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The effect of thyroid dysfunction and treatment on adropin, asprosin and preptin levels in rats.

Horm Mol Biol Clin Investig 2020 Dec 14;42(1):37-42. Epub 2020 Dec 14.

Medical School, Deparment of Biochemistry, Selcuk University, Konya, Turkey.

Objectives: Thyroid hormones have important roles in normal development and energy regulating mechanisms as well as signaling mechanisms that affect energy consumption through central and peripheral pathways. The aim of this study was to determine the effects of thyroid dysfunction on adropin, asprosin and preptin levels in rat.

Methods: The study was performed on the 38 male Wistar-albino rats. Read More

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December 2020

Frontal lobe growth is impaired in fetuses with congenital heart disease.

Ultrasound Obstet Gynecol 2020 Jun 23. Epub 2020 Jun 23.

Fetal Medicine and Surgery Unit, Istituto G.Gaslini, Genoa, Italy.

Objective: The primary objective of this study is to assess whether foetuses with congenital heart disease (CHD) have smaller frontal brain areas than normal controls. Secondary objective is to evaluate whether there is any difference among CHD with different haemodynamics.

Methods: Retrospective cross-sectional study, including 421 normal foetuses and 101 fetuses with isolated CHD. Read More

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[Circulating endothelial cells in patients with alcohol withdrawal syndrome (uncomplicated and complicated delirium)].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(3):60-64

Chita State Medical Academy, Chita, Russia.

Aim: To study the content of circulating endothelial cells in the blood of patients with alcohol withdrawal syndrome (uncomplicated and complicated delirium).

Material And Methods: Thirty patients, aged from 18 to 40 years, with the diagnosis of 'alcohol withdrawal, uncomplicated' (F10.302) or 'alcohol withdrawal complicated by delirium' (F10. Read More

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Sleep assessment in a randomized trial of hyperbaric oxygen in U.S. service members with post concussive mild traumatic brain injury compared to normal controls.

Sleep Med 2018 11 30;51:66-79. Epub 2018 Jun 30.

Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, UT, USA; Division of Hyperbaric Medicine, Intermountain LDS Hospital, Salt Lake City, USA; Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address:

Study Objective: In this exploratory, double-blind, longitudinal sham-controlled trial of hyperbaric oxygen (HBO) for military personnel with post concussive mild traumatic brain injury (mTBI), self-reports and objective measures of sleep-wake disturbances were assessed and compared to normals.

Methods: Self-reports consisting of Pittsburg Sleep Quality Index (PSQI), sleep diary, screening for obstructive sleep apnea (OSA) risk, restless legs syndrome (RLS), cataplexy, and objective actigraphic measures of sleep-wake were obtained on 71 military personnel with mTBI [baseline, 13 weeks and six months post-randomization (post-intervention)], of which 35 met post-traumatic stress disorder (PTSD) criteria, and 75 healthy volunteers (baseline). Baseline between-group and follow-up changes from baseline overall and within subgroups were evaluated. Read More

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November 2018

Sustained Impairment of Lurasidone Clearance After Discontinuation of Posaconazole: Impact of Obesity, and Implications for Patient Safety.

J Clin Psychopharmacol 2018 Aug;38(4):289-295

Emerald Lake Safety, Newport Beach, CA.

Purpose/background: The antipsychotic agent lurasidone (Latuda®) is metabolized by Cytochrome P450-3A (CYP3A) enzymes. Coadministration with strong CYP3A inhibitors (such as ketoconazole, posaconazole, and ritonavir) is contraindicated due to the risk of sedation and movement disorders from high levels of lurasidone. This study evaluated the time-course of recovery from the posaconazole drug interaction, and the effect of obesity on the recovery process. Read More

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Persistence of a Posaconazole-Mediated Drug-Drug Interaction With Ranolazine After Cessation of Posaconazole Administration: Impact of Obesity and Implications for Patient Safety.

J Clin Pharmacol 2018 11 11;58(11):1436-1442. Epub 2018 May 11.

Tufts University School of Medicine, Boston, MA, USA.

The antianginal agent ranolazine (Ranexa®) is metabolized primarily by cytochrome P450-3A (CYP3A) enzymes. Coadministration with strong CYP3A inhibitors, such as ketoconazole and posaconazole, is contraindicated due to risk of QT prolongation from high levels of ranolazine. This study evaluated the time course of recovery from the posaconazole drug interaction in normal-weight and otherwise healthy obese subjects. Read More

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November 2018

The natural history of fetal long QT syndrome.

J Electrocardiol 2016 Nov - Dec;49(6):807-813. Epub 2016 Jul 28.

The Biomagnetism Laboratory, Department of Medical Physics, University of Wisconsin, Madison, WI.

Introduction: Fetal magnetocardiography (fMCG), the magnetic analog of ECG, has provided invaluable insight into the mechanisms of fetal arrhythmias. In the past 15years, we have evaluated over 300 fetuses with arrhythmia by fMCG. We review the unique characteristics and natural history of the long QT syndrome (LQTS) rhythms. Read More

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November 2017

[The effects of blood serum from schizophrenia patients under olanzapine monotherapy on the ultrastructure of astrocytes in human fetal brain organotypic culture].

Zh Nevrol Psikhiatr Im S S Korsakova 2016 ;116(5):65-70

Mental Health Research Center, Moscow, Russia.

Objective: To study effects of blood serum (BS) from schizophrenia patients under olanzapine monotherapy on astrocytes in the human fetal brain organotypic culture.

Material And Methods: Authors studied the human fetal brain organotypic culture after the application of BS from 20 normals and 33 patients (ICD-10 schizophrenia, paranoid type, F20.02; F20. Read More

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Myocardial strain can be measured from first trimester fetal echocardiography using velocity vector imaging.

Prenat Diagn 2016 May 7;36(5):483-8. Epub 2016 Apr 7.

Children's National Medical Center, Children's National Heart Institute, Washington, DC, USA.

Objectives: Alterations in myocardial strain can identify cardiac dysfunction and can be measured in the mid-gestation fetus. This study evaluates feasibility of strain measurements in early fetuses and establishes normal early fetal strain values.

Methods: Normal fetal echocardiograms were reviewed for image adequacy for strain measurements in 12- to 14-week gestation fetuses. Read More

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Apelin in Normal Pregnancy and Pregnancies Complicated by Placental Insufficiency.

Reprod Sci 2016 08 14;23(8):1037-43. Epub 2016 Feb 14.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Canada Centre for Research in Women's and Infant's health, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada.

Introduction: Apelin is a potent inotropic agent and causes endothelium-mediated vasodilation. Its cardiovascular profile suggests a role in the regulation of gestational hemodynamics.

Methods: We longitudinally assessed maternal serum apelin levels and hemodynamics (cardiac output and total peripheral resistance) between 20 and 34 weeks gestation in 18 women at high risk of placental dysfunction. Read More

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MRI shows limited mixing between systemic and pulmonary circulations in foetal transposition of the great arteries: a potential cause of in utero pulmonary vascular disease.

Cardiol Young 2015 Apr 16;25(4):737-44. Epub 2014 Jun 16.

1Department of Paediatrics,Hospital for Sick Children and University of Toronto,Toronto,Canada.

Objectives: To investigate the relationship between foetal haemodynamics and postnatal clinical presentation in patients with transposition of the great arteries using phase-contrast cardiovascular magnetic resonance.

Background: A severe and irreversible form of persistent pulmonary hypertension of the newborn occurs in up to 5% of patients with transposition and remains an important cause of morbidity and mortality in these infants. Restriction at the foramen ovale and ductus arteriosus has been identified as a risk factor for the development of pulmonary hypertension, and this can now be studied with magnetic resonance imaging using a new technique called metric optimised gating. Read More

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A pilot study of an acupuncture protocol to improve visual function in retinitis pigmentosa patients.

Clin Exp Optom 2014 May 29;97(3):240-7. Epub 2013 Oct 29.

Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland, USA.

Background: Patients with retinitis pigmentosa are motivated to try complementary or integrative therapies to slow disease progression. Basic science, clinical research and retinitis pigmentosa patients' self-reports support the hypothesis that acupuncture may improve visual function.

Methods: A prospective, case series, pilot study enrolled 12 adult patients with RP treated at an academic medical centre with a standardised protocol that combined electroacupuncture to the forehead and below the eyes and acupuncture to the body, at 10 half-hour sessions over two weeks. Read More

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Echocardiographic follow-up and pregnancy outcome of fetuses with cardiac asymmetry at 18-22 weeks of gestation.

Prenat Diagn 2014 Sep 29;34(9):900-7. Epub 2014 May 29.

Department of Ultrasonography, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, 410011, China.

Objective: The goal of our study was to evaluate the evolution of cardiac findings and assess the pregnancy outcome of fetuses with cardiac asymmetry at midgestation.

Methods: We reviewed all fetuses with cardiac asymmetry at echocardiograms performed at 18-22 weeks of gestation from 2006 to 2013. The data collected included the gestational age at diagnosis, serial echocardiographic findings, karyotype testing, and pregnancy outcome. Read More

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September 2014

Nocturnal Awakening & Sleep Duration in Veterans with PTSD: An Actigraphic Study.

Pak J Med Sci 2013 Jul;29(4):991-6

Thomas Hurwitz, MD, Minneapolis VA Medical Center, University of Minnesota, State of Minnesota, USA.

Objective: To assess whether awakenings from sleep and sleep duration in Post Traumatic Stress Disorder (PTSD) were related to demography, posttraumatic or depressive symptoms, subjective sleep quality, and daytime sleepiness.

Methods: Sample consisted of 23 veterans with lifetime PTSD and current sleep disturbance not due to apnea or other diagnosable conditions. Data collection included demography, two weeks of actigraphy, Beck Depression Inventory, Posttraumatic Checklist, Clinical Assessment of Posttraumatic Symptoms, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale. Read More

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Fetal functional brain age assessed from universal developmental indices obtained from neuro-vegetative activity patterns.

PLoS One 2013 18;8(9):e74431. Epub 2013 Sep 18.

Jena University Hospital, Biomagnetic Center, Hans Berger Department of Neurology, Jena, Germany.

Fetal brain development involves the development of the neuro-vegetative (autonomic) control that is mediated by the autonomic nervous system (ANS). Disturbances of the fetal brain development have implications for diseases in later postnatal life. In that context, the fetal functional brain age can be altered. Read More

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Fetal circulation in left-sided congenital heart disease measured by cardiovascular magnetic resonance: a case-control study.

J Cardiovasc Magn Reson 2013 Jul 27;15:65. Epub 2013 Jul 27.

Department of Diagnostic Imaging, Hospital for Sick Children, University of Toronto, Toronto, Canada.

Background: The distribution of blood flow in fetuses with congenital heart disease (CHD) is likely to influence fetal growth, organ development, and postnatal outcome, but has previously been difficult to study. We present the first measurements of the distribution of the fetal circulation in left-sided CHD made using phase contrast cardiac magnetic resonance (CMR).

Methods: Twenty-two fetuses with suspected left-sided CHD and twelve normal controls underwent fetal CMR and echocardiography at a mean of 35 weeks gestation (range 30-39 weeks). Read More

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Determination of placental growth factor (PlGF) levels in healthy pregnant women without signs or symptoms of preeclampsia.

Pregnancy Hypertens 2013 Apr 19;3(2):124-32. Epub 2013 Jan 19.

The University of Texas Medical School at Houston, 6431 Fannin, MSB 3.286, Houston, TX 77030, United States. Electronic address:

Objective: To identify a reference range for placental growth factor (PlGF) in normotensive women without symptoms or signs of preeclampsia.

Study Design: Comprising the study cohort were 247 term pregnancies without preeclampsia or adverse neonatal outcomes from 16 sites in the US and Canada. Serial plasma samples were collected in 6 gestational age (GA) intervals between 20+0 and 40+0weeks. Read More

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Serum Cholesterol and Ceruloplasmin Levels in Second Trimester can Predict Development of Pre-eclampsia.

N Am J Med Sci 2013 Jan;5(1):41-6

Department of Obstetrics and Gynaecology, Armed Forces Medical Services, India.

Background: Pre-eclampsia is one of the leading causes of high rates of maternal and perinatal mortality and morbidity. Pathophysiology of pre-eclampsia is still obscure. Currently, there are no screening tests for pre-eclampsia that are reliable, valid, and economical. Read More

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January 2013

Impact of Chikungunya on health related quality of life Chennai, South India.

PLoS One 2012 12;7(12):e51519. Epub 2012 Dec 12.

Training Division, National Institute of Epidemiology, Indian Council of Medical Research, Chennai, Tamil Nadu, India.

Background: Chikungunya Virus (CHIKV) infection affects large populations and leads to prolonged and debilitating pain affecting health related quality of life (HRQoL). We assess the impact of CHIKV on HRQoL of clinical CHIKV (C-CHIKV) patients in a suburban locality of Chennai City, South India. Further, we determined factors associated with clinical recovery among C-CHIKV patients. Read More

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Muscle function in a canine model of X-linked myotubular myopathy.

Muscle Nerve 2012 Oct;46(4):588-91

Department of Human Nutrition, Foods and Exercise, College of Agriculture & Life Sciences, Virginia Polytechnic and State University, Blacksburg, Virginia, USA 24060.

Introduction: We established a colony of dogs that harbor an X-linked MTM1 missense mutation.Muscle from affected male dogs exhibits reduction and altered localization of the MTM1 gene product, myotubularin, and provides a model analogous to X-linked myotubular myopathy (XLMTM).

Methods: We studied hindlimb muscle function in age-matched canine XLMTM genotypes between ages 9 and 18 weeks. Read More

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October 2012

Effects of CPAP on systemic hypertension in OSAH: a monocentric, observational, cohort study.

Respir Med 2012 Sep 28;106(9):1329-34. Epub 2012 Jun 28.

Divisione di Medicina Interna, Laboratorio per le patologie sonno-correlate, Ospedale di Umbertide, Perugia, Italy.

Background: Obstructive sleep apnea-hypopnea (OSAH) is a risk factor for development of systemic arterial hypertension (SAH) and can worse the control of established SAH. We investigated the effects of long-term continuous positive airway pressure (CPAP) treatment in controlling and preventing SAH in a large cohort of subjects referred for sleep study for suspected OSAH.

Methods: In 495 subjects of whom 422 with OSAH and 73 without OSAH, the clinical history was obtained, arterial blood pressure was measured and the current anti-hypertensive drugs was recorded at diagnosis and/or at CPAP start. Read More

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September 2012

Hepatic aminotransferases of normal and IUGR fetuses in cord blood at birth.

Early Hum Dev 2012 Jul 2;88(7):461-5. Epub 2011 Dec 2.

Dept. of Obstet. and Gynecol., Poznan University of Medical Sciences, Poland.

Background: The accepted standard for assessing the wellbeing of the newborn is the Apgar score and blood gas analysis. However, the prediction of neonatal morbidity or mortality is limited. In small-for-gestation (SGA) fetuses at 18-38 weeks of gestation, pO(2) is <5th centile both in the umbilical artery and vein in 30%. Read More

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Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina.

PLoS One 2011 30;6(9):e24074. Epub 2011 Sep 30.

School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvanis, United States of America.

A homozygous mutation in STK38L in dogs impairs the late phase of photoreceptor development, and is followed by photoreceptor cell death (TUNEL) and proliferation (PCNA, PHH3) events that occur independently in different cells between 7-14 weeks of age. During this period, the outer nuclear layer (ONL) cell number is unchanged. The dividing cells are of photoreceptor origin, have rod opsin labeling, and do not label with markers specific for macrophages/microglia (CD18) or Müller cells (glutamine synthetase, PAX6). Read More

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[Changes of spectral EEG parameters in normals at two week follow-up].

Zh Nevrol Psikhiatr Im S S Korsakova 2011 ;111(2):64-71

Computer EEG is commonly used in longitudinal clinical studies though physiological changes of electrical brain activity during repeated EEG recordings are poorly known. Resting eyes-closed EEG was recorded twice in two weeks in 14 healthy subjects (13 women, aged 25-69 years). At follow-up, the significant decrease of alpha and theta-2 power, along with changes of alpha-1 and alpha-2 mean frequencies in the right hemisphere, was observed. Read More

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Reduction of novel circulating long-chain fatty acids in colorectal cancer patients is independent of tumor burden and correlates with age.

BMC Gastroenterol 2010 Nov 29;10:140. Epub 2010 Nov 29.

Phenomenome Discoveries Inc, Saskatoon, Saskatchewan, Canada.

Background: Serum levels of novel hydroxy polyunsaturated ultra long-chain fatty acids (hPULCFAs) have been previously shown to be reduced in pre-treatment CRC patients compared to disease-free subjects, independent of disease stage. However, whether reduced levels of hPULCFAs result from the presence of cancer is currently unknown, as is the distribution of hPULCFAs in the general population. The following studies were carried out to assess whether conventional therapy would result in restoration of systemic hPULCFAs in CRC patients, and to investigate the relationship between hPULCFA levels and age. Read More

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November 2010

Trans-catheter aortic valve implantation--early recovery of left and preservation of right ventricular function.

Interact Cardiovasc Thorac Surg 2011 Jan 18;12(1):35-9. Epub 2010 Oct 18.

Heart Centre, Umeå University, Umeå, Sweden.

This study aimed to assess the early effect of trans-catheter aortic valve implantation (TAVI) on right (RV) and left ventricular (LV) function in severe aortic stenosis (AS) patients. Twenty AS patients (age 79±6 years) were examined before, one week and six weeks after TAVI using Doppler echocardiography. LV ejection fraction (EF), long-axis [mitral annular plane systolic excursion (MAPSE)] and RV long-axis [tricuspid annular plane systolic excursion (TAPSE)] function, septal radial motion were studied. Read More

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January 2011

Establishing the proteome of normal human cerebrospinal fluid.

PLoS One 2010 Jun 11;5(6):e10980. Epub 2010 Jun 11.

Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, USA.

Background: Knowledge of the entire protein content, the proteome, of normal human cerebrospinal fluid (CSF) would enable insights into neurologic and psychiatric disorders. Until now technologic hurdles and access to true normal samples hindered attaining this goal.

Methods And Principal Findings: We applied immunoaffinity separation and high sensitivity and resolution liquid chromatography-mass spectrometry to examine CSF from healthy normal individuals. Read More

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Transperineal ultrasound in the assessment of haemorrhoids and haemorrhoidectomy: a pilot study.

Authors:
A P Zbar R Murison

Tech Coloproctol 2010 Jun;14(2):175-9

Department of Surgery, Tamworth Rural Referral Centre, Universities of New England and Newcastle, PO Box 2064, Tamworth, NSW 2340, Australia.

Background: The purpose of the study was the measurement of the anal cushion area using static transperineal ultrasound in a group of patients with symptomatic grade III and IV haemorrhoids about to undergo haemorrhoidectomy and compare them with a group of age-matched normals and the measured area following haemorrhoidectomy.

Methods: Transperineal sonography was performed using a linear transducer measuring the anal cushion area by subtracting the measured luminal diameter of the undisturbed anal canal from the inner border of the internal anal sphincter. Measures were made 6 weeks following haemorrhoidectomy. Read More

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Primary cell culture of meningothelial cells--a new model to study the arachnoid in glaucomatous optic neuropathy.

Graefes Arch Clin Exp Ophthalmol 2010 Sep 8;248(9):1273-8. Epub 2010 Apr 8.

Department of Biomedicine, University Eye Clinic, University Hospital Basel, Basel, Switzerland.

Background: In a previous report, we found that the occurrence and amount of meningothelial cell nests in the subarachnoid space are significantly increased in glaucomatous optic nerves compared to normals. In order to allow research into the role of meningothelial cells during diseases of the optic nerve, an in vitro model is necessary. For this purpose, we developed a culture method for porcine meningothelial cells from the arachnoid layer covering the optic nerve. Read More

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September 2010

[Effect of Cordceps Sinensis on the expression of ICAM-1 and VCAM-1 in the kidney of spontaneously hypertensive rats].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010 Feb;35(2):152-8

Department of Nephrology, Xiangya Hospital of Central South University, Changsha 410008, China.

Objective: To observe the effect of Cordceps Sinensis (CS) on the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in the kidney of spontaneously hypertensive rats(SHR), and to investigate the mechanism of CS.

Methods: Male SHRs (23 week old) were randomly divided into 4 groups: a group without any treatment (Group S), a group treated with Cordceps sinensis at 4 g/(kg.d)(Group C), a group treated with fosinopril at 10 mg/(kg. Read More

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February 2010