes (2D symmetry, representative of the most common plasma membrane geometry), and cubic membranes (3D symmetry, representative of non-lamellar membranes, found in Nature under certain biological conditions). Read More

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October 2021

Hair analysis for New Psychoactive Substances (NPS): Still far from becoming the tool to study NPS spread in the community?

Toxicol Rep 2021 28;8:1699-1720. Epub 2021 Sep 28.

Department of Forensic Medicine and Toxicology, Faculty of Medicine School of Health Sciences, University of Ioannina, University Campus, 45110 Ioannina, Greece.

In this review article, we performed an overview of extraction and chromatographic analysis methods of NPS in hair from 2007 to 2021, evaluating the limit of detection (LOD), limit of quantification (LOQ), limit of reporting (LOR), and limit of identification (LOI) values reported for each NPS. Our review aimed to highlight the limitations of modern hair analytical techniques, and the prerequisites for the proper evaluation and use of analytical results in relation to the objectives of NPS hair analysis. In the selected studies the detection of a total of 280 NPS was reported. Read More

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September 2021

Polyamino acid calcified nanohybrids induce immunogenic cell death for augmented chemotherapy and chemo-photodynamic synergistic therapy.

Theranostics 2021 21;11(19):9652-9666. Epub 2021 Sep 21.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing 400715, P. R. China.

Monotherapy for cancer treatment is limited by unstable efficacy and uncontrollable toxic side effects, while the multifunctional nanoplatform with complex preparation process cannot avoid the potential toxicity of each functional component. We exploited tumor-specific activated polyamino acid calcified nanoparticles (CHC NPs) as new-type oxidative stress amplification of anticancer drugs building a safe and biodegradable multifunctional nanoplatform. Giving priority to chemotherapy, and synergizing chemodynamic therapy (CDT) with photodynamic therapy (PDT), this strategy was to achieve enhanced chemotherapy, simultaneously inducing immunogenic cell death and inhibiting tumor cell invasion. Read More

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September 2021

Ultrasound (US)-activated redox dyshomeostasis therapy reinforced by immunogenic cell death (ICD) through a mitochondrial targeting liposomal nanosystem.

Theranostics 2021 13;11(19):9470-9491. Epub 2021 Sep 13.

State Key Laboratory of Silkworm Genome Biology, School of Materials and Energy, Southwest University, Chongqing 400715, China.

An imbalance in redox homeostasis consistently inhibits tumor cell proliferation and further causes tumor regression. Thus, synchronous glutaminolysis inhibition and intracellular reactive oxygen (ROS) accumulation cause severe redox dyshomeostasis, which may potentially become a new therapeutic strategy to effectively combat cancer. Mitochondrial-targeting liposomal nanoparticles (abbreviated MLipRIR NPs) are synthesized by the encapsulation of R162 (inhibitor of glutamate dehydrogenase 1 [GDH1]) and IR780 (a hydrophobic sonosensitizer) within the lipid bilayer, which are exploited for ultrasound (US)-activated tumor dyshomeostasis therapy reinforced by immunogenic cell death (ICD). Read More

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September 2021

Shining light on chiral inorganic nanomaterials for biological issues.

Theranostics 2021 7;11(19):9262-9295. Epub 2021 Sep 7.

Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, China.

The rapid development of chiral inorganic nanostructures has greatly expanded from intrinsically chiral nanoparticles to more sophisticated assemblies made by organics, metals, semiconductors, and their hybrids. Among them, lots of studies concerning on hybrid complex of chiral molecules with achiral nanoparticles (NPs) and superstructures with chiral configurations were accordingly conducted due to the great advances such as highly enhanced biocompatibility with low cytotoxicity and enhanced penetration and retention capability, programmable surface functionality with engineerable building blocks, and more importantly tunable chirality in a controlled manner, leading to revolutionary designs of new biomaterials for synergistic cancer therapy, control of enantiomeric enzymatic reactions, integration of metabolism and pathology bio-to nano or structural chirality. Herein, in this review our objective is to emphasize current research state and clinical applications of chiral nanomaterials in biological systems with special attentions to chiral metal- or semiconductor-based nanostructures in terms of the basic synthesis, related circular dichroism effects at optical frequencies, mechanisms of induced optical chirality and their performances in biomedical applications such as phototherapy, bio-imaging, neurodegenerative diseases, gene editing, cellular activity and sensing of biomarkers so as to provide insights into this fascinating field for peer researchers. Read More

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September 2021

Silicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy.

Theranostics 2021 3;11(19):9234-9242. Epub 2021 Sep 3.

Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China.

Sonodynamic therapy (SDT) triggered by ultrasound (US) can overcome pivotal limitations of photo-therapy owing to its high depth-penetration and low phototoxicity. However, there is still a need to develop more efficient sonosensitizes to enhance the therapy efficiency. In this study, Pt nanoparticles (Pt NPs) are reduced on silicon nanowires (SiNWs) by reduction to prepare Si-Pt nanocomposites (Si-Pt NCs). Read More

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September 2021

Analysis of cytotoxicity and genotoxicity in a short-term dependent manner induced by a new titanium dioxide nanoparticle in murine fibroblast cells.

Toxicol Mech Methods 2021 Oct 13:1-32. Epub 2021 Oct 13.

Morphology and Pathology Department, Federal University of São Carlos, São Carlos, Brazil.

The extensive use of titanium dioxide nanoparticles (TiO NPs) in cosmetics, food, personal care products, and industries brought concerns about their possible harmful effects. Nowadays it has become important to assess TiO NPs toxic effects as a way to understand their primary risks. In the cellular environment, after cell uptake, TiO NPs were described to induce reactive oxygen species (ROS) production, unbalance oxidative state, and activate apoptosis in several cell lines. Read More

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October 2021

Bacteria-Targeting Chitosan/Carbon Dots Nanocomposite with Membrane Disruptive Properties Improve Eradication Rate of .

J Biomater Sci Polym Ed 2021 Oct 13:1-19. Epub 2021 Oct 13.

College of Marine Life Science, Ocean University Of China, Qingdao, P.R. China.

We designed a bacteria-targeting and membrane disrupting nanocomposite for successful antibiotic treatment of () infections in the present study. The antibacterial nanocomposite was prepared from thiolated-Ureido-Chitosan (Cys-U-CS) and anionic poly (malic acid) (PMLA) electrostatic interaction decorated with dual functional ammonium citrate carbon quantum dots (CDs). Cys-U-CS serves as a targeting building block for attaching antibacterial nanocomposite onto bacterial cell surface through Urel-mediated protein channel. Read More

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October 2021