58,984 results match your criteria north american


Methodology for altering omega-3 EPA+DHA and omega-6 linoleic acid as controlled variables in a dietary trial.

Clin Nutr 2021 May 12;40(6):3859-3867. Epub 2021 May 12.

Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background & Aims: Increasing dietary intake of n-3 EPA+DHA and lowering dietary n-6 LA is under investigation as a therapeutic diet for improving chronic pain syndromes as well as other health outcomes. Herein we describe the diet methodology used to modulate intake of n-3 and n-6 PUFA in a free living migraine headache population and report on nutrient intake, BMI and diet acceptability achieved at week 16 of the intensive diet intervention and week 22 follow-up time-point.

Methods: A total of 178 participants were randomized and began one of three diet interventions: 1) a high n-3 PUFA, average n-6 PUFA (H3) diet targeting 1500 mg EPA+DHA/day and 7% of energy (en%) from n-6 linoleic acid (LA), 2) a high-n-3 PUFA, low-n-6 PUFA (H3L6) targeting 1500 mg EPA+DHA/day and <1. Read More

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A 1-km hourly air-temperature model for 13 northeastern U.S. states using remotely sensed and ground-based measurements.

Environ Res 2021 Jun 12:111477. Epub 2021 Jun 12.

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, USA.

Background: Accurate and precise estimates of ambient air temperatures that can capture fine-scale within-day variability are necessary for studies of air temperature and health.

Method: We developed statistical models to predict temperature at each hour in each cell of a 927-m square grid across the Northeast and Mid-Atlantic United States from 2003 to 2019, across ∼4000 meteorological stations from the Integrated Mesonet, using inputs such as elevation, an inverse-distance-weighted interpolation of temperature, and satellite-based vegetation and land surface temperature. We used a rigorous spatial cross-validation scheme and spatially weighted the errors to estimate how well model predictions would generalize to new cell-days. Read More

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Gynogenetic diploids, tetraploids, or octoploids, and a path to polyploidy in Anuran Amphibians.

Authors:
James P Bogart

Genome 2021 Jun 15. Epub 2021 Jun 15.

University of Guelph, Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada, N1G 2W1;

Unreduced gametes have been implicated in the evolution of polyploid species of plants and animals and are normally produced by female anuran amphibians. Such eggs may initiate the evolution of polyploid species that have independently arisen in several anuran families. Polyploid females could also produce unreduced eggs that might lead to species with higher ploidy levels or their eggs may develop gynogenetically to reduce the ploidy level. Read More

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Interventions to prevent preterm delivery in twin-twin transfusion with short cervix.

Ultrasound Obstet Gynecol 2021 Jun 15. Epub 2021 Jun 15.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology and Reproductive Sciences, UTHealth The University of Texas McGovern Medical School and the Fetal Center at Children's Memorial Hermann Hospital, Houston, TX.

Objective: Pre-operative short cervical length (CL) remains a major risk factor for preterm birth after laser surgery for twin-twin transfusion syndrome (TTTS). Interventions to prolong pregnancy remain elusive. The objective of this study is to compare secondary preventive methods used in the setting of short CL at the time of laser surgery by five North American Fetal Treatment Network (NAFTNet) centers. Read More

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Clinical Ethics Consultation during the First COVID-19 Lock Down in France: The "Commitment Model": Balancing General Questions and Individual Cases.

J Clin Ethics 2021 ;32(2):155-164

Centre d'éthique clinique, 27 Rue du Faubourg St. Jacques, 75014 Paris, France.

During the first outbreak of COVID-19, the French governmental advisory council on bioethics suggested the need to support healthcare providers with ad hoc "ethical support units." Several units engaged in such endeavors across the country. This article outlines some methodological considerations made by the Cochin Hospital Clinical Ethics Center (the Cec). Read More

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Putting the Patient First: A Scoping Review of Patient Desires in Canada.

Healthc Policy 2021 May;16(4):46-69

Director, North American Observatory on Health Systems and Policies; Professor, Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON.

Patient-centred care is a key priority for governments, providers and stakeholders, yet little is known about the care preferences of patient groups. We completed a scoping review that yielded 193 articles for analysis. Five health states were used to account for the diversity of possible preferences based on health needs. Read More

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ginal Article Unintended Consequences of Expanding Electronic Pathology Reporting: The Inverse Relationship Between Data Completeness and Data Quality.

J Registry Manag 2020 ;47(3):122-126

Background: In 2016, the New Jersey State Cancer Registry (NJSCR) began expanding electronic laboratory reporting. As a result, the number of electronic pathology reports (EPRs) submitted to NJSCR increased markedly from 2015 to 2017. EPRs are more likely to contain incomplete or missing race than North American Association of Central Cancer Registry (NAACCR) abstracts from hospitals and physician offices. Read More

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"Shouldn't You Spend Your Time Curing Cancer or Something?" Why an African American Female Physician Chose a Career in Palliative Care.

J Palliat Med 2021 Jul;24(7):1109-1110

Division of Geriatrics and Duke Palliative Care, Duke University School of Medicine, Durham, North Carolina, USA.

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Is multidisciplinary rehabilitation for low back pain effective in patients above 65 years? An observational cohort study with 12-month follow-up.

Eur J Phys Rehabil Med 2021 Jun 15. Epub 2021 Jun 15.

Department of Orthopaedics, Physical Medicine and Rehabilitation, University Hospital, LMU Munich, Germany -

Background: In contrast to the broad evidence for the effectiveness of multidisciplinary biopsychosocial rehabilitation (MBR) in chronic low back pain (CLBP) patients of working age, little is known about the benefit in patients aged ≥ 65 years.

Aim: To quantify the short-term and 12-month effects of a 3-week CLBP specific MBR program in patients ≥ 65 years of age; to compare the effects in patients ≥ 65 years of age to the effects in younger patients.

Design: Observational prospective cohort study. Read More

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Secondary Traumatic Stress in Emergency Services Systems (STRESS) Project: Quantifying and Predicting Compassion Fatigue in Emergency Medical Services Personnel.

Prehosp Emerg Care 2021 Jun 15:1-16. Epub 2021 Jun 15.

Department of Emergency Medical Science, Wake Technical Community College, Raleigh, North Carolina.

Compassion fatigue (CF) is defined as the acute or gradual loss of benevolence that occurs after exposure to critical incident stress. Colloquially referred to as the "cost of caring," CF can affect an individual's future response to stressful situations and is unhealthy for caregivers.To identify the prevalence and predictors of CF in EMS professionals. Read More

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American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 2.

Arthritis Rheumatol 2021 Jun 15. Epub 2021 Jun 15.

University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha.

Objective: To provide guidance to rheumatology providers on the use of coronavirus disease 2019 (COVID-19) vaccines for patients with rheumatic and musculoskeletal diseases (RMDs).

Methods: A task force was assembled that included 9 rheumatologists/immunologists, 2 infectious disease specialists, and 2 public health physicians. After agreeing on scoping questions, an evidence report was created that summarized the published literature and publicly available data regarding COVID-19 vaccine efficacy and safety, as well as literature for other vaccines in RMD patients. Read More

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SARS-CoV-2 infection and transmission in the North American deer mouse.

Nat Commun 2021 06 14;12(1):3612. Epub 2021 Jun 14.

Zoonotic Diseases and Special Pathogens Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.

Widespread circulation of SARS-CoV-2 in humans raises the theoretical risk of reverse zoonosis events with wildlife, reintroductions of SARS-CoV-2 into permissive nondomesticated animals. Here we report that North American deer mice (Peromyscus maniculatus) are susceptible to SARS-CoV-2 infection following intranasal exposure to a human isolate, resulting in viral replication in the upper and lower respiratory tract with little or no signs of disease. Further, shed infectious virus is detectable in nasal washes, oropharyngeal and rectal swabs, and viral RNA is detectable in feces and occasionally urine. Read More

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Approach to allergic contact dermatitis caused by topical medicaments.

Can Fam Physician 2021 Jun;67(6):414-419

Medical Director of the Contact Dermatitis Clinic at St Paul's Hospital in Vancouver.

Objective: To provide an approach to identifying topical medicament ingredients that cause allergic contact dermatitis (ACD) and to recognizing common clinical scenarios in which these ingredients might present.

Sources Of Information: A retrospective chart review was conducted of patients patch tested at the Contact Dermatitis Clinic at St Paul's Hospital in Vancouver, BC, between November 2016 and June 2019. Data from the North American Contact Dermatitis Group from 2015 to 2016 and The Ottawa Hospital patch test clinic from 2000 to 2010 were also reviewed. Read More

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HIV mortality across the 30 largest U.S. cities: assessing overall trends and racial inequities.

AIDS Care 2021 Jun 14:1-10. Epub 2021 Jun 14.

Loyola University Parkinson School of Health Sciences and Public Health, Maywood, IL, USA.

Background: Despite decreases in overall HIV mortality in the U.S., large racial inequities persist. Read More

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Intracranial Traumatic Hematoma Detection in Children Using a Portable Near-infrared Spectroscopy Device.

West J Emerg Med 2021 Mar 24;22(3):782-791. Epub 2021 Mar 24.

Alpert Medical School of Brown University, Departments of Emergency Medicine and Pediatrics, Providence, Rhode Island.

Introduction: We sought to validate a handheld, near-infrared spectroscopy (NIRS) device for detecting intracranial hematomas in children with head injury.

Methods: Eligible patients were those <18 years old who were admitted to the emergency department at three academic children's hospitals with head trauma and who received a clinically indicated head computed tomography (HCT). Measurements were obtained by a blinded operator in bilateral frontal, temporal, parietal, and occipital regions. Read More

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Boron Oxide Nanoparticles Exhibit Minor, Species-Specific Acute Toxicity to North-Temperate and Amazonian Freshwater Fishes.

Front Bioeng Biotechnol 2021 28;9:689933. Epub 2021 May 28.

Department of Chemistry and Biochemistry, Mount Allison University, Sackville, NB, Canada.

Boron oxide nanoparticles (nBO) are manufactured for structural, propellant, and clinical applications and also form spontaneously through the degradation of bulk boron compounds. Bulk boron is not toxic to vertebrates but the distinctive properties of its nanostructured equivalent may alter its biocompatibility. Few studies have addressed this possibility, thus our goal was to gain an initial understanding of the potential acute toxicity of nBO to freshwater fish and we used a variety of model systems to achieve this. Read More

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The relationship between walk score® and perceived walkability in ultrahigh density areas.

Prev Med Rep 2021 Sep 5;23:101393. Epub 2021 May 5.

Faculty of Sport Sciences, Waseda University, Japan.

Walk Score® is a free web-based tool that provides a walkability score for any given location. A limited number of North American studies have found associations between Walk Score® and perceived built environment attributes, yet it remains unknown whether similar associations exist in Asian countries. The study's objective is to examine the covariate-adjusted correlations between the Walk Score® metric and measures of the perceived built environment in ultrahigh density areas of Japan. Read More

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September 2021

Evaluating Sentinel-5P TROPOMI tropospheric NO column densities with airborne and Pandora spectrometers near New York City and Long Island Sound.

Atmos Meas Tech 2020 Nov;13(11):6113-6140

Office of Research and Development, United States Environmental Protection Agency, Triangle Research Park, NC 27709, USA.

Airborne and ground-based Pandora spectrometer NO column measurements were collected during the 2018 Long Island Sound Tropospheric Ozone Study (LISTOS) in the New York City/Long Island Sound region, which coincided with early observations from the Sentinel-5P TROPOspheric Monitoring Instrument (TROPOMI) instrument. Both airborne- and ground-based measurements are used to evaluate the TROPOMI NO Tropospheric Vertical Column (TrVC) product v1.2 in this region, which has high spatial and temporal heterogeneity in NO. Read More

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November 2020

Modular Molecular Weaponry Plays a Key Role in Competition Within an Environmental Population.

Front Microbiol 2021 21;12:671092. Epub 2021 May 21.

Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada.

The type VI secretion system (T6SS) operons of contain extraordinarily diverse arrays of toxic effector and cognate immunity genes, which are thought to play an important role in the environmental lifestyle and adaptation of this human pathogen. Through the T6SS, proteinaceous "spears" tipped with antibacterial effectors are injected into adjacent cells, killing those not possessing immunity proteins to these effectors. Here, we investigate the T6SS-mediated dynamics of bacterial competition within a single environmental population of . Read More

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Trade-offs between fighting and breeding: a social network analysis of bison male interactions.

J Mammal 2021 Apr 29;102(2):504-519. Epub 2021 Jan 29.

Department of Biology, Point Loma Nazarene University, San Diego, CA, USA.

In most polygynous species, males compete for access to females using agonistic interactions to establish dominance hierarchies. Typically, larger and stronger males become more dominant and thus gain higher mating and reproductive success over subordinate males. However, there is an inherent trade-off between time and energy invested in dominance interactions versus courtship and mating activities. Read More

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Telemedicine in Spine Surgery: Global Perspectives and Practices.

Global Spine J 2021 Jun 14:21925682211022311. Epub 2021 Jun 14.

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA.

Study Design: Cross-sectional, anonymous, international survey.

Objectives: The COVID-19 pandemic has resulted in the rapid adoption of telemedicine in spine surgery. This study sought to determine the extent of adoption and global perspectives on telemedicine in spine surgery. Read More

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Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia.

Infect Agent Cancer 2021 Jun 13;16(1):42. Epub 2021 Jun 13.

Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.

Background: Epigenetic mechanisms are hypothesized to contribute substantially to the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer, although empirical data are limited.

Methods: Women (n = 419) were enrolled at colposcopic evaluation at Duke Medical Center in Durham, North Carolina. Human papillomavirus (HPV) was genotyped by HPV linear array and CIN grade was ascertained by biopsy pathologic review. Read More

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Super-Refractory Status Epilepticus in Children: A Retrospective Cohort Study.

Pediatr Crit Care Med 2021 Jun 14. Epub 2021 Jun 14.

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA. Division of Child and Adolescent Neurology, Department of Neurology, Mayo Clinic, Rochester, MN. Department of Neurology, Division of Pediatric Neurology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI. Department of Child Neurology, Hospital Sant Joan de Déu, Universidad de Barcelona, Barcelona, Spain. Division of Neurology, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Pediatric Neurology Unit, Department of Pediatrics, Hospital Universitari Son Espases, Universitat de les Illes Balears, Palma, Spain. Section of Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX. Division of Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH. Department of Neurology and Pediatrics, University of Virginia Health System, Charlottesville, VA. Center for Neuroscience, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC. Departments of Pediatrics and Neurology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO. Ruth D. & Ken M. Davee Pediatric Neurocritical Care Program, Northwestern University Feinberg School of Medicine, Chicago, IL. Division of Pediatric Neurology, Washington University Medical Center, Washington University School of Medicine, Saint Louis, MO. Section of Pediatric Critical Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX. Division of Child Neurology, Department of Neurology, Columbia University Medical Center, Columbia University, New York, NY. Division of Pediatric Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. Division of Pediatric Neurology, Duke University Medical Center, Duke University, Durham, NC. Department of Neurology, Division of Pediatric Neurology, University of Washington, Seattle, WA. Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA. Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University. Columbus, OH. Department of Pediatrics, Division Pediatric Neurology, Neuro-Critical Care Program, Oregon Health and Science University, Portland, OR. Division of Critical Care, Departments of Neurology, Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA. Critical Care and Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Department of Child Health, University of Arizona College of Medicine and Barrow's Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ.

Objectives: To characterize the pediatric super-refractory status epilepticus population by describing treatment variability in super-refractory status epilepticus patients and comparing relevant clinical characteristics, including outcomes, between super-refractory status epilepticus, and nonsuper-refractory status epilepticus patients.

Design: Retrospective cohort study with prospectively collected data between June 2011 and January 2019.

Setting: Seventeen academic hospitals in the United States. Read More

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Air quality in Canadian port cities after regulation of low-sulphur marine fuel in the North American Emissions Control Area.

Sci Total Environ 2021 May 23;791:147949. Epub 2021 May 23.

Environmental Protection Branch, Environment and Climate Change Canada, Vancouver, British Columbia, Canada.

Large marine vessels have historically used high-sulphur (S) residual fuel oil (RFO), with substantial airborne releases of sulphur dioxide (SO₂) and fine particulate matter (PM) enriched in vanadium (V), nickel (Ni) and other air pollutants. To address marine shipping air pollution, Canada and the United States have jointly implemented a North American Emissions Control Area (NA ECA) within which ships are regulated to use lower-sulphur marine fuel or equivalent SO scrubbers (i.e. Read More

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Impacts of large-scale teleconnection indices on chill accumulation for specialty crops in California.

Sci Total Environ 2021 May 26;791:148025. Epub 2021 May 26.

USDA California Climate Hub, Davis, CA, United States; John Muir Institute of the Environment, University of California, Davis, CA, United States; USDA-ARS Sustainable Agriculture Water Systems Research Unit, Davis CA, United States.

Although the impacts of teleconnection indices on climate metrics such as precipitation and temperature in California have been widely studied, less attention has been given to the impact on integrated climate indices such as chill accumulation. This study investigates the linkages between large-scale teleconnections and winter chill accumulation for specialty crops in California, which may enable more effective and dynamic adaptation to in-season climate variability. Three large-scale teleconnection indices were selected: Oceanic Nino Index (ONI), Pacific-North American teleconnection pattern (PNA), and Pacific Decadal Oscillation (PDO) index to assess their effects on chill accumulation. Read More

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Physical Activity, Subclinical Myocardial Injury, and Risk of Heart Failure Subtypes in Black Adults.

JACC Heart Fail 2021 Jun 3. Epub 2021 Jun 3.

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:

Objectives: This study sought to evaluate the independent associations and interactions between high-sensitivity cardiac troponin I (hs-cTnI) and physical activity (PA) with risk of heart failure (HF) subtypes, HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF).

Background: Black adults are at high risk for developing HF. Physical inactivity and subclinical myocardial injury, as assessed by hs-cTnI concentration, are independent risk factors for HF. Read More

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Validation of a novel online depression symptom severity rating scale: the R8 Depression.

Health Qual Life Outcomes 2021 Jun 12;19(1):163. Epub 2021 Jun 12.

Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.

Background: An automated web-based assessment and monitoring system ( www.psynary.com ) has been developed to assist non-specialist clinicians in managing common mood and anxiety disorders. Read More

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When a house is never a home: Housing instability among youth affected by parental drug abuse.

Child Abuse Negl 2021 Jun 9;118:105131. Epub 2021 Jun 9.

Johns Hopkins Bloomberg School of Public Health, Department of Population, Family and Reproductive Health, 615 North Wolfe Street, Baltimore, MD 21215, USA.

Background: The negative consequences of parental substance abuse are significant and longstanding for children. Among other risks, these youth are more likely to experience housing instability. The most common predictor of a child not living with their biological parent is parental substance use. Read More

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Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and European Society for Pharmacogenomics and Personalized Therapy.

J Mol Diagn 2021 Jun 9. Epub 2021 Jun 9.

The Pharmacogenomics (PGx) Working Group of the Clinical Practice Committee*, Association for Molecular Pathology (AMP), Rockville, MD; Department of Pathology and Laboratory Medicine and Department of Genetics, University of North Carolina, Chapel Hill, NC.

The goals of the Association for Molecular Pathology (AMP) Clinical Practice Committee's Pharmacogenomics (PGx) Working Group are to define the key attributes of pharmacogenetic alleles recommended for clinical testing and determine a minimum set of variants that should be included in clinical PGx genotyping assays. This document series provides recommendations for a minimum panel of variant alleles ("Tier 1") and an extended panel of variant alleles ("Tier 2") that will aid clinical laboratories when designing assays for PGx testing. The AMP PGx Working Group considered functional impact of the variant alleles, allele frequencies in multiethnic populations, the availability of reference materials, as well as other technical considerations for PGx testing when developing these recommendations. Read More

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