Placenta 2021 Apr 2;107:13-23. Epub 2021 Mar 2.
Division of Experimental Medicine, McGill University, Montreal, Canada; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, Canada; Department of Obstetrics and Gynecology, McGill University, Montreal, Canada; Department of Biology, McGill University, Montreal, Canada. Electronic address:
Introduction: The growth and survival of the mammalian fetus is highly dependent on the placenta. Several research groups have demonstrated the involvement of different transforming growth factor-beta (TGFβ) superfamily members and their related receptors in placentation. Cripto is a member of the epidermal growth factor-Cripto1/FRL1/Cryptic protein family and plays a critical role in embryonic development, stem cell maintenance and tumor progression through TGFβ-dependent and independent pathways. Read More