6,660 results match your criteria novel topical


Photodynamic Therapy of Vitiligo: A Pilot Study.

Photodiagnosis Photodyn Ther 2021 Jul 25:102439. Epub 2021 Jul 25.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shohada-e Tajrish Hospital, Shahrdari St, 1989934148, Tehran, Iran; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.. Electronic address:

Back Ground: Vitiligo is an acquired autoimmune skin disorder with depigmented macules and patches. There are several possible treatments for vitiligo, none of which could be considered as a definitive cure. Photodynamic therapy (PDT) is a novel treatment with controversial outcomes in vitiligo patients. Read More

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Changes in tear protein profile in dogs with keratoconjunctivitis sicca following topical treatment using cyclosporine A.

Vet World 2021 Jun 30;14(6):1711-1717. Epub 2021 Jun 30.

Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.

Background And Aim: Keratoconjunctivitis sicca (KCS) is a chronic inflammatory ocular disease that occurs in many dog breeds worldwide. This study aimed to investigate the tear protein pattern of healthy dogs, KCS dogs, and KCS dogs after treatment with cyclosporine A (CsA).

Materials And Methods: Twenty-eight dogs of any breed were enrolled in the study. Read More

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Local administration of ReveromycinA ointment suppressed alveolar bone loss in mice.

J Pharmacol Sci 2021 Sep 27;147(1):40-47. Epub 2021 May 27.

Department of Orthodontics, School of Dentistry, Aichi Gakuin University, 2-11 Suemori-Dori, Chikusa-ku, Nagoya 464-8651, Aichi, Japan. Electronic address:

ReveromycinA (RMA) was developed and is a unique agent for inhibiting osteoclast activity. In a previous study, we experimentally induced periodontal disease in a high-turnover osteoporosis osteoprotegerin-knockout mice (OPG KO) model and found that intraperitoneal administration of RMA inhibited alveolar bone resorption. We prepared a novel RMA-containing ointment for topical non-invasive administration in the oral cavity, in preparation for possible future clinical application. Read More

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September 2021

Exploiting dentine matrix proteins in cell-free approaches for periradicular tissue engineering.

Tissue Eng Part B Rev 2021 Jul 26. Epub 2021 Jul 26.

University of Birmingham College of Medical and Dental Sciences, 150183, School of Dentistry, Institute of Clinical Sciences, 5 Mill Pool Way, Edgbaston, Birmingham, Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland, B5 7EG.

The recent discovery of mesenchymal stem cells within periapical lesions (PL-MSC) has presented novel opportunities for managing periradicular diseases in adult teeth by way of enhancing tissue regeneration. This discovery coincides with the current paradigm shift towards biologically driven treatment strategies in endodontics, which have typically been reserved for non-vital immature permanent teeth. One such approach that shows promise is utilising local endogenous non-collagenous dentine extracellular matrix components (dECM) to recruit and upregulate the intrinsic regenerative capacity of PL-MSCs in situ. Read More

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Resolution of a neurotrophic keratopathy associated hypopyon with cenegermin.

Am J Ophthalmol Case Rep 2021 Sep 23;23:101113. Epub 2021 May 23.

Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: We present a novel case of a neurotrophic keratopathy associated inflammatory hypopyon that resolved after initiation of therapy with cenegermin (Oxervate; Dompe, Milan, Italy), a recombinant human nerve growth factor (rhNGF). This finding illustrates the potential of cenegermin in advanced inflammatory neurotrophic disease.

Observations: A 60-year-old female with a history of herpes zoster keratitis was evaluated in our clinic for stage 2 neurotrophic keratopathy. Read More

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September 2021

Super absorbent chitosan-based hydrogel sponges as carriers for caspofungin antifungal drug.

Int J Pharm 2021 Jul 22:120925. Epub 2021 Jul 22.

Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki. Electronic address:

Novel chitosan copolymers (CS-g-SBMA) grafted with [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) in various molar ratio 1.5:1, 5:1, 11.5:1 and 20:1, were synthesized in the present study. Read More

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Nanosponge Approach -A Plethora Of Opportunities As A Promising Nanocarrier For Novel Drug Delivery.

Recent Pat Nanotechnol 2021 Jul 20. Epub 2021 Jul 20.

Babaria Institute of Pharmacy, BITS Edu Campus, Vadodara, Gujarat, India.

Background: Nanotechnology is the need of the hour! The design of nanotechnology aided carriers as a tool for the delivery of low solubility molecules offers a potential platform to overcome the issues of current clinical treatment and achieve good targeted release and bioaccessibility.

Objective: Nanosponges (NS) are encapsulating type of nanocarriers capable of carrying both lipophilic and hydrophilic substances. They are synthesized by mixing a solution of polyester which is biodegradable with cross linkers. Read More

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Fabrication of amphotericin B-loaded electrospun core-shell nanofibers as a novel dressing for superficial mycoses and cutaneous leishmaniasis.

Int J Pharm 2021 Jul 20:120911. Epub 2021 Jul 20.

School of Mediciane, Shiraz University of Medical Sciences, Shiraz, Iran; Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Amphotericin B (AmB) is an antifungal and antiparasitic agent that is the main drug used for the treatment of mycoses infections and leishmaniasis. However, its high toxicity and side effects are the main difficulties attributed to its application. In this study, to minimize its harmful effects, AmB-loaded core-shell nanofibers were fabricated, using polyvinyl alcohol, chitosan, and AmB as the core, and polyethylene oxide and gelatin as the shell-forming components. Read More

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Polymeric Nanoparticles for Transdermal Delivery of Polyphenols.

Curr Drug Deliv 2021 Jul 20. Epub 2021 Jul 20.

School of Pharmacy and Health Professionals Creighton University, Omaha, NE 68178, United States.

Polyphenols comprises of a large group of naturally occurring plant secondary metabolites having various nutritional and health benefits. They are safe and are found abundantly in the diet. Current research on polyphenols focuses on their mechanism and their benefits on the human health. Read More

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ASSESSMENT OF RECURRENT ANAL FISTULAS TREATMENT WITH PLATELET-RICH PLASMA.

Arq Gastroenterol 2021 Jul 16. Epub 2021 Jul 16.

Poznan University of Medical Sciences, Department of General, Endocrinological Surgery and Gastroenterological Oncology, Poznań, Poland.

Background: Surgical treatment of recurrent anal fistulas can lead to numerous complications, including fecal incontinence. Therefore, sphincter preserving techniques are gaining more popularity.

Objective: The aim of the study was to assess effectiveness of platelet-rich plasma (PRP) therapy in the patients with recurrent cryptoglandular anal fistulas. Read More

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Development of Novel Biopolymer-Based Nanoparticles Loaded Cream for Potential Treatment of Topical Fungal Infections.

Drug Dev Ind Pharm 2021 Jul 19:1-26. Epub 2021 Jul 19.

Department of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

Objective: Biodegradable polymers are extensively used due to their efficient safety profiles. The aim of the current study was to fabricate, evaluate and characterize biodegradable, biocompatible fluconazole (FLZ) loaded chitosan (CHS) chondroitin sulphate (CS) nanoparticles (NPs) for topical delivery. Polymers utilized in the formulation not only served as a carrier system but also aided in fighting with complex etiology of the disease due to their innate antifungal activities. Read More

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Ocular mucous membrane pemphigoid: novel treatment strategies.

Curr Opin Allergy Clin Immunol 2021 Jul 15. Epub 2021 Jul 15.

Moorfields Eye Hospital NHS Foundation Trust Institute of Ophthalmology, University College London, London, UK.

Purpose Of Review: To describe current treatments of ocular mucous membrane pemphigoid (OMMP), including conventional systemic immunosuppression (CIST) and novel biologic agents.

Recent Findings: CIST remains the main stay therapy for the management of OMMP. The choice of agents is tailored to disease severity - mild disease is treated with dapsone, whereas moderately severe cases are often treated with mycophenolate mofetil or sulfa-based drugs and severe cases are treated with cyclophosphamide. Read More

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Pharmaceutical nanocrystals: A promising approach for improved topical drug delivery.

Drug Discov Today 2021 Jul 13. Epub 2021 Jul 13.

Solid State Pharmaceutics Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, Mohali, Punjab 160 062, India. Electronic address:

The barrier function of skin and the non-optimal physicochemical properties of drugs present challenges to the skin penetration of many drugs, motivating the development of novel drug-delivery systems. Recently, nanocrystal-based formulations have been investigated for topical drug delivery and have demonstrated improved skin penetration. This review highlights barriers in skin penetration, current techniques to improve topical delivery and the application of nanocrystals to conquer obstacles for topical delivery. Read More

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Perspectives for immunotherapy in noninfectious immune mediated uveitis.

Expert Rev Clin Immunol 2021 Jul 26:1-13. Epub 2021 Jul 26.

Department of Ophthalmology, DHU ViewRestore, Sorbonne Université, Paris, France.

: Noninfectious uveitis (NIU) is one of the leading causes of blindness worldwide. In adult patients, anterior NIU is usually managed with topical corticosteroids. In intermediate, posterior uveitis. Read More

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The influence of a biofilm-dispersing wound gel on the wound healing process.

Int Wound J 2021 Jul 15. Epub 2021 Jul 15.

Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.

Topical antimicrobials that reduce the bacterial bioburden within a chronically-infected wound may have helpful or harmful effects on the healing process. We used murine models of full-thickness skin wounds to determine the effects of the novel biofilm-dispersing wound gel (BDWG) and its gel base on the healing of uninfected wounds. The rate of wound closure over 19 days was comparable among the BDWG-treated (BT) wounds and the controls. Read More

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High-Resolution Quantitative Mapping of Macaque Cervicovaginal Epithelial Thickness: Implications for Mucosal Vaccine Delivery.

Front Immunol 2021 28;12:660524. Epub 2021 Jun 28.

Southwest National Primate Research Center, San Antonio, TX, United States.

Vaginal mucosal surfaces naturally offer some protection against sexually transmitted infections (STIs) including Human Immunodeficiency Virus-1, however topical preventative medications or vaccine designed to boost local immune responses can further enhance this protection. We previously developed a novel mucosal vaccine strategy using viral vectors integrated into mouse dermal epithelium to induce virus-specific humoral and cellular immune responses at the site of exposure. Since vaccine integration occurs at the site of cell replication (basal layer 100-400 micrometers below the surface), temporal epithelial thinning during vaccine application, confirmed with high resolution imaging, is desirable. Read More

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LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas.

Am J Physiol Cell Physiol 2021 Jul 14. Epub 2021 Jul 14.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China.

Leucine-rich α-2-glycoprotein-1 (LRG1) is a novel pro-fibrotic factor that modulates Transforming Growth Factor-β (TGF -β) signaling. However, its role in the corneal fibrotic response remains unknown. In the present study, we found that the LRG1 level increased in alkali-burned mouse corneas. Read More

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A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection.

Front Microbiol 2021 25;12:685698. Epub 2021 Jun 25.

Research Unit of Clinical Microbiology, University of Southern Denmark and Odense University Hospital, Odense, Denmark.

Catheter-associated urinary tract infection (CAUTI) is a frequent community-acquired infection and the most common nosocomial infection. Here, we developed a novel antimicrobial catheter concept that utilizes a silicone-based interpenetrating polymer network (IPN) as balloon material to facilitate a topical slow-release prophylaxis of antibacterial agents across the balloon to the urinary bladder. The balloon material was achieved by modifying low shore hardness silicone tubes with a hydrogel interpenetrating polymer in supercritical CO using the sequential method. Read More

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Efficacy and Safety of a Thrombin-Containing Collagen-based Haemostatic Agent in Spinal Surgery: A Randomized Clinical Trial.

World Neurosurg 2021 Jul 8. Epub 2021 Jul 8.

Department of Neurosurgery, Spine and Spinal Cord Institute, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea. Electronic address:

Objective: When common haemostatic methods, such as suturing, cautery, and compression, fail to arrest bleeding during surgery, various local haemostatic agents are used. We aimed to evaluate the haemostatic efficacy and safety of CollaStat® (Dalim Tissen Co. Ltd. Read More

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Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea.

J Antimicrob Chemother 2021 Jul 10. Epub 2021 Jul 10.

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Background: Novel therapeutic strategies are urgently needed for Neisseria gonorrhoeae, given its increasing antimicrobial resistance. Treatment of oropharyngeal N. gonorrhoeae infections has proven particularly challenging, with most reported treatment failures of the first-line drug ceftriaxone occurring at this site and lower cure rates in recent trials of new antibiotics reported for oropharyngeal infections compared with other sites of infection. Read More

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Clascoterone: a new topical anti-androgen for acne management.

Int J Dermatol 2021 Jul 9. Epub 2021 Jul 9.

Department of Dermatology, Malabar Medical College Hospital and Research Centre, Kozhikode, India.

Clascoterone is an androgen receptor inhibitor which has been approved by the United States Food and Drug Administration for the topical treatment of acne vulgaris in patients 12 years of age and older. It competes with androgens, especially dihydrotestosterone, for androgen-receptor binding and limits their binding, thus inhibiting downstream signaling of pathways involved in the pathogenesis of acne. It inhibits androgen receptor-regulated gene transcription, and antagonizes lipid and inflammatory cytokine production in a dose-dependent manner in human primary sebocytes. Read More

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Hyaluronic-Coated Albumin Nanoparticles for the Non-Invasive Delivery of Apatinib in Diabetic Retinopathy.

Int J Nanomedicine 2021 2;16:4481-4494. Epub 2021 Jul 2.

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Purpose: Apatinib (Apa) is a novel anti-vascular endothelial growth factor with the potential to treat diabetic retinopathy (DR); a serious condition leading to visual impairment and blindness. DR treatment relies on invasive techniques associated with various complications. Investigating topical routes for Apa delivery to the posterior eye segment is thus promising but also challenging due to ocular barriers. Read More

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Impact of repeated remote ischemic conditioning on diabetic foot ulcers: A proof-of-concept study.

Wound Repair Regen 2021 Jul 8. Epub 2021 Jul 8.

LifeCuff Technologies, Inc., Philadelphia, Pennsylvania, USA.

Patients with a diabetic foot ulcer (DFU) suffer disabilities and are at increased risk for lower extremity amputation. Current standard of care includes debridement, topical antibiotics, and weight off-loading-still resulting in low rates of healing. Previous small-scale research has indicated that repeated remote ischemic conditioning (rRIC) is a novel modality that delivers significantly higher DFU healing rates. Read More

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MITOCHONDRIA-TARGETED HYDROGEN SULFIDE DELIVERY MOLECULES PROTECT AGAINST UVA-INDUCED PHOTOAGING IN DERMAL FIBROBLASTS, AND IN MOUSE SKIN IN VIVO.

Antioxid Redox Signal 2021 Jul 8. Epub 2021 Jul 8.

Mahidol University Faculty of Medicine Siriraj Hospital, 65106, Pharmacology, Faculty of Medicine Siriraj Hospital, 2 Prannok, Bangkoknoi, Bangkok, Thailand, 10700;

Oxidative stress and mitochondrial dysfunction play a role in the process of skin photoaging via activation of matrix metalloproteases (MMPs) and the subsequent degradation of collagen. The activation of nuclear factor E2-related factor 2 (Nrf2), a transcription factor controlling antioxidant and cytoprotective defense systems, might offer a pharmacological approach to prevent skin photoaging. We therefore investigated might offer a pharmacological approach to prevent skin photoaging. Read More

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COVID-19 and environmental concerns: A rapid review.

Renew Sustain Energy Rev 2021 Sep 10;148:111239. Epub 2021 Jun 10.

University School of Management Studies, Guru Gobind Singh Indraprastha University, Sector 16 C, Dwarka, New Delhi, India.

COVID-19 has slowed global economic growth and consequently impacted the environment as well. Parallelly, the environment also influences the transmission of this novel coronavirus through various factors. Every nation deals with varied population density and size; air quality and pollutants; the nature of land and water, which significantly impact the transmission of coronavirus. Read More

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September 2021

Tyrosine Kinase 2 and Janus Kinase‒Signal Transducer and Activator of Transcription Signaling and Inhibition in Plaque Psoriasis.

J Am Acad Dermatol 2021 Jul 2. Epub 2021 Jul 2.

Oregon Medical Research Center, Portland, Oregon. Electronic address:

Plaque psoriasis is a common, chronic, systemic, immune-mediated inflammatory disease. The Janus kinase‒signal transducer and activator of transcription (JAK-STAT) pathway plays a major role in intracellular cytokine signaling in inflammatory processes involved in psoriasis. Although JAK1-3 inhibitors have demonstrated efficacy in patients with moderate-to-severe psoriasis, safety concerns persist and no JAK inhibitor has received regulatory approval to treat psoriasis. Read More

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[Topical and novel device-based therapies for mild hidradenitis suppurativa].

Hautarzt 2021 Aug 5;72(8):676-685. Epub 2021 Jul 5.

Klinik für Dermatologie und Venerologie, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the skin folds, which requires more outpatient treatment alternatives. Although the disease was previously treated using surgery, new treatment modalities now allow the effective treatment of mild and moderate cases in an ambulatory care setting.

Aim Of Study: Local and instrument-based therapies are presented and their efficacy and safety profiles are highlighted. Read More

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Topical Sevoflurane: A Novel Treatment for Chronic Pain Caused by Venous Stasis Ulcers.

Anesth Pain Med 2021 Feb 24;11(1):e112832. Epub 2021 Feb 24.

LSU Health Shreveport, Department of Anesthesiology, Shreveport, LA, USA.

In the US, an estimated 1 - 2% of chronic venous insufficiency (CVI) patients (of 6 - 7 million nationwide) develop at least one venous stasis ulcer (VSU) during their illness. Of these, approximately 40% develop subsequent ulcers, making VSU prognostically poor. Current management of VSU is costly, with poor prognosis, high recurrence rate, inadequate pain management, and significantly reduced quality of life (QoL). Read More

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February 2021

Biochemical and histopathological changes related to the topical application of ointment for canine pyoderma.

Vet World 2021 May 28;14(5):1354-1362. Epub 2021 May 28.

Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.

Background And Aim: Pyoderma is common in dogs, and its treatment requires a novel medication rather than antibiotic therapy. This study aimed to determine the biochemical and histopathological changes associated with the topical application of 20% and 40% ointments, compared with gentamicin 0.1% ointment, in dogs suffering from pyoderma. Read More

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The effect of cattle-administered ivermectin and fipronil on the mortality and fecundity of Anopheles arabiensis Patton.

Parasit Vectors 2021 Jul 2;14(1):349. Epub 2021 Jul 2.

Mammal Research Institute, Department of Zoology & Entomology, University of Pretoria, Pretoria, South Africa.

Background: Malaria control primarily depends on two vector control strategies: indoor residual spraying (IRS) and long-lasting insecticide-treated nets (LLINs). Both IRS and LLIN target indoor-biting mosquitoes. However, some of the most important malaria vectors have developed resistance against the chemical compounds used in IRS and LLINs. Read More

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