9,133 results match your criteria novel nutritional

Self-assembled caseinate-laponite® nanocomposites for curcumin delivery.

Food Chem 2021 Jun 9;363:130338. Epub 2021 Jun 9.

Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA. Electronic address:

In this study, novel self-assembled protein-clay nanocomposites were developed for curcumin delivery. Experimentally, curcumin was dissolved and deprotonated in sodium caseinate-laponite® (NaCas-LAP) dispersion at pH 12.0 for 30 min followed by neutralization to pH = 7. Read More

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Obesity, oxidative DNA damage and vitamin D as predictors of genomic instability in children and adolescents.

Int J Obes (Lond) 2021 Jun 22. Epub 2021 Jun 22.

School of Life Sciences, University of Westminster, London, UK.

Background/objectives: Epidemiological evidence indicates obesity in childhood and adolescence to be an independent risk factor for cancer and premature mortality in adulthood. Pathological implications from excess adiposity may begin early in life. Obesity is concurrent with a state of chronic inflammation, a well-known aetiological factor for DNA damage. Read More

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Knowledge and attitudes towards baby-led-weaning by health professionals and parents: A cross-sectional study.

Enferm Clin 2021 Jun 19. Epub 2021 Jun 19.

Escuela Universitaria de Enfermería Dr. Dacio Crespo, Universidad de Valladolid, Av. San Telmo, s/n, 34004 Palencia, Spain; Facultad de Ciencias de la Salud, Universidad Isabel I de Castilla, C/ Fernán González, 76, 09003 Burgos, Spain.

Objective: Baby-led-weaning (BLW) is a novel model of complementary feeding. Although there is little scientific evidence to support the suitability or superiority of this complementary feeding model, BLW is followed by many families today. The aim was to evaluate the knowledge and attitudes of a group of parents and health professionals regarding BLW in Spain. Read More

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A Novel Nitrogen and Carbon Metabolism Regulatory Cascade Is Implicated in Entomopathogenicity of the Fungus Metarhizium robertsii.

mSystems 2021 Jun 22:e0049921. Epub 2021 Jun 22.

MOE Key Laboratory of Biosystems Homeostasis & Protection, Institute of Microbiology, College of Life Science, Zhejiang Universitygrid.13402.34, Hangzhou, China.

The entomopathogenic fungus Metarhizium robertsii can switch among parasitic, saprophytic, and symbiotic lifestyles in response to changing nutritional conditions, which is attributed to its extremely versatile metabolism. Here, we found that the Fus3-mitogen-activated protein kinase (MAPK) and the transcription factor regulator of nutrient selection 1 (RNS1) constitute a novel fungal cascade that regulates the degradation of insect cuticular lipids, proteins, and chitin to obtain nutrients for hyphal growth and enter the insect hemocoel for subsequent colonization. On the insect cuticle, Fus3-MAPK physically contacts and phosphorylates RNS1, which facilitates the entry of RNS1 into nuclei. Read More

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Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway.

Oncogene 2021 Jun 21. Epub 2021 Jun 21.

Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, College of Biological Sciences, China Agricultural University, Beijing, China.

Metastasis is the main cause of death in breast cancer patients. The initial step of metastasis is invadopodia-mediated extracellular matrix (ECM) degradation, which enables local breast tumor cells to invade surrounding tissues. However, the molecular mechanism underlying invadopodia-mediated metastasis remains largely unknown. Read More

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[Sarcopenia and Cachexia-associated Risk in Surgery].

Zentralbl Chir 2021 Jun 21;146(3):277-282. Epub 2021 Jun 21.

Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Uniklinik RWTH Aachen, Deutschland.

Cachexia is defined as a multifactorial syndrome characterised by involuntary progressive weight loss due to a decrease in skeletal muscle mass, with or without a reduction in adipose tissue. The breakdown of muscle tissue is known as sarcopenia. This is clinically defined as loss of muscle mass and/or muscle strength, with loss of muscle strength being more important than muscle mass. Read More

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Incarceration and mortality in the United States.

SSM Popul Health 2021 Sep 1;15:100827. Epub 2021 Jun 1.

University of Massachusetts Amherst, Department of Economics, Crotty Hall, 412 North Pleasant Street, University of Massachusetts, Amherst, MA, 01002, USA.

The ongoing COVID-19 pandemic has spotlighted the role of America's overcrowded prisons as vectors of ill health, but robust analyses of the degree to which high rates of incarceration impact population-level health outcomes remain scarce. In this paper, we use county-level panel data from 2927 counties across 43 states between 1983 and 2014 and a novel instrumental variable technique to study the causal effect of penal expansion on age-standardised cause-specific and all-cause mortality rates. We find that higher rates of incarceration have substantively large effects on deaths from communicable, maternal, neonatal, and nutritional diseases in the short and medium term, whilst deaths from non-communicable disease and from all causes combined are impacted in the short, medium, and long run. Read More

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September 2021

Grass as a Novel Functional Fiber Source in Extruded Feline Diets.

Front Vet Sci 2021 4;8:668288. Epub 2021 Jun 4.

Department of Animal Sciences, University of Illinois, Urbana, IL, United States.

Although dietary fiber is not considered an essential nutrient in a complete and balanced diet for felines, it provides a substrate for fermentation by gut microbiota, thus promoting gastrointestinal health through the production of fermentative metabolites, as well as improving laxation. The aim of this research was to evaluate the novel fiber source, grass (), in comparison with traditional fiber sources and their effects on fecal quality, apparent total tract digestibility (ATTD), fecal fermentative end products, and microbiota of healthy adult cats. Four dietary treatments were evaluated, differing in dietary fiber source. Read More

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Circular RNAs as novel potential biomarkers for pancreatic cancer.

J Cancer 2021 1;12(15):4604-4615. Epub 2021 Jun 1.

Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jinshan District, Shanghai 201508, China.

Pancreatic cancer (PaCa) is the fourth leading cause of cancer-related deaths in the United States, and the vast majority of these malignancies are pancreatic ductal adenocarcinomas (PDAC), but there is still a lack of early detection biomarkers for PaCa. Unlike linear RNAs, circRNAs form covalently closed continuous loops and can act as mammalian gene regulators. They may be diagnostic or predictive biomarkers for some tumors, also be novel potential therapeutic targets in different diseases. Read More

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Anticancer potential of novel α,β-unsaturated γ-lactam derivatives targeting the PI3K/AKT signaling pathway.

Biochem Pharmacol 2021 Jun 17:114659. Epub 2021 Jun 17.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende (CS), Italy. Electronic address:

Six recently synthesized alkyl (Z)-2-(2-oxopyrrolidin-3-ylidene)acetates were evaluated for their potential as cytotoxic and anticancer agents. All compounds were tested in the ERα positive MCF-7, triple negative MDA-MB-231, and Her2 SKBR-3 breast cancer cell lines. The most lipophilic derivatives, bearing the 4-isopropylphenyl (2) or 4-tert-butylphenyl (3) group at the γ-lactam nitrogen, proved to be cytotoxic against all the cancer cell lines tested (IC values ranging from 18 to 63 μM), exerting their greatest activity in SKBR-3 cells, with IC values of 33 and 18 μM, respectively. Read More

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The effect of short-term phytase supplementation on the apparent total tract digestibility of calcium and phosphorus and the reproductive performance of late-gestation and lactating sows fed diets without mineral phosphorus.

J Anim Sci 2021 Jun 19. Epub 2021 Jun 19.

DSM (China) Animal Nutrition Research Center, Bazhou, P. R. China.

The objective of this study was to measure apparent total tract digestibility (ATTD) of Ca and P as well as reproductive performance in late-gestation and lactating sows supplemented with a novel phytase and to compare the response to phytase supplementation between late-gestation and lactating sows. Forty-five late-gestation sows and 45 lactating sows were used in experiments 1 and 2, respectively, in a completely randomized design. The sows were provided with a control diet or the control diet supplemented with 187. Read More

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Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis.

FASEB J 2021 Jul;35(7):e21688

Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.

The mitochondria-associated membrane (MAM) is a functional subdomain of the endoplasmic reticulum membrane that tethers to the mitochondrial outer membrane and is essential for cellular homeostasis. A defect in MAM is involved in various neurological diseases, including amyotrophic lateral sclerosis (ALS). Recently, we and others reported that MAM was disrupted in the models expressing several ALS-linked genes, including SOD1, SIGMAR1, VAPB, TARDBP, and FUS, suggesting that MAM disruption is deeply involved in the pathomechanism of ALS. Read More

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Novel application of nutritional biomarkers from a controlled feeding study and observational study toward dietary pattern characterization in postmenopausal women.

Am J Epidemiol 2021 Jun 18. Epub 2021 Jun 18.

Division of Public Health Sciences. Fred Hutchinson Cancer Research Center, Seattle, WA.

Dietary guidance emphasizes healthy dietary patterns, but supporting evidence comes from measurement-error prone self-reported diet. We explored whether nutritional biomarkers from the Women's Health Initiative Nutrition and Physical Activity Assessment Study Feeding Study (n=153; 2010-2014) and the WHI-NPAAS Observational Study (NPAAS-OS; n=450; 2006-2009) could identify biomarker signatures of dietary patterns for development of corresponding regression calibration equations to help mitigate measurement error. Fasting blood was assayed for a specific panel of vitamins, carotenoids and phospholipid fatty acids; 24-hour urine was assayed for nitrogen, sodium and potassium. Read More

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Efficacy of an infant formula manufactured from a specific protein hydrolysate derived from whey protein isolate and concentrate produced by Société des Produits Nestlé S.A. in reducing the risk of developing atopic dermatitis.

EFSA J 2021 Jun 16;19(6):e06603. Epub 2021 Jun 16.

The European Commission asked EFSA to evaluate the efficacy of an infant formula, containing a specific protein hydrolysate derived from whey protein isolate and concentrate and manufactured by Société des Produits Nestlé S.A., in reducing the risk of developing atopic dermatitis in infants with a family history of allergy. Read More

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Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity.

Clin Nutr 2021 May 21;40(6):3959-3972. Epub 2021 May 21.

Molecular and Cellular Endocrinology Group. Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS) and Santiago de Compostela University (USC), Spain; CIBER Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Spain.

Background: The molecular mechanisms underlying the potential health benefits of a ketogenic diet are unknown and could be mediated by epigenetic mechanisms.

Objective: To identify the changes in the obesity-related methylome that are mediated by the induced weight loss or are dependent on ketosis in subjects with obesity underwent a very-low calorie ketogenic diet (VLCKD).

Methods: Twenty-one patients with obesity (n = 12 women, 47. Read More

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A novel highly sensitive soy aptasensor for antigen β-conglycinin determination.

Anal Methods 2021 Jun 17. Epub 2021 Jun 17.

National Engineering Laboratory for Cereal Fermentation Technology (NELCF), Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China. and School of Biotechnology, Jiangnan University, 1800 Lihu Rd, Wuxi, Jiangsu 214122, China.

β-Conglycinin, composed of three subunits (α', α and β), is the main allergen of soy protein which can cause severe allergic reactions, such as diarrhea, decreased growth performance and even death. Among them, the β subunit is more stable and difficult to remove, being one of the main nutritional inhibitors, which can be used to evaluate the concentration of β-conglycinin. However, there is no effective, accurate method for its β subunit rapid detection. Read More

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Can prognostic nutritional index and systemic immune-inflammatory index predict disease severity in COVID-19?

Int J Clin Pract 2021 Jun 17:e14544. Epub 2021 Jun 17.

Sakarya University, Faculty of Medicine, Department of Infectious Diseases, Sakarya, Turkey.

Background: Prognostic nutritional index (PNI) and systemic immune-inflammatory index (SII) are inflammation-based novel markers that predict the prognosis in various patient populations. We have investigated the relationship between the disease severity in COVID-19, and the PNI and SII scores in the present study.

Materials And Methods: This cross-sectional retrospective study included 118 consecutive hospitalized patients with a confirmed diagnosis of COVID-19. Read More

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Nanotechnology: A novel tool to enhance the bioavailability of micronutrients.

Food Sci Nutr 2021 Jun 4;9(6):3354-3361. Epub 2021 May 4.

Department of Food Engineering and Technology Faculty of Engineering and Technology University of Gezira Wad Medani Sudan.

Nanotechnology has revolutionized the field of food systems, diagnostics, therapeutics, pharmaceuticals, the agriculture sector, and nutraceuticals. Nanoparticles are playing important role in giving the solution to enhance bioavailability of oral delivery of bioactive compounds. This review revealed that nanoparticles can improve the bioavailability of micronutrients, for example, vitamin B, vitamin A, folic acid, and iron. Read More

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Comparative Analysis of MicroRNA Expression Profiles Between Skeletal Muscle- and Adipose-Derived Exosomes in Pig.

Front Genet 2021 31;12:631230. Epub 2021 May 31.

Guangdong Province Key Laboratory of Animal Nutritional Regulation, College of Animal Science, South China Agricultural University, Guangzhou, China.

Skeletal muscle and adipose tissues are both involved in regulation of metabolism. In the skeletal muscle-adipose tissue crosstalk, exosomes may play an important role but the main components of exosomes are not clear. In this study, we found skeletal muscle-derived exosomes can inhibit adipogenesis of porcine preadipocytes. Read More

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The role of regulated necrosis in endocrine diseases.

Nat Rev Endocrinol 2021 Jun 16. Epub 2021 Jun 16.

Clinic of Internal Medicine III, Division of Nephrology, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.

The death of endocrine cells is involved in type 1 diabetes mellitus, autoimmunity, adrenopause and hypogonadotropism. Insights from research on basic cell death have revealed that most pathophysiologically important cell death is necrotic in nature, whereas regular metabolism is maintained by apoptosis programmes. Necrosis is defined as cell death by plasma membrane rupture, which allows the release of damage-associated molecular patterns that trigger an immune response referred to as necroinflammation. Read More

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Rehabilitation of patients after COVID-19 recovery: An experience at the Physical and Rehabilitation Medicine Institute and Lucy Montoro Rehabilitation Institute.

Clinics (Sao Paulo) 2021;76:e2804. Epub 2021 Jun 14.

Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: As patients recovering from the novel coronavirus disease 2019 (COVID-19) present with physical, respiratory, cognitive, nutritional, and swallowing-related impairments and mental health complications, their rehabilitation needs are complex. This study aimed to describe the demographic, clinical, and functional status after the discharge of COVID-19 survivors who underwent intensive multidisciplinary inpatient rehabilitation at the Physical and Rehabilitation Medicine Institute of the University of Sao Paulo Medical School General Hospital and Lucy Montoro Rehabilitation Institute. We determined the most important factors related to the length of inpatient rehabilitation treatment and present the functional outcomes. Read More

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Vegan versus meat-based pet foods: Owner-reported palatability behaviours and implications for canine and feline welfare.

PLoS One 2021 16;16(6):e0253292. Epub 2021 Jun 16.

Centre for Animal Welfare, University of Winchester, Winchester, United Kingdom.

Consumer suspicion of conventional pet foods, along with perceived health benefits of alternative diets, are fuelling development of the latter. These include raw meat diets, in vitro meat products, and diets based on novel protein sources such as terrestrial and marine plants, insects, yeast and fungi. However, some claim vegan diets may be less palatable, or may compromise animal welfare. Read More

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Diet and Exercise for FRAILty (DEFRAIL): protocol for a study to examine the effect of a novel community-based group exercise and nutritional intervention, designed to reverse frailty in older adults.

BMJ Open 2021 06 15;11(6):e042408. Epub 2021 Jun 15.

Department of Geriatric Medicine, University Hospital Waterford, Waterford, Ireland.

Introduction: Frailty refers to a multifaceted age-related loss of physiological reserve. Aside from the immediate challenges it presents, it is also associated with various adverse health outcomes. Given our ageing population, the healthcare and societal costs resulting from frailty present a significant and growing public health challenge. Read More

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Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.

ACS Infect Dis 2021 Jun 15. Epub 2021 Jun 15.

School of Public Health, Division of Infectious Diseases and Vaccinology, University of California, Berkeley, Berkeley, California 94720, United States.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has emerged as a major global health threat. The COVID-19 pandemic has resulted in over 168 million cases and 3.4 million deaths to date, while the number of cases continues to rise. Read More

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A Novel Multi-Ingredient Supplement Reduces Inflammation of the Eye and Improves Production and Quality of Tears in Humans.

Ophthalmol Ther 2021 Jun 15. Epub 2021 Jun 15.

G7 Synergon Private Limited, 537, 5th Main, 9th Cross, Sahakarnagar Post, Tatanagar, Bangalore, Karnataka, 560092, India.

Introduction: Dry eye is a multifactorial condition of the eye caused by insufficient tear production and imbalance in tear composition leading to faster evaporation of tear fluid. It is also associated with inflammation that often leads to ocular surface damage. Symptoms of dry eyes include itchiness, soreness, red eyes, a burning sensation, eye fatigue and blurred vision. Read More

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A global chromatin compaction pathway that represses germline gene expression during starvation.

J Cell Biol 2021 Sep 15;220(9). Epub 2021 Jun 15.

Molecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA.

While much is known about how transcription is controlled at individual genes, comparatively little is known about how cells regulate gene expression on a genome-wide level. Here, we identify a molecular pathway in the C. elegans germline that controls transcription globally in response to nutritional stress. Read More

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September 2021

The Athlete Food Choice Questionnaire (AFCQ): Validity and Reliability in a Sample of International High-Performance Athletes.

Med Sci Sports Exerc 2021 Jul;53(7):1537-1543

School of Health and Behavioural Sciences, University of the Sunshine Coast, Queensland, AUSTRALIA.

Purpose: The Athlete Food Choice Questionnaire (AFCQ) is a novel tool for understanding factors influencing athlete food selection and providing context to nutrition knowledge and diet quality data. Reliability, face, and content validity have been previously established during development. The aim of this study is to evaluate the AFCQ's factorial structure, reliability, and construct validity in an independent sample of international high-performance athletes. Read More

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Nutrition in acute pancreatitis.

Curr Opin Clin Nutr Metab Care 2021 Jun 14. Epub 2021 Jun 14.

Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Purpose Of Review: This review aims to discuss recent developments in different topics regarding nutrition and acute pancreatitis (AP), including oral refeeding, nutritional therapy, and implications of gut microbiota.

Recent Findings: Obesity increases the risk for severe AP and mortality. Considering the worldwide obesity rates, this finding could have major implications in the global outcomes of patients admitted with AP. Read More

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Naples Prognostic Score: A Novel Prognostic Score in Predicting Cancer-Specific Survival in Patients With Resected Esophageal Squamous Cell Carcinoma.

Front Oncol 2021 28;11:652537. Epub 2021 May 28.

Department of Thoracic Oncological Surgery, Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, China.

Background: Naples prognostic score (NPS) serves as a new prognostic index based on nutritional and inflammatory status in recent years. The aim of the current study was to explore the prognostic effect of NPS and to develop and validate a reliable nomogram based on NPS for individual cancer-specific survival (CSS) prediction in patients with resected ESCC without neoadjuvant therapy.

Methods: The clinical data for 287 (Jan. Read More

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A pH-sensitive semi-interpenetrating polymer network hydrogels constructed by konjac glucomannan and poly (γ-glutamic acid): Synthesis, characterization and swelling behavior.

Int J Biol Macromol 2021 Jun 10. Epub 2021 Jun 10.

Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China. Electronic address:

A novel pH-sensitive semi-interpenetrating polymer network (semi-IPN) hydrogel was prepared by using konjac glucomannan (KGM) and poly (γ-glutamic acid) (γ-PGA) with sodium trimetaphosphate (STMP) as the crosslinking agent. The structure of the semi-IPN hydrogels was characterized by FTIR spectra, thermogravimetric analysis (TGA), X-ray diffraction (XRD), rheological measurements, and scanning electron microscopy (SEM). The pH-sensitive effects were investigated by calculating the equilibrium swelling ratio (ESR) in buffer solutions (pH 2, 4, 6, and 8, respectively) at 37 °C. Read More

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