15,540 results match your criteria novel formulation

Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics.

Mol Pharm 2021 Jul 22. Epub 2021 Jul 22.

Division of Internal Medicine, Universitätsspital and University of Zurich, Zurich 8091, Switzerland.

Cell-free hemoglobin (Hb) is a driver of disease progression in conditions with intravascular or localized hemolysis. Genetic and acquired anemias or emergency medical conditions such as aneurysmal subarachnoid hemorrhage involve tissue Hb exposure. Haptoglobin (Hp) captures Hb in an irreversible protein complex and prevents its pathophysiological contributions to vascular nitric oxide depletion and tissue oxidation. Read More

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Pharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity.

Drug Deliv 2021 Dec;28(1):1569-1584

Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.

To prepare glutaraldehyde-based cross-linked medium molecular weight chitosan nanoparticles encapsulated with 5-Fluorouracil (5-FU), to overcome dosing frequency as well as reducing acute oral toxicity and poor bioavailability of the drug. Medium molecular weight chitosan nanoparticles (MMWCH-NPs) were prepared by reverse micelles method based on glutaraldehyde (GA) cross-linking and optimized by the process as well as formulation variables like a various drug to polymer ratio, cross-linker volumes, varying stirring speeds (rpm), different time of rotation/stirring, respectively and their effects on the mean particles size distribution and entrapment efficiency %EE and %LC of NPs. Characterization of formulations was done by FTIR studies, TEM, PXRD, TGA, Stability, and dissolution drug release studies were performed by dialysis bag technique at both pH (1. Read More

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December 2021

Development of chitosan-coated nanoemulsions of two sulfides present in onion (Allium cepa) essential oil and their nematicidal activities against the pine wood nematode, Bursaphelenchus xylophilus.

Environ Sci Pollut Res Int 2021 Jul 21. Epub 2021 Jul 21.

Department of Agriculture, Forestry and Bioresources, College of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, Republic of Korea.

Pine wood nematode, Bursaphelenchus xylophilus, is a plant parasitic nematode which causes severe damage to several Pinus species. Two natural compounds, dipropyl trisulfide (DPTS) and methyl propyl trisulfide (MPTS), showed strong nematicidal activity against the pine wood nematode, presenting 4.24 and 17. Read More

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Hypoxia-Overcoming Breast-Conserving Treatment by Magnetothermodynamic Implant for a Localized Free-Radical Burst Combined with Hyperthermia.

ACS Appl Mater Interfaces 2021 Jul 22. Epub 2021 Jul 22.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

For the purpose of improving the quality of life and minimizing the psychological morbidity of a mastectomy, breast-conserving treatment (BCT) has become the more preferable choice in breast cancer patients. Meanwhile, tumor hypoxia has been increasingly recognized as a major deleterious factor in cancer therapies. In the current study, a novel, effective, and noninvasive magnetothermodynamic strategy based on an oxygen-independent free-radical burst for hypoxia-overcoming BCT is proposed. Read More

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Development of a novel formulation method to prepare liposomal Epacadostat.

Eur J Pharm Sci 2021 Jul 18;165:105954. Epub 2021 Jul 18.

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: One of the important metabolic pathways in cancer progression is tryptophan catabolism by the indoleamin-2,3-dioxygenase (IDO) enzyme, which suppresses the immune system and induces tolerance. Inhibition of IDO1 is an important therapeutic goal for immunotherapy in many cancers such as metastatic melanoma. Epacadostat (EPA) is a very strong inhibitor of IDO1, and its clinical studies are being performed in a higher clinical phase than other inhibitors. Read More

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Strategies to improve insulin delivery through oral route: A review.

Curr Drug Deliv 2021 Jul 20. Epub 2021 Jul 20.

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreshwara Nagara, Bannimantap, Mysuru- 570015, Karnataka, India.

Diabetes mellitus is found to be among the most suffered and lethal diseases for mankind. Diabetes mellitus type-1 is caused by the demolition of pancreatic islets responsible for the secretion of insulin. Insulin is the peptide hormone (anabolic] that regulates the metabolism of carbohydrates, fats, and proteins. Read More

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A new 2D-3D registration gold-standard dataset for the hip joint based on uncertainty modeling.

Med Phys 2021 Jul 21. Epub 2021 Jul 21.

Geneva School of Health Sciences, University of Applied Sciences and Arts of Western Switzerland (HES-SO), Geneva, 1206, Switzerland.

Purpose: Estimation of the accuracy of 2D-3D registration is paramount for a correct evaluation of its outcome in both research and clinical studies. Publicly available datasets with standardized evaluation methodology are necessary for validation and comparison of 2D-3D registration techniques. Given the large use of 2D-3D registration in biomechanics, we introduced the first gold standard validation dataset for Computed Tomography (CT)-to-X-ray registration of the hip joint, based on fluoroscopic images with large rotation angles. Read More

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The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging.

Eur J Drug Metab Pharmacokinet 2021 Jul 21. Epub 2021 Jul 21.

Functional Polymer Materials, Chair for Chemical Technology of Material Synthesis, Institute for Functional Materials and Biofabrication, Faculty of Chemistry and Pharmacy, University of Würzburg, Röntgenring 11, 97070, Würzburg, Germany.

Adrenocortical carcinoma (ACC) is a malignant tumor originating from the adrenal gland cortex with a heterogeneous but overall dismal prognosis in advanced stages. For more than 50 years, mitotane has remained a cornerstone for the treatment of ACC as adjuvant and palliative therapy. It has a very poor aqueous solubility of 0. Read More

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A Novel In Vitro Model for Determining the Optimum pH and Dose Volume of New Liquid Alginate for Infant Reflux Suppression.

Drugs R D 2021 Jul 20. Epub 2021 Jul 20.

Technostics Limited, Castle Hill Hospital, Daisy Building, Castle Road, Cottingham, HU16 5JQ, East Yorkshire, UK.

Background: Gastroesophageal reflux frequently occurs in infants from birth to 2 years and is characterised by reflux and regurgitation often occurring during or immediately after feeds. These reflux events can range in both frequency and severity, and as the reflux events increase, they become increasingly distressing for both the infant and the parent. The study aimed to characterise the properties of a new infant liquid alginate product, determining the optimum gastric pH and dose volume for maximum reflux suppressant activity. Read More

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Wide-Range, Rapid, and Specific Identification of Pathogenic Bacteria by Surface-Enhanced Raman Spectroscopy.

ACS Sens 2021 Jul 20. Epub 2021 Jul 20.

State Key Laboratory of Biochemical Engineering, PLA Key Laboratory of Biopharmaceutical Production & Formulation Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Sensitive, selective, rapid, and label-free detection of pathogenic bacteria with high generality is of great importance for clinical diagnosis, biosecurity, and public health. However, most traditional approaches, such as microbial cultures, are time-consuming and laborious. To circumvent these problems, surface-enhanced Raman spectroscopy (SERS) appears to be a powerful technique to characterize bacteria at the single-cell level. Read More

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Targeting TLR4 Signaling to Blunt Viral-Mediated Acute Lung Injury.

Front Immunol 2021 2;12:705080. Epub 2021 Jul 2.

Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD, United States.

Respiratory viral infections have been a long-standing global burden ranging from seasonal recurrences to the unexpected pandemics. The yearly hospitalizations from seasonal viruses such as influenza can fluctuate greatly depending on the circulating strain(s) and the congruency with the predicted strains used for the yearly vaccine formulation, which often are not predicted accurately. While antiviral agents are available against influenza, efficacy is limited due to a temporal disconnect between the time of infection and symptom development and viral resistance. Read More

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Long non-coding RNA DDX11-AS1 promotes esophageal carcinoma cell proliferation and migration through regulating the miR-514b-3p/RBX1 axis.

Bioengineered 2021 Dec;12(1):3772-3786

Department of Thoracic Surgery, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Esophageal carcinoma (ESCA) is one of the most aggressive malignancies with extremely high morbidity and mortality. At present, limited advancement in ESCA treatment has achieved. Therefore, it is urgent to explore the pathogenesis and progression mechanism of ESCA to provide the basis for the formulation of novel therapeutic strategies. Read More

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December 2021

Development of Novel Biopolymer-Based Nanoparticles Loaded Cream for Potential Treatment of Topical Fungal Infections.

Drug Dev Ind Pharm 2021 Jul 19:1-26. Epub 2021 Jul 19.

Department of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

Objective: Biodegradable polymers are extensively used due to their efficient safety profiles. The aim of the current study was to fabricate, evaluate and characterize biodegradable, biocompatible fluconazole (FLZ) loaded chitosan (CHS) chondroitin sulphate (CS) nanoparticles (NPs) for topical delivery. Polymers utilized in the formulation not only served as a carrier system but also aided in fighting with complex etiology of the disease due to their innate antifungal activities. Read More

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Modeling a flexible staff scheduling problem in the Era of Covid-19.

Optim Lett 2021 Jul 12:1-21. Epub 2021 Jul 12.

DIMEG, University of Calabria, Rende, CS Italy.

In this paper, we propose optimization models to address flexible staff scheduling problems and some main issues arising from efficient workforce management during the Covid-19 pandemic. The adoption of precautionary measures to prevent the pandemic from spreading has raised the need to rethink quickly and effectively the way in which the workforce is scheduled, to ensure that all the activities are conducted in a safe and responsible manner. The emphasis is on novel optimization models that take into account demand requirements, employees' personal and family responsibilities, and anti-Covid-19 measures at the same time. Read More

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How Our Caregivers Shape Who We Are: The Seven Dimensions of Attachment at the Core of Personality.

Front Psychol 2021 1;12:657628. Epub 2021 Jul 1.

Department of Computer Science, The University of Sheffield, Sheffield, United Kingdom.

Psychology defines personality as the stable traits of an individual, and cognitive research suggests that a set of core beliefs is at the root of these traits. From this perspective, two major questions remain unanswered: (1) What are the core beliefs that make up personality? (2) How are they acquired? An interesting answer is provided by attachment theory, according to which attachment is at the basis of personality. The current theoretical formulation, however, does not sufficiently clarify the relationship between the two. Read More

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Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Model of Alzheimer's Disease.

Front Neurosci 2021 30;15:691222. Epub 2021 Jun 30.

Division of Molecular Therapeutics and Formulation, School of Pharmacy, The University of Nottingham, University Park, Nottingham, United Kingdom.

Alzheimer's disease is a neurodegenerative disease characterized by disrupted memory, learning functions, reduced life expectancy, and locomotor dysfunction, as a result of the accumulation and aggregation of amyloid peptides that cause neuronal damage in neuronal circuits. In the current study, we exploited a transgenic line, expressing amyloid-β peptides to investigate the efficacy of a newly synthesized acetylcholinesterase inhibitor, named XJP-1, as a potential AD therapy. Behavioral assays and confocal microscopy were used to characterize the drug effect on AD symptomatology and amyloid peptide deposition. Read More

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15-hydroxystearate micelles for the delivery of aprepitant: Preparation, characterization, pharmacokinetics and tissue distribution in mice.

Pak J Pharm Sci 2021 Mar;34(2):635-639

College of Pharmaceutical Sciences, Southwest University, Chongqing, China / Chongqing Engineering Research Center for Pharmaceutical Process and Quality Control, Chongqing, China.

This study developed a novel Aprepitant micells (APPT-Ms) formulation that uses a mixture of 15-hydroxystearate (HS15) as surfactant to solubilize AAPT. This article determines the content of APPT by HPLC. The in vitro test results show that the optimized APPT-Ms has small particle size, excellent stability and long-lasting release. Read More

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Research on Transfer Rate of Heavy Metals and Harmful Elements in Traditional Chinese Medicine Extraction and Refining Processes and Product Health Risk Assessment.

Biol Trace Elem Res 2021 Jul 18. Epub 2021 Jul 18.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.

Ramulus Mori alkaloids, also known as SangZhi alkaloids (SZ-A), is a natural medicine used for the treatment of type 2 diabetes mellitus in China. SZ-A is extracted from Morus alba L., which grows in the natural environment and may be contaminated by heavy metals and harmful elements. Read More

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Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer.

Drug Deliv Transl Res 2021 Jul 17. Epub 2021 Jul 17.

Pharmaceutics Research Laboratory, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.

Essential oils have been proposed as promising non-toxic transdermal permeation enhancers. Their use is limited because of their low water solubility. The use of nanotechnology-based strategies is one of the ways to overcome this limitation. Read More

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Triple negative breast cancer and non-small cell lung cancer: Clinical challenges and nano-formulation approaches.

J Control Release 2021 Jul 14;337:27-58. Epub 2021 Jul 14.

Department of Pharmaceutics, Faculty of Pharmacy, Kalabhavan Campus, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat 390001, India; Formulation Research & Development, Novel Drug Delivery Systems, Sun Pharmaceutical Industries Ltd, Vadodara, Gujarat 390012, India. Electronic address:

Triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC) are amongst the most aggressive forms of solid tumors. TNBC is highlighted by absence of genetic components of progesterone receptor, HER2/neu and estrogen receptor in breast cancer. NSCLC is characterized by integration of malignant carcinoma into respiratory system. Read More

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Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Omeprazole, a Proton Pump Inhibitor, in Healthy Subjects.

Clin Pharmacol Drug Dev 2021 Jul 16. Epub 2021 Jul 16.

Amgen Inc, Thousand Oaks, California, USA.

Omecamtiv mecarbil (OM) is a novel cardiac myosin activator in development for the treatment of heart failure (HF) with reduced ejection fraction. OM is administered as a 25-, 37.5-, or 50-mg modified-release formulation in patients with HF. Read More

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Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity.

J Immunother Cancer 2021 Jul;9(7)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China

Background: Mesenteric lymph nodes (MLNs) are critical draining lymph nodes of the immune system that accommodate more than half of the body's lymphocytes, suggesting their potential value as a cancer immunotherapy target. Therefore, efficient delivery of immunomodulators to the MLNs holds great potential for activating immune responses and enhancing the efficacy of antitumor immunotherapy. Self-microemulsifying drug delivery systems (SMEDDS) have attracted increasing attention to improving oral bioavailability by taking advantage of the intestinal lymphatic transport pathway. Read More

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Model-based multi-parameter mapping.

Med Image Anal 2021 Jun 29;73:102149. Epub 2021 Jun 29.

Wellcome Center for Human Neuroimaging, Queen Square Institute of Neurology, University College London, London, UK.

Quantitative MR imaging is increasingly favoured for its richer information content and standardised measures. However, computing quantitative parameter maps, such as those encoding longitudinal relaxation rate (R), apparent transverse relaxation rate (R) or magnetisation-transfer saturation (MT), involves inverting a highly non-linear function. Many methods for deriving parameter maps assume perfect measurements and do not consider how noise is propagated through the estimation procedure, resulting in needlessly noisy maps. Read More

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Salt- and pH-Dependent Viscosity of SDS/LAPB Solutions: Experiments and a Semiempirical Thermodynamic Model.

Langmuir 2021 Jul 16. Epub 2021 Jul 16.

The Procter & Gamble Company, 8700 Mason Montgomery Road, Mason, Ohio 45040, United States.

We present novel data on the composition-, pH-, and salt-dependent zero shear viscosity of the commercially important mixture of anionic sodium dodecyl sulfate (SDS) and zwitterionic lauramidopropyl betaine (LAPB). We show proton NMR experiments that the notionally zwitterionic LAPB exhibits a large p shift in the presence of SDS and can become partially cationic at formulation-relevant pH ranges of 4.5-6. Read More

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Exploring the Rescue Strategy for Cardiac Arrest in Makeshift (FangCang) Hospital Workers during the Pneumonia Outbreak Associated with COVID-19.

Iran J Public Health 2020 Oct;49(Suppl 1):76-81

Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750004, China.

Background: Beginning in Dec 2019, a novel coronavirus, designated SARS-CoV-2, has caused an international outbreak of respiratory illness termed COVID-19. The workers in the FangCang hospital have to work for more than 8 h and the work is high strength. Furthermore, to protect health and prevent serious cross-infection, they need to wear isolation equipment when working in FangCang hospital. Read More

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October 2020

Pharmaceutical nanocrystals: A promising approach for improved topical drug delivery.

Drug Discov Today 2021 Jul 13. Epub 2021 Jul 13.

Solid State Pharmaceutics Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, Mohali, Punjab 160 062, India. Electronic address:

The barrier function of skin and the non-optimal physicochemical properties of drugs present challenges to the skin penetration of many drugs, motivating the development of novel drug-delivery systems. Recently, nanocrystal-based formulations have been investigated for topical drug delivery and have demonstrated improved skin penetration. This review highlights barriers in skin penetration, current techniques to improve topical delivery and the application of nanocrystals to conquer obstacles for topical delivery. Read More

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Path towards efficient paediatric formulation development based on partnering with clinical pharmacologists and clinicians, a c4c expert group White paper.

Br J Clin Pharmacol 2021 Jul 15. Epub 2021 Jul 15.

University College London School of Pharmacy, London, UK.

Improved global access to novel age-appropriate formulations for paediatric subsets, either of new chemical entities or existing drugs, is a priority to ensure that medicines meet the needs of these patients. However, despite regulatory incentives, the introduction to the market of paediatric formulations still lags behind adult products. This is mainly caused by additional complexities associated with the development of acceptable age-appropriate paediatric medicines. Read More

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Intercalated disk nanoscale structure regulates cardiac conduction.

J Gen Physiol 2021 Aug 15;153(8). Epub 2021 Jul 15.

The Ohio State University, Columbus, OH.

The intercalated disk (ID) is a specialized subcellular region that provides electrical and mechanical connections between myocytes in the heart. The ID has a clearly defined passive role in cardiac tissue, transmitting mechanical forces and electrical currents between cells. Recent studies have shown that Na+ channels, the primary current responsible for cardiac excitation, are preferentially localized at the ID, particularly within nanodomains such as the gap junction-adjacent perinexus and mechanical junction-associated adhesion-excitability nodes, and that perturbations of ID structure alter cardiac conduction. Read More

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Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches.

Planta 2021 Jul 15;254(2):29. Epub 2021 Jul 15.

Department of Botany, Aligarh Muslim University, Aligarh, 202 002, India.

Main Conclusion: This review analyses the most recent scientific research conducted for the purpose of enhancing artemisinin production. It may help to devise better artemisinin enhancement strategies, so that its production becomes cost effective and becomes available to masses. Malaria is a major threat to world population, particularly in South-East Asia and Africa, due to dearth of effective anti-malarial compounds, emergence of quinine resistant malarial strains, and lack of advanced healthcare facilities. Read More

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Epithelium-on Corneal Collagen Cross-Linking with Hypotonic Riboflavin Solution in Progressive Keratoconus.

Clin Ophthalmol 2021 7;15:2921-2932. Epub 2021 Jul 7.

Comprehensive EyeCare of Central Ohio, Westerville, OH, USA.

Introduction: Epithelium-off cross-linking (epi-off CXL) has long been established as the gold standard treatment for progressive keratoconus. Several protocols for epithelium-on (epi-on) CXL have been proposed to help reduce post-operative pain and facilitate visual recovery, but there is no epi-on treatment approach that is currently approved in the United States. The hydrophilic and macromolecular characteristics of conventional epi-off riboflavin formulations may create clinical challenges for absorption through an intact epithelium. Read More

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