8,746 results match your criteria novel substance


Mephentermine Misuse: An Impending Crisis among Sportspersons.

J Psychoactive Drugs 2021 Jun 14:1-3. Epub 2021 Jun 14.

Institute of Mental Health, Pt. B.D. Sharma University of Health Sciences, Rohtak, India.

Mephentermine is a sympathomimetic amine, frequently used as a vasopressor. It is structurally comparable to amphetamines, and World Anti-Doping Agency has prohibited its use as a performance-enhancing drug. However, its illegal consumption by several sportspersons and those appearing for physical endurance tests is a growing concern for health-care professionals. Read More

View Article and Full-Text PDF

Identification of novel benzothiopyranones with ester and amide motifs derived from active metabolite as promising leads against Mycobacterium tuberculosis.

Eur J Med Chem 2021 Jun 5;222:113603. Epub 2021 Jun 5.

Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, 97 Ma Chang Street, Beijing, 101149, PR China. Electronic address:

We reported three distinct series of novel benzothiopyranones, derived from an active metabolite (M-1) of anti-TB agent 6b. These small molecules were evaluated for their biological activities against a range of Mycobacterium tuberculosis (M. tuberculosis) strains. Read More

View Article and Full-Text PDF

Time trends in the risk of HIV infection among men who have sex with men in Chiang Mai, Thailand: an observational study.

Int J STD AIDS 2021 Jun 14:9564624211021338. Epub 2021 Jun 14.

Research Institute for Health Sciences, 26682Chiang Mai University, Chiang Mai, Thailand.

A cross-sectional study on men who have sex with men (MSM) for the HIV prevention project was conducted to assess the prevalence of HIV infection-related behaviors among 551 MSM recruited in 2008-2009 and 1910 MSM in 2014-2018 for voluntary counseling and testing at a HIV clinic in Chiang Mai. Overall, the study found that the prevalence of HIV infection was significantly decreased from 12.9% (71/551) in the earlier study (2008-2009) to 8. Read More

View Article and Full-Text PDF

A One-Two-Three Multifunctional System for Enhanced Imaging and Detection of Intracellular MicroRNA and Chemogene Therapy.

ACS Appl Mater Interfaces 2021 Jun 14. Epub 2021 Jun 14.

Weifang Customs, Yuqing East Street, No.15789, High tech District, Weifang 261000, Shandong Province, China.

Simultaneous imaging, diagnosis, and therapy can offer an effective strategy for cancer treatment. However, the complex probe design, poor drug release efficiency, and multidrug resistance remain tremendous challenges to cancer treatment. Here, a novel one-two-three system is built for enhanced imaging and detection of miRNA-21 (miR-21) overexpressed in cancer cell and chemogene therapy. Read More

View Article and Full-Text PDF

Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.

Explor Med 2021 28;2:60-73. Epub 2021 Feb 28.

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA 02118, USA.

Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden. Despite their high heritability, few genetic risk loci have been identified for either opioid or cocaine dependence (OD or CD, respectively). Read More

View Article and Full-Text PDF
February 2021

Vermicomposting: A management tool to mitigate solid waste.

Saudi J Biol Sci 2021 Jun 4;28(6):3284-3293. Epub 2021 Mar 4.

Department of Botany & Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Solid waste management is a serious ecological problem in Saudi Arabia due to rapid industrialization, population growth and urbanization. Recycling and sorting are in their infancy in Saudi Arabia and huge amounts of mixed household and industrial wastes are still dumped without any pre-treatment. Solid waste management techniques such as incineration, pyrolysis and gasification have high investment costs. Read More

View Article and Full-Text PDF

Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating IGFR/AKT/NF-kB/IkB signaling.

Biomaterials 2021 Jun 4;275:120946. Epub 2021 Jun 4.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China; Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai, 200240, PR China. Electronic address:

Multi-functional nanovectors based on exosomes from cancer cell culture supernatants in vitro has been successfully utilized for tumor-specific targeting and immune escape. However, the labor-intensive purification procedures for rich-dose and high-purity homogeneous exosomes without using targeting ligands are still a challenging task. Herein, we developed a nanovector Exo-PMA/[email protected] through cloaked by urinary exosome membrane as a chemo/chemodynamic theranostic nano-platform for targeted homologous prostate cancer therapy which pertain to the abrogation of Epidermal Growth Factor Receptor (EGFR) and its downstream AKT/NF-kB/IkB signaling instead of ERK signaling cascades. Read More

View Article and Full-Text PDF

Feasibility and early experience of a novel multidisciplinary alcohol-associated liver disease clinic.

J Subst Abuse Treat 2021 Apr 9;130:108396. Epub 2021 Apr 9.

Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, United States of America.

Background: Alcohol cessation improves mortality in alcohol-associated liver disease (ALD), but access to treatment is limited. To address this gap, implementation and early feasibility and outcomes of a multidisciplinary ALD clinic are described.

Methods: The clinic comprised a hepatologist, psychiatrist, psychologist, nurse, and social worker. Read More

View Article and Full-Text PDF

Where did the specialty behavioral health workforce grow between 2011 and 2019? Evidence from census data.

J Subst Abuse Treat 2021 May 19;130:108482. Epub 2021 May 19.

Indiana University, Bloomington, IN, USA; National Bureau of Economic Research, Cambridge, MA, USA.

Importance: Given that mental health and substance use conditions are ongoing major public health problems in the United States, it is important for researchers to understand the behavioral health treatment workforce landscape and to assess whether increases in treatment capacity exist in areas with public health needs.

Objectives: This study quantified national and county-level changes in specialty behavioral health (SBH) workforce outcomes and assessed associations between these measures and age-adjusted drug mortality rate.

Design: Using a novel longitudinal dataset from the U. Read More

View Article and Full-Text PDF

Self-reported reductions in tobacco and nicotine use following medical cannabis initiation: Results from a cross-sectional survey of authorized medical cannabis patients in Canada.

J Subst Abuse Treat 2021 May 14;130:108481. Epub 2021 May 14.

Faculty of Medicine, University of British Columbia, St. Paul's Hospital 806-1081, Burrard St., Vancouver, BC, Canada; British Columbia Centre on Substance Use, 400-1045 Howe St., Vancouver, BC V6Z 2A9, Canada. Electronic address:

Background: Despite decades of campaigns aimed at reducing tobacco/nicotine (T/N) use and the development of many different T/N reduction and cessation strategies, the impacts on international public health remain significant. Some studies have found an association between medical and non-medical cannabis use and T/N use, although the evidence on whether cannabis/cannabinoids increase or decrease the odds of reducing or ceasing T/N use remain contradictory. This paper explores the self-reported use of cannabis and associated changes in T/N use among a Canadian medical cannabis patient population. Read More

View Article and Full-Text PDF

Host nutrition-based approach for biotechnological production of the antifungal cyclic lipopeptide jagaricin.

J Biotechnol 2021 Jun 9;336:1-9. Epub 2021 Jun 9.

Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Adolf-Reichwein-Str. 23, 07745, Jena, Germany. Electronic address:

In today's, society multi-resistant pathogens have become an emerging threat, which makes the search for novel anti-infectives more urgent than ever. A promising class of substances are cyclic lipopeptides like the antifungal jagaricin. Jagaricin is formed by the bacterial mushroom pathogen Janthinobacterium agaricidamnosum. Read More

View Article and Full-Text PDF

Discovery and Validation of a Novel Target of Molluscicides against Oncomelania hupensis, the Intermediate Host of Schistosoma japonicum.

Acta Trop 2021 Jun 9:106003. Epub 2021 Jun 9.

School of Pharmaceutical Science, Jiangnan University,Wuxi, Jiangsu,214122, China. Electronic address:

In this study, 196 strains of actinomycetes isolated from marshland soil samples were tested for molluscicidal activity against Oncomelania hupensis. Five strains demonstrated molluscicidal activity, of which the molluscicidal efficiency of Actinomycetes strain A183 was the maximum. After the fermentation supernatant of actinomycetes A183 was extracted with ethyl acetate (EWEA), the LC50 of the EWEA after leaching for 48 h and 72 h were 0. Read More

View Article and Full-Text PDF

Design, synthesis, and biological evaluation of 1-methyl-1H-pyrazolo[4,3-b]pyridine derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction.

Bioorg Chem 2021 May 30;114:105034. Epub 2021 May 30.

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address:

Blockade of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signalling pathway is a promising tumour immunotherapeutic approach, and small molecule drugs have more advantages than monoclonal antibody macromolecules in clinical applications. Therefore, a series of 1-methyl-1H-pyrazolo[4,3-b]pyridine derivatives as PD-1/PD-L1 interaction novel small-molecule inhibitors were designed employing a ring fusion strategy. The inhibitory activity of compounds was evaluated by the HTRF assay, among which D38 was identified as the most potent PD-1/PD-L1 interaction inhibitor with an IC value of 9. Read More

View Article and Full-Text PDF

Rb[Li5Si2O7] - A Latecomer in the Family of Alkali Lithosilicates Hiding a Green-Emitting Lithosilicate.

Chemistry 2021 Jun 10. Epub 2021 Jun 10.

Universitat Innsbruck, Institut für Allgemeine, Anorganische und Theoretische Chemie, Innrain 80-82, 6020, Innsbruck, AUSTRIA.

In order to expand the field of alkali lithosilicates, a new representative of the substance class with a previously unknown structure type was found based on solid-state synthesis. The novel compound with the sum formula Rb[Li 5 Si 2 O 7 ] crystallizes in the orthorhombic space group Pbcm (no. 57) with a = 7. Read More

View Article and Full-Text PDF

Genetically influenced externalizing and internalizing risk pathways as novel prevention targets.

Psychol Addict Behav 2021 Jun 10. Epub 2021 Jun 10.

Department of Psychology.

Risky substance use among college students is widespread, and associated with numerous adverse consequences. Current interventions focus primarily on students' current substance use; we hypothesize that shifting focus from to is a complementary approach that may improve effectiveness of prevention/intervention programming. This approach aligns with the personalized medicine movement, which aims to harness knowledge about underlying etiological factors to provide individuals with specific information about their unique risk profiles and personalized recommendations, to motivate and enable individuals to better self-regulate their health. Read More

View Article and Full-Text PDF

Simultaneous determination of five diuretic drugs using quantitative analysis of multiple components by a single marker.

BMC Chem 2021 Jun 9;15(1):39. Epub 2021 Jun 9.

School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shanxi, People's Republic of China.

Background: Loop diuretics are commonly used in clinical practice to manage high fluid loads and to control fluid balance. In this paper, a novel quantitative analysis method for multiple components with a single marker (QAMS) was developed for the simultaneous determination of 5 diuretic drugs furosemide, torasemide, azosemide, etacrynic acid, and bumetanide, by HPLC. Qualitative analysis was performed using relative retention time and ultraviolet (UV) spectral similarity as the double indicator. Read More

View Article and Full-Text PDF

Training the Addiction Treatment Workforce in HIV Endemic Regions: An Overview of the South Africa HIV Addiction Technology Transfer Center Initiative.

Train Educ Prof Psychol 2020 Feb;14(1):78-85

Brown University.

The South Africa HIV Addiction Technology Transfer Center (ATTC) was formed in 2017 to train health professionals and nonprofessional lay workers in evidence-based addiction interventions as a strategy for addressing the country's HIV epidemic. This article describes the Year 1 activities of the South Africa HIV ATTC including an initial needs assessment with high-level stakeholders, an advisory board meeting with South African government and nongovernment agencies, a learning exchange with other international ATTCs, and the identification of Screening, Brief Intervention, and Referral to Treatment (SBIRT) as a focal intervention for widespread training. The article details the culmination of Year 1 activities via a national forum on SBIRT and presents posttraining satisfaction data across SBIRT events. Read More

View Article and Full-Text PDF
February 2020

Psilocybin: A brief overview for psychiatric mental health nurse practitioners.

Authors:
Dina Fradkin

Perspect Psychiatr Care 2021 Jun 8. Epub 2021 Jun 8.

Department of Health and Community Systems (Class of May 2021), School of Nursing, PMHNP Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

The use of psychedelics, such as psilocybin, has emerged in recent literature as a novel therapeutic treatment for various psychiatric disorders, including substance use, depression, and anxiety. While international and domestic trials are currently underway, there is data demonstrating both the relative safety and potential efficacy of psilocybin. Psychiatric mental health nurse practitioners are essential mental health providers that may be at the forefront of delivering these new treatment modalities. Read More

View Article and Full-Text PDF

Low-barrier buprenorphine during the COVID-19 pandemic: A rapid transition to on-demand telemedicine with wide-ranging effects.

J Subst Abuse Treat 2021 Apr 29;131:108444. Epub 2021 Apr 29.

Department of Medicine, Division of General Internal Medicine and Geriatrics, Section of Addiction Medicine, Oregon Health and Science University, Portland, OR, USA.

Low barrier addiction clinics increase access to medications to treat substance use disorders, while emphasizing harm reduction. The Harm Reduction and BRidges to Care (HRBR) Clinic is an on demand, low barrier addiction clinic that opened in October 2019. In the first three months of operation (November through January 2020), HRBR saw steadily increasing numbers of patients. Read More

View Article and Full-Text PDF

Determination of specific urinary nonylphenol metabolites by online-SPE-LC-MS/MS as novel human exposure biomarkers.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 25;1177:122794. Epub 2021 May 25.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, Bochum 44789, Germany. Electronic address:

Nonylphenol (NP) is an endocrine disrupting and ecotoxic substance that has been detected in a variety of environmental matrices. It is utilized for the production of non-ionic nonylphenol ethoxylate (NPEO) detergents and other high production volume chemicals. Human biomonitoring data are scarce and mostly limited to the non-oxidized NP, which is ubiquitous in the (laboratory) environment and susceptible to external contamination. Read More

View Article and Full-Text PDF

Mental Health Symptoms Unexpectedly Increased in Students Aged 11-19 Years During the 3.5 Years After the 2016 Fort McMurray Wildfire: Findings From 9,376 Survey Responses.

Front Psychiatry 2021 20;12:676256. Epub 2021 May 20.

Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.

In Fort McMurray, Alberta, Canada, the wildfire of May 2016 forced the population of 88,000 to rapidly evacuate in a traumatic and chaotic manner. Ten percentage of the homes in the city were destroyed, and many more structures were damaged. Since youth are particularly vulnerable to negative effects of natural disasters, we examined possible long-term psychological impacts. Read More

View Article and Full-Text PDF

Recreational ketamine-related deaths notified to the National Programme on Substance Abuse Deaths, England, 1997-2019.

J Psychopharmacol 2021 Jun 5:2698811211021588. Epub 2021 Jun 5.

Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, Department of Clinical, Pharmaceutical and Biological Sciences, University of Hertfordshire, Hatfield, Hertfordshire, UK.

Background: Ketamine is a phencyclidine derivative with dissociative anaesthetic properties. Increasing numbers of individuals in England take ketamine recreationally. Information on deaths arising from such use in England is presented. Read More

View Article and Full-Text PDF

Capped polyethylene glycol esters of fatty acids as novel active principles for weed control.

Pest Manag Sci 2021 Jun 6. Epub 2021 Jun 6.

CropPromotion Advice, Schulstr. 5, 86938, Schondorf am Ammersee, Germany.

Background: Ever since the beginning of agriculture, yields have been threatened by weeds. Chemical control is far more effective and economical than other weed control methods. The frequent use of herbicides has led to environmental and human health concerns, causing the ban of several herbicides and challenges for the future of important actives like glyphosate. Read More

View Article and Full-Text PDF

N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research.

Pharmacol Rep 2021 Jun 6. Epub 2021 Jun 6.

Maj Institute of Pharmacology Polish Academy of Sciences, Department of Drug Addiction Pharmacology, Smętna 12, 31-343, Kraków, Poland.

Substance use disorder (SUD) is a chronic brain condition, with compulsive and uncontrollable drug-seeking that leads to long-lasting and harmful consequences. The factors contributing to the development of SUD, as well as its treatment settings, are not fully understood. Alterations in brain glutamate homeostasis in humans and animals implicate a key role of this neurotransmitter in SUD, while the modulation of glutamate transporters has been pointed as a new strategy to diminish the excitatory glutamatergic transmission observed after drugs of abuse. Read More

View Article and Full-Text PDF

"Etazene, safer than heroin and fentanyl": Non-fentanyl novel synthetic opioid listings on one darknet market.

Drug Alcohol Depend 2021 May 31;225:108790. Epub 2021 May 31.

Center for Interventions, Treatment, and Addictions Research, Department of Population and Public Health Sciences, Wright State University, Dayton, OH, United States.

Background: Novel synthetic opioids are fueling the overdose deaths epidemic in North America.Recently, non-fentanyl novel synthetic opioids have emerged in forensic toxicological results. Cryptomarkets have become important platforms of distribution for illicit substances. Read More

View Article and Full-Text PDF

Metabolism of oral turinabol by human brain cholesterol 24-hydroxylase CYP46A1.

J Steroid Biochem Mol Biol 2021 Jun 2:105927. Epub 2021 Jun 2.

Institute of Biochemistry, Saarland University, D-66123, Saarbruecken, Germany. Electronic address:

The human microsomal cytochrome P450 enzyme CYP46A1 plays a crucial role in cholesterol elimination from the brain. It performs a 24-hydroxylation of cholesterol and is of outstanding significance for memory and cognition. This study demonstrates the catalytic activity of human CYP46A1 towards an anabolic androgenic steroid, oral turinabol (dehydrochloromethyltestosterone, 4-chloro-17β-dihydroxy,17α-methylandrosta-1,4-dien-3-one), which is a doping substance. Read More

View Article and Full-Text PDF

Sensory and Physicochemical Quality Characteristics of Haddock Fish Cake Enriched with Atlantic Mackerel Quality of Fish Cakes.

Food Technol Biotechnol 2021 Mar;59(1):4-15

Department of Biotechnology and Food Science, Norwegian University of Science and Technology, Sem Saelands vei 6/8, 7491 Trondheim, Norway.

Research Background: It is desirable to increase the consumption of pelagic fish rich in long-chain omega-3 fatty acids. Partial replacement of traditionally used white fish species by pelagic fish will increase the content of omega-3 fatty acids, and thus improve the nutritional value but it may also affect the consumer acceptance. The aim of this study is to assess the physicochemical and sensory quality of novel fish cake prototypes prepared from haddock and mackerel mince. Read More

View Article and Full-Text PDF

Injectable Cryogels Associate with Adipose-Derived Stem Cells for Cardiac Healing After Acute Myocardial Infarctions.

J Biomed Nanotechnol 2021 May;17(5):981-988

Department of Cardiovascular Surgery, People's Liberation Army General Hospital, Beijing 100853, China.

Treatment of adipose-derived stem cells (ADSCs) provides support for novel methods of conveying baseline cell protein endothelial cells to promote acute myocardial infarction in gelatin sericin (GS) lamin-coated antioxidant systems ([email protected]). The ratio of fixity modules, pores, absorption, and inflammation in the range of ka (65 ka), 149 ±39.8 μm, 92. Read More

View Article and Full-Text PDF

Significance of Hall currents on hybrid nano-blood flow through an inclined artery having mild stenosis: Homotopy perturbation approach.

Microvasc Res 2021 Sep 1;137:104192. Epub 2021 Jun 1.

Department of Physiology, University of Gour Banga, Malda 732 103, India.

The rheological perspective of blood flow with the suspension of metallic or non-metallic nanoparticles through arteries having cardiovascular diseases is getting more attention due to momentous applications in obstructed hemodynamics, nano-hemodynamics, nano-pharmacology, blood purification system, treatment of hemodynamic ailments, etc. Motivated by the novel significance and research in this direction, a mathematical hemodynamics model is developed to mimic the hemodynamic features of blood flow under the concentration of hybrid nanoparticles through an inclined artery with mild stenosis in the existence of dominating electromagnetic field force, Hall currents, heat source, and porous substance. Copper (Cu) and copper oxide (CuO) nanoparticles are submerged into the blood to form hybrid nano-blood suspension (Cu-CuO/blood). Read More

View Article and Full-Text PDF
September 2021

Impact of COVID-19 on service delivery for an evidence-based behavioral treatment for families involved in the child welfare system.

J Subst Abuse Treat 2021 Apr 8;129:108388. Epub 2021 Apr 8.

Oregon Social Learning Center, 10 Shelton McMurphey Blvd, Eugene, OR 97401, United States of America. Electronic address:

The novel coronavirus, COVID-19, has dramatically impacted clinical service delivery, particularly substance use treatment. The Families Actively Improving Relationships (FAIR) program is an action-oriented, evidence-based behavioral treatment for opioid and methamphetamine disorders in parents involved in the child welfare (CW) system. A seven-clinician team operates out of a Medicaid-funded clinic, primarily delivering services in the community. Read More

View Article and Full-Text PDF