873,755 results match your criteria novel function

Comparison of linear and nonlinear function to describe and predict componential evolution of biomass pyrolysis vapors during condensation in a tubular indirect heat exchanger.

Bioresour Technol 2021 Jul 24;340:125654. Epub 2021 Jul 24.

Department of Thermal Science and Energy Engineering, University of Science and Technology of China, Hefei, Anhui 230026, PR. China.

A novel experimental method based on the combination of bio-oil composition inversion and function fitting was purposed and verified for describing the componential evolution curves during the liquefaction of biomass pyrolysis vapors. The evolution curves of representative condensable components were fitted by linear and Slogistic function in the short, middle and long three condensing fields. Linear function exhibited a significant effectiveness for the description and prediction of low-boiling water and furfural and the relative deviations were no more than 5% between actual values in long condenser and predictive values from the elongation of curves in short and middle condensers. Read More

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Inverted microbial community stratification and spatial-temporal stability in hypersaline anaerobic sediments from the S'Avall solar salterns.

Syst Appl Microbiol 2021 Jul 15;44(5):126231. Epub 2021 Jul 15.

Marine Microbiology Group, Department of Animal and Microbial Biodiversity, Mediterranean Institute for Advanced Studies (IMEDEA UIB-CSIC), Esporles, Spain.

The anaerobic hypersaline sediments of an ephemeral pond from the S'Avall solar salterns constituted an excellent study system because of their easy accessibility, as well as the analogy of their microbial assemblages with some known deep-sea hypersaline anaerobic brines. By means of shotgun metagenomics and 16S rRNA gene amplicon sequencing, the microbial composition of the sediment was shown to be stable in time and space. The communities were formed by prokaryote representatives with a clear inferred anaerobic metabolism, mainly related to the methane, sulfur and nitrate cycles. Read More

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Internal manipulation of perceptual representations in human flexible cognition: A computational model.

Neural Netw 2021 Jul 15;143:572-594. Epub 2021 Jul 15.

Laboratory of Computational Embodied Neuroscience, Institute of Cognitive Sciences and Technologies, National Research Council of Italy, Rome, Italy. Electronic address:

Executive functions represent a set of processes in goal-directed cognition that depend on integrated cortical-basal ganglia brain systems and form the basis of flexible human behaviour. Several computational models have been proposed for studying cognitive flexibility as a key executive function and the Wisconsin card sorting test (WCST) that represents an important neuropsychological tool to investigate it. These models clarify important aspects that underlie cognitive flexibility, particularly decision-making, motor response, and feedback-dependent learning processes. Read More

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TMEM180 contributes to SW480 human colorectal cancer cell proliferation through intra-cellular metabolic pathways.

Transl Oncol 2021 Jul 28;14(10):101186. Epub 2021 Jul 28.

Division of Developmental Therapeutics, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan; Research division, RIN Institute Inc, 2-5-10, Shintomi, Chuo-Ku, Tokyo, 104-0041, Japan; Department of Immune Medicine, National Cancer Center Research Institute, National Cancer Center, 5-1-1, Tsukiji, Chuo-Ku, Tokyo 104-0045, Japan. Electronic address:

TMEM180, a novel colon cancer-specific protein with a 12-transmembrane topology, is upregulated at low oxygen. Previously, we established a humanized monoclonal antibody against TMEM180 aimed at clinical trials. Prior to such trials, it is necessary to clarify the function of TMEM180 in cancer. Read More

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Is executive dysfunction a risk marker or consequence of psychopathology? A test of executive function as a prospective predictor and outcome of general psychopathology in the adolescent brain cognitive development study®.

Dev Cogn Neurosci 2021 Jul 22;51:100994. Epub 2021 Jul 22.

Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA; Harvard Medical School, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA.

A general psychopathology ('p') factor captures shared variation across mental disorders. One hypothesis is that poor executive function (EF) contributes to p. Although EF is related to p concurrently, it is unclear whether EF predicts or is a consequence of p. Read More

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Short carboxyl terminal parathyroid hormone peptides modulate human parathyroid hormone signaling in mouse osteoblasts.

Biochem Biophys Res Commun 2021 Jul 28;572:15-19. Epub 2021 Jul 28.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic Rochester, 200 First Street Southwest, Rochester, MN, 55905, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic Rochester, 200 First Street Southwest, Rochester, MN, 55905, USA. Electronic address:

Background: Novel human parathyroid hormone (hPTH) peptides of unknown biological activity have recently been identified in the serum of subjects with normal renal function, chronic renal failure, and end-stage renal disease through the application of liquid chromatography-high resolution mass spectrometry.

Purpose: of experiments: To determine the bioactivity of these peptides, we synthesized hPTH28-84, hPTH38-84, and hPTH45-84 peptides by solid phase peptide synthesis and tested their bioactivity in MC3T3-E1 mouse osteoblasts, either individually or together with the native hormone, hPTH1-84, by assessing the accumulation of 3´,5´-cyclic adenosine monophosphate (cAMP) and the induction of alkaline phosphatase activity.

Results: Increasing doses of hPTH1-84 (1-100 nM) increased the accumulation of cAMP and alkaline phosphatase activity in osteoblasts. Read More

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Identification, characterization and evaluation of novel antifungal cyclic peptides from Neobacillus drentensis.

Bioorg Chem 2021 Jul 17;115:105180. Epub 2021 Jul 17.

Organic Synthesis and Process Chemistry Department, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India; School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi 110 062, India. Electronic address:

Marine microbes secrete exopolymeric substances (EPS), which surrounds the biofilm and inhibits the fungal growth. Elucidation of the structure and function of the extracellular exopolymeric substances is of vital relevance therapeutically. The active compound responsible for bioactivity was purified and characterized using TLC, LC/MS/MS, GC/MS and FT-IR. Read More

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Strategies for Multivariate Analyses of Imaging Genetics Study in Alzheimer's disease.

Neurosci Lett 2021 Jul 28:136147. Epub 2021 Jul 28.

School of Computer Science and Technology, Hangzhou Dianzi University, Hangzhou, Zhejiang, 310018, China; Key Laboratory of Intelligent Image Analysis for Sensory and Cognitive Health, Ministry of Industry and Information Technology of China, Hangzhou, Zhejiang, 310018, China.

Alzheimer's disease (AD) is an incurable neurodegenerative disease primarily affecting the elderly population. Early diagnosis of AD is critical for the management of this disease. Imaging genetics examines the influence of genetic variants (i. Read More

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Gabra6100Q Allele Sprague-Dawley Rats Have a Higher Sensitivity to Hypnosis Induced by Isoflurane and Ethanol than the Wild Type Rats.

Neurosci Lett 2021 Jul 28:136142. Epub 2021 Jul 28.

Department of Anesthesiology, Pharmacology and Physiology, Rutgers-New Jersey Medical School, Newark, NJ, USA. Electronic address:

Background: The neurobiological mechanisms underlying how general anesthetics render a patient's unconsciousness (hypnosis) remains elusive. The role of the cerebellum in hypnosis induced by general anesthetics is unknown. Gabra6 allele Sprague-Dawley (SD) rats have a naturally occurring single nucleotide polymorphism in the GABA receptor α6 subunit gene that is expressed exclusively in cerebellum granule cells. Read More

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Targeting Executive Function for Weight Loss in Adults with Overweight or Obesity.

Physiol Behav 2021 Jul 28:113540. Epub 2021 Jul 28.

Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, San Diego, CA 92093 USA; Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, San Diego, CA 92093 USA; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Dr, San Diego, CA 92093 USA.

Obesity is associated with a multitude of negative health sequalae. Behavioral weight loss (BWL) is currently the recommended behavioral treatment for obesity; however, it is not effective for approximately half of the individuals who participate. BWL requires individuals to carry out many tasks requiring executive function (EF; i. Read More

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Embedded adaptive deep brain stimulation for cervical dystonia controlled by motor cortex theta oscillations.

Exp Neurol 2021 Jul 28:113825. Epub 2021 Jul 28.

Movement Disorders and Neuromodulation Centre, University of California San Francisco, San Francisco, CA, USA. Electronic address:

Dystonia is a disabling movement disorder characterized by excessive muscle contraction for which the underlying pathophysiology is incompletely understood and treatment interventions limited in efficacy. Here we utilize a novel, sensing-enabled, deep brain stimulator device, implanted in a patient with cervical dystonia, to record local field potentials from chronically implanted electrodes in the sensorimotor cortex and subthalamic nuclei bilaterally. This rechargeable device was able to record large volumes of neural data at home, in the naturalistic environment, during unconstrained activity. Read More

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Novel Prediction Models for Patients With Oral Squamous Cell Carcinoma at Different Anatomical Sites.

J Oral Maxillofac Surg 2021 Jun 22. Epub 2021 Jun 22.

Professor, Department of Orthodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China; Professor, Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China. Electronic address:

Purpose: The individualized prediction of oral cavity squamous cell carcinoma (OC-SCC) is essential and should be as comprehensive as possible. The aim of this study was to identify new risk factors and develop nomograms comparing all anatomic sites of the oral cavity.

Materials And Methods: We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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Genetic analysis and prenatal diagnosis in a Chinese with growth retardation, abnormal liver function, and microcephaly.

Mol Genet Genomic Med 2021 Jul 31:e1751. Epub 2021 Jul 31.

Precision Medical Laboratory, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, PR China.

Background: Congenital disorders of glycosylation (CDG) are a genetically heterogeneous group of disorders caused by defects in the synthesis and processing of glycoproteins. COG6-CDG is a kind of disorder caused by conserved oligomeric golgi complex 6 (COG6) deficiency. To date, only 19 patients with COG6-CDG have been reported. Read More

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Biocompatible Micron-Scale Silk Fibers Fabricated by Microfluidic Wet Spinning.

Adv Healthc Mater 2021 Jul 31:e2100898. Epub 2021 Jul 31.

Chemical Process Engineering, RWTH Aachen University, Forckenbeckstr. 51, Aachen, 52074, Germany.

For successful material deployment in tissue engineering, the material itself, its mechanical properties, and the microscopic geometry of the product are of particular interest. While silk is a widely applied protein-based tissue engineering material with strong mechanical properties, the size and shape of artificially spun silk fibers are limited by existing processes. This study adjusts a microfluidic spinneret to manufacture micron-sized wet-spun fibers with three different materials enabling diverse geometries for tissue engineering applications. Read More

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The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation.

Nucleic Acids Res 2021 Jul 31. Epub 2021 Jul 31.

Program of Hepatology, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona 31008, Spain.

Gene expression is finely and dynamically controlled through the tightly coordinated and interconnected activity of epigenetic modulators, transcription and splicing factors and post-translational modifiers. We have recently identified the splicing factor SLU7 as essential for maintaining liver cell identity and genome integrity and for securing cell division both trough transcriptional and splicing mechanisms. Now we uncover a new function of SLU7 controlling gene expression at the epigenetic level. Read More

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Investigating the spectral features of the brain meso-scale structure at rest.

Hum Brain Mapp 2021 Jul 31. Epub 2021 Jul 31.

Rehab Technologies Lab, Istituto Italiano di Tecnologia, Genova, Italy.

Recent studies provide novel insights into the meso-scale organization of the brain, highlighting the co-occurrence of different structures: classic assortative (modular), disassortative, and core-periphery. However, the spectral properties of the brain meso-scale remain mostly unexplored. To fill this knowledge gap, we investigated how the meso-scale structure is organized across the frequency domain. Read More

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Transient Transgenics: An Efficient Method to Identify Gene Regulatory Elements.

Methods Mol Biol 2021 ;2319:119-136

Department of Biology & Biochemistry, University of Houston, Houston, TX, USA.

We describe a novel, efficient method to identify cis-acting DNA sequences that drive cell-specific gene expression during development. We utilize transfer of Bacterial Artificial Chromosome (BAC) genomic DNAs, modified to contain a reporter gene, into fertilized mouse embryos and placing the injected embryos into pseudopregnant recipient females. The embryos are allowed to develop in utero for defined times after which they are collected for analysis. Read More

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January 2021

A hybrid novel SVM model for predicting CO emissions using Multiobjective Seagull Optimization.

Environ Sci Pollut Res Int 2021 Jul 30. Epub 2021 Jul 30.

Institute of Energy Infrastructure, Universiti Tenaga Nasional, Jalan IKRAM-UNITEN, 43000, Kajang, Selangor, Malaysia.

The agricultural sector is one of the most important sources of CO emissions. Thus, the current study predicted CO emissions based on data from the agricultural sectors of 25 provinces in Iran. The gross domestic product (GDP), the square of the GDP (GDP), energy use, and income inequality (Gini index) were used as the inputs. Read More

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Weighted Lindley frailty model: estimation and application to lung cancer data.

Lifetime Data Anal 2021 Jul 30. Epub 2021 Jul 30.

Institute of Mathematical and Computer Sciences, University of São Paulo, São Paulo, São Carlos, 13566-590, Brazil.

In this paper, we propose a novel frailty model for modeling unobserved heterogeneity present in survival data. Our model is derived by using a weighted Lindley distribution as the frailty distribution. The respective frailty distribution has a simple Laplace transform function which is useful to obtain marginal survival and hazard functions. Read More

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MASTL regulates EGFR signaling to impact pancreatic cancer progression.

Oncogene 2021 Jul 30. Epub 2021 Jul 30.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

Pancreatic cancer (PC) remains a major cause of cancer-related deaths primarily due to its inherent potential of therapy resistance. Checkpoint inhibitors have emerged as promising anti-cancer agents when used in combination with conventional anti-cancer therapies. Recent studies have highlighted a critical role of the Greatwall kinase (microtubule-associated serine/threonine-protein kinase-like (MASTL)) in promoting oncogenic malignancy and resistance to anti-cancer therapies; however, its role in PC remains unknown. Read More

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Characterisation of seizure induction methods in .

eNeuro 2021 Jul 30. Epub 2021 Jul 30.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PL, UK

Epilepsy is one of the most common neurological disorders. Around one third of patients do not respond to current medications. This lack of treatment indicates a need for better understanding of the underlying mechanisms and, importantly, the identification of novel targets for drug manipulation. Read More

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Learning and Representation of Hierarchical Concepts in Hippocampus and Prefrontal Cortex.

J Neurosci 2021 Jul 30. Epub 2021 Jul 30.

Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

A key aspect of conceptual knowledge is that it can be flexibly applied at different levels of abstraction, implying a hierarchical organization. It is yet unclear how this hierarchical structure is acquired and represented in the brain. Here we investigate the computations underlying the acquisition and representation of the hierarchical structure of conceptual knowledge in the hippocampal-prefrontal system of 32 human participants (22 females). Read More

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Early Clinical, Functional, and Mortality Outcomes for Heel Ulcers Treated With a Vertical Contour Calcanectomy.

J Foot Ankle Surg 2021 Jul 3. Epub 2021 Jul 3.

Attending Physician, Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington DC. Electronic address:

Heel ulcerations are common complications seen in patients suffering from chronic conditions such as diabetes mellitus, peripheral vascular disease, and in bed ridden patients. When these systemic pathologies lead to heel ulcers, an increased risk of calcaneal osteomyelitis often significantly limits the benefits of conventional therapeutic interventions and increases risk of major lower extremity amputation. The Vertical Contour Calcanectomy (VCC) is a novel surgical procedure specific for the surgical management of these complex and often recalcitrant heel ulcerations. Read More

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A case of neovagina surgical creation using the uterine cervix remnant in a patient with Mayer-Rokitansky-Küster-Hauser syndrome.

Fertil Steril 2021 Jul 27. Epub 2021 Jul 27.

Limited Liability Company "Clinika Doktora Medvedeva", Dnipro, Ukraine.

Objective: To study the efficacy of a novel approach to vaginoplasty in a patient with vaginal aplasia and a preserved cervix.

Design: We present the case of a 28-year-old patient who was referred with a history of absent menstruation and vaginal intercourse was absent as well as abnormal development of the internal genitals. The patient underwent a laparoscopic cystectomy in 2012 because of an ovarian cyst and later that year underwent laparotomic supracervical hysterectomy with bilateral salpingectomy because of severe pain caused by a hematometra in their uterine remnant. Read More

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Associations of Circulating microRNA-221 and 222 With the Severity of Coronary Artery Lesions in Acute Coronary Syndrome Patients.

Angiology 2021 Jul 30:33197211034286. Epub 2021 Jul 30.

Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.

Circulating levels of microRNA-221 and 222 (miR-221/222) in patients with coronary artery disease (CAD) are elevated, yet the relationship between circulating miR-221/222 and the severity of coronary lesions in patients with acute coronary syndrome (ACS) remains unknown. In this study, the relative expression levels of circulating miR-221/222 in patients with ACS (n = 267) and controls (n = 71) were compared by real-time fluorescence quantitative-polymerase chain reaction (RT-qPCR). The ACS group was further divided into unstable angina pectoris (UA) group (n = 191) and acute myocardial infarction (AMI) group (n = 76). Read More

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ARTS: A novel In-vivo classifier of arteriolosclerosis for the older adult brain.

Neuroimage Clin 2021 Jul 24;31:102768. Epub 2021 Jul 24.

Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Dept. of Diagnostic Radiology & Nuc Med, Rush University Medical Center, Chicago, IL, USA. Electronic address:

Brain arteriolosclerosis, one of the main pathologies of cerebral small vessel disease, is common in older adults and has been linked to lower cognitive and motor function and higher odds of dementia. In spite of its frequency and associated morbidity, arteriolosclerosis can only be diagnosed at autopsy. Therefore, the purpose of this work was to develop an in-vivo classifier of arteriolosclerosis based on brain MRI. Read More

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LC-HRMS/MS phytochemical profiling of Symphytum officinale L. and Anchusa ochroleuca M. Bieb. (Boraginaceae): Unveiling their multi-biological potential via an integrated approach.

J Pharm Biomed Anal 2021 Jul 24;204:114283. Epub 2021 Jul 24.

Biothermodynamics, TUM School of Life Sciences, Technical University of Munich, 85354, Freising, Germany. Electronic address:

This study was aimed at providing a comprehensive phytochemical characterization and multi-biological assessment of Symphytum officinale L., a medicinal plant with a noteworthy traditional use, and Anchusa ochroleuca M. Bieb. Read More

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Polymeric nanoparticle mediated inhibition of miR-21 with enhanced miR-124 expression for combinatorial glioblastoma therapy.

Biomaterials 2021 Jul 20;276:121036. Epub 2021 Jul 20.

Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan, 475004, China; Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences & School of Pharmacy, Henan University, Kaifeng, Henan, 475004, China; Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia. Electronic address:

Glioblastoma (GBM) is the most common and fatal form of malignant brain tumor. Despite intensive effort, there is still no effective GBM treatment. Therefore, novel and more effective GBM therapeutic approaches are highly desired. Read More

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Angiography-based estimation of coronary physiology: A frame is worth a thousand words.

Trends Cardiovasc Med 2021 Jul 27. Epub 2021 Jul 27.

First Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration Hospital, Athens, Greece.

Cumulative evidence has shown that coronary revascularization should be guided by functional significance of coronary lesions. Fractional flow reserve (FFR) is the gold standard for assessment of hemodynamic significance of coronary stenosis and FFR-guided percutaneous coronary intervention has improved clinical outcomes in patients with coronary artery disease. However, limitations of FFR such as increased operational time and cost, requirement of pressure wire and adenosine and technical difficulties have led to significant underutilization of the method in clinical practice. Read More

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Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis.

Cell Metab 2021 Jul 26. Epub 2021 Jul 26.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, and the Key Laboratory of Molecular Cardiovascular Science (Peking University), Ministry of Education, Beijing, China; Center of Basic Medical Research, Institute of Medical Innovation and Research, Third Hospital, Peking University, Beijing, China; Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, Peking University, Beijing, China. Electronic address:

Accumulating evidence suggests that the gut microbiota regulates obesity through metabolite-host interactions. However, the mechanisms underlying such interactions have been unclear. Here, we found that intestinal hypoxia-inducible factor 2α (HIF-2α) positively regulates gut lactate by controlling the expression of intestinal Ldha. Read More

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